Fatty Acids and Omega

Fatty Acids and Omega Tests assess the balance of fats that support your heart, brain, eyes, immune system, and cell membranes. The most used metrics are the RBC Omega-3 Index (EPA+DHA in red blood cells), omega-6:omega-3 ratioAA/EPA ratio, and individual fatty acids such as EPA, DHA, DPA, ALA, LA, and AA.

Testing is helpful if you’re optimizing cardiometabolic health, planning pregnancy (DHA needs), following a vegan/vegetarian diet, managing inflammation-related concerns, monitoring supplement response, or dealing with malabsorption risks. Red-blood-cell (RBC) profiles reflect average intake over 8–12 weeks, while plasma tests reflect recent intake (days). Lab results can support screeningdiagnostic triage (e.g., suspected essential fatty acid deficiency), and monitoring—but they do not diagnose disease, determine treatment, or replace clinician guidance.

Signs, Symptoms & Related Situations

  • Cardiometabolic context: high triglycerides, central weight gain, family history of heart disease

  • Brain, mood, and eyes: attention or mood concerns, dry eyes, light sensitivity

  • Skin, hair, joints: dry/itchy skin, brittle nails, hair shedding, joint stiffness

  • Digestive or absorption risks: celiac disease, inflammatory bowel disease, bariatric surgery, chronic diarrhea, pancreatic disorders

  • Life stages & performance: pregnancy or planning (DHA), adolescence growth, older adults, endurance or strength training

  • Diet patterns: low-seafood intake, vegan/vegetarian diets, very low-fat or highly processed diets

  • Urgent care now: chest pain, severe shortness of breath, neurologic deficits, or rapidly worsening weakness—seek immediate medical care

Symptoms are nonspecific and should be evaluated by a qualified clinician.

Why These Tests Matter

What testing can do

  • Quantify status of omega-3 and omega-6 fats and identify imbalances

  • Track trends after diet or supplement changes (RBC profiles show medium-term effects)

  • Support targeted evaluations (e.g., suspected essential fatty acid deficiency, malabsorption)

What testing cannot do

  • Diagnose heart, brain, or eye disease by itself

  • Replace clinician judgment on nutrition, pregnancy, or medication decisions

  • Guarantee immediate detection of short-term changes when using RBC-based tests

What These Tests Measure (at a glance)

  • RBC Omega-3 Index (EPA+DHA % of total RBC fatty acids): longer-term status (~8–12 weeks). Useful for cardiometabolic and wellness tracking. Caveat: desirable ranges vary by lab; interpret with your clinician.

  • EPA, DHA, DPA (n-3): individual omega-3s; DHA is emphasized in pregnancy/brain/eye health.

  • ALA (n-3): plant omega-3; limited conversion to EPA/DHA.

  • LA and AA (n-6): essential omega-6s; AA relates to eicosanoid balance and is used in the AA/EPA ratio.

  • Omega-6:Omega-3 ratio & AA/EPA ratio: context for inflammatory balance; interpretation depends on the full profile.

  • Trans fatty acids: industrial or ruminant trans fats; lower is generally favorable.

  • Plasma/serum fatty acid profiles: reflect recent intake (days). Caveat: day-to-day diet strongly influences results.

  • Pre-analytical notes: Most profiles don’t require fasting, but some plasma tests prefer 8–12 hours fasting and avoiding high-dose omega-3 the morning of your draw. Follow the specific collection instructions.

Quick Build Guide

Goal / Scenario Start with Add if needed
Wellness baseline RBC Omega-3 Index RBC omega-3/omega-6 panel • Trans fats
Cardiometabolic focus RBC Omega-3 Index Omega-6:Omega-3 & AA/EPA ratios • Lipid panel (context)
Pregnancy/planning RBC DHA (within omega-3 panel) Full RBC profile for broader status
Vegan/vegetarian RBC Omega-3 Index ALA, EPA, DHA detail • B12 ± MMA (context)
Inflammation/aches RBC omega-3/omega-6 panel AA/EPA ratio • hs-CRP (steady-state context)
Malabsorption risk RBC omega-3/omega-6 panel Fat-soluble vitamins (vitamin D) • CMP
Supplement monitoring RBC Omega-3 Index Repeat in ~8–12 weeks to assess change

How the Testing Process Works

  1. Choose RBC vs. plasma: RBC profiles reflect long-term status; plasma reflects recent intake.

  2. Prepare for accuracy: fasting is usually not required; some plasma tests request 8–12 hours fasting and no morning omega-3 dose. Follow your order’s instructions.

