Uric Acid, 24-Hour Urine without Creatinine

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Also known as: Uric Acid 24 Hour Urine WO Creatinine

Uric Acid, 24 Hour Urine

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The Uric Acid, 24-Hour Urine without Creatinine test contains 1 test with 1 biomarker.

Test Description: Uric Acid, 24-hour Urine without Creatinine

Purpose: This test measures the amount of uric acid present in the urine collected over a 24-hour period. Unlike the more common serum uric acid test, which measures the amount of uric acid in the blood, this test provides insight into how much uric acid is being excreted by the kidneys.

Benefits of the Test and Conditions it Assists With:

  1. Gout: One of the most common reasons to perform this test is to diagnose and monitor gout. Gout is a type of arthritis caused by an accumulation of uric acid crystals in the joints. It can be due to the overproduction of uric acid or decreased excretion by the kidneys. This test helps in distinguishing between these mechanisms.

  2. Lesch-Nyhan Syndrome: This is a rare inherited disorder characterized by self-mutilation and neurological symptoms. Affected individuals have an enzyme deficiency leading to overproduction and excretion of uric acid.

  3. Kidney Stones: Uric acid can crystallize in the kidneys, leading to the formation of kidney stones. If a patient has recurrent kidney stones, this test can determine if they are due to excessive uric acid excretion.

  4. Tumor Lysis Syndrome: This is a rapid release of cells into the blood, often after chemotherapy in patients with certain types of cancer like leukemia. It can lead to elevated uric acid levels, which the kidneys try to excrete.

  5. Monitoring Diet and Medications: For patients known to have high uric acid levels or who are at risk of related complications, this test can be used to monitor the effects of a purine-restricted diet or medications meant to reduce uric acid production or increase its excretion.

The 24-hour urine uric acid test is valuable in various clinical scenarios, particularly when it is necessary to ascertain how much uric acid is being excreted by the kidneys over a day. This can guide diagnosis, treatment, and dietary recommendations, especially in conditions like gout, kidney stones, or certain genetic disorders.

Reference Range(s)

Male 120-820 mg/24 h
Female 65-630 mg/24 h

Interpretation of Results:

  • Increased Levels: Elevated uric acid excretion may suggest conditions like gout, Lesch-Nyhan syndrome, increased cell turnover due to conditions like leukemia, or a diet high in purines.

  • Decreased Levels: Reduced uric acid excretion might indicate kidney disease or conditions like Wilson's disease.

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