Erectile Dysfunction (ED)

Erectile dysfunction (ED) is the ongoing difficulty achieving or maintaining an erection firm enough for sex. ED can be vascular, hormonal, neurologic, medication-related, or psychological—and it is often multifactorial. Because ED may be an early sign of cardiometabolic disease or a hormonal imbalance, lab testing helps you and your clinician identify drivers you can act on.

A proactive approach starts with morning total testosterone (with free testosterone/SHBG when indicated) and adds pituitary hormones (LH/FSH) and prolactin to clarify causes of low testosterone or libido changes. Pair endocrine testing with thyroid labs (TSH ± free T4), diabetes markers (fasting glucose, A1c), lipids (± ApoB, Lp(a)), and general health checks (CMPCBC). Results support screeningdiagnostic triage, and monitoring, but they do not replace a clinician’s exam, medication review, counseling, or imaging when needed.

Signs, Symptoms & Related Situations

  • Sexual/urogenital

    • Difficulty achieving or maintaining erections; reduced morning erections; low libido

    • Ejaculatory changes; penile curvature or pain (specialist evaluation may be needed)

  • Hormonal clues

    • Low energy, depressed mood, decreased muscle mass, increased body fat, hot flashes

  • Cardiometabolic context

    • High blood pressure, central weight gain, high triglycerides/low HDL, high blood sugar

  • Neurologic/medication factors

    • Neuropathy, spinal injury, pelvic surgery; medicines associated with ED (some BP, prostate, depression/anxiety drugs)

  • When to seek urgent care

    • Chest pain or severe shortness of breath during sexual activity; priapism (erection >4 hours); sudden testicular pain; new weakness, numbness, or vision changes

Symptoms and risk factors require evaluation by a qualified clinician.

Why These Tests Matter

What testing can do

  • Identify hormonal causes (low total or free testosterone; abnormal LH/FSH; elevated prolactin; thyroid dysfunction)

  • Uncover cardiometabolic risks linked to ED (diabetes, dyslipidemia, metabolic syndrome)

  • Establish baselines (CBC, CMP) that guide safe follow-up and broader evaluation

What testing cannot do

  • Diagnose ED by one value or determine psychological contributors

  • Replace a clinician’s exam, cardiovascular risk assessment, or medication review

  • Provide treatment or dosing guidance—use results to plan next steps with your clinician

What These Tests Measure (at a glance)

  • Total Testosterone (morning): primary screen for androgen status; repeat on a morning sample if low/borderline. Levels vary by lab and time of day; confirm on repeat.

  • Free Testosterone & SHBG: clarifies bioavailable testosterone, especially when total T is borderline or SHBG is abnormal (age, thyroid, liver, obesity).

  • LH & FSH: help distinguish primary testicular from central (pituitary/hypothalamic) causes when testosterone is low.

  • Prolactin: high values can suppress gonadal function and libido; persistent elevation needs clinician evaluation.

  • Thyroid (TSH ± Free T4): both hypo- and hyperthyroidism can affect libido, mood, and erectile function.

  • Diabetes markers (A1c, fasting glucose ± fasting insulin): hyperglycemia and insulin resistance damage blood vessels and nerves.

  • Lipid Panel (± ApoB, Lp(a)): vascular risk profiling; ED can be an early marker of atherosclerosis.

  • Comprehensive Metabolic Panel (CMP): liver/kidney function, electrolytes; overall safety context.

  • Complete Blood Count (CBC): anemia and some blood disorders can affect energy and sexual performance.

  • Estradiol: optional in select cases (e.g., gynecomastia, obesity, unexplained low T).

  • PSA (as directed): prostate context in age-appropriate men when clinically relevant.

Quick Build Guide

Clinical goal Start with Add if needed
First-line ED workup Morning total testosterone • TSH • A1c/fasting glucose • Lipid panel • CMP • CBC Free T/SHBG • LH/FSH • Prolactin
Low libido/fatigue with borderline T Repeat morning total T • Free T/SHBG LH/FSH • Prolactin • Estradiol
Cardiometabolic risk present A1c • Lipid panel • CMP ApoB • Lp(a) per clinician
Suspected pituitary/central cause Total/Free T • LH/FSH • Prolactin Thyroid panel; additional endocrine tests as directed
Medication contributors possible CMP • CBC • A1c • Lipid panel Review meds with clinician; add hormonal panel if symptoms fit
Normal hormones, persistent ED Cardiometabolic labs (A1c, lipids) • CMP • CBC Clinician-directed imaging or specialty evaluation

How the Testing Process Works

  1. Choose your starting set: many begin with morning total testosteroneTSHA1clipid panelCMP, and CBC.

  2. Collect correctly: schedule morning blood draw (typically 7–10 a.m.) for testosterone; fasting is needed only for certain lipid/glucose orders.