  3. Provide a sample: standard blood draw.

  4. Access secure results: most post within a few days.

  5. Plan next steps: review with your clinician; results guide dietary discussions and monitoring cadence.

Interpreting Results (General Guidance)

  • Low RBC Omega-3 Index → consistent with low EPA/DHA status; discuss diet/sources and retest timing.

  • Borderline values → consider full profile (EPA, DHA, DPA, AA, ratios) and overall nutrition pattern.

  • High omega-6:omega-3 or high AA/EPA ratio → suggests a relative omega-3 shortfall or high omega-6 intake; interpret with the complete profile.

  • Elevated trans fats → may reflect processed-food patterns; trend after nutrition changes.
    Ranges and cutoffs vary by lab and population. Always interpret with a qualified healthcare professional.

Choosing Panels vs. Individual Tests

  • Core choice: RBC Omega-3 Index for medium-term status

  • Comprehensive view: RBC omega-3/omega-6 profile with omega-6:omega-3 and AA/EPA ratios ± trans fats

  • Targeted adds: Plasma fatty acid profile (short-term changes), vitamin Dlipid panelhs-CRP for context
    Use bundled panels for efficient screening; add individual markers to answer specific questions or to monitor change.

FAQs

Do I need to fast?
Usually no. Some plasma tests prefer 8–12 hours fasting; follow your order’s instructions.

Which is better—RBC or plasma?
RBC reflects 8–12 weeks of intake; plasma reflects recent intake (days). Choose based on your goal.

How soon after changing my diet should I retest?
For RBC measures, 8–12 weeks shows a meaningful change. Plasma can change within days.

Should I stop supplements before testing?
For plasma tests, avoid a large omega-3 dose the morning of your draw. RBC tests are less affected by a single dose. Follow your kit instructions.

Can these tests diagnose heart disease or depression?
No. They quantify fatty acid status and support nutrition planning; they don’t diagnose disease.

Are these tests useful in pregnancy?
They can help assess DHA status. Review results and goals with your obstetric clinician.

Related Test Categories & Key Tests

  • Nutrition Tests Hub

  • All Vitamin & Mineral Tests • Micronutrient Testing • Diet Tests • Metabolism Tests • Cholesterol Tests • Heart Health Tests

  • Key Tests: RBC Omega-3 Index (EPA+DHA) • RBC Omega-3/-6 Profile • Omega-6:Omega-3 Ratio • AA/EPA Ratio • DHA • EPA • DPA • ALA • LA • AA • Trans Fatty Acids • Plasma Fatty Acid Profile • Vitamin D • Lipid Panel • hs-CRP

References

  • NIH Office of Dietary Supplements — Omega-3 Fatty Acids Fact Sheet.
  • American Heart Association — Scientific statements on omega-3 fatty acids and cardiovascular health.
  • International Society for the Study of Fatty Acids and Lipids (ISSFAL) — Position papers on fatty acid analysis and health.
  • Academy of Nutrition and Dietetics — Evidence analyses on dietary fats and chronic disease.
  • Harris WS, von Schacky C — The Omega-3 Index as a risk factor for coronary heart disease; subsequent reviews.
  • World Health Organization/FAO — Fats and fatty acids in human nutrition reports.

Available Tests & Panels

Your Fatty Acids and Omega Tests menu is pre-populated in the Ulta Lab Tests system. Select an RBC Omega-3 Indexfor medium-term status, or a comprehensive RBC omega-3/omega-6 profile with ratios and trans fats for deeper insight. Use filters to add plasma profiles for short-term changes and context labs (vitamin D, lipids, hs-CRP). Follow collection instructions and review results with your clinician to align nutrition goals and set a retesting timeline.

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The Omega-3 and Omega-6 Fatty Acids Test measures essential fatty acids, including EPA, DHA, and arachidonic acid, to assess balance between omega-3 and omega-6 in the blood. This ratio is linked to heart health, inflammation, brain function, and metabolic wellness. Doctors use this test to evaluate diet quality, detect deficiencies or excess, and guide nutrition or supplement plans that support cardiovascular, cognitive, and overall long-term health.

