QUEST AD-Detect™ Apolipoprotein E (ApoE) Isoform, Plasma

The QUEST AD-Detect™ Apolipoprotein E (ApoE) Isoform, Plasma test contains 1 test.

QUEST AD-Detect™ Apolipoprotein E (ApoE) Isoform, Plasma

Clinical Significance

QUEST AD-Detect™ Apolipoprotein E (ApoE) Isoform, Plasma - Apolipoprotein E (ApoE) is a well-defined genetic risk factor for late-onset Alzheimer's disease (AD). The human APOE gene has three polymorphic alleles, E2, E3 and E4 that result in six different genotypes: E2/E2, E2/E3, E3/E3, E2/ E4, E3/E4 and E4/E4. About half of AD patients carry the E4 allele (compared with 14% in the general population), with the majority being heterozygotes (E3/E4). The number of inherited E4 alleles is associated with both increased disease risk and decreased average age of onset compared with inheritance of the E2 or E3 alleles. The differences between the three ApoE isoforms are based on two amino acids that affect its structure and hence the interaction and binding of the protein with various lipids and beta-amyloid (AB). ApoE and AB can co-localize in the brain; therefore, their complementary roles in AD have been studied extensively. Circulating plasma and CSF ApoE levels were recently found to be potential biomarkers for AD.

Alternative Name(s)
Alzheimer's Disease (AD), ApoE2,ApoE3, ApoE4

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

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