  3. Review results: if testosterone is low or borderlinerepeat a morning sample and add free T/SHBG and LH/FSH.

  4. Clarify the picture: add prolactin and targeted tests based on symptoms.

  5. Plan next steps: discuss results with your clinician; they may recommend cardiovascular assessment, counseling, or specialty referral.

Interpreting Results (General Guidance)

  • Low total testosterone: confirm with a repeat morning test; consider free T/SHBG and LH/FSH to localize (primary vs central).

  • Normal testosterone with ED: look for vascular/metabolic drivers (A1c/lipids), thyroid issues, medication effects, or psychological factors.

  • High prolactin: may suppress testosterone—requires clinician evaluation and confirmation.

  • Abnormal TSH or Free T4: thyroid imbalance can impair libido and energy; address with your clinician.

  • A1c or lipids elevated: indicates cardiometabolic risk that often tracks with ED severity.
    Interpret labs with a qualified healthcare professional; patterns, timing, and symptoms matter more than any single value.

Choosing Panels vs. Individual Tests

  • Foundational ED panel: Morning total testosterone • TSH • A1c • Lipid panel • CMP • CBC

  • Hormone-focused add-ons: Free T/SHBG • LH/FSH • Prolactin • Estradiol (select cases)

  • Cardiometabolic risk refinement: ApoB • Lp(a) where available

  • Age-appropriate context: PSA as directed by your clinician

FAQs

Do I need to test testosterone in the morning?
Yes. Testosterone follows a daily rhythm; morning testing improves accuracy. Repeat a low result.

Can ED be an early sign of heart disease?
It can. ED often reflects vascular health, so A1c and lipid testing help assess risk.

If my testosterone is normal, why do I still have ED?
Many cases are vascular, neurologic, medication-related, or psychological. Labs guide the next steps but don’t tell the whole story.

Do I have to fast?
Only if your order includes fasting lipids or fasting glucose. Hormone tests typically don’t require fasting.

What does a high prolactin mean?
It can lower testosterone and libido. Mild elevations may need repeat confirmation and clinical evaluation.

Will these tests diagnose ED by themselves?
No. They clarify contributors. Diagnosis and care planning require a clinician’s evaluation.

Can medications cause ED?
Some can. Do not stop medicines on your own—review your list with your clinician.

Related Categories & Key Tests

  • Men’s Health Tests Hub

  • Testosterone & Men’s Hormone Tests • Thyroid Tests • Diabetes Health • Heart & Cardiovascular Risk • Prostate Health

  • Key Tests: Total Testosterone (AM) • Free Testosterone • SHBG • LH • FSH • Prolactin • TSH • Free T4 • Estradiol • A1c • Fasting Glucose • Lipid Panel (± ApoB, Lp[a]) • CMP • CBC • PSA (as directed)

References

  • American Urological Association. Guideline on the Management of Erectile Dysfunction.
  • American Urological Association. Testosterone Deficiency Guideline.
  • Endocrine Society. Testosterone Therapy in Men with Hypogonadism: Clinical Practice Guideline.
  • American Diabetes Association. Standards of Care—Cardiometabolic risk assessment.
  • American College of Cardiology/American Heart Association. Cholesterol guideline—risk assessment and treatment thresholds.
  • Clinical reviews on endocrine, vascular, and psychogenic contributors to ED and the role of laboratory testing.

Available Tests & Panels

Your Erectile Dysfunction (ED) Tests menu is pre-populated in the Ulta Lab Tests system. Start with morning total testosteroneTSHA1clipid panelCMP, and CBC. Use filters to add free T/SHBGLH/FSHprolactinestradiol, and risk-refining markers (ApoB, Lp[a]) as needed. Review results with your clinician to decide on next steps and monitoring.

