Organ Function and Kidney Health Panel

Comprehensive organ function and kidney health panel including a full metabolic panel and complete urinalysis. Evaluates kidney filtration (creatinine, eGFR), liver enzymes, electrolytes, glucose, protein balance, and detailed urine analysis to assess renal function, metabolic health, and urinary tract status in one integrated evaluation.

Serum, Random
Phlebotomist

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Also known as: Chem 12, Chemistry Panel, Chemistry Screen, CMP, Complete Metabolic Panel, Comprehensive Metabolic Panel CMP, SMA 12, SMA 20

Albumin

Albumin is a protein made by the liver. A serum albumin test measures the amount of this protein in the clear liquid portion of the blood.

Albumin/Globulin Ratio

The ratio of albumin to globulin (A/G ratio) is calculated from measured albumin and calculated globulin (total protein - albumin). Normally, there is a little more albumin than globulins, giving a normal A/G ratio of slightly over 1. Because disease states affect the relative amounts of albumin and globulin, the A/G ratio may provide a clue as to the cause of the change in protein levels. A low A/G ratio may reflect overproduction of globulins, such as seen in multiple myeloma or autoimmune diseases, or underproduction of albumin, such as may occur with cirrhosis, or selective loss of albumin from the circulation, as may occur with kidney disease (nephrotic syndrome). A high A/G ratio suggests underproduction of immunoglobulins as may be seen in some genetic deficiencies and in some leukemias. More specific tests, such as liver enzyme tests and serum protein electrophoresis, must be performed to make an accurate diagnosis. With a low total protein that is due to plasma expansion (dilution of the blood), the A/G ratio will typically be normal because both albumin and globulin will be diluted to the same extent.

Alkaline Phosphatase

Alkaline phosphatase (ALP) is a protein found in all body tissues. Tissues with higher amounts of ALP include the liver, bile ducts, and bone.

Alt

Alanine transaminase (ALT) is an enzyme found in the highest amounts in the liver. Injury to the liver results in release of the substance into the blood.

AST

AST (aspartate aminotransferase) is an enzyme found in high amounts in liver, heart, and muscle cells. It is also found in lesser amounts in other tissues.

Bilirubin, Total

Bilirubin is a yellowish pigment found in bile, a fluid made by the liver. A small amount of older red blood cells are replaced by new blood cells every day. Bilirubin is left after these older blood cells are removed. The liver helps break down bilirubin so that it can be removed from the body in the stool.

Bun/Creatinine Ratio

A ratio between a person’s BUN and blood creatinine to help determine what is causing these concentrations to be higher than normal. The ratio of BUN to creatinine is usually between 10:1 and 20:1. An increased ratio may be due to a condition that causes a decrease in the flow of blood to the kidneys, such as congestive heart failure or dehydration. It may also be seen with increased protein, from gastrointestinal bleeding, or increased protein in the diet. The ratio may be decreased with liver disease (due to decrease in the formation of urea) and malnutrition.

Calcium

You have more calcium in your body than any other mineral. Calcium has many important jobs. The body stores more than 99 percent of its calcium in the bones and teeth to help make and keep them strong. The rest is throughout the body in blood, muscle and the fluid between cells. Your body needs calcium to help muscles and blood vessels contract and expand, to secrete hormones and enzymes and to send messages through the nervous system.

Carbon Dioxide

CO2 is carbon dioxide. Measures the amount of carbon dioxide in the liquid part of your blood, called the serum. In the body, most of the CO2 is in the form of a substance called bicarbonate (HCO3-). Therefore, the CO2 blood test is really a measure of your blood bicarbonate level.

Chloride

Chloride is a type of electrolyte. It works with other electrolytes such as potassium, sodium, and carbon dioxide (CO2). These substances help keep the proper balance of body fluids and maintain the body's acid-base balance. This is a measure of the amount of chloride in the fluid portion (serum) of the blood.

Creatinine

The creatinine blood test measures the level of creatinine in the blood. This test is done to see how well your kidneys work.

Egfr African American

Glomerular filtration rate (GFR) is a test used to check how well the kidneys are working. Specifically, it estimates how much blood passes through the glomeruli each minute. Glomeruli are the tiny filters in the kidneys that filter waste from the blood.

Egfr Non-Afr. American

Glomerular filtration rate (GFR) is a test used to check how well the kidneys are working. Specifically, it estimates how much blood passes through the glomeruli each minute. Glomeruli are the tiny filters in the kidneys that filter waste from the blood.

