Estrogen Dominance Panel - Cycling Women

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The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.


Estradiol (estradiol-17 beta, E2) is part of an estrogen that is a group of steroids that regulate the menstrual cycle and function as the main female sex hormones. Estrogens are responsible for the development of female sex organs and secondary sex characteristics and are tied to the menstrual cycle and pregnancy. They are considered the main sex hormones in women and are present in small quantities in men. Estradiol (E2) is the predominant form of estrogen and is produced primarily in the ovaries with additional amounts produced by the adrenal glands in women and in the testes and adrenal glands in men. Estradiol levels are used in evaluating ovarian function. Estradiol levels are increased in cases of early (precocious) puberty in girls and gynecomastia in men. Its main use has been in the differential diagnosis of amenorrhea – for example, to determine whether the cause is menopause, pregnancy, or a medical problem. In assisted reproductive technology (ART), serial measurements are used to monitor follicle development in the ovary in the days prior to in vitro fertilization. Estradiol is also sometimes used to monitor menopausal hormone replacement therapy.

Also known as: Progesterone Immunoassay


Serum progesterone is a test to measure the amount of progesterone in the blood. Progesterone is a hormone produced mainly in the ovaries. In women, progesterone plays a vital role in pregnancy. After an egg is released by the ovaries (ovulation), progesterone helps make the uterus ready for implantation of a fertilized egg. It prepares the womb (uterus) for pregnancy and the breasts for milk production. Men produce some amount of progesterone, but it probably has no normal function except to help produce other steroid hormones.
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The Estrogen Dominance Panel - Cycling Women panel contains 2 tests with 2 biomarkers.

Brief Description: The Estrogen Dominance Panel for Cycling Women is specifically designed to assess the balance of key hormones in women who are still experiencing menstrual cycles. This panel focuses on the relationship between estradiol and progesterone, two crucial hormones that play significant roles in the menstrual cycle, fertility, and overall health. Understanding the levels and interaction of these hormones can help identify hormonal imbalances that may affect a woman's health and menstrual regularity.

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: No preparation required

When and Why the Estrogen Dominance Panel Cycling Women Panel May Be Ordered

This panel is often ordered for women experiencing symptoms suggestive of hormonal imbalances such as irregular menstrual cycles, severe premenstrual syndrome, fertility issues, or unexplained mood changes. It is also crucial for those undergoing treatments that may affect hormonal balance, such as hormone replacement therapy or certain types of birth control. The panel helps guide treatment decisions by providing detailed insights into the hormonal dynamics during the menstrual cycle.

What the Estrogen Dominance Panel Cycling Women Panel Checks For

The panel includes comprehensive testing of two primary hormones:

  • Estradiol: Estradiol is the most potent form of estrogen produced by the ovaries and plays a vital role in developing and maintaining female reproductive tissues. It also influences bone density, skin health, and mood. Measuring estradiol levels can help determine if hormonal imbalances related to excess or deficient estrogen production are occurring.

  • Progesterone: Progesterone is produced in the ovaries following ovulation and is critical for regulating the menstrual cycle and maintaining early stages of pregnancy. It balances the effects of estrogen. Testing progesterone levels can help assess ovulatory function and overall hormonal balance throughout the menstrual cycle.

Conditions and Diseases Detected by the Estrogen Dominance Panel Cycling Women Panel

This hormonal evaluation is instrumental in diagnosing and managing several conditions:

  • Estrogen Dominance: This occurs when there is an excessive amount of estrogen relative to progesterone. Symptoms can include weight gain, mood swings, and menstrual irregularities. Identifying estrogen dominance is crucial for preventing more severe hormonal disorders.

  • Polycystic Ovary Syndrome (PCOS): Characterized by hormonal imbalances that may affect menstrual cycles and fertility. Abnormal levels of estradiol and progesterone can be indicative of PCOS.

  • Menstrual Disorders: Various disorders, such as amenorrhea (absence of menstruation) or dysmenorrhea (painful menstruation), can be linked to imbalances in estradiol and progesterone levels.

Using the Results of the Estrogen Dominance Panel Cycling Women Panel

Healthcare professionals utilize the results from this panel to:

  • Diagnose and Treat Hormonal Imbalances: Accurate hormone level measurements enable the diagnosis of conditions like estrogen dominance or luteal phase defects and guide appropriate treatment strategies.

  • Monitor and Adjust Hormone Therapy: For women undergoing hormone replacement or contraceptive therapy, periodic testing ensures that hormone levels remain in a healthy range, and treatments are adjusted as needed.

  • Fertility Planning: Understanding the hormonal cycles can assist in fertility planning, providing insights into the best times for conception or the need for further fertility treatments.

The Estrogen Dominance Panel for Cycling Women is a valuable tool for exploring the intricate balance of hormones that regulate the reproductive system and overall health in women. By providing critical insights into estradiol and progesterone levels, this panel helps in diagnosing, treating, and monitoring conditions influenced by hormonal imbalances, thereby supporting women in achieving optimal health and well-being.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

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