Also Known As: OmegaCheck® Test

The Very Long Chain Fatty Acids (VLCFA) Test measures C22:0, C24:0, C26:0 and ratios (C24/C22, C26/C22), with phytanic and pristanic acids, by GC/MS to assess peroxisomal function. Abnormal VLCFAs support evaluation of X-linked adrenoleukodystrophy and Zellweger spectrum disorders, informing diagnosis of peroxisomal and neuro-metabolic disease in the right clinical context.

Blood
Blood Draw

The Comprehensive Fatty Acid Profile (C8–C26) analyzes 40+ fatty acids in serum—including medium, long, and very long chain species—to evaluate mitochondrial β-oxidation, peroxisomal disorders, essential fatty acid deficiency, or nutritional status. Abnormal patterns (e.g. elevated VLCFAs, altered w3/w6 ratios) help detect metabolic or peroxisomal defects and guide dietary or therapeutic interventions.

Blood
Blood Draw
Also Known As: Comprehensive Fatty Acid Test, Fatty Acids C8-C26 Test

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Blood Draw

 The Vitamins & Minerals + (Omegas, CMP & CBC) - Basic Panel is a foundational health assessment tool that integrates essential vitamin and mineral evaluations with omega fatty acid profiling, comprehensive metabolic analysis, and a complete blood count. This panel is meticulously designed to provide a holistic view of an individual's nutritional status, metabolic functioning, and overall hematological health, making it an invaluable resource for preventive health strategies and the management of various health conditions.
Blood
Blood Draw, Phlebotomist

 The Vitamins & Minerals + (Omegas, CMP & CBC) - Basic Plus panel is a thorough health assessment tool that combines critical evaluations of vitamins and minerals, omega fatty acid levels, comprehensive metabolic function, and a complete blood profile. This panel is designed to provide a holistic view of an individual's health, identifying potential nutritional deficiencies, metabolic disorders, and hematological conditions. It's an essential panel for those seeking a detailed understanding of their overall health status and nutritional needs.
Blood
Blood Draw, Phlebotomist

 The Vitamins & Minerals + (Omegas, CMP & CBC) - Advanced Panel is a comprehensive diagnostic tool designed to assess a broad spectrum of health indicators, including vital nutrients, metabolic health markers, omega fatty acid levels, and a detailed blood profile. This panel is meticulously curated to provide an in-depth understanding of various health aspects, from nutritional status and metabolic health to immune function and cardiovascular risk. It serves as a crucial resource for identifying potential health issues, guiding dietary and lifestyle modifications, and tailoring individualized treatment plans.
Blood, Other
Blood Draw, Phlebotomist

 The Vitamins & Minerals + (Omegas, CMP & CBC) - Comprehensive panel is an extensive diagnostic tool designed to provide an all-encompassing view of an individual's health. This panel evaluates a wide array of nutritional markers, metabolic functions, essential fatty acids, and blood health indicators. It's tailored to offer deep insights into the body's current nutritional status, identify potential deficiencies or excesses, and understand the overall metabolic and hematological health, making it an invaluable asset for comprehensive health assessments and personalized healthcare strategies.
Blood, Other
Blood Draw, Phlebotomist

The Complete Blood Count with Differential and Platelets Test is a comprehensive blood test that checks red blood cells, white blood cells, hemoglobin, hematocrit, and platelets. The differential analyzes types of white blood cells to detect infections, anemia, clotting abnormalities, immune conditions, and certain cancers. This essential test is often ordered for routine health exams, diagnosis, and monitoring treatment progress.

Blood
Blood Draw
Also Known As: CBC Test, CBC with Differential and Platelets Test, CBC w/Diff and Platelets Test, Full Blood Count Test, Complete Blood Count Test

The Comprehensive Metabolic Panel (CMP) Test measures 21 markers to assess metabolic health, liver and kidney function, and electrolyte balance. It includes glucose, calcium, sodium, potassium, chloride, CO2, albumin, globulin, A/G ratio, total protein, bilirubin, ALP, AST, ALT, BUN, creatinine, BUN/creatinine ratio, and eGFR. The CMP helps detect diabetes, liver or kidney disease, and supports routine screening and chronic condition monitoring.

