Iron Excessive (Hemochromatosis)

Iron Excessive (Hemochromatosis)—often called iron overload—happens when the body absorbs or retains too much iron. Extra iron is stored in organs like the liver, heart, and pancreas, where it can cause inflammation and long-term damage. Causes include hereditary hemochromatosis (HFE gene variants such as C282Y/H63D) and secondary iron overload from repeated transfusions or certain blood/ liver conditions.

Because early symptoms are subtle—fatigue, joint pain, or abnormal liver tests—lab testing is essential for screening, confirming iron overload, and monitoring trends over time. Ulta Lab Tests provides convenient access to ferritintransferrin saturationiron/TIBCliver enzymes, and HFE genetic testing, with fast, secure results you can review with your clinician.


Signs & Symptoms (When to consider testing)

  • General: persistent fatigue, weakness, low energy

  • Joints/skin: hand joint pain (2nd/3rd knuckles), stiffness; bronze or gray skin tone

  • Liver & abdomen: enlarged liver, right-upper abdominal discomfort, abnormal ALT/AST

  • Endocrine/metabolic: high blood sugar, new diabetes, low libido; menstrual changes

  • Heart: palpitations, shortness of breath, swelling; clinician may suspect cardiomyopathy/arrhythmia

  • Infections/risk clues: frequent skin infections; history of heavy alcohol use or hepatitis; many transfusions; family history of hemochromatosis

  • Population clue: Northern European ancestry is over-represented in HFE hereditary hemochromatosis

Related searches: iron overload tests, hemochromatosis labs, ferritin test, transferrin saturation, iron & TIBC, HFE genetic test, C282Y, H63D, secondary iron overload.


Why These Tests Matter

What iron overload labs can do

  • Detect excess iron stores (elevated ferritin) and increased iron absorption (high transferrin saturation)

  • Help differentiate hereditary (HFE variants) from secondary causes (transfusions, liver disease)

  • Provide baseline and trend data to monitor organ risk with your clinician

What they cannot do

  • Replace a clinical exam or imaging (e.g., MRI liver iron), which may be needed to quantify organ iron

  • Determine treatment by themselves—results must be interpreted by a qualified healthcare professional


What These Tests Measure (at a glance)

  • Ferritin: key indicator of stored iron; rises with overload but also with inflammation, infection, liver disease, alcohol use, or metabolic syndrome

  • Serum Iron, TIBC/Transferrin & Transferrin Saturation (%TS): %TS = (iron ÷ TIBC) × 100; elevated %TSsuggests increased absorption

  • Liver panel (ALT, AST, ALP, bilirubin, albumin): gauges liver involvement

  • CBC: looks for anemia/polycythemia; secondary causes may affect counts

  • HFE Genetic Testing (C282Y, H63D, others): identifies common hereditary risk variants; genotype helps with family counseling and risk stratification

  • Optional/clinician-ordered: CRP (inflammation context), MRI liver iron quantification, or specialty tests when indicated


How the Testing Process Works

  1. Order online: select an iron overload/hemochromatosis screen (Ferritin + Iron/TIBC with %TS) and add liver enzymes; consider HFE genetics if labs suggest overload or there’s a strong family history.

  2. Visit a nearby lab: quick blood draw (many providers prefer morning/fasting for iron/TIBC to reduce variability—follow your test instructions).

  3. Get results fast: most results post within 24–48 hours to your secure account.

  4. Review with your clinician: discuss whether follow-up (genetics, imaging, or other labs) is appropriate.


Interpreting Results (general guidance)

  • Transferrin saturation≥45% is commonly used as a screening threshold for iron overload (context matters).

  • Ferritin: persistently elevated values support excess stores; however, ferritin also rises with inflammation, fatty liver, alcohol, and infections—pair with %TS and clinical context.

  • HFE genotypeC282Y homozygous or C282Y/H63D compound heterozygous increases hereditary risk; penetrance varies (not all carriers develop organ damage).

  • Liver enzymes (ALT/AST): elevations may suggest liver stress from iron or other causes.

Only a clinician can integrate labs with history, exam, and (when needed) imaging to confirm diagnosis and plan next steps.


Choosing Panels vs. Individual Tests

  • Initial screen (symptoms/family history): Ferritin + Iron/TIBC with %TS + Liver panel

  • If screen suggests overload or strong family history: add HFE genetic testing

  • Transfusion-related or secondary causes: repeat ferritin/%TS to trend; clinician may add imaging to quantify organ iron

  • Monitoring: track ferritin and %TS at intervals recommended by your clinician


FAQs

What’s the difference between ferritin and transferrin saturation?
Ferritin reflects stored iron%TS reflects how much iron is bound to transferrin (absorption/availability). High %TSoften appears earlier in hereditary hemochromatosis.

