N-Methylhistamine, 24 Hour, Urine

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The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

COLLECTION DURATION

CREATININE CONCENTRATION

CREATININE, 24 HOUR, U

N METHYLHISTAMINE, 24HR,U

URINE VOLUME

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The N-Methylhistamine, 24 Hour, Urine test contains 1 test with 5 biomarkers.

Clinical Significance

N-Methylhistamine, 24 Hour, Urine - Screening for and monitoring of mastocytosis and disorders of systemic mast-cell activation, such as anaphylaxis and other forms of severe systemic allergic reactions using 24-hour urine collection specimens. Monitoring therapeutic progress in conditions that are associated with secondary, localized, low-grade persistent, mast-cell proliferation and activation such as interstitial cystitis.

Cautions:
While an average North American diet has no effect on urinary N-methylhistamine (NMH) levels, mild elevations (around 30%) may be observed on very histamine-rich diets. This problem is more pronounced if random-urine specimens are used and collected following a histamine-rich meal. NMH levels may be depressed in individuals who have an alteration in the histamine-N-methyl transferase gene, which encodes the enzyme that catalyzes NMH formation. This alteration results in an amino acid change that decreases the rate of NMH synthesis. When N-acetylcysteine is administered at levels sufficient to act as an antidote for the treatment of acetaminophen overdose, it may lead to falsely decreased creatinine results.

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