Zinc Transporter 8 (ZnT8) Antibody

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

ZINC TRANSPORTER 8 (ZnT8)

*Important Information on Lab Test Processing Times: Ulta Lab Tests is committed to informing you about the processing times for your lab tests processed through Quest Diagnostics. Please note that the estimated processing time for each test, indicated in business days, is based on data from the past 30 days across the 13 Quest Diagnostics laboratories for each test. These estimates are intended to serve as a guide and are not guarantees. Factors such as laboratory workload, weather conditions, holidays, and the need for additional testing or maintenance can influence actual processing times. We aim to offer estimates to help you plan accordingly. Please understand that these times may vary, and processing times are not guaranteed. Thank you for choosing Ulta Lab Tests for your laboratory needs.

The Zinc Transporter 8 (ZnT8) Antibody test contains 1 test with 1 biomarker.

Zinc Transporter 8 (ZnT8) Antibody

Clinical Significance

Zinc Transporter 8 (ZnT8) Antibody - Patient population is primarily children and adolescents to confirm a diagnosis of type 1 diabetes.

Reference Range(s)

<15 U/mL

Quest Information: education.questdiagnostics.com/faq/FAQ168

 Question 1. What is the primary clinical use of the ZnT8 antibody test?

This test is mainly used to assist in the diagnosis of type 1 diabetes mellitus. For this purpose, it can be used alone or in combination with other antibody tests such as the glutamic acid decarboxylase-65 (GAD-65), insulinoma antigen-2 (IA-2), and insulin antibody tests.

 Question 2. Which individuals may be suitable for ZnT8 antibody testing?

ZnT8 antibody testing can be considered for:

Individuals with diabetes of uncertain etiology

Young person with atypical diabetes

Person with ketosis-prone diabetes that is not clearly type 1

Person suspected of having maturity-onset diabetes of the young (MODY)

Woman with gestational diabetes (help clarify risk of future diabetes)

Obese individuals with acute-onset diabetes with ketoacidosis

Lean individuals with nonketotic diabetes

Individuals at high risk of developing type 1 diabetes (eg, those with a first-degree relative with type 1 diabetes) in context of a clinical research study1

 Question 3. How frequently are ZnT8 antibodies detected in patients with type 1 diabetes mellitus?

Sixty-five percent to 80% of children with recently diagnosed type 1 diabetes2,3 and 20% to 40% of adults with type 1 diabetes3,4 have antibodies to ZnT8.

 Question 4. To what degree does the ZnT8 antibody test complement other more commonly used autoantibody tests?

The ZnT8 antibody can add 3% to 4% to the antibody sensitivity for type 1 diabetes. This is because ZnT8 antibody is positive in 3% to 4% of patients who are negative for GAD-65, IA-2, and insulin antibodies.2,5,6Use of these 4 antibodies results in 93% to 98% sensitivity.2,5,6

 Question 5. Are there other clinical uses of the ZnT8 antibody test?

ZnT8 antibody testing may help to assess the risk of type 1 diabetes. Achenbach et al found that almost half of children with ZnT8 antibody developed type 1 diabetes within 5 years.7 Moreover, since risk of type 1 diabetes increases with the number of antibodies, a positive ZnT8 antibody test can reclassify individuals into a higher risk category.

 Question 6. How early can ZnT8 antibodies be detected in patients?

ZnT8 antibodies can be detected as early as 9 months of age but are more common after 2 years.2,7 Antibody titers decrease over the course of the disease, and patients who are initially ZnT8 antibody-positive may later become antibody- negative.3,5,8

 

Customer Reviews