Neurofilament Light Chain (NfL), Plasma

Blood
Blood Draw
There are no preparation instructions.

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

NEUROFILAMENT LIGHT

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The Neurofilament Light Chain (NfL), Plasma test contains 1 test with 1 biomarker .

Clinical Significance

Neurofilament Light Chain (NfL), Plasma - Neurofilament light (NfL) is an intermediate filament protein found specifically in the neuronal cytoskeleton. It can be released into the extracellular space through axonal degradation, and it has been shown that varying NfL levels are an indicator of neuroaxonal damage, irrespective of the cause, and can therefore be associated with a variety of neurological diseases such as multiple sclerosis, amyotrophic lateral sclerosis, frontotemporal dementia, or Alzheimer's disease, as well as acute situations such as traumatic brain injury and others. NfL is thus considered a promising biomarker for, disease activity, progression, prognosis, and monitoring effectiveness of therapies. As NfL can be measured in both cerebrospinal fluid (CSF) and blood, it holds great potential for routine clinical use.

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