Can a high ferritin mean inflammation instead of iron overload?
Yes. Ferritin is an acute-phase reactant. That’s why clinicians interpret ferritin with %TS, liver tests, and history.

Do I need to fast?
Many clinicians prefer morning/fasting for iron/TIBC/%TS to reduce variability. Follow the prep instructions on your order.

Who should consider genetic testing?
People with elevated %TS and/or ferritin, a family history of hemochromatosis, or unexplained liver enzyme elevations—decide with your clinician.

If I carry an HFE variant, will I definitely get sick?
Not necessarily. Penetrance is variable. Your clinician will pair genotype with labs and, if needed, imaging to assess risk.

How quickly will I get results?
Most iron studies and liver tests are available within 24–48 hoursgenetic testing may vary by assay.

Can supplements affect my results?
Iron or high-dose vitamin C can affect iron measures. Do not change supplements/medications without clinician guidance.


Internal Links & Cross-References

  • Blood Disorders Hub

  • Iron Deficiency Anemia

  • Blood Chemistry Tests

  • Hemoglobin Abnormalities

  • Liver Function Tests

  • Key Lab Tests: Ferritin • Iron & TIBC (Transferrin Saturation) • HFE Genetic Test • Liver Panel • CBC


Available Tests & Panels

Tip: Begin with Ferritin + Iron/TIBC (%TS) + Liver enzymes; add HFE genetics when screening labs or family history raise suspicion.

  • Page
  • 1
  • of
  • 1
  • Total Rows
  • 19
Name Matches
Blood, Varied
Blood Draw, Phlebotomist

The Hereditary Hemochromatosis DNA Mutation Analysis evaluates mutations in the HFE gene that contribute to hereditary iron overload. Abnormal results may explain unexplained fatigue, liver dysfunction, joint issues, or heart disease. This test supports assessment of genetic predisposition, metabolic balance, and systemic conditions caused by excess iron accumulation and hemochromatosis-related complications.

Blood
Blood Draw


Blood, Varied
Blood Draw, Phlebotomist

Most Popular

The Transferrin Test measures transferrin, a blood protein that transports iron, to evaluate iron status and nutritional health. High levels may suggest iron deficiency anemia, while low levels may indicate liver disease, malnutrition, or chronic illness. Doctors use this test alongside iron and TIBC to investigate fatigue, weakness, or anemia symptoms. Results provide vital insight into iron balance, red blood cell production, and overall metabolic function.

Blood
Blood Draw

Most Popular

The Ferritin Test measures ferritin, a protein that stores iron in the body, to evaluate iron levels and detect deficiency or overload. It helps diagnose anemia, iron deficiency, hemochromatosis, and chronic disease-related inflammation. Doctors often order the ferritin test to investigate fatigue, weakness, or unexplained symptoms. It is also used to monitor iron supplementation, treatment effectiveness, and overall iron metabolism health.

Blood
Blood Draw
Also Known As: Iron Storage Test

The Ferritin, Iron and Total Iron Binding Capacity Panel evaluates ferritin, total iron, TIBC, and % iron saturation to understand iron balance and storage. It helps identify anemia, iron deficiency, or overload that may affect energy, red blood cell production, and overall wellness.

Blood
Blood Draw

The Complete Blood Count with Differential and Platelets Test is a comprehensive blood test that checks red blood cells, white blood cells, hemoglobin, hematocrit, and platelets. The differential analyzes types of white blood cells to detect infections, anemia, clotting abnormalities, immune conditions, and certain cancers. This essential test is often ordered for routine health exams, diagnosis, and monitoring treatment progress.

Blood
Blood Draw
Also Known As: CBC Test, CBC with Differential and Platelets Test, CBC w/Diff and Platelets Test, Full Blood Count Test, Complete Blood Count Test

The Comprehensive Metabolic Panel (CMP) Test measures 21 markers to assess metabolic health, liver and kidney function, and electrolyte balance. It includes glucose, calcium, sodium, potassium, chloride, CO2, albumin, globulin, A/G ratio, total protein, bilirubin, ALP, AST, ALT, BUN, creatinine, BUN/creatinine ratio, and eGFR. The CMP helps detect diabetes, liver or kidney disease, and supports routine screening and chronic condition monitoring.

Blood
Blood Draw
Also Known As: CMP Test, Chemistry Panel Test, Chem Test, Chem 21 Test, Chem 14 Test 

The Fecal Globin by Immunochemistry Test detects hidden (occult) blood in stool using antibodies that identify human globin protein. This test helps screen for colorectal cancer, polyps, ulcers, and gastrointestinal bleeding. Doctors order it when patients have anemia, abdominal pain, or changes in bowel habits. Results provide early detection of digestive tract bleeding, guiding further evaluation with colonoscopy or other diagnostic procedures.

