Ulcerative Colitis Differentiation Panel

There are no preparation instructions.

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Anca Screen

Myeloperoxidase Antibody

Antineutrophil cytoplasmic antibodies (ANCA) are a group of autoantibodies produced when a person's immune system mistakenly targets and attacks its own neutrophil proteins. Two of the most commonly targeted proteins are myeloperoxidase (MPO) and proteinase 3 (PR3). This results in the production of antibodies to MPO and/or PR3. The ANCA blood test detects the presence or absence of these autoantibodies. Antineutrophil cytoplasmic antibodies may be present in a variety of autoimmune disorders that cause inflammation and damage to blood vessels throughout the body (systemic vasculitis). Vasculitis can cause tissue and organ damage due to the narrowing and obstruction of blood vessels and the subsequent loss of blood supply. It can also produce areas of weakness in blood vessel walls, known as aneurysms, which have the potential to rupture.

Proteinase-3 Antibody

S Cerevisiae Ab (Iga)

S Cerevisiae Ab (IgG)

*Important Information on Lab Test Processing Times: Ulta Lab Tests is committed to informing you about the processing times for your lab tests processed through Quest Diagnostics. Please note that the estimated processing time for each test, indicated in business days, is based on data from the past 30 days across the 13 Quest Diagnostics laboratories for each test. These estimates are intended to serve as a guide and are not guarantees. Factors such as laboratory workload, weather conditions, holidays, and the need for additional testing or maintenance can influence actual processing times. We aim to offer estimates to help you plan accordingly. Please understand that these times may vary, and processing times are not guaranteed. Thank you for choosing Ulta Lab Tests for your laboratory needs.

The Ulcerative Colitis Differentiation Panel test contains 1 test with 5 biomarkers.

Test Description: Ulcerative Colitis Differentiation Panel

Purpose: The Ulcerative Colitis Differentiation Panel is a specialized serological test panel designed to assist in the diagnosis and differentiation of Ulcerative Colitis (UC), a subtype of Inflammatory Bowel Disease (IBD). By measuring specific antibodies commonly associated with UC, this panel helps clinicians distinguish UC from Crohn’s Disease (CD) and other gastrointestinal conditions.

Important Notice: Please be advised that this panel includes tests that may trigger reflexive testing. By ordering this panel, you acknowledge and consent to be charged for any additional tests that may be conducted based on reflex criteria, as detailed in the aforementioned fee schedule.
Potential Reflex Charges
C-ANCA TITER  $                   69 
P-ANCA TITER  $                   64 
ATYP P-ANCA TITER  $                   69 



  1. ANCA Screen with Reflex to ANCA Titer:

    • This test screens for the presence of anti-neutrophil cytoplasmic antibodies (ANCA), which are associated with various autoimmune conditions, including certain types of vasculitis and IBD. If the ANCA screen is positive, additional reflex testing to determine the specific ANCA titer (C-ANCA, P-ANCA, or atypical P-ANCA) will be automatically performed at an additional charge, providing a detailed analysis to aid in diagnosis.
  2. Myeloperoxidase Antibody (MPO):

    • MPO antibodies are part of the ANCA profile and are commonly associated with P-ANCA. Their presence can indicate certain autoimmune conditions and vasculitides.
  3. Proteinase-3 Antibody:

    • Proteinase-3 antibodies are typically associated with C-ANCA and can be found in patients with Wegener’s Granulomatosis, a form of vasculitis.
  4. Saccharomyces cerevisiae Antibodies (ASCA) (IgG):

    • ASCA IgG antibodies are more commonly associated with Crohn’s Disease, but their presence or absence can also provide valuable information in the context of differentiating UC.
  5. Saccharomyces cerevisiae Antibodies (ASCA) (IgA):

    • Like ASCA IgG, ASCA IgA antibodies are used in the differentiation of IBD subtypes, aiding in the diagnostic process.

Reflex Testing:

  • If the ANCA screen is positive, reflex testing to ANCA titer will be performed at an additional charge (CPT code(s): 86037 for each titer performed). This reflex testing allows for a comprehensive evaluation and detailed characterization of the type of ANCA antibodies present.


  • A positive P-ANCA result, in conjunction with other clinical findings, is commonly associated with Ulcerative Colitis.
  • ASCA antibodies are more commonly associated with Crohn’s Disease; however, their presence or absence, along with ANCA results, can provide valuable information in differentiating UC from CD and other gastrointestinal conditions.
  • Results should be interpreted in the context of the patient’s clinical presentation, other laboratory tests, and imaging studies.


  • This panel provides a targeted approach for the diagnosis and differentiation of Ulcerative Colitis, aiding clinicians in making timely and accurate decisions regarding patient management and treatment.
  • It is particularly valuable in complex cases where the clinical presentation may be ambiguous, and additional laboratory data is required for a comprehensive evaluation.


  • The presence of these antibodies alone is not diagnostic of Ulcerative Colitis or any specific subtype of IBD.
  • Seronegative cases of UC are possible, and a negative result does not rule out the disease.
  • Additional clinical correlation and further diagnostic evaluation are required for a definitive diagnosis.

The Ulcerative Colitis Differentiation Panel is an essential tool in the diagnostic arsenal for IBD, providing clarity and aiding clinicians in the complex process of diagnosing and managing Ulcerative Colitis.


Immunoassay (IA)

Reference Range(s)


ANCA Screen Negative
  P-ANCA Titer <1:20
  C-ANCA Titer <1:20
  Atypical P-ANCA Titer <1:20

Myeloperoxidase Antibody

<1.0 AI No antibody detected
≥1.0 AI Antibody detected

Proteinase-3 Antibody

<1.0 AI No antibody detected
≥1.0 AI Antibody detected

Saccharomyces cerevisiae Ab (IgG)

≤20.0 U Negative
20.1-29.9 U Equivocal
≥30.0 U Positive

Saccharomyces cerevisiae Ab (IgA)

≤20.0 U Negative
20.1-24.9 U Equivocal
≥25.0 U Positive

Customer Reviews