Phosphatidylserine/Prothrombin (PS/PT) Antibodies (IgG, IgM)

The Phosphatidylserine/Prothrombin (PS/PT) Antibodies (IgG, IgM) test contains 1 test with 2 biomarkers.

Phosphatidylserine/Prothrombin (PS/PT) Antibodies (IgG, IgM)

Clinical Significance

Phosphatidylserine/Prothrombin (PS/PT) Antibodies (IgG, IgM) - Antiphospholipid Syndrome (APS) is an acquired autoimmune thrombophilia characterized by thrombosis (venous and/or arterial or microvascular) and/or pregnancy loss or morbidity in association with persistent positivity of a heterogenous group of autoantibodies known as anti-phospholipid antibodies (APL). 
The international laboratory consensus criteria for the diagnosis of APS includes a positive lupus anticoagulant and/or moderate to high positivity for IgG/IgM Cardiolipin and Beta-2-Glycoprotein I antibodies. Although not included in the criteria classification for APS diagnosis, antibodies directed against a phosphatidylserine/prothrombin complex (PS/PT) have been reported to have a high association with venous thrombosis and obstetric abnormalities but not with arterial thrombosis. In addition, a very high degree of concordance between the concentration of aPS/PT and lupus anticoagulant activity has been demonstrated. 

Reference Range(s)

Alternative Name(s)

PSPT IgM Antibodies,aPS/PT IgG, IgM