Sjögren's Antibodies (SS-A, SS-B)

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Also known as: Sjgrens Antibodies SSA SSB, SS-A & SS-B

Sjogren's Antibody (Ss-A)

Sjogren's Antibody (Ss-B)

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The Sjögren's Antibodies (SS-A, SS-B) test contains 1 test with 2 biomarkers.

Brief Description: The Sjögren's SS-A SS-B Antibodies test is a critical diagnostic tool used to identify Sjögren's syndrome, an autoimmune disorder primarily affecting the exocrine glands, leading to dry eyes and mouth. This test aids healthcare providers in confirming the presence of specific antibodies associated with this condition.

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: No preparation required

When and Why the Test is Ordered:

A Sjögren's SS-A SS-B Antibodies test is typically ordered when a patient presents with symptoms of dry eyes and dry mouth, which are characteristic of Sjögren's syndrome. The test is especially relevant if there is a suspicion of autoimmune involvement due to the systemic nature of the condition.

What the Test Checks For:

The Sjögren's SS-A SS-B Antibodies test measures the presence and levels of antibodies directed against SS-A (Ro) and SS-B (La) antigens. These antibodies are associated with Sjögren's syndrome and can be indicative of the autoimmune nature of the disorder.

Other Lab Tests and Their Purpose:

When a Sjögren's SS-A/SS-B Antibodies test is ordered, it's often part of a broader evaluation for autoimmune disorders and related symptoms. Here are some tests commonly ordered alongside it:

  1. Antinuclear Antibody (ANA) Test:

    • Purpose: To detect antibodies that target the body’s own tissues, indicative of autoimmune disorders.
    • Why Is It Ordered: To screen for autoimmune diseases, including Sjögren's syndrome, as ANA is often positive in these conditions.
  2. Rheumatoid Factor (RF):

    • Purpose: To detect an antibody (RF) that is often present in autoimmune diseases like rheumatoid arthritis (RA).
    • Why Is It Ordered: To assess for overlapping autoimmune conditions, as Sjögren's syndrome can occur in conjunction with RA and other autoimmune disorders.
  3. Erythrocyte Sedimentation Rate (ESR) and C-Reactive Protein (CRP):

    • Purpose: To measure markers of inflammation in the body.
    • Why Is It Ordered: To assess the level of systemic inflammation, which can be elevated in autoimmune diseases.
  4. Complete Blood Count (CBC) with Differential:

    • Purpose: To evaluate overall blood health.
    • Why Is It Ordered: To check for signs of anemia or other hematological changes that can occur with autoimmune diseases.
  5. Thyroid Function Tests:

    • Purpose: To assess thyroid function.
    • Why Is It Ordered: Because autoimmune thyroid disorders, such as Hashimoto's thyroiditis, can coexist with Sjögren's syndrome.

These tests, when ordered alongside a Sjögren's SS-A/SS-B Antibodies test, provide a comprehensive evaluation of autoimmune status and help in diagnosing Sjögren's syndrome. They are crucial for assessing related symptoms, ruling out or identifying coexisting autoimmune conditions, and guiding appropriate treatment. The specific combination of tests will depend on the individual’s symptoms, clinical presentation, and medical history.

Conditions Requiring the Test:

The Sjögren's SS-A SS-B Antibodies test is ordered to confirm or diagnose Sjögren's syndrome, an autoimmune disorder characterized by:

  • Dry Eyes and Dry Mouth: Sjögren's syndrome predominantly affects the exocrine glands, leading to dry eyes (keratoconjunctivitis sicca) and dry mouth (xerostomia).

  • Autoimmune Component: The presence of SS-A and SS-B antibodies points to the autoimmune nature of the disorder.

Utilization of Test Results:

The results of the Sjögren's SS-A SS-B Antibodies test are pivotal for patient management:

  • Diagnosis: A positive test result, indicating the presence of SS-A and/or SS-B antibodies, supports the diagnosis of Sjögren's syndrome.

  • Treatment Planning: Test results contribute to the development of a targeted treatment plan to manage symptoms and halt disease progression.

  • Monitoring: For individuals diagnosed with Sjögren's syndrome, regular testing aids in monitoring disease activity and treatment effectiveness.

  • Prognosis: Test results help predict the course of the disease and guide healthcare providers in anticipating potential complications.

  • Research and Development: Data from the Sjögren's SS-A SS-B Antibodies test contribute to ongoing research into autoimmune disorders, antibody interactions, and potential therapeutic interventions.

In conclusion, the Sjögren's SS-A SS-B Antibodies test is an essential tool in diagnosing and managing Sjögren's syndrome. By detecting specific antibodies associated with the disorder, this test assists in providing timely treatment and improving patients' quality of life. It's not only a diagnostic tool but also a key asset in ongoing research and the advancement of autoimmune disorder understanding.

Most Common Questions About the Sjögren's SS-A SS-B Antibodies test:

Purpose and Applications

Why is the Sjögren's SS-A SS-B Antibodies test ordered?

The Sjögren's SS-A SS-B Antibodies test is primarily ordered to help diagnose Sjögren's syndrome, an autoimmune disorder characterized by dry eyes and mouth. It can also be used to diagnose other related rheumatic diseases.

What are the clinical indications for the Sjögren's SS-A SS-B Antibodies test?

This test may be ordered when a patient presents symptoms consistent with Sjögren's syndrome, such as persistent dry eyes, dry mouth, joint pain, and fatigue. It can also be relevant in the diagnosis of other autoimmune disorders, such as systemic lupus erythematosus (SLE).

Clinical Significance

What do elevated Sjögren's SS-A SS-B Antibodies levels indicate?

Elevated levels of these antibodies suggest an immune response typically associated with Sjögren's syndrome. While SS-A (also known as Ro) and SS-B (also known as La) antibodies are commonly found in Sjögren's syndrome, they can also be present in other autoimmune disorders.

How are the results of the Sjögren's SS-A SS-B Antibodies test interpreted in the absence of clinical symptoms?

If the antibodies are detected without the typical clinical symptoms of Sjögren's syndrome, it may indicate a subclinical or early form of the disease. Alternatively, it could suggest another autoimmune disorder or a false-positive result. It's crucial to correlate the test results with clinical findings and consider other diagnostic tests.


Can a person test positive for only one of the antibodies (SS-A or SS-B) and still have Sjögren's syndrome?

Yes, it's possible. Some patients with Sjögren's syndrome might only test positive for SS-A (Ro) without the presence of SS-B (La) antibodies and vice versa. However, a positive result for both antibodies together is more specifically associated with Sjögren's syndrome.

Do elevated Sjögren's SS-A SS-B Antibodies levels indicate disease severity?

Not necessarily. While the presence of these antibodies can confirm an autoimmune response, the levels do not typically correlate with the severity or progression of Sjögren's syndrome.

Additional Considerations

What other tests might be ordered alongside the Sjögren's SS-A SS-B Antibodies test?

Other tests that might be ordered include the Schirmer's test (to measure tear production), salivary flow test, and antinuclear antibody (ANA) test. These tests can provide a more comprehensive picture of the patient's condition and further support the diagnosis of Sjögren's syndrome.

If my Sjögren's SS-A SS-B Antibodies test results are abnormal, what's the next step?

If your results are abnormal, your healthcare provider will likely consider these findings in conjunction with your clinical symptoms, medical history, and results from other tests. Depending on the context, further diagnostic procedures or treatment recommendations might be initiated.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

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