GFR-AFRICAN AMERICAN

GFR-NON AFRICAN AMERICAN

Globulin

Globulins is the collective term for most blood proteins other than albumin. Identifying the types of globulins can help diagnose certain disorders. Globulins are roughly divided into three groups: alpha, beta, and gamma globulins. Gamma globulines include various types of antibodies such as immunoglobulins (Ig) M, G, and A.

Glucose

A blood glucose test measures the amount of a sugar called glucose in a sample of your blood. Glucose is a major source of energy for most cells of the body, including those in the brain. The hormones insulin and glucagon help control blood glucose levels.

Potassium

Potassium is a mineral that the body needs to work normally. It helps nerves and muscles communicate. It also helps move nutrients into cells and waste products out of cells. A diet rich in potassium helps to offset some of sodium's harmful effects on blood pressure.

Protein, Total

The total protein is the total amount of two classes of proteins, albumin and globulin that are found in the fluid portion of your blood. Proteins are important parts of all cells and tissues. Your albumin helps prevent fluid from leaking out of blood vessels and your globulins are an important part of your immune system.

Sodium

Sodium is a substance that the body needs to work properly it is vital to normal body processes, including nerve and muscle function

Urea Nitrogen (Bun)

BUN stands for blood urea nitrogen. Urea nitrogen is what forms when protein breaks down. BUN measures the amount of urea nitrogen in the blood.

Also known as: UA, Complete, Urinalysis UA Complete, Urine Analysis, Complete

Amorphous Sediment (Only Reported If Detected)

Appearance

Bacteria

Bacteria are living things that have only one cell. Most bacteria won't hurt you - less than 1 percent of the different types make people sick. Many are helpful. Some bacteria help to digest food, destroy disease-causing cells, and give the body needed vitamins. But infectious bacteria can make you ill. They reproduce quickly in your body. Many give off chemicals called toxins, which can damage tissue and make you sick. Examples of bacteria that cause infections include Streptococcus, Staphylococcus, and E. coli.

Bilirubin

Bilirubin is a yellowish pigment found in bile, a fluid made by the liver. A small amount of older red blood cells are replaced by new blood cells every day. Bilirubin is left after these older blood cells are removed. The liver helps break down bilirubin so that it can be removed from the body in the stool.

Calcium Oxalate Crystals (Only Reported If Detected)

Calcium oxalate is a chemical compound that forms envelope-shaped crystals. A major constituent of human kidney stones.

Casts (Only Reported If Detected)

Urinary casts are cylindrical structures produced by the kidney and present in the urine in certain disease states. They form in the distal convoluted tubule and collecting ducts of nephrons, then dislodge and pass into the urine, where they can be detected by microscopy.

Color

Crystals (Only Reported If Detected)

Abnormal crystals may appear in urine as a result of pathology or due to normal catabolism

Glucose

A blood glucose test measures the amount of a sugar called glucose in a sample of your blood. Glucose is a major source of energy for most cells of the body, including those in the brain. The hormones insulin and glucagon help control blood glucose levels.

Granular Cast (Only Reported If Detected)

The second-most common type of cast, granular casts can result either from the breakdown of cellular casts or the inclusion of aggregates of plasma proteins (e.g., albumin) or immunoglobulin light chains. Depending on the size of inclusions, they can be classified as fine or coarse, though the distinction has no diagnostic significance. Their appearance is generally more cigar-shaped and of a higher refractive index than hyaline casts. While most often indicative of chronic renal disease, these casts, as with hyaline casts, can also be seen for a short time following strenuous exercise

Hyaline Cast

Urinary casts are tiny tube-shaped particles. Urinary casts may be made up of white blood cells, red blood cells, kidney cells, or substances such as protein or fat. The most common type of cast, hyaline casts are solidified Tamm-Horsfall mucoprotein secreted from the tubular epithelial cells of individual nephrons. Low urine flow, concentrated urine, or an acidic environment can contribute to the formation of hyaline casts, and, as such, they may be seen in normal individuals in dehydration or vigorous exercise. Hyaline casts are cylindrical and clear, with a low refractive index,

Ketones

Ketones are substances produced in the liver when fat cells break down in the blood. A serum ketone test is a measurement of how many ketones are in the blood.

Leukocyte Esterase

Leukocyte esterase is a urine test to look for white blood cells and other signs associated with infection.

Nitrite

Occult Blood

The test looks for hidden (occult) blood in a specimen sample. It can find blood even if you cannot see it yourself.

