The Vitamin D, 1,25-Dihydroxy, LC/MS/MS test contains 1 test with 3 biomarkers.
Description: Vitamin D, 1,25-Dihydroxy, LC/MS/MS is a blood test that measures calcitriol (1,25-Dihydroxyvitamin) in your blood's serum.
Also Known As: Calcitriol Test
Collection Method: Blood Draw
Specimen Type: Serum
Test Preparation: No preparation required
Average Processing Time: 4 to 5 days
When is a Vitamin D 1,25-Dihydroxy test ordered?
When renal illness or problems of the enzyme that converts 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D are suspected, 1,25-dihydroxyvitamin D tests may be requested. This test is only performed in rare cases when calcium levels are high or a person has an illness that produces excessive amounts of vitamin D, such as sarcoidosis or some types of lymphoma.
Vitamin D levels are sometimes evaluated to check therapy success when vitamin D, phosphorus, calcium or magnesium supplementation is required.
What does a Vitamin D 1,25-Dihydroxy blood test check for?
Vitamin D is a group of chemicals that are necessary for the healthy development and growth of teeth and bones. The level of vitamin D in the blood is determined by this test.
Vitamin D is tested in the blood in two forms: 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D. The primary form of vitamin D found in the blood is 25-hydroxyvitamin D, which is a relatively inactive precursor to the active hormone 1,25-dihydroxyvitamin D. 25-hydroxyvitamin D is routinely evaluated to assess and monitor vitamin D status in humans due to its longer half-life and higher concentration.
Endogenous vitamin D is created in the skin when exposed to sunshine, whereas exogenous vitamin D is taken through foods and supplements. Vitamin D2 and vitamin D3 are two separate kinds of vitamin D with somewhat different chemical structures. Fortified foods, as well as most vitamin preparations and supplements, include the D2 form. The type of vitamin D3 produced by the body is also used in some supplements. When the liver and kidneys convert vitamin D2 and D3 into the active form, 1,25-dihydroxyvitamin D, they are equally effective.
Vitamin D's major function is to assist balance calcium, phosphorus, and magnesium levels in the blood. Vitamin D is necessary for bone growth and health; without it, bones become fragile, misshapen, and unable to mend themselves properly, leading to disorders such as rickets in children and osteomalacia in adults. Vitamin D has also been proven to influence the growth and differentiation of a variety of other tissues, as well as to aid in immune system regulation. Other illnesses, such as autoimmune and cancer, have been linked to vitamin D's other roles.
According to the Centers for Disease Control and Prevention, two-thirds of the US population has adequate vitamin D, while one-quarter is at risk of inadequate vitamin D and 8% is at risk of insufficiency, as defined by the Institute of Medicine's Dietary Reference Intake.
The elderly or obese, persons who don't receive enough sun exposure, people with darker skin, and people who take certain drugs for lengthy periods of time are all at risk of insufficiency. Adequate sun exposure is usually defined as two intervals of 5-20 minutes each week. Vitamin D can be obtained through dietary sources or supplements by people who do not get enough sun exposure.
Lab tests often ordered with a Vitamin D 1,25-Dihydroxy test:
- Vitamin D 25-Hydroxy (D2 and D3)
- Calcium
- Phosphorus
- PTH
- Magnesium
- Bone Markers
- Trace Minerals
Conditions where a Vitamin D 1,25-Dihydroxy test is recommended:
- Osteoporosis
- Kidney Disease
- Lymphoma
- Autoimmune Disorders
- Cystic Fibrosis
- Celiac Disease
- Malabsorption
- Malnutrition
How does my health care provider use a Vitamin D 1,25-Dihydroxy test?
Determine whether a deficit or excess of vitamin D is causing bone weakening, deformity, or improper calcium metabolism.
Because PTH is required for vitamin D activation, it can aid in diagnosing or monitoring problems with parathyroid gland function.
Because vitamin D is a fat-soluble vitamin that is absorbed from the intestine like a fat, it can help monitor the health of people with conditions that interfere with fat absorption, such as cystic fibrosis and Crohn's disease.
People who have had gastric bypass surgery and may not be able to absorb adequate vitamin D should be closely monitored.
When vitamin D, calcium, phosphorus, and/or magnesium supplementation is suggested, it can help assess the success of the treatment.
What do my Vitamin D, 1,25-Dihydroxy test results mean?
In kidney illness, a low level of 1,25-dihydroxyvitamin D is one of the first alterations to appear in people with early renal failure.
A high amount of 1,25-dihydroxyvitamin D can arise when there is an excess of parathyroid hormone or when there are disorders that can produce 1,25-dihydroxyvitamin D outside of the kidneys, such as sarcoidosis or some lymphomas.
We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.
