Ulta Lab Tests

TPMT Activity Test

The TPMT Activity Test measures thiopurine S-methyltransferase enzyme activity to assess how a patient metabolizes thiopurine drugs. Abnormal results may indicate low or absent activity, increasing risk for toxicity from medications such as azathioprine, 6-mercaptopurine, or 6-thioguanine. This test supports safe dosing, helps prevent bone marrow suppression, and guides individualized therapy for autoimmune disease or leukemia.

Blood
Blood Draw
Azathioprine Toxicity Test, Mercaptopurine Toxicity Test, TPMT Deficiency Test
There are no preparation instructions.

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Tpmt Activity

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The TPMT Activity Test test contains 1 test with 1 biomarker .

Help prevent hepatotoxicity from thiopurine therapy. This test helps identify individuals at increased risk of hepatotoxicity from thiopurine dose escalation. Patients with a TMPT activity of 4-12 nmol 6-MMP/hr/mL RBC (heterozygote/low metabolizer) are at increased risk and may require a lower dose of thiopurine drug.

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