Blood
Blood Draw
Also Known As: CMP Test, Chemistry Panel Test, Chem Test, Chem 21 Test, Chem 14 Test 

The Copper Micronutrient Plasma Test measures copper levels in the blood to evaluate nutritional status and detect deficiencies or excess. Copper is essential for red blood cell formation, connective tissue health, energy production, and nervous and immune system function. This test helps identify imbalances from poor diet, malabsorption, or toxicity, supporting diagnosis and management of overall health.

Patient must be 18 years of age or older.
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Blood Draw

Most Popular

The Copper Test measures copper levels in blood to evaluate nutritional status, liver function, and metabolic health. Abnormal levels may indicate Wilson’s disease, Menkes disease, liver disorders, or malnutrition. Both deficiency and excess copper can affect nervous system, immune function, and energy metabolism. Doctors use this test to investigate unexplained symptoms, monitor treatment, or assess copper-related disorders, providing key insight into overall health.

Blood
Blood Draw
Also Known As: Cu Test, Copper Serum Test, Copper Plasma Test

Most Popular

The Ferritin Test measures ferritin, a protein that stores iron in the body, to evaluate iron levels and detect deficiency or overload. It helps diagnose anemia, iron deficiency, hemochromatosis, and chronic disease-related inflammation. Doctors often order the ferritin test to investigate fatigue, weakness, or unexplained symptoms. It is also used to monitor iron supplementation, treatment effectiveness, and overall iron metabolism health.

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Blood Draw
Also Known As: Iron Storage Test

The Antioxidants Micronutrients Panel measures key antioxidants; Alpha Tocopherol, Beta Gamma Tocopherol, Coenzyme Q10, Vitamin A, and Vitamin C to evaluate the body’s defense against oxidative stress. These nutrients support immune health, cellular protection, energy production, and overall wellness. The test helps detect deficiencies or imbalances that may affect long-term health and disease prevention.

Patient must be 18 years of age or older.
Also Known As: Antioxidants Test

The Folate Micronutrient Test measures blood folate levels to assess nutritional status and detect deficiencies. Folate is essential for DNA synthesis, red blood cell production, and proper fetal development. This test helps identify dietary insufficiency, malabsorption issues, or increased nutrient needs, supporting the diagnosis and management of anemia, pregnancy health, and overall wellness.

Patient must be 18 years of age or older.
Blood
Blood Draw
Also Known As: Serum Folic Acid Test, Vitamin B9 Test

Most Popular

The Folate Serum Test measures folate (vitamin B9) levels in blood to evaluate nutritional status and overall health. Low folate may cause anemia, fatigue, weakness, or pregnancy complications, while high levels may reflect supplementation. Doctors order this test to investigate unexplained anemia, monitor prenatal health, or assess dietary deficiencies. It provides valuable insight into red blood cell production, metabolism, and nutritional balance.

Blood
Blood Draw
Also Known As: Serum Folic Acid Test, Vitamin B9 Test, Folate Test

Most Popular

The Homocysteine Test measures homocysteine levels in blood to assess risk for heart disease, stroke, and vascular problems. Elevated homocysteine may result from vitamin B6, B12, or folate deficiency and is linked to blood clots, cognitive decline, and osteoporosis. Doctors use this test to evaluate cardiovascular risk, monitor nutritional deficiencies, and guide treatment for metabolic or genetic conditions affecting homocysteine metabolism.

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Blood Draw
Also Known As: Homocysteine Cardiac Risk Test

The Iodine Serum/Plasma Test measures iodine levels in blood to evaluate thyroid health, hormone production, and nutritional balance. Abnormal levels may indicate iodine deficiency, leading to hypothyroidism or goiter, or excess iodine, which can disrupt thyroid function. Doctors use this test to investigate fatigue, weight changes, or thyroid disorders and to monitor supplementation. It provides valuable insight into endocrine, metabolic, and overall health.

Blood
Blood Draw
Also Known As: Iodine Test, Iodine Blood Test

The Iron Total and Total Iron Binding Capacity (TIBC) Test measures iron levels in blood along with the blood’s ability to transport iron. It helps diagnose iron deficiency anemia, iron overload (hemochromatosis), and monitor nutritional or chronic health conditions. Low iron or high TIBC may indicate anemia, while high iron or low TIBC can suggest overload. Doctors use this test to evaluate fatigue, weakness, or other symptoms linked to iron and metabolic health.