Ph

Level of acid

Protein

Body fluids contain many different proteins that serve diverse functions such as transport of nutrients, removal of toxins, control of metabolic processes, and defense against invaders. Protein electrophoresis is a method for separating these proteins based on their size and electrical charge. When body fluids are separated by electrophoresis, they form a characteristic pattern of bands of different widths and intensities, reflecting the mixture of proteins present. This pattern is divided into five fractions, called albumin, alpha 1, alpha 2, beta, and gamma. In some cases, the beta fraction is further divided into beta 1 and beta 2. Albumin, which is produced in the liver, accounts for about 60% of the protein in the blood. "Globulins" is a collective term used to refer to proteins other than albumin. With the exception of the immunoglobulins and some complement proteins, most of the globulins are also produced in the liver. Immunofixation electrophoresis (IFE) is a method used to identify abnormal bands seen on serum, urine, or CSF protein electrophoresis, as to which type of antibody (immunoglobulin) is present.

Rbc

RBCs contain hemoglobin, which carries oxygen. How much oxygen your body tissues get depends on how many RBCs you have and how well they work.

Reducing Substances (Only Reported If Detected)

Renal Epithelial Cells (Only Reported If Detected)

Specific Gravity

Squamous Epithelial Cells

Transitional Epithelial (Only Reported If Detected)

Triple Phosphate Crystals (Only Reported If Detected)

Struvite stones (triple phosphate/magnesium ammonium phosphate) - about 10–15% of urinary calculi are composed of struvite (ammonium magnesium phosphate, NH4MgPO4·6H2O).[44] Struvite stones (also known as "infection stones", urease or triple-phosphate stones), form most often in the presence of infection by urea-splitting bacteria

Uric Acid Crystals (Only Reported If Detected)

Abnormal crystals may appear in urine as a result of pathology or due to normal catabolism

WBC

WBCs help fight infections. They are also called leukocytes. There are five major types of white blood cells: basophils, eosinophils, lymphocytes (T cells and B cells), monocytes and neutrophils

YEAST (Only Reported If Detected)

Candida is the scientific name for yeast. It is a fungus that lives almost everywhere, including in your body. Usually, your immune system keeps yeast under control. If you are sick or taking antibiotics, it can multiply and cause an infection.
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The Organ Function and Kidney Health Panel panel contains 2 tests with 48 biomarkers .

Brief Description

A Comprehensive Evaluation of Kidney, Liver, and Metabolic Organ Function

The Organ Function and Kidney Health Panel is a comprehensive laboratory assessment designed to evaluate kidney performance, liver function, electrolyte balance, and overall metabolic health. By combining a Comprehensive Metabolic Panel (CMP) with a Complete Urinalysis, this panel provides a broad yet detailed overview of how major organ systems are functioning.

The kidneys and liver play essential roles in maintaining internal balance. The kidneys filter waste products from the blood, regulate fluid and electrolyte levels, and help control blood pressure. The liver supports metabolism, detoxification, protein production, and nutrient processing. Because these organs work together to maintain homeostasis, evaluating both blood chemistry and urine findings offers a more complete picture of systemic health.

The Comprehensive Metabolic Panel assesses blood glucose, kidney filtration markers, liver enzymes, electrolyte levels, and protein balance. The Complete Urinalysis evaluates physical, chemical, and microscopic properties of urine, offering insight into kidney filtration, hydration status, urinary tract health, and possible metabolic abnormalities.

This integrated approach allows healthcare providers to detect early changes in kidney or liver function, monitor chronic conditions, and assess metabolic patterns that may affect long-term health. Whether used for preventive screening or ongoing monitoring, the Organ Function and Kidney Health Panel delivers clinically meaningful data that supports informed healthcare decision-making.

When and Why Someone Would Order This Panel

Routine Preventive Health Screening

Many individuals undergo organ function testing as part of routine preventive care. Kidney and liver disorders may develop gradually and without noticeable symptoms in early stages. Regular monitoring of metabolic markers and urinalysis findings can help identify subtle changes before more advanced dysfunction occurs.

This panel may be appropriate for individuals who:

  • Are undergoing annual wellness screening

  • Have high blood pressure or diabetes

  • Have a family history of kidney or liver disease

  • Are taking medications that require liver or kidney monitoring

  • Have abnormal prior laboratory results

  • Are experiencing fatigue, swelling, or changes in urination

Evaluation of Kidney Health

Kidney function can be affected by conditions such as hypertension, diabetes, autoimmune disease, infections, or medication use. The combination of blood-based kidney markers and urinalysis provides complementary insight. Blood testing evaluates filtration efficiency, while urinalysis can detect protein, blood, or other abnormalities in the urine.