Varied
Phlebotomist
Also Known As: Fecal Immunochemical Test, Fecal Occult Blood Test, Stool Occult Blood Test, FIT Test, FOBT

The Hepatic Function Panel Test measures liver enzymes, proteins, and bilirubin to assess liver health and function. It includes ALT, AST, ALP, albumin, total protein, and bilirubin levels. Abnormal results may indicate hepatitis, cirrhosis, fatty liver, or bile duct problems. Doctors use this test to investigate jaundice, nausea, abdominal pain, or fatigue and to monitor liver disease, alcohol use, or medication side effects affecting liver function.

Blood
Blood Draw
Also Known As: Liver Function Panel Test, LFT

The Liver Function Panel, also known as a Hepatic Function Panel, measures proteins, enzymes, and bilirubin to assess liver health and function. It helps detect liver disease, monitor liver conditions, and evaluate the effects of medications or other factors on liver performance.

Blood
Blood Draw
Also Known As: Hepatic Function Panel Test, HFP Test

The Iron Total and Total Iron Binding Capacity (TIBC) Test measures iron levels in blood along with the blood’s ability to transport iron. It helps diagnose iron deficiency anemia, iron overload (hemochromatosis), and monitor nutritional or chronic health conditions. Low iron or high TIBC may indicate anemia, while high iron or low TIBC can suggest overload. Doctors use this test to evaluate fatigue, weakness, or other symptoms linked to iron and metabolic health.

Blood
Blood Draw
Also Known As: Serum Iron Test, Total Iron Binding Capacity Test, TIBC Test, UIBC Test

The Iron Micronutrient Test measures blood iron levels to evaluate nutritional status and detect deficiencies or excess. Iron is essential for hemoglobin production, oxygen transport, energy metabolism, and immune function. This test helps identify anemia, iron overload, absorption issues, or dietary imbalances, supporting diagnosis and management of overall health and vital body functions.

Patient must be 18 years of age or older.
Blood
Blood Draw
Also Known As: Serum Iron Test, Serum Fe Test

Most Popular

The Iron Total Test measures iron levels in blood to evaluate nutritional status, red blood cell production, and overall metabolic health. Abnormal levels may indicate iron deficiency anemia, chronic blood loss, or poor absorption, while high levels may suggest hemochromatosis, liver disease, or iron overload. Doctors use this test to investigate fatigue, weakness, or pallor and to monitor treatment. Results provide key insight into anemia and iron balance.

Blood
Blood Draw
Also Known As: Serum Iron Test, Serum Fe Test

The Mineral Micronutrients Test Panel measures minerals: Calcium, Chromium, Copper, Iron, Magnesium RBC, Manganese, Molybdenum, Selenium, and Zinc to assess nutritional balance and overall health. These minerals are essential for bone strength, metabolism, energy production, antioxidant defense, and immune function. The panel helps detect deficiencies, excesses, or absorption issues, guiding health management.

Patient must be 18 years of age or older.

The Soluble Transferrin Receptor Test evaluates blood sTfR concentration to assess iron metabolism and red blood cell production. It is particularly useful for differentiating iron deficiency anemia from anemia of chronic disease, since sTfR remains stable in the presence of inflammation. This test helps clinicians identify hidden iron deficiency, monitor treatment response, and evaluate hematopoietic activity in various clinical contexts.

Blood
Blood Draw

The Zinc Protoporphyrin (ZPP) Test measures ZPP levels in red blood cells to detect iron deficiency and lead exposure. When iron is low or lead interferes with hemoglobin production, ZPP accumulates, making it a sensitive early marker. Doctors use this test to screen for iron-deficiency anemia, monitor occupational lead exposure, and evaluate unexplained anemia, helping guide diagnosis, prevention, and treatment strategies.

Blood
Blood Draw
Also Known As: ZPP Test, ZP Test, Free Erythrocyte Protoporphyrin Test, FEP Test

Blood
Blood Draw, Phlebotomist

Hemochromatosis is a disease that causes too much iron to build up in your body, which is problematic because excessive iron damages your organs, especially your liver, your heart, and your pancreas. An estimated one million people in the United States suffer from this condition.

Fortunately, if hemochromatosis is diagnosed early on, it can be treated before serious complications arise. Read on to learn more about this condition, including risk factors, signs and symptoms, and where and how to get hemochromatosis tests.

