Total Glutathione in Whole Blood

The Total Glutathione in Whole Blood test contains 1 test.

Clinical Significance

Total Glutathione in Whole Blood - Glutathione is a tripeptide formed by a peptide linkage between the amine group of cysteine linked to glycine and the carboxyl group of the glutamate side-chain. It is an abundant cellular reducing agent, whose major biological function is mitigating oxidative damage to biological macromolecules. Glutathione is also important in the metabolism and excretion of xenobiotic compounds. Glutathione is consumed to maintain cells in a reduced condition. Consequently, glutathione levels in patient samples are expected to be diminished in disease states where oxygen reactive species are involved, such as rheumatoid arthritis and atherosclerosis. Low glutathione levels have been linked to reduced dopamine production in neurons, which suggests a relationship to dopamine based neurological disorders such as parkinson's disease. High levels of glutathione have been linked to chemotherapy resistance in cancer treatments.

Preferred Specimen(s)

10 mL whole blood collected in an ACD (yellow-top) tube
Solution A volume: 8.5 mL; Solution B volume: 6 mL

Minimum Volume

1 mL (from a fully drawn ACD solution A or B tube)

Collection Instructions

Do not centrifuge. Send whole tube.
ACD collection tubes must be >50% filled in order to ensure proper mixture of ACD solution.

 

Methodology

Kinetic

Assay Category

The performance characteristics of the listed assay was validated by BioAgilytix Diagnostics. The US FDA has not approved or cleared this test. The results of this assay can be used for clinical diagnosis without FDA approval. BioAgilytix Diagnostics is a CLIA certified, CAP accredited laboratory for performing high complexity assays such as this one.

Reference Range(s)

373-838 uM

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

*Process times are an estimate and are not guaranteed. The lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

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