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Blood, Urine
Blood Draw, Urine Collection

Blood, Urine
Blood Draw, Phlebotomist, Urine Collection

Blood
Blood Draw, Phlebotomist

Blood
Blood Draw, Phlebotomist

Blood
Blood Draw, Phlebotomist

Blood, Urine
Blood Draw, Phlebotomist, Urine Collection

Blood, Urine
Blood Draw, Phlebotomist, Urine Collection

Blood, Urine
Blood Draw, Phlebotomist, Urine Collection

The Calcium Micronutrient Test measures calcium levels in the blood to assess nutritional status and detect imbalances. Calcium is essential for strong bones and teeth, muscle contraction, nerve signaling, and heart function. This test helps identify deficiencies, excess, or issues with absorption and metabolism, supporting diagnosis and management of bone health, hormonal balance, and overall wellness.

Patient must be 18 years of age or older.
Blood
Blood Draw
Also Known As: Ca Test, Serum Calcium Test, Calcium Blood Test

Most Popular

The Calcium Test measures calcium levels in blood to assess bone health, parathyroid function, and metabolic balance. Abnormal levels may indicate bone disease, parathyroid disorders, kidney disease, or certain cancers. Both low and high calcium can cause muscle spasms, weakness, or irregular heartbeat. Doctors order this test to monitor osteoporosis, kidney stones, or endocrine disorders. Results provide essential insight into bone, nerve, and overall metabolic health.

Blood
Blood Draw
Also Known As: Ca Test, Serum Calcium Test, Calcium Blood Test

The Heavy Metals Micronutrients Blood Test Panel measures levels of arsenic, cadmium, cobalt, lead, and mercury to assess exposure and potential toxicity. These metals, found in the environment, food, or workplaces, can affect the nervous system, kidneys, bones, and overall health. This panel helps detect harmful accumulation, guide treatment, and monitor risks from environmental or occupational exposure.

Patient must be 18 years of age or older.

The Complete Blood Count with Differential and Platelets Test is a comprehensive blood test that checks red blood cells, white blood cells, hemoglobin, hematocrit, and platelets. The differential analyzes types of white blood cells to detect infections, anemia, clotting abnormalities, immune conditions, and certain cancers. This essential test is often ordered for routine health exams, diagnosis, and monitoring treatment progress.

Blood
Blood Draw
Also Known As: CBC Test, CBC with Differential and Platelets Test, CBC w/Diff and Platelets Test, Full Blood Count Test, Complete Blood Count Test

The Comprehensive Metabolic Panel (CMP) Test measures 21 markers to assess metabolic health, liver and kidney function, and electrolyte balance. It includes glucose, calcium, sodium, potassium, chloride, CO2, albumin, globulin, A/G ratio, total protein, bilirubin, ALP, AST, ALT, BUN, creatinine, BUN/creatinine ratio, and eGFR. The CMP helps detect diabetes, liver or kidney disease, and supports routine screening and chronic condition monitoring.

Blood
Blood Draw
Also Known As: CMP Test, Chemistry Panel Test, Chem Test, Chem 21 Test, Chem 14 Test 

The Cortisol Test with 2 specimens measures adrenal gland function by evaluating cortisol levels at two collection times. Tracking changes in this stress hormone helps assess adrenal performance, circadian rhythm, and the body’s stress response, while offering insight into conditions such as adrenal insufficiency, Cushing’s syndrome, Addison’s disease, and overall endocrine balance.

Blood
Blood Draw
Also Known As: 2 Specimen Cortisol Blood Test

The Cortisol Test with 3 specimens measures adrenal gland function by evaluating cortisol levels at three collection times. Monitoring this stress hormone helps assess circadian rhythm, adrenal performance, and daily hormone balance, while providing insight into adrenal insufficiency, Addison’s disease, Cushing’s syndrome, and overall endocrine and metabolic health.

Blood
Blood Draw
Also Known As: 3 Specimen Cortisol Blood Test

The Cortisol Test with 5 specimens measures adrenal gland function by evaluating cortisol levels at five collection times. Monitoring this stress hormone throughout the day provides insight into circadian rhythm, adrenal performance, and hormone balance, while helping detect adrenal insufficiency, Addison’s disease, Cushing’s syndrome, stress dysregulation, and overall endocrine health.

Blood
Blood Draw
Also Known As: 5 Specimen Cortisol Blood Test

The Cortisol Test with 6 specimens measures adrenal gland function by evaluating cortisol levels at six collection times. Monitoring this stress hormone across the day provides insight into circadian rhythm, adrenal performance, and hormone balance, while supporting detection of adrenal insufficiency, Addison’s disease, Cushing’s syndrome, stress dysregulation, and overall endocrine health.

