Ulta Lab Tests

Inflammation, NF-KB Regulation & Healthy Aging Panel

Blood, Serum, Varied
Phlebotomist

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Also known as: Apolipoprotein B Cardio IQ, Cardio IQ Apolipoprotein B

Apolipoprotein B

Also known as: C-Reactive Protein, CReactive Protein CRP, CRP

C-REACTIVE PROTEIN

C-reactive protein is produced by the liver. The level of CRP rises when there is inflammation throughout the body.

Also known as: Cardio IQ Homocysteine , Homocysteine, Homocysteine Cardio IQ

HOMOCYSTEINE,

Also known as: Chem 12, Chemistry Panel, Chemistry Screen, CMP, Complete Metabolic Panel, Comprehensive Metabolic Panel CMP, SMA 12, SMA 20

Albumin

Albumin is a protein made by the liver. A serum albumin test measures the amount of this protein in the clear liquid portion of the blood.

Albumin/Globulin Ratio

The ratio of albumin to globulin (A/G ratio) is calculated from measured albumin and calculated globulin (total protein - albumin). Normally, there is a little more albumin than globulins, giving a normal A/G ratio of slightly over 1. Because disease states affect the relative amounts of albumin and globulin, the A/G ratio may provide a clue as to the cause of the change in protein levels. A low A/G ratio may reflect overproduction of globulins, such as seen in multiple myeloma or autoimmune diseases, or underproduction of albumin, such as may occur with cirrhosis, or selective loss of albumin from the circulation, as may occur with kidney disease (nephrotic syndrome). A high A/G ratio suggests underproduction of immunoglobulins as may be seen in some genetic deficiencies and in some leukemias. More specific tests, such as liver enzyme tests and serum protein electrophoresis, must be performed to make an accurate diagnosis. With a low total protein that is due to plasma expansion (dilution of the blood), the A/G ratio will typically be normal because both albumin and globulin will be diluted to the same extent.

Alkaline Phosphatase

Alkaline phosphatase (ALP) is a protein found in all body tissues. Tissues with higher amounts of ALP include the liver, bile ducts, and bone.

Alt

Alanine transaminase (ALT) is an enzyme found in the highest amounts in the liver. Injury to the liver results in release of the substance into the blood.

AST

AST (aspartate aminotransferase) is an enzyme found in high amounts in liver, heart, and muscle cells. It is also found in lesser amounts in other tissues.

Bilirubin, Total

Bilirubin is a yellowish pigment found in bile, a fluid made by the liver. A small amount of older red blood cells are replaced by new blood cells every day. Bilirubin is left after these older blood cells are removed. The liver helps break down bilirubin so that it can be removed from the body in the stool.

Bun/Creatinine Ratio

A ratio between a person’s BUN and blood creatinine to help determine what is causing these concentrations to be higher than normal. The ratio of BUN to creatinine is usually between 10:1 and 20:1. An increased ratio may be due to a condition that causes a decrease in the flow of blood to the kidneys, such as congestive heart failure or dehydration. It may also be seen with increased protein, from gastrointestinal bleeding, or increased protein in the diet. The ratio may be decreased with liver disease (due to decrease in the formation of urea) and malnutrition.

Calcium

You have more calcium in your body than any other mineral. Calcium has many important jobs. The body stores more than 99 percent of its calcium in the bones and teeth to help make and keep them strong. The rest is throughout the body in blood, muscle and the fluid between cells. Your body needs calcium to help muscles and blood vessels contract and expand, to secrete hormones and enzymes and to send messages through the nervous system.

Carbon Dioxide

CO2 is carbon dioxide. Measures the amount of carbon dioxide in the liquid part of your blood, called the serum. In the body, most of the CO2 is in the form of a substance called bicarbonate (HCO3-). Therefore, the CO2 blood test is really a measure of your blood bicarbonate level.

Chloride

Chloride is a type of electrolyte. It works with other electrolytes such as potassium, sodium, and carbon dioxide (CO2). These substances help keep the proper balance of body fluids and maintain the body's acid-base balance. This is a measure of the amount of chloride in the fluid portion (serum) of the blood.

Creatinine

The creatinine blood test measures the level of creatinine in the blood. This test is done to see how well your kidneys work.

Egfr African American

Glomerular filtration rate (GFR) is a test used to check how well the kidneys are working. Specifically, it estimates how much blood passes through the glomeruli each minute. Glomeruli are the tiny filters in the kidneys that filter waste from the blood.

Egfr Non-Afr. American

Glomerular filtration rate (GFR) is a test used to check how well the kidneys are working. Specifically, it estimates how much blood passes through the glomeruli each minute. Glomeruli are the tiny filters in the kidneys that filter waste from the blood.

