Quest AD-Detect™, Beta-Amyloid 42/40 Ratio, Plasma

The Quest AD-Detect™, Beta-Amyloid 42/40 Ratio, Plasma test contains 1 test with 3 biomarkers.

Quest AD-Detect™, Beta-Amyloid 42/40 Ratio, Plasma

AD-Detect Test for Alzheimer's Disease: A Beacon of Early Detection Alzheimer's disease (AD) is a relentless disorder affecting the brain, impairing memory, and undermining understanding. Striking nearly 7 million individuals annually in the US alone, AD ranks as the country's 6th leading cause of death. The AD-Detect Test for Alzheimer's Disease is a vital tool in this scenario, offering a ratio derived from two essential biomarkers. These biomarkers have been recognized for their role in pinpointing the early warning signs linked with the risk of Alzheimer's onset. The information gathered from the AD-Detect test can empower you and your healthcare provider to craft interventions and a personalized management plan, paving the way for more effective and beneficial care.

Understanding the Test: A Crucial Step in Combating Alzheimer's Disease

Alzheimer's disease (AD) is a relentless brain-related disorder that gradually erodes memory and cognitive understanding, leading, in extreme cases, to total mental and physical incapacitation. The test for Alzheimer's focuses on measuring two specific biomarkers, A-beta 42 and A-beta 40, and computes their blood level ratio. This calculated ratio between these molecular indicators may provide early warnings and pinpoint the risk of Alzheimer's disease even before substantial cognitive decline sets in.

For the majority suffering from Alzheimer's – specifically, those experiencing the late-onset form of the disease – symptoms often first manifest in the mid-60s or later. Conversely, early-onset Alzheimer's, which may arise as precociously as in a person's 30s (though rarely), is diagnosed when the disease develops before the age of 65.

Presently, there is no known cure for AD. However, when detected early, treatments exist that can decelerate its progression. In tandem, the scientific community continues to innovate with ongoing clinical trials, testing, and developing new therapies. Early detection thus becomes an empowering tool, fostering necessary dialogues with healthcare professionals. This allows for a strategic approach to minimize further risk through lifestyle alterations and proactive engagement in treatment discussions as and when new therapies emerge.

Who Should Consider Testing?

If you find yourself in any of the following categories, it may be prudent to consider Alzheimer's disease testing:

  • Family History: Those who have a family history of Alzheimer's disease, especially among immediate family members, may be at a higher risk.
  • Memory Loss: Individuals experiencing unexplained or persistent memory loss that affects daily life.
  • Early Cognitive Decline: Anyone noticing a decrease in cognitive abilities, such as difficulty in thinking, reasoning, or decision-making, may benefit from an evaluation.

These signs may be indicative of early-stage Alzheimer's, and early detection can be critical in developing a personalized care plan. It's always best to consult with a healthcare provider to assess your specific situation and decide on the appropriate course of action.

Determining if This Test is Suited for You: A Guide to Assessment

Wondering whether this Alzheimer's disease test is the right fit for you? It might be particularly relevant and beneficial if you find yourself aligned with any of the following conditions:

  • You have an immediate family connection, such as a parent or sibling, diagnosed with AD.
  • A family history reveals a genetic predisposition to Alzheimer's disease.
  • You've reached the age of 65 or are older.
  • You've encountered a significant brain trauma or head injury in the past.
  • You've been experiencing ongoing memory challenges or cognitive difficulties.

Should any of these situations resonate with you, it may be wise to consider this test. It's a proactive step toward understanding your health, potentially detecting early signs of Alzheimer's disease, and creating a path for timely intervention and care. Consultation with a healthcare provider is recommended to evaluate your specific situation further and determine the best course of action.

Examining What's Tested: A Comprehensive Look at the AD-Detect Test

The AD-Detect Test for Alzheimer's Disease is part of a new era of diagnostic tools, focusing specifically on the blood-biomarkers associated with peptide amyloid-β (commonly referred to as A-beta). This test zeroes in on two specific amyloid-β peptides: A-beta 42 and A-beta 40, calculating their blood levels ratio to provide insights into early detection of Alzheimer's.

Amyloid beta proteins play a pivotal role in the progression of Alzheimer's disease, as they tend to accumulate and form plaques within the brain. These specific biomarkers, A-beta 42 and A-beta 40, result from the breakdown of amyloid precursor protein (APP), with A-beta 42 being the longer fragment and A-beta 40 the shorter.

The A-beta 42/A-beta 40 ratio serves as a vital metric within Alzheimer's research, signaling the presence of amyloid beta proteins within the brain. This ratio is particularly significant since A-beta 42 is prone to clump together, leading to plaque formation and reduced detectability, while A-beta 40 is more soluble and less likely to form plaques. Consequently, a lower ratio of A-beta 42 to A-beta 40 correlates with an increased risk of developing Alzheimer's.

Prior to the advent of blood-biomarker testing, neurologists primarily depended on cognitive evaluations and brain imaging for Alzheimer's diagnosis. Unfortunately, these traditional techniques often led to difficulties in distinguishing Alzheimer's from other dementia forms. The AD-Detect Test offers a more nuanced approach, assisting in pinpointing Alzheimer's as the probable underlying cause of a patient's mild cognitive impairment. It serves as a significant stride toward precise diagnosis, empowering healthcare providers and patients with actionable insights.

Recognizing the Signs and Symptoms: The Varied Faces of Alzheimer's Disease

Alzheimer's disease unfolds across several stages, manifesting in a spectrum of signs and symptoms that may intensify as the condition progresses. The potential indicators can range from subtle changes in memory to more noticeable shifts in behavior and cognitive abilities. Here's a closer look at some common signs:

  1. Forgetfulness: Initial forgetfulness can evolve into more profound memory loss, affecting daily life.

  2. Language Struggles: Trouble recalling common words, names of familiar places, or everyday objects.

  3. Decision-making Difficulties: Challenges in making everyday decisions, even those that were once simple and routine.

  4. Confusion and Disorientation: Periods of confusion about time, dates, or locations, leading to a sense of being lost or disoriented.

  5. Emotional Fluctuations: Unpredictable mood swings, with sudden shifts into anger or aggression.

  6. Eating Challenges: Difficulties in eating or swallowing, possibly leading to changes in diet or weight.

  7. Physical and Mental Struggles: Increasing trouble in performing simple mental calculations and physical tasks, such as dressing or managing personal hygiene.

  8. Cognitive Decline: A gradual reduction in thinking abilities, encompassing reasoning, judgment, and complex thought.

  9. Severe Memory Loss: Advanced stages may bring about substantial loss of memory, affecting recognition of loved ones and essential aspects of personal history.

Each of these symptoms may vary in intensity and can overlap across different stages of Alzheimer's disease. Recognizing these signs early can lead to timely intervention and care, providing a more targeted approach to managing and potentially slowing the progression of this complex and multifaceted disorder.


Reference Range(s)

ABeta 42 Not established pg/mL
ABeta 40 Not established pg/mL
ABeta 42/40 Ratio ≥0.170  

Alternative Name(s)

ABeta 42,ABeta 40,AB40,AB42,Alzheimer's Disease (AD),AB42/40,AD,ABeta 42/40

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.




*Process times are an estimate and are not guaranteed. The lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

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