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The Lymphogranuloma Venereum (LGV) Differentiation Antibody Panel uses micro-immunofluorescence (MIF) to measure IgG, IgA, and IgM antibodies to Chlamydia trachomatis (LGV L1 and non-LGV D–K) and related Chlamydiaspecies (C. pneumoniae and C. psittaci). It helps differentiate antibody patterns consistent with LGV versus other chlamydial exposures when cross-reactivity may complicate interpretation.