Lyme Disease - Direct and Indirect Panel

The Lyme Disease - Direct and Indirect Panel panel contains 2 tests with 17 biomarkers.

Lyme Disease - Direct and Indirect Panel

Both indirect (Serology) and direct tests (PCR) should be routinely used for the accurate, sensitive, and specific laboratory detection of Lyme disease. Because of the complex nature of the disease, no single test is adequate for all clinical situations.

  1. Lyme Disease (Borrelia spp) DNA, Qualitative, Real-Time PCR, Blood
  2. Lyme Disease Antibodies (IgG, IgM), Immunoblot

Clinical Significance

The diagnosis of Lyme disease is most often made by clinical examination combined with evidence of tick bite or exposure in endemic areas. Amplification of Borrelia genomic DNA from blood, fluids or tissues can support the diagnosis. 

Lyme disease is transmitted by a tick vector carrying Borreliaburgdorferi. Immunoblot testing qualitatively examines, with high specificity, antibodies in a patient's specimen. Immunoblot testing is appropriate for confirming a detected EIA or IFA test result.

Result Name LOINC Code Component Name
45059500 Lyme Disease Ab (IgG),Blot 6320-6 Borrelia burgdorferi Ab.IgG
45059600 18 kD (IgG) Band 9588-5 Borrelia burgdorferi 18kD Ab.IgG
45059700 23 kD (IgG) Band 9589-3 Borrelia burgdorferi 23kD Ab.IgG
45059800 28 kD (IgG) Band 9590-1 Borrelia burgdorferi 28kD Ab.IgG
45059900 30 kD (IgG) Band 9591-9 Borrelia burgdorferi 30kD Ab.IgG
45060500 45 kD (IgG) Band 9594-3 Borrelia burgdorferi 45kD Ab.IgG
45060600 58 kD (IgG) Band 9595-0 Borrelia burgdorferi 58kD Ab.IgG
45060700 66 kD (IgG) Band 9596-8 Borrelia burgdorferi 66kD Ab.IgG
45060800 93 kD (IgG) Band 9597-6 Borrelia burgdorferi 93kD Ab.IgG
45060900 Lyme Disease Ab (IgM),Blot 6321-4 Borrelia burgdorferi Ab.IgM
45061200 41 kD (IgM) Band 9587-7 Borrelia burgdorferi 41kD Ab.IgM
45061300 39 kD (IgG) Band 9592-7 Borrelia burgdorferi 39kD Ab.IgG
45061400 41 kD (IgG) Band 9593-5 Borrelia burgdorferi 41kD Ab.IgG
45061500 23 kD (IgM) Band 9598-4 Borrelia burgdorferi 23kD Ab.IgM
45061600 39 kD (IgM) Band 9599-2 Borrelia burgdorferi 39kD Ab.IgM
Result Name LOINC Code Component Name
86007023 Lyme Disease DNA 32667-8

Borrelia burgdorferi DNA

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Also known as: Lyme Disease Borrelia Spp Dna Ql Blood

Lyme Disease (Borrelia


Also known as: Borrelia burgdorferi, Lyme Disease Antibodies IgG IgM Immunoblot

18 Kd (IgG) Band

23 Kd (IgG) Band

23 Kd (IgM) Band

28 Kd (IgG) Band

30 Kd (IgG) Band

39 Kd (IgG) Band

39 Kd (IgM) Band

41 Kd (IgG) Band

41 Kd (IgM) Band

45 Kd (IgG) Band

58 Kd (IgG) Band

66 Kd (IgG) Band

93 Kd (IgG) Band

Lyme Disease Ab(IgG),Blot

Lyme Disease Ab(IgM),Blot

*Process times are an estimate and are not guaranteed. The lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

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