Blood
Blood Draw
Also Known As: Serum Iron Test, Total Iron Binding Capacity Test, TIBC Test, UIBC Test

Most Popular

The Magnesium Serum Test measures magnesium levels in blood to evaluate electrolyte balance, nerve and muscle function, and overall metabolic health. Abnormal levels may indicate kidney disease, malnutrition, gastrointestinal disorders, or uncontrolled diabetes. Low magnesium can cause weakness, cramps, or irregular heartbeat, while high levels may signal kidney dysfunction. Doctors use this test to diagnose deficiencies, monitor therapy, or assess chronic health conditions.

Blood
Blood Draw
Also Known As: Mg Test, Mag Test

The Magnesium Micronutrient RBC Test measures magnesium levels within red blood cells, providing a more accurate assessment of long-term magnesium status than serum tests. Magnesium is vital for muscle and nerve function, energy production, bone strength, and heart health. This test helps detect deficiencies or imbalances from poor diet, absorption issues, or medical conditions, supporting overall wellness.

Patient must be 18 years of age or older.
Other
Phlebotomist
Also Known As:

Magnesium Red Bood Cell Test, Mg Test, Mag Test


The Magnesium RBC Test measures magnesium inside red blood cells, providing a more accurate assessment of magnesium status than serum tests. Magnesium is vital for energy production, muscle and nerve function, heart rhythm, and bone health. Low levels may cause fatigue, cramps, arrhythmias, or weakness, while high levels may signal kidney issues. Doctors order this test to detect deficiency, monitor therapy, and evaluate overall metabolic and nutritional health.

Other
Phlebotomist
Also Known As: Magnesium Red Bood Cell Test, Mg Test, Mag Test

Most Popular

The Prealbumin Test measures levels of prealbumin, a protein made by the liver that reflects short-term nutritional status. Low levels may indicate malnutrition, liver disease, inflammation, or chronic illness, while high levels may be linked to kidney disease or steroid use. Doctors use this test to assess protein-calorie nutrition, monitor patients receiving nutritional support, and guide treatment for conditions affecting metabolism and recovery.

Blood
Blood Draw
Also Known As: Thyroxine-binding Prealbumin Test, Transthyretin Test

The Selenium Micronutrient Blood Test measures selenium levels in the blood to assess nutritional status and detect deficiencies or excess. Selenium is a powerful antioxidant that supports thyroid function, immune defense, and protection against oxidative stress. This test helps identify dietary insufficiency, malabsorption, or toxicity, supporting diagnosis and management of overall health and wellness.

Patient must be 18 years of age or older.
Blood
Blood Draw

Most Popular

The Selenium Test measures selenium levels in blood to evaluate nutritional status and overall health. Selenium is essential for thyroid function, antioxidant defense, and immune support. Low levels may cause fatigue, muscle weakness, thyroid problems, or impaired immunity, while high levels may indicate toxicity. Doctors use this test to monitor nutrition, supplementation, or suspected deficiency. Results provide key insight into metabolic health and antioxidant balance.

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Blood Draw

While dietary fatty acid deficiency is rare, people who suffer from it could experience different debilitating effects. However, it’s quite difficult to establish whether you have it or not. After all, the symptoms could be an indication of other conditions.

The chances are that if you are on this page, you have good reason to suspect a possible fatty acid dietary deficiency. If that’s the case, consider ordering fatty acid lab tests with Ulta Lab Tests today. We offer a highly accurate and reliable test to screen for abnormal levels of fatty acids along with other dietary deficiencies. But first, you may want to understand what this condition is all about and whether you have a reason to be concerned.

Keep reading to learn more about what a dietary fatty acid deficiency is. We will cover a general overview of dietary fatty acid deficiency and the test that can be used to diagnose or deny the condition.

What is a Fatty Acid?

Fatty acids are simply energy storage units that usually makeup components of cell membranes. They are an important composition of:

  • Red blood cells
  • White blood cells
  • Tissue cells
  • Plasma phosphatidylcholine.

