Sickle Cell Trait Screen Test with Reflex

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Also known as: HB A2, HB F, HB S, Hemoglobin A2, Hemoglobin Electrophoresis, Hemoglobin F, Hemoglobin S, Hemoglobin Variants, HGB Electrophoresis, HGB Evaluation, HGB Variants, Thalassemia Screen


Hematocrit is a blood test that measures the percentage of the volume of whole blood that is made up of red blood cells. This measurement depends on the number of red blood cells and the size of red blood cells.


Serum hemoglobin is a blood test that measures the level of free hemoglobin in the liquid part of the blood (the serum). Free hemoglobin is the hemoglobin outside of the red blood cells. Most of the hemoglobin is found inside the red blood cells, not in the serum.

Hemoglobin A

Hemoglobin A2 (Quant)

Hemoglobin C

Hemoglobin E

Hemoglobin F

Hemoglobin S



Mean corpuscular hemoglobin (MCH) is a calculation of the average amount of oxygen-carrying hemoglobin inside a red blood cell.


Mean corpuscular volume (MCV) is a measurement of the average size of RBCs.

Other Hemoglobin 1


Red cell distribution width (RDW), which may be included in a CBC, is a calculation of the variation in the size of RBCs.

Red Blood Cell Count

An RBC count is a blood test that tells how many red blood cells (RBCs) you have. RBCs contain hemoglobin, which carries oxygen. How much oxygen your body tissues get depends on how many RBCs you have and how well they work.

Also known as: Hemoglobin S

Sickle Cell Screen

Screening test to determine presence of sickling hemoglobins, e.g., Hemoglobin S; Hemoglobin C, Harlem; Hemoglobin Georgetown.
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The Sickle Cell Trait Screen Test with Reflex panel contains 2 tests with 15 biomarkers.

Sickle Cell Trait Screen Test with Reflex

Intended Use:

This test screens for the presence of abnormal hemoglobin types such as Hemoglobin-S and Hemoglobin C Harlem. Physicians use it to help diagnose sickle cell anemia, a genetic blood disorder.

About the Test:

The test focuses on detecting Hemoglobin-S and Hemoglobin C Harlem, abnormal types of hemoglobin responsible for sickle cell anemia. Hemoglobin is the protein in red blood cells that carries oxygen. In sickle cell anemia, some red blood cells take on a sickle or crescent shape, becoming rigid and leading to blockages in blood flow. This can cause pain, anemia, and infections. Hemoglobin-S cells have a shorter lifespan, leading to a shortage of healthy red blood cells.

Sickle Cell Trait Screen:

This part of the test can indicate a positive or negative presence of Hemoglobin-S and/or Hemoglobin-C Harlem. If positive, a hemoglobinopathy evaluation will be conducted at no additional charge to further determine the presence of sickle cell disease or trait.

Hemoglobinopathy (Hb) Evaluation:

Includes several methods to provide results for Hemoglobin A, Hemoglobin A2, and any hemoglobin variants:

  • Hemoglobin Electrophoresis
  • Hemoglobin Fractionation by HPLC
  • Isoelectric Focusing
  • Mass Spectrometry
  • Capillary Zone

Sickle Cell Trait Screen Test with Reflex:

This detects abnormal types of hemoglobin in the blood. If abnormalities are found after the initial screening, additional tests are performed to determine the specific type of abnormal hemoglobin. A screen for the presence of abnormal types of hemoglobin, and if positive, a reflex test for the presence of sickle hemoglobin proteins (Hemoglobin S and Hemoglobin C-Harlem), is done.

Benefits of the Test:

Early Detection: Important for newborn screening, diagnosing, and monitoring sickle cell disease.
Comprehensive Analysis: A combination of tests gives a detailed view of different hemoglobin types.
Genetic Insight: Helps in understanding genetic predisposition to sickle cell anemia.
Interpretation of Results:

Positive/Negative Sickle Cell Trait Screen:

Indicates the presence or absence of Hemoglobin-S and/or Hemoglobin-C Harlem.
Hemoglobinopathy Evaluation: Details the types and quantities of various hemoglobins, aiding in diagnosis and monitoring.

Preparation and Precautions:

Specific instructions provided by the healthcare provider should be followed.
Inform the medical staff of any current medications or supplements.


A blood sample is required, and various laboratory techniques are applied to identify and measure different hemoglobin types.

Risks and Considerations:

Minimal risks associated with blood sampling.
Results should be interpreted by healthcare providers specializing in hematology.


The Sickle Cell Trait Screen Test with Reflex is a critical diagnostic tool in detecting, diagnosing, and understanding sickle cell anemia. Identifying abnormal hemoglobin types, such as Hemoglobin-S and Hemoglobin C Harlem, offers insight into this genetic disorder that affects red blood cells' shape and function. This comprehensive test plays a vital role in early detection, ongoing management, and genetic counseling related to sickle cell disease.

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