About Hemochromatosis

There are two types of hemochromatosis, primary and secondary. Primary hemochromatosis is a genetic condition, meaning it is caused by a mutation in your genes. This type of hemochromatosis is passed down from family members.

Secondary hemochromatosis is caused by excessive amounts of iron in your body. This type of hemochromatosis is not as common, and it can't be detected through a hemochromatosis DNA test.

Risk Factors of Hemochromatosis

The HFE gene is the primary cause of genetic hemochromatosis. If you have two abnormal genes, one from each parent, you are more likely to develop hemochromatosis.

Not everyone who has two abnormal genes develops the condition. Even if you have two abnormal genes and do not develop hemochromatosis, you may still pass the condition down to your children. If you are worried about passing an HFE gene abnormality onto a child, you may want to consider speaking with a genetic counselor.

If you have one abnormal gene, it is possible, but unlikely, that you will ever develop hemochromatosis. You can pass that gene on to your children, but they will not be considered at high risk unless your partner also carries an abnormal gene.

While anyone can suffer from hemochromatosis, males are at a higher risk for developing it than females. Caucasians, particularly those from Northern Europe, are also at a higher risk than other ethnic groups.

Because iron is stored in your blood, people who are required to have regular blood transfusions are at risk of developing secondary hemochromatosis. A person would rarely develop secondary hemochromatosis from diet alone. However, people who are taking iron supplements are also at a higher risk of developing this condition.

Signs and Symptoms of Hemochromatosis

Symptoms of hemochromatosis can vary by person and in severity. They may include:

  • Abdominal Pain
  • Bronze or gray skin color
  • Diabetes
  • Heart or liver failure
  • Impotence
  • Joint Pain
  • Loss of sex drive or impotence in men
  • Memory fog and fatigue

The early signs of hemochromatosis are fatigue, abdominal and joint pain, and a change in skin color or complexion. Since they are mild, they are often overlooked or attributed to other conditions. Conditions such as diabetes and heart and liver failure don't arise unless hemochromatosis has gone undiagnosed and untreated for a considerable length of time. If you know you have some of the risk factors listed above, it is a good idea to stay on top of your health and get tested before serious problems arise.

Treatment for Hemochromatosis

Treatment for hemochromatosis can involve changes to your diet, including discontinuing iron supplements. You may also be prescribed certain medications or need to undergo regular phlebotomy to remove blood to keep your iron levels in check. 

Hemochromatosis Tests

If you know that one or both of your parents suffers from hemochromatosis or has inherited a gene for the condition, it is a good idea to do a hemochromatosis DNA test. If left untreated, the complications from hemochromatosis are severe, so staying on top of the condition is strongly recommended.

A DNA test will tell you if you have one or both gene abnormalities for hemochromatosis, but a positive test doesn’t mean you have hemochromatosis. Not everyone who has both gene abnormalities develops the condition. 

There are several ways to obtain a hemochromatosis DNA test, but the simplest way is to order one online. Ulta Lab Tests offers two types of hemochromatosis tests. These tests can even identify other family members who are at risk.

In addition to DNA tests, blood tests that measure the amount of iron in your blood are also used to diagnose hemochromatosis. A total iron-binding capacity (TIBC test) shows your total iron levels and how well your body carries or transports iron throughout your body. It can assist your healthcare provider in diagnosing hemochromatosis.

Two other lab tests that help diagnose hemochromatosis are a transferrin lab test and a ferritin lab test. High ferritin levels can indicate hemochromatosis. It is always a good idea to share your test results with your healthcare provider, even if your levels are within a normal range.

Benefits of Hemochromatosis Lab Testing with Ulta Lab Tests

There are several benefits to ordering your lab test through Ulta Lab Tests. First, tests from Ulta Lab Tests are more affordable than going through a doctor’s office. This is because we keep overhead costs low, so we can pass the savings directly along to our customers.

Another advantage is that your test results will come quickly, within one to two business days for most tests. They will be delivered directly to your patient portal. You do not need an insurance card or a doctor’s referral to order a test which saves you time and money.

If you are not sure which test to order, Ulta Lab Tests offers live customer support. They can answer any questions you may have. All tests also come with a 100 percent satisfaction guarantee, so there is no risk in ordering.

Ordering Your Tests with Ulta Lab Tests

Ulta Lab Tests offers tests that are highly accurate and reliable so you can make informed decisions about your health.

• You'll get secure and confidential results
• You don't need health insurance
• You don't need a physician's referral
• You'll get affordable pricing
• We offer 100% satisfaction guarantee

Order your hemochromatosis lab tests today and your results will be provided to you securely and confidentially online in 24 to 48 hours for most tests.

Take control of your health with Ulta Lab Tests today!