Lp-PLA2 Activity Most Popular

The Lp-PLA2 Activity test contains 1 test with 1 biomarker.

Description: The Lp-PLA2 test is a blood test that measures the levels and activity of Lp-PLA2, an enzyme that plays a role in inflammation, in your blood’s serum.

Also Known As: LpPLA2 Test, Ps-PLA2 Activity Test, Platelet-activating Factor Acetylhydrolase Test, PAF-AH Test, PLAC Test, Lipoprotein-associated phospholipase A2 Test

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: No preparation required

When is a Lp-PLA2 Activity test ordered?

Lp-PLA2 is a newer test. When someone has a family history of CHD, metabolic syndrome, and/or is deemed to be at a moderate to elevated risk for CHD or ischemic stroke, certain health practitioners may request it along with other cardiac risk markers.

What does a Lp-PLA2 Activity blood test check for?

Lp-PLA2 is an enzyme that appears to play a role in blood vessel inflammation and is thought to contribute to atherosclerosis. This test determines the amount of Lp-PLA2 in the blood as well as its activity.

Lp-PLA2 has been demonstrated in recent research to be an independent risk factor for cardiovascular disease, such as coronary heart disease and ischemic stroke. Increased levels of Lp-PLA2 were seen in many persons diagnosed with CHD and ischemic stroke in these investigations, regardless of other risk factors. These findings suggest that this relatively new test could be beneficial as one of an increasing number of cardiac risk markers for determining a person's CVD risk.

According to the Centers for Disease Control and Prevention, cardiovascular disease causes more deaths in the United States each year than any other cause. Both coronary heart disease and ischemic stroke are caused by the formation of unstable fatty plaque deposits in the arteries, which can cause blood vessel blockages and heart attacks or brain damage. High blood pressure, diabetes, metabolic syndrome, smoking, obesity, high cholesterol levels, elevated LDL, and decreased HDL are all risk factors linked to both illnesses.

CVD affects many people who have one or more of the generally recognized risk factors, but it also affects a large number of persons who have few or none of these risk factors. This has prompted researchers to hunt for new markers that could help them identify those who are at a higher risk of cardiovascular disease.

A low level of chronic, systemic inflammation and blood vessel inflammation, in addition to the usual risk factors listed above, is thought to contribute to overall risk of developing CVD. The hs-CRP test is linked to systemic inflammation, and high levels are linked to an increased risk of cardiovascular disease. The Lp-PLA2 test is linked to vascular inflammation, and high levels have been linked to an increased risk of cardiovascular events such as heart attack or stroke.

Lab tests often ordered with a Lp-PLA2 Activity test:

  • Lipid Panel
  • Lipoprotein Fractionation, Ion Mobility
  • Lipoprotein Subfractionation
  • Hs-CRP
  • Cholesterol Total
  • LDL Cholesterol
  • HDL Cholesterol

RelateConditions where a Lp-PLA2 Activity test is recommended:

  • Heart Disease
  • Cardiovascular Disease
  • Stroke
  • Metabolic Syndrome
  • Hypertension

How does my health care provider use a Lp-PLA2 Activity test?

The Lp-PLA2 test is sometimes used to determine a person's risk of coronary heart disease or suffering an ischemic stroke.

Lp-PLA2 is an enzyme that appears to play a role in blood vessel inflammation and is thought to contribute to atherosclerosis. Lp-PLA2 has been demonstrated in recent research to be an independent risk factor for cardiovascular disease, such as coronary heart disease and ischemic stroke.

The test is often used to assess someone who is at a moderate to high risk of CHD or stroke, as well as someone who has one or more other risk factors. When someone has normal or minimally raised lipid levels, borderline high blood pressure, or metabolic syndrome, it may be ordered.

To assess a person's level of underlying inflammation linked to CVD risk, a Lp-PLA2 test may be utilized in conjunction with a hs-CRP test. Unlike the hs-CRP test, the Lp-PLA2 test is unaffected by disorders other than CVD that can produce general inflammation, hence it can be used to diagnose inflammatory conditions like arthritis.

Lp-PLA2 is a relatively new test that is rarely requested, and its clinical utility has yet to be determined. Its purpose is to provide extra information rather than to replace cholesterol and other lipid monitoring.

Some academics are looking at whether lowering Lp-PLA2 levels can reduce the risk of CHD and ischemic stroke. If lowering Lp-PLA2 lowers the risk of CVD and stroke, the Lp-PLA2 test may be requested more regularly and used to track a person's response to treatment.

What do my Lp-PLA2 test results mean?

A highly elevated Lp-PLA2 level implies an increased chance of developing CHD or having an ischemic stroke, as well as providing extra information to a health practitioner about the examined person's overall risk.

A low or normal Lp-PLA2 level indicates that this factor does not add to the risk of CVD in the person being examined.

The test is a risk indicator, not a diagnosis of CHD or ischemic stroke. Many persons with high quantities will not get these symptoms, whereas others with normal concentrations may.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.


*Process times are an estimate and are not guaranteed. The lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

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