Blood
Blood Draw
Also Known As: Cortisol Total Test, Cortisol 6 Specimen Test, 6 Specimen Cortisol Test, Cortisol Blood Test, Cortisol Serum Test

Most Popular

The Cortisol AM Test measures morning cortisol levels in blood to evaluate adrenal gland function and stress response. Cortisol peaks in the morning, making this test critical for detecting adrenal insufficiency (Addison’s disease), Cushing’s syndrome, or other hormone imbalances. Doctors also use it to investigate fatigue, weight changes, or high blood pressure. This test provides important insight into endocrine health, metabolism, and long-term stress regulation.

Blood
Blood Draw
Also Known As: Morning Cortisol Test

Most Popular

The Cortisol PM Test measures afternoon cortisol levels to evaluate adrenal and pituitary function. Cortisol normally drops later in the day, so abnormal results may indicate Cushing’s syndrome, adrenal insufficiency (Addison’s disease), or hormone imbalance. Doctors order this test to investigate fatigue, obesity, high blood pressure, or irregular sleep patterns and to monitor adrenal disorders. It provides key insight into stress response and endocrine health.

Blood
Blood Draw
Also Known As: Afternoon Cortisol Test

The Cortisol Total Test measures cortisol levels in blood to assess adrenal gland and pituitary function. Cortisol regulates stress response, metabolism, and immune health. Abnormal results may indicate Cushing’s syndrome, Addison’s disease, or other hormone disorders. Doctors order this test to evaluate symptoms like fatigue, weight changes, weakness, or high blood pressure and to monitor treatment. It provides essential insight into hormone balance and endocrine health.

Blood
Blood Draw
Also Known As: Cortisol Blood Test

Most Popular

The DHEA Sulfate (DHEA-S) Test measures levels of DHEA-S, a hormone made by the adrenal glands, to evaluate adrenal function and hormone balance. It helps detect adrenal tumors, hyperplasia, or insufficiency and assess abnormal hair growth, infertility, or early/late puberty. Doctors also use it to investigate irregular menstrual cycles, monitor androgen disorders, and evaluate symptoms of hormone imbalance affecting reproductive and metabolic health.

Blood
Blood Draw
Also Known As: DHEA Sulfate Test, Dehydroepiandrosterone Sulfate Test

The Dihydrotestosterone (DHT) Test measures levels of DHT, a potent androgen derived from testosterone, to evaluate hormone balance. Abnormal results may indicate hair loss, prostate disorders, infertility, or hormonal imbalance. Doctors order this test for men and women with symptoms such as hair thinning, acne, irregular periods, or low libido. It is also used to monitor treatment for prostate disease or hormone therapy, providing insight into reproductive and endocrine health.

Blood
Blood Draw
Also Known As: DHT Test

Most Popular

The Estradiol (E2) Test measures levels of estradiol, the primary form of estrogen, to evaluate reproductive and hormonal health. It helps assess menstrual irregularities, fertility issues, menopause status, and estrogen-producing disorders. In men, it aids in diagnosing hormonal imbalances. Doctors use the estradiol test to monitor hormone therapy, ovarian function, and conditions affecting puberty, bone health, and overall endocrine balance.

Blood
Blood Draw
Also Known As: E2 Test, Estrogen 2 Test

Most Popular

The FSH and LH Test measures follicle-stimulating hormone (FSH) and luteinizing hormone (LH) to evaluate reproductive and endocrine health in both men and women. In women, it helps assess menstrual irregularities, infertility, menopause, or polycystic ovary syndrome (PCOS). In men, it aids in diagnosing low testosterone, infertility, or testicular dysfunction. Doctors also use this test to investigate puberty disorders, hormone imbalance, and pituitary function.

Also Known As: Follitropin Test, Lutropin Test, Interstitial Cell Stimulating Hormone Test, ICSH Test

Most Popular

The Glucose Test measures blood sugar levels to evaluate energy metabolism and screen for diabetes or prediabetes. Abnormal glucose may indicate hyperglycemia, hypoglycemia, or metabolic disorders. Doctors use this test during routine exams, to investigate symptoms like fatigue, excessive thirst, or frequent urination, and to monitor treatment for diabetes. It provides essential insight into how the body regulates blood sugar and overall metabolic health.

Blood
Blood Draw
Also Known As: Fasting Glucose Test, Fasting Blood Sugar Test

Erectile dysfunction (ED) is an issue that plagues far too many men in the United States. In fact, more than 30 million men are currently struggling with ED.

Beyond its physical implications, ED puts a significant mental burden on men. It can also lead to marital strife as ED hinders a couple’s sex life.

