The Systemic Lupus Erythematosus Disease Activity Panel assesses key lupus markers, including complement proteins, autoantibodies, and inflammatory indicators. It supports detection of lupus flares, monitoring of renal and systemic involvement, and evaluation of immune system dysregulation. This panel aids in tracking lupus severity, disease activity, and response to ongoing management.

The Systemic Lupus Erythematosus (SLE) Comprehensive Diagnostic Panel measures key autoimmune markers to aid in lupus diagnosis and monitoring. This panel includes ANA Screen with reflex, dsDNA, chromatin, Sm, RNP, Sjögren’s (SS-A, SS-B), and complement levels (C3c, C4c, CH50). Doctors order this test for patients with fatigue, joint pain, rash, or organ involvement. Results provide critical insight into immune activity, disease severity, and treatment guidance.

The Ribosomal P Antibody Test detects autoantibodies targeting ribosomal P proteins, which are strongly associated with systemic lupus erythematosus (SLE). These antibodies may indicate neuropsychiatric lupus, lupus nephritis, or other severe complications. By identifying ribosomal P autoantibodies, the test supports evaluation of autoimmune activity, disease progression, and differential diagnosis in lupus-related disorders.

The Lupus Anticoagulant Evaluation with Reflex measures PTT-LA and dRVVT to detect lupus anticoagulant antibodies, which increase risk of abnormal clotting. Reflex tests such as Hexagonal Phase Confirmation, Thrombin Clotting Time, and dRVVT mixing are performed if results are prolonged. Doctors use this panel to evaluate unexplained clotting, recurrent miscarriage, or autoimmune disease, aiding in diagnosis of antiphospholipid syndrome.

The C3a DesArg Fragment Test measures levels of C3a desarginated, a stable breakdown product of complement activation. Elevated concentrations reflect immune system activation and may indicate autoimmune disease, sepsis, allergic reactions, or inflammatory conditions. This test provides insight into complement pathway activity, helping evaluate immune dysregulation, monitor disease progression, or assess systemic inflammation.

The Sm Antibody Test measures antibodies against Smith antigens, strongly associated with systemic lupus erythematosus. It helps identify autoimmune activity, connective tissue disorders, and systemic inflammation. This test provides information about persistent symptoms including fatigue, arthritis, rash, or kidney involvement, supporting evaluation of lupus and related autoimmune disease.

The Cardiolipin IgG IgA IgM Antibodies Test detects autoantibodies linked to antiphospholipid syndrome (APS), a disorder that increases the risk of blood clots, stroke, and pregnancy complications. Measuring IgG, IgA, and IgM helps identify abnormal immune responses. Doctors use this test to evaluate patients with unexplained clotting, recurrent miscarriages, or autoimmune disease, guiding diagnosis and treatment of APS and related conditions.

The Complement Component C4c Test measures blood levels of C4c, a protein in the complement system that supports immune defense and inflammation control. Abnormal levels may indicate autoimmune disorders such as lupus, rheumatoid arthritis, or immune complex disease, as well as certain kidney conditions. Doctors use this test to evaluate complement activation, confirm diagnosis, and monitor treatment response in patients with suspected immune-related diseases.

The Complement Component C3c and C4c Test measures levels of two key proteins in the complement system, which supports immune defense and inflammation control. Abnormal results may indicate autoimmune disease, lupus, rheumatoid arthritis, or certain infections. Doctors use this test to investigate unexplained inflammation, monitor disease activity, and guide treatment decisions in patients with suspected immune or inflammatory disorders.

The Cardiolipin IgA Antibody Test detects IgA antibodies to cardiolipin, helping assess clotting disorders, autoimmune disease, and vascular complications. High levels are often linked to antiphospholipid syndrome, pregnancy loss, or thrombotic conditions. This test provides insight into immune activity, coagulation balance, and systemic disorders influenced by antibody-mediated vascular dysfunction.

The Sm and Sm/RNP Antibodies Test detects autoantibodies associated with systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD). Sm antibodies are highly specific for lupus, while Sm/RNP antibodies appear in MCTD and sometimes overlap syndromes. Physicians use this test to support diagnosis, evaluate autoimmune activity, and guide monitoring alongside other clinical findings and laboratory markers.

The Sjögren's SS-A Antibody Test detects SS-A (Ro) antibodies often linked to Sjögren’s syndrome, lupus, and other autoimmune disorders. These antibodies are associated with dry eyes, dry mouth, joint pain, and systemic inflammation. By measuring SS-A levels, the test supports evaluation of autoimmune activity, connective tissue disease, and overall immune system health in patients with persistent symptoms.

The RNP Antibody Test detects antibodies to ribonucleoprotein, an autoantigen linked to connective tissue and autoimmune diseases. Elevated levels may indicate mixed connective tissue disease, systemic lupus erythematosus, or other autoimmune disorders. This test provides valuable insight into immune system activity and is often performed alongside ANA and ENA panels for a broader evaluation of autoimmune health.

The Complement Component C3c Test measures levels of C3c, a protein involved in the immune complement system. Abnormal results may indicate autoimmune disorders, recurrent infections, or kidney disease linked to immune activity. Doctors use this blood test to evaluate complement activation, diagnose immune-related conditions, and monitor disease progression or treatment effectiveness in patients with suspected lupus, glomerulonephritis, or other immune disorders.

The Cardiolipin IgM Antibody Test measures IgM antibodies linked to antiphospholipid syndrome and autoimmune disorders. It helps evaluate unexplained blood clots, recurrent miscarriages, or abnormal clotting events. By detecting immune system activity against phospholipids, this test supports the assessment of vascular health, autoimmune activity, and risks related to thrombosis or systemic lupus erythematosus.

The Cardiolipin IgG Antibody Test detects IgG antibodies to cardiolipin, often associated with autoimmune disease. Abnormal results may indicate antiphospholipid syndrome, blood clotting disorders, or pregnancy complications. This test provides insight into thrombotic risk, vascular health, systemic inflammation, and immune activity linked to autoimmune conditions and antibody-mediated disease.

The Histone Antibodies Test detects autoantibodies against histone proteins, often associated with autoimmune disease. Positive findings may suggest drug-induced lupus, systemic lupus erythematosus, or other connective tissue disorders. This test aids in assessing immune response, identifying systemic inflammation, and providing information about autoimmunity and antibody-mediated disease.

The Lambda Light Chain Free Serum Test measures the concentration of free lambda light chains in the blood to evaluate plasma cell activity and detect abnormal immunoglobulin production. Elevated or imbalanced levels may indicate multiple myeloma, light chain disease, or other monoclonal gammopathies, helping monitor immune and bone marrow disorders.

The Complement Total CH50 Test measures overall activity of the complement system, a key part of the immune response that helps fight infections and regulate inflammation. Abnormal results may indicate autoimmune diseases such as lupus, complement deficiencies, or immune complex disorders. Doctors use this blood test to evaluate immune function, investigate recurrent infections, and monitor treatment in patients with suspected immune or autoimmune conditions.