Assessment of Liver and Metabolic Function

The liver is central to metabolic processes, including glucose regulation, protein synthesis, and detoxification. Abnormal liver enzymes may indicate inflammation or injury. Electrolyte imbalances or abnormal protein levels may reflect broader systemic issues that warrant further evaluation.

Monitoring Chronic Conditions

For individuals with known kidney disease, liver conditions, or metabolic disorders, this panel may be used periodically to track trends and assess stability. Consistent monitoring allows healthcare providers to evaluate disease progression and response to treatment.

Overall, this panel serves as a foundational assessment of organ function and metabolic health.

What Does the Panel Measure?

Comprehensive Metabolic Panel (CMP)

The Comprehensive Metabolic Panel evaluates multiple key biomarkers:

Kidney Function Markers

  • Creatinine: Waste product filtered by the kidneys; used to estimate filtration efficiency.

  • Blood Urea Nitrogen (BUN): Reflects protein metabolism and kidney excretory function.

  • Estimated Glomerular Filtration Rate (eGFR): Calculation based on creatinine to assess kidney filtration capacity.

Liver Function Markers

  • Alanine Aminotransferase (ALT)

  • Aspartate Aminotransferase (AST)

  • Alkaline Phosphatase (ALP)

  • Bilirubin

These markers help evaluate liver cell integrity and bile flow.

Electrolytes and Metabolic Markers

  • Sodium, Potassium, Chloride, and Carbon Dioxide (CO2)

  • Glucose: Assesses blood sugar levels.

  • Calcium: Important for bone and metabolic function.

  • Total Protein and Albumin: Reflect nutritional and liver function status.

Complete Urinalysis

A complete urinalysis evaluates:

Physical Characteristics

  • Color and clarity

Chemical Analysis

  • pH

  • Specific gravity (hydration status)

  • Protein

  • Glucose

  • Ketones

  • Blood

  • Bilirubin

  • Nitrites and leukocyte esterase

Microscopic Examination

  • Red blood cells

  • White blood cells

  • Epithelial cells

  • Bacteria or crystals

Together, these urine findings help assess kidney filtration, urinary tract health, and metabolic abnormalities.

By combining blood chemistry with urine analysis, this panel provides a comprehensive evaluation of organ function.

How Patients and Healthcare Providers Use the Results

Detecting Early Kidney Disease

Elevated creatinine, reduced eGFR, or abnormal BUN levels may suggest decreased kidney filtration. The presence of protein or blood in the urine can be an early indicator of kidney involvement. Conditions such as chronic kidney disease, diabetic nephropathy, or hypertensive kidney damage may be identified through these patterns.

Evaluating Liver Function

Abnormal liver enzyme levels may indicate liver inflammation, fatty liver disease, medication-related liver stress, or other hepatic conditions. Monitoring these markers allows healthcare providers to assess liver health over time.

Assessing Metabolic and Electrolyte Balance

Electrolyte imbalances can influence cardiovascular, neuromuscular, and metabolic function. Abnormal glucose levels may indicate impaired glucose regulation or diabetes. Reviewing these markers together provides insight into systemic metabolic health.

Investigating Urinary Symptoms

Urinalysis findings such as white blood cells, bacteria, or nitrites may suggest urinary tract infection. Blood or protein in the urine may require further evaluation to determine the underlying cause.

Monitoring Chronic Conditions and Medications

For individuals with diabetes, hypertension, kidney disease, or those taking medications processed by the liver or kidneys, periodic testing supports safe and effective long-term management.

Healthcare providers interpret results in clinical context, integrating laboratory findings with medical history and symptoms to guide appropriate follow-up.

A Foundational Assessment of Organ and Kidney Health

The Organ Function and Kidney Health Panel provides a comprehensive evaluation of kidney filtration, liver function, electrolyte balance, and urinary health. By combining a Comprehensive Metabolic Panel with a Complete Urinalysis, this assessment offers a broad yet detailed overview of essential organ systems that support overall health.

Early detection of changes in kidney or liver function can be critical in preventing progression of disease. Objective laboratory data allows healthcare providers to identify patterns, monitor trends, and guide appropriate evaluation when needed.

Whether used for preventive screening or ongoing monitoring, this panel supports a clear, data-driven understanding of organ health. Through integrated blood and urine analysis, it offers a reliable foundation for informed healthcare discussions and long-term wellness planning.

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