TH-4. Thyroid Health

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Also known as: Reverse T3, Reverse Triiodothyronine, RT3, T3 Reverse RT3 LCMSMS, Triiodothyronine Reverse

T3 Reverse, LC/MS/MS

Reverse T3 produced in the thyroid comes from the conversion of the storage hormone T4. Your body, especially the liver, can constantly be converting T4 to RT3 as a way to get rid of any unneeded T4. In any given day approx. 40% of T4 goes to T3 and 20% of T4 goes to Reverse T3. However in any situation where your body needs to conserve energy and focus on something else, it will change the above percentages, changing the conversion of RT3 to 50% or more, and the T3 goes down, down. Examples are emotional, physical, or biological stress, such as being chronically or acutely sick (the flu, pneumonia, etc), after surgery, after a car accident or any acute injury, chronic stress causing high cortisol, being exposed to an extremely cold environment, diabetes, aging, or even being on drugs like beta blockers and amiodarone.

Also known as: Triiodothyronine

T3, Total

Triiodothyronine (T3) is a thyroid hormone. It plays an important role in the body's control of metabolism.

Also known as: Free T3, FT3, T3 Free

T3, Free

This test measures the amount of triiodothyronine, or T3, in the blood.

Also known as: T4 Thyroxine Total

Free T4 Index (T7)

FTI stands for the Free Thyroxine Index and is also sometimes referred to as T7. It is a calculated value determined from the T3 uptake test and total T4 test and provides an estimate of the level of free T4 in the blood.

T4 (Thyroxine), Total

This test measures the amount of thyroxine, or T4, in the blood. T4 is one of two major hormones produced by the thyroid gland. The total T4 test is used to help diagnose hyperthyroidism and hypothyroidism. It is a useful test but can be affected by the amount of protein available in the blood to bind to the hormone.

Also known as: Free T4, FT4, T4 Free

T4, Free

The free T4 test is not affected by protein levels. Since free T4 is the active form of thyroxine, the free T4 test is may be a more accurate reflection of thyroid hormone function.

Thyroglobulin Antibodies

Measurement of thyroglobulin antibodies is useful in the diagnosis and management of a variety of thyroid disorders including Hashimoto's thyroiditis, Graves Disease and certain types of goiter.

Thyroid Peroxidase

TRAB

Also known as: Thyroid Stimulating Hormone, Thyroid Stimulating Hormone (TSH), Thyrotropin

TSH

A TSH test is a lab test that measures the amount of thyroid stimulating hormone (TSH) in your blood. TSH is produced by the pituitary gland. It tells the thyroid gland to make and release thyroid hormones into the blood.

TSH

Also known as: Thyroid Receptor Antibody, Thyroid Stimulating Immunoglobulin, TSI Thyroid Stimulating Immunoglobulin

TSI

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The TH-4. Thyroid Health panel contains 9 tests with 12 biomarkers.

Brief Description: The TH-4 Thyroid Health panel represents the most comprehensive evaluation in the series, designed to assess thyroid function extensively, including thyroid hormone levels, autoimmunity, and specific markers indicative of autoimmune thyroid diseases. This panel is particularly valuable for diagnosing complex thyroid conditions and monitoring autoimmune thyroid disorders.

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: Specifc to TSH: Specimen collection after fluorescein dye angiography should be delayed for at least 3 days. For patients on hemodialysis, specimen collection should be delayed for 2 weeks.

According to the assay manufacturer Siemens: "Samples containing fluorescein can produce falsely depressed values when tested with the Advia Centaur TSH3 Ultra assay."

When and Why the TH-4 Thyroid Health Panel May Be Ordered

Healthcare providers may order the TH-4 Thyroid Health panel for individuals with symptoms suggestive of thyroid dysfunction or autoimmune thyroid disease, such as Graves' disease or Hashimoto's thyroiditis. It's also ordered for patients with known thyroid conditions to monitor the disease progression and the effectiveness of treatment, especially in cases where conventional treatment has been ineffective or when a detailed autoimmune profile is necessary.

What the TH-4 Thyroid Health Panel Checks For

  • T3 Reverse: Measures the inactive form of T3, providing insight into thyroid hormone metabolism and potential conversion issues.
  • T3 Total: Assesses the total amount of triiodothyronine in the blood, reflecting overall thyroid hormone production.
  • T3 Free: Evaluates the unbound and biologically active form of T3, offering insights into the functional thyroid hormone available to body tissues.
  • T4 Total: Measures the total amount of thyroxine, including both bound and free T4, to assess the thyroid gland's output.
  • T4 Free: Assesses the unbound portion of thyroxine, providing a direct indicator of the hormone available for physiological actions.
  • Thyroid Peroxidase Antibodies (TPOAb): Checks for antibodies against thyroid peroxidase, an enzyme involved in thyroid hormone production, indicative of autoimmune thyroid disease.
  • Thyroglobulin Antibodies (TgAb): Measures antibodies against thyroglobulin, a protein involved in thyroid hormone storage, suggesting autoimmune involvement.
  • TSH Receptor Binding Antibody (TRAb): Indicates an immune response targeting the TSH receptor, characteristic of Graves' disease.
  • Thyroid Stimulating Hormone (TSH): A central regulator of thyroid function, with its levels reflecting the pituitary gland's response to circulating thyroid hormone levels.
  • Thyroid Stimulating Immunoglobulin (TSI): Assesses the presence of antibodies that stimulate the thyroid, characteristic of Graves' disease.

Conditions or Diseases the TH-4 Thyroid Health Panel Can Check For

The TH-4 Thyroid Health panel is instrumental in diagnosing and managing autoimmune thyroid diseases such as Graves' disease and Hashimoto's thyroiditis. It also helps in evaluating more subtle forms of thyroid dysfunction and in distinguishing between various thyroid disorders.

Use of TH-4 Thyroid Health Panel Results by Healthcare Professionals

Healthcare professionals use the results from the TH-4 Thyroid Health panel to diagnose thyroid disorders, determine the autoimmune status, guide treatment decisions, and monitor the progression of thyroid diseases. The detailed thyroid hormone profile, along with specific autoimmune markers, provides a comprehensive overview necessary for effective management.

The TH-4 Thyroid Health panel offers an extensive evaluation of thyroid function and autoimmunity, providing essential insights for diagnosing and managing complex thyroid disorders. By combining detailed assessments of thyroid hormones with specific markers of thyroid autoimmunity, this panel enables healthcare providers to identify underlying conditions, tailor treatment strategies effectively, and monitor patient outcomes, ensuring comprehensive thyroid health management.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

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