The body usually acquires fatty acids through the consumption of dietary fat. It’s nearly impossible for the body to produce fatty acids on its own, which is why it’s integral for individuals to ensure that they are consuming enough fatty acids in their diet. There are only two forms of fatty acids that are considered essential to humans. These are:

  • Omega-3 fatty acid (alpha linolenic acid)
  • Omega-6 fatty acid (linoleic acid)

Other fatty acids are generally considered conditionally essential, meaning they might be essential for people with specific developmental conditions or diseases.

Why are Essential Fatty Acids Important?

Essential fatty acids are essential to your health. Your body needs an adequate intake of enough dietary fats to perform a number of vital functions. Some of these functions are:

  • Joint and bone health
  • Energy storage
  • Neurological health
  • Hair, skin, and eye health
  • Mental health
  • Minimizing risk factors for heart disease

Of course, there are many other factors than the one listed here. Still, a proper intake of dietary fatty acids isn't simply supplementary to your health. It’s absolutely necessary.

What Is Fatty Acid and Omega Deficiency?

Dietary fatty acids deficiency is also commonly referred to as essential fatty acids deficiency (EFAD). And just as the names indicate, it’s a lack of adequate fatty acid levels in the body. In many cases, it means an inadequacy in terms of linoleic acid or alpha-linolenic acid levels in the body.

It’s quite a rare condition, both in adults and children. Fortunately, EFAD is fairly uncommon in the US and can be caused by an inadequate intake of dietary fats. It’s a lot more common to have a deficiency in DHA and EPA, which are Omega-3 fatty acids.

What are the Main Causes of Deficiency in Fatty Acids?

The main cause for fatty acid deficiency is when an individual lacks adequate dietary fat intake. Adequate dietary fat intake can be ascertained by making sure you eat the proper amounts of the following foods:

  • Nuts
  • Cooking oils
  • Fish oil
  • Seeds
  • Animal fat

Eating whole foods is a great way to ensure that you’re consuming dietary fats. However, many individuals take Omega-3 supplements like vegan omega-3 supplements or fish oil to boost their otherwise inadequate dietary fat intake. Studies even show that there’s a link between reduced heart disease deaths and the higher omega-3 intake.

What Are the Risk Factors for Omega and Fatty Acids Deficiency?

The US has a great number of fatty food sources, and EFAD is quite uncommon. Still, there are individuals who develop this condition through fat-free or low-fat diets. For these cases, raising the dietary fat intake might be enough to regulate the essential fatty acid levels.

People at the end-stage of liver disease might also suffer from EFAD. This condition is part of a host of other problems related to malnutrition that people suffering from liver disease may experience. There are also populations that are specifically at risk for developing EFAD, both due to environmental or developmental conditions. The populations might suffer from conditions like:

  • Fat malabsorption conditions
  • Chronic malnutrition
  • Sjogren-Larsson syndrome
  • Acrodermatitis enteropathica

What Are the Signs and Symptoms of a Deficiency in Dietary Fatty Acids?

Essential fatty acid deficiency could be manifested through several signs and symptoms. Some of these include:

  • Anemia
  • Scaly, dry rash
  • Alopecia
  • Increased frequency of stools
  • Slowed growth rate

Which Lab Tests Can Diagnose, Screen, and Monitor Deficiencies in Dietary Fatty Acids?

At Ulta lab tests, we offer an omega-3 and omega-6 test to screen and diagnose any deficiencies in omega-3 and omega-6. The omega-3 and omega-6 fatty acid lab test is conducted as outlined below:

  • The patient has their blood drawn to provide a plasma sample
  • The plasma will then be tested for omega-3 and omega-6 levels
  • Once results are available, they are posted to the patient’s secure online patient portal

Why Choose Ulta Lab Tests for Fatty Acids and Omega Deficiency Lab Testing?

We offer reliable and highly accurate lab tests, enabling you to make informed decisions about your health. Below are some of the things you will love about Ulta Lab Tests:

  • Every patient gets confidential and secure results
  • Patients don’t need health insurance
  • Affordable pricing for all tests
  • No need for physician’s referral
  • 100% satisfaction guarantee

Place your omega-3 and omega-6 fatty acid test order today to find out if you have any deficiencies in your fatty acid levels. Your test results will be confidentially and securely sent to you online within 24 to 48 hours for most tests.

Take control of your health today by contacting Ulta Lab Tests today.