Alkaline Phosphatase Isoenzymes Most Popular

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Alkaline Phosphatase

Alkaline phosphatase (ALP) is a protein found in all body tissues. Tissues with higher amounts of ALP include the liver, bile ducts, and bone.

Bone Isoenzymes


Intestinal Isoenzymes

Liver Isoenzymes

Macrohepatic Isoenzymes

Placental Isoenzymes

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The Alkaline Phosphatase Isoenzymes test contains 1 test with 7 biomarkers.

Brief Description: The Alkaline Phosphatase Isoenzymes test is a diagnostic tool that measures the different forms (isoenzymes) of the enzyme alkaline phosphatase (ALP) present in the blood. ALP is an enzyme found in various tissues throughout the body, with the highest concentrations being in the liver, bones, kidneys, and intestines. Each tissue produces a slightly different version of ALP, and these different versions are known as isoenzymes.

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: Overnight fasting is preferred

When and Why the Alkaline Phosphatase Isoenzymes Test May be Ordered

This test is typically ordered when an individual has an elevated total alkaline phosphatase level to determine the source of the elevation. By identifying the specific isoenzyme causing the elevation, clinicians can determine which tissue or organ is likely affected. This is essential for differential diagnosis, especially when trying to determine if the source of elevation is hepatic (from the liver) or osseous (from the bones).

What the Alkaline Phosphatase Isoenzymes Test Checks For

The test distinguishes between the different forms of ALP present in the blood. By doing so, it helps identify which tissue is releasing more ALP into the bloodstream. Common isoenzymes assessed include:

  • Liver (hepatic) ALP
  • Bone (osseous) ALP
  • Intestinal ALP
  • Placental ALP

Other Lab Tests Ordered Alongside the Alkaline Phosphatase Isoenzymes Test

When an ALP Isoenzymes test is ordered, it's usually part of a broader evaluation of liver and bone health. Here are some tests commonly ordered alongside it:

  1. Total Alkaline Phosphatase (ALP):

    • Purpose: To measure the overall level of alkaline phosphatase in the blood.
    • Why Is It Ordered: To confirm elevation of ALP, which prompts further investigation with isoenzymes to determine the source.
  2. Liver Function Test and GGT:

    • Purpose: To assess liver health.
    • Why Is It Ordered: To evaluate liver function and to help determine if the source of elevated ALP is hepatic. GGT (Gamma-glutamyl transferase) in particular is useful, as it is more specific to the liver and can help confirm hepatic origin of increased ALP.
  3. Calcium and Phosphorus Levels:

    • Purpose: To measure levels of calcium and phosphorus, minerals crucial for bone health.
    • Why Is It Ordered: To evaluate for imbalances that may be associated with bone diseases.
  4. Vitamin D Levels (25-Hydroxyvitamin D):

    • Purpose: To assess vitamin D status.
    • Why Is It Ordered: Low vitamin D can be associated with bone metabolism disorders.
  5. Parathyroid Hormone (PTH):

    • Purpose: To measure the level of PTH, a hormone important for regulating calcium metabolism.
    • Why Is It Ordered: To evaluate for hyperparathyroidism, which can cause bone turnover and affect alkaline phosphatase levels.
  6. Serum Electrophoresis:

    • Purpose: To separate and analyze various proteins in the blood.
    • Why Is It Ordered: To evaluate for certain conditions like multiple myeloma, which can elevate bone-specific ALP.

These tests, when ordered alongside an Alkaline Phosphatase Isoenzymes test, provide a comprehensive evaluation of potential sources of elevated ALP, helping to diagnose the underlying cause, whether related to liver or bone disorders, or less commonly, other sources. The specific combination of tests will depend on the individual’s symptoms, clinical presentation, and medical history.

Conditions Necessitating the Alkaline Phosphatase Isoenzymes Test

Conditions that might prompt a clinician to order this test include:

  • Liver diseases: Such as hepatitis, cirrhosis, or bile duct obstruction.
  • Bone disorders: Including osteomalacia, Paget’s disease, or bone tumors.
  • Certain cancers: That might metastasize to the liver or bone.
  • Gastrointestinal diseases: Like celiac disease, which can elevate intestinal ALP.

Usage of Alkaline Phosphatase Isoenzymes Test Results by Health Care Providers

The results of the ALP isoenzymes test provide clinicians with insights into which organ system might be malfunctioning. For example:

  • An elevated liver ALP in conjunction with other liver tests might point to a hepatic condition.
  • Increased bone ALP suggests a bone disorder.

By differentiating the source of elevated ALP, healthcare providers can narrow down their differential diagnoses and manage the patient's condition more effectively, determining the next steps in terms of more specialized tests, treatment plans, or referrals to specialists.

Most Common Questions About the Alkaline Phosphatase Isoenzymes test:

Purpose and Indications for the Alkaline Phosphatase Isoenzymes Test

Why is the Alkaline Phosphatase Isoenzymes test ordered?

The Alkaline Phosphatase Isoenzymes test is often ordered to determine the source of increased alkaline phosphatase (ALP) activity in the blood. ALP can be elevated due to liver disease, bone disorders, or other conditions. By evaluating the different isoenzymes, clinicians can pinpoint the origin of the elevation, be it from the liver, bones, intestines, or other tissues.

Can the Alkaline Phosphatase Isoenzymes test differentiate between liver and bone diseases?

Yes, this is one of the primary uses of the test. Different tissues produce distinct isoenzymes of ALP. By analyzing the specific isoenzymes present, doctors can determine if the source of increased ALP activity is primarily from the liver or the bones.

Interpreting the Results

What do elevated liver isoenzymes of ALP indicate?

Elevated liver isoenzymes of ALP often suggest liver damage or disease, such as hepatitis, cirrhosis, or bile duct obstructions.

If bone isoenzymes of ALP are raised, what might that imply?

Increased bone isoenzymes can be seen in conditions like Paget's disease of bone, osteomalacia, or bone cancers. They can also be elevated after bone surgery or in growing children and adolescents.

Follow-up and Treatment

If the Alkaline Phosphatase Isoenzymes test results are abnormal, what might be the next step?

Abnormal results would typically prompt further diagnostic tests to confirm and identify the specific underlying condition. For instance, if liver isoenzymes are elevated, a doctor might order liver imaging or a biopsy. Elevated bone isoenzymes might lead to bone scans or X-rays.

How do results from the Alkaline Phosphatase Isoenzymes test guide treatment decisions?

Identifying the source of elevated ALP helps tailor treatment. For instance, liver-related elevations might be addressed with medications, lifestyle changes, or surgical interventions for liver disease, while bone-related increases might require treatments for bone disorders.

Disease Monitoring and Complications

Can the Alkaline Phosphatase Isoenzymes test monitor the progress of liver or bone disease?

Yes, repeated testing can help assess the progression of the disease or the effectiveness of treatments. For instance, decreasing levels of liver isoenzymes might indicate that liver treatment is working.

Are there any conditions that can simultaneously raise both liver and bone isoenzymes of ALP?

While some conditions predominantly raise one type of isoenzyme, there are situations where both can be elevated. Metastatic cancers, especially those that spread to both liver and bones, are a prime example. Also, some rare genetic conditions might affect both tissues.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

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