The Fructosamine test contains 1 test with 1 biomarker.

Description: A Fructoasmine test is used to measure levels of glycated serum protein in your blood.

Also Known As: Glycated Serum Protein Test, GSP Test

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: No preparation required

When is a Fructosamine test ordered?

The fructosamine test, albeit not extensively utilized, can be ordered if a health care provider wants to track a person's average glucose levels over the previous two to three weeks. It's usually requested when a diabetes treatment plan is being begun or altered in order to track the impact of dietary, exercise, or medication changes.

Fructosamine levels may also be ordered on a regular basis if a diabetic woman is pregnant or if a person has an illness that alters their glucose and insulin needs for a period of time. When monitoring is needed but an A1c test isn't reliable, such as when a person's RBC life span is shortened or when the individual being examined has an abnormal hemoglobin, the fructosamine test may be utilized.

What does a Fructosamine blood test check for?

When glucose reacts with protein, a substance called fructosamine is generated. The total amount of fructosamine in the blood is determined by this test.

Glycation is a process in which glucose molecules permanently bind with proteins in the blood. Albumin, the main protein in the fluid portion of blood, as well as other serum proteins and hemoglobin, the key protein found inside red blood cells, are all affected proteins. The amount of glycated proteins generated is proportional to the amount of glucose in the blood. These mixed molecules remain in the circulation for as long as the protein or RBC is present, providing a record of the average quantity of glucose present in the blood throughout time.

Glycated hemoglobin is a measurement of the average blood glucose level during the previous 2 to 3 months, because RBCs have a lifespan of around 120 days. Because serum proteins only stay in the blood for 14 to 21 days, glycated proteins and the fructosamine test indicate average glucose levels over a two- to three-week period.

Keeping blood glucose levels as near to normal as possible helps diabetics avoid many of the difficulties and long-term harm that come with high glucose levels. In insulin-treated diabetics, good glycemic control is established and maintained through daily self-monitoring of glucose levels and occasional monitoring of treatment effectiveness with either a fructosamine or A1c test.

Lab tests often ordered with a Fructosamine test:

  • Glucose
  • Hemoglobin A1c
  • Albumin
  • Protein Total
  • Hemoglobinopathy Evaluation

Conditions where a Fructosamine test is recommended:

  • Diabetes

How does my health care provider use a Fructosamine test?

Fructosamine testing can assist a diabetic in monitoring and controlling his or her blood glucose level. Fructosamine levels in the blood are a reflection of glucose levels over the previous two to three weeks.

Both the fructosamine and A1c tests are largely used as monitoring tools to assist diabetics in controlling their blood sugar levels. The A1c test, on the other hand, is far more well-known and widely recognized since there is solid evidence that a chronically elevated A1c result indicates an increased risk of diabetic complications such as eye difficulties that could lead to blindness, kidney illness, and nerve damage.

The American Diabetes Association acknowledges the value of both tests and suggests that fructosamine could be used as a replacement in cases where A1c cannot be determined consistently. Fructosamine may be a better monitoring option than A1c in the following situations:

  • Fructosamine provides for rapid changes in diabetes management, allowing the effectiveness of dietary or pharmacological changes to be assessed after a few weeks rather than months.
  • Diabetic pregnancy – Good glycemic control is essential in diabetic women who are pregnant, and the mother's needs frequently change during pregnancy; fructosamine measurements may be ordered alongside glucose levels to help monitor and facilitate shifting insulin, glucose, or other medication requirements.
  • When a person has a disorder that affects the typical lifespan of red blood cells, such as hemolytic anemia or blood loss, an A1c test will be inaccurate. The A1c result is deceptively low when the lifespan of RBCs in circulation is limited, and it is an inconsistent indicator of a person's average glucose over time.
  • Hemoglobin variants - The existence of some hemoglobin variants, such as hemoglobin S in sickle cell anemia, may alter A1c measurement methodologies. Fructosamine can be used to check glucose management in these situations.

What do my Fructosamine test results mean?

A high fructosamine level indicates that a diabetic's average glucose level has been increased for the past two to three weeks. The higher the level of fructosamine, the higher the average blood glucose level. It's possible that tracking the trend of values is more significant than tracking a single high value. A rise in fructosamine levels from normal to high may suggest that a person's glycemic management is inadequate. This, however, does not identify the source of the problem. To assist get the person's glucose under control, a review and change to the person's diet and/or medication may be required. Acute illness and considerable stress can boost blood glucose levels briefly, thus these factors should be considered when interpreting data.

A normal fructosamine level may signal that a diabetic is in good control of their diabetes and that their present treatment strategy is working for them. A shift from high to normal fructosamine levels, on the other hand, may suggest that a person's treatment plan has been effective.

The effects of fructosamine must be considered in the context of a person's overall clinical findings. Reduced blood total protein and/or albumin levels, diseases linked with greater protein loss in the urine or gastrointestinal system, or changes in the type of protein produced by the body can all cause falsely low fructosamine levels. In this instance, there may be a disagreement between the findings of daily glucose monitoring and fructosamine testing. Also, someone with fluctuating glucose levels (high to low) may have normal or near-normal fructosamine and A1c values but yet have a disease that necessitates frequent monitoring. However, the majority of persons with such poor diabetes management have high fructosamine and A1c levels.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.


*Process times are an estimate and are not guaranteed. The lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

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