The good news is that there are erectile dysfunction tests to help identify the issue. With a solid diagnosis, doctors can prescribe the proper ED treatments to solve the issue.

Read on to learn all about ED tests. Explore how an ED lab test can confirm the existence of an issue and lead to its resolution.

What Is Erectile Dysfunction?

Before diving into the various ED tests, it is important to define this medical condition. With ED, a male cannot get or maintain an erection. ED has a significant impact on sexual intercourse as the male now has difficulty satisfying his partner.

Some patients with ED cannot get an erection at all. Others get an erection initially, but it goes away during sexual intercourse, causing issues for their partner. Another group of men get an erection sometimes, but other times are unable to.

Patients with ED often schedule an appointment with their primary care physician. A urologist is another doctor that treats men with ED.

These doctors prescribe an ED lab test to verify the presence of an issue. A separate issue may cause a patient's ED, and the doctors will investigate all possibilities.

What Are the Causes of Erectile Dysfunction?

Many people associate ED with older men. They think that this is a common issue with aging men.

However, the truth is that ED is not a normal part of the aging process. In fact, ED can plague men in any age group.

Taking certain medications or other supplements can lead to ED. Your doctor will certainly assess your current medication to determine if there is a link to ED.

Particular behaviors are also known to cause ED. Obesity and smoking tobacco are two known causes of ED.

There are various medical conditions and diseases that lead to ED. Your doctor will ask about your medical history to look for potential causes. Even psychological or emotional conditions can directly cause ED.

The end result is not good for patients with ED. The effects go well beyond having a positive sex life.

Patients with ED suffer from low self-esteem and depression resulting from their condition. Naturally, ED patients have fertility issues and it often causes emotional duress when a couple cannot get pregnant.

How Is Erectile Dysfunction Diagnosed?

As stated earlier, the doctor is going to ask about your medical history. They are interested in what medicines you take, prior surgeries, and conditions you are dealing with. Additionally, your doctor will ask about your family history to see if there is a potential genetic linkage.

The doctor is certainly going to inquire about your sex life. This is a time to embrace honesty so that the doctor can figure out what is going on.

A physical examination by the doctor follows. Of course, examination of the testicles and penis is part of this process. The doctor also looks for hair loss and breast size. The latter two signs may indicate a hormonal imbalance.

Checking your pulse at the wrists is a common part of the physical examination. The doctor wants to make sure that blood is flowing properly to your extremities.

Listening to your heartbeat for any abnormalities and checking blood pressure are also important steps. Any cardiovascular issues may be the root cause behind ED.

Lab tests of your blood and urine are on deck. These lab tests yield clues to what is causing ED.

For example, your lab results may indicate issues like heart disease or diabetes. These conditions, along with kidney disease, are common root causes of ED. Your doctor also looks for hormonal imbalances that may trigger ED.

Thyroid operation is another possibility that the doctors check for using blood work. The thyroid is critical for the flow of sex hormones. If it is not working properly, it may be difficult to get an erection.

What Are Some Other Erectile Dysfunction Tests?

The doctor may want to run some additional tests. There are several different tests to confirm the presence of ED.

Men get several erections per night when they are sleeping. Your doctor may ask to perform an overnight erection test. This involves wearing a device that measures the strength and frequency of your nightly erections. If you are still getting erections at night, it suggests your ED issues are rooted in mental or emotional issues.

The doctor may call for an intracavernosal test. This is where the doctor injects medicine into the base of the penis to check for an erection. Failure to get an erection means there is a blood flow issue. Lastly, the doctor may want to do an ultrasound, which is another proven method to check for blood flow.

What Are the Benefits of Lab Tests for Erectile Dysfunction?

There are many benefits to going for erectile dysfunction lab tests. For starters, the results are secure and confidential. No one, not even your partner, has access to the results unless you grant it.

At our lab, you do not even need a doctor’s prescription or referral. You can get ED lab results directly if you do not want to involve your primary care physician.

Another benefit to our testing is that you do not need health insurance. The testing is affordable and 100% satisfaction is guaranteed. The results are available to the patient in no more than 48 hours.

How Can ED Tests Get You Back on Track Today?

ED tests are the most effective way to get your personal life back on track. Here, you can confirm the issue and determine what the root cause is. Whether it is a medical condition or mentally induced, knowing the root cause is key to fixing it.

If you are interested in getting erectile dysfunction tests, we offer a selection of Erectile Dysfunction (ED) panels that include lab tests and biomarkers to evaluate if they are out of balance.