GFR-AFRICAN AMERICAN

GFR-NON AFRICAN AMERICAN

Globulin

Globulins is the collective term for most blood proteins other than albumin. Identifying the types of globulins can help diagnose certain disorders. Globulins are roughly divided into three groups: alpha, beta, and gamma globulins. Gamma globulines include various types of antibodies such as immunoglobulins (Ig) M, G, and A.

Glucose

A blood glucose test measures the amount of a sugar called glucose in a sample of your blood. Glucose is a major source of energy for most cells of the body, including those in the brain. The hormones insulin and glucagon help control blood glucose levels.

Potassium

Potassium is a mineral that the body needs to work normally. It helps nerves and muscles communicate. It also helps move nutrients into cells and waste products out of cells. A diet rich in potassium helps to offset some of sodium's harmful effects on blood pressure.

Protein, Total

The total protein is the total amount of two classes of proteins, albumin and globulin that are found in the fluid portion of your blood. Proteins are important parts of all cells and tissues. Your albumin helps prevent fluid from leaking out of blood vessels and your globulins are an important part of your immune system.

Sodium

Sodium is a substance that the body needs to work properly it is vital to normal body processes, including nerve and muscle function

Urea Nitrogen (Bun)

BUN stands for blood urea nitrogen. Urea nitrogen is what forms when protein breaks down. BUN measures the amount of urea nitrogen in the blood.

Also known as: Cortisol AM

Cortisol, A.M.

A cortisol level is a blood test that measures the amount of cortisol, a steroid hormone produced by the adrenal gland. The test is done to check for increased or decreased cortisol production. Cortisol is a steroid hormone released from the adrenal gland in response to ACTH, a hormone from the pituitary gland in the brain. Cortisol affects many different body systems. It plays a role in: bone, circulatory system, immune system. metabolism of fats, carbohydrates, and protein. ervous system and stress responses.

Also known as: Cortisol PM

Cortisol, P.M.

Also known as: Dehydroepiandrosterone Sulfate, DHEA SO4, DHEA Sulfate Immunoassay, DHEAS, Transdehydroandrosterone

DHEA SULFATE

DHEA-sulfate test measures the amount of DHEA-sulfate in the blood. DHEA-sulfate is a weak male hormone (androgen) produced by the adrenal gland in both men and women.

Ferritin

Ferritin is a protein found inside cells that stores iron so your body can use it later. A ferritin test indirectly measures the amount of iron in your blood. The amount of ferritin in your blood (serum ferritin level) is directly related to the amount of iron stored in your body.

Also known as: Factor I, Fibrinogen, Fibrinogen Activity Clauss

Fibrinogen Activity,

Fibrinogen is a protein produced by the liver. This protein helps stop bleeding by helping blood clots to form. A blood test can be done to tell how much fibrinogen you have in the blood.

Also known as: A1c, Glycated Hemoglobin, Glycohemoglobin, Glycosylated Hemoglobin, HA1c, HbA1c, Hemoglobin A1c, Hemoglobin A1c HgbA1C, Hgb A1c

HEMOGLOBIN A1C

The A1c test evaluates the average amount of glucose in the blood over the last 2 to 3 months. It does this by measuring the concentration of glycated (also often called glycosylated) hemoglobin A1c. Hemoglobin is an oxygen-transporting protein found inside red blood cells (RBCs). There are several types of normal hemoglobin, but the predominant form – about 95-98% – is hemoglobin A. As glucose circulates in the blood, some of it spontaneously binds to hemoglobin A. The hemoglobin molecules with attached glucose are called glycated hemoglobin. The higher the concentration of glucose in the blood, the more glycated hemoglobin is formed. Once the glucose binds to the hemoglobin, it remains there for the life of the red blood cell – normally about 120 days. The predominant form of glycated hemoglobin is referred to as HbA1c or A1c. A1c is produced on a daily basis and slowly cleared from the blood as older RBCs die and younger RBCs (with non-glycated hemoglobin) take their place. This test is used to monitor treatment in someone who has been diagnosed with diabetes. It helps to evaluate how well their glucose levels have been controlled by treatment over time. This test may be used to screen for and diagnose diabetes or risk of developing diabetes. In 2010, clinical practice guidelines from the American Diabetes Association (ADA) stated that A1c may be added to fasting plasma glucose (FPG) and oral glucose tolerance test (OGTT) as an option for diabetes screening and diagnosis. For monitoring purposes, an A1c of less than 7% indicates good glucose control and a lower risk of diabetic complications for the majority of diabetics. However, in 2012, the ADA and the European Association for the Study of Diabetes (EASD) issued a position statement recommending that the management of glucose control in type 2 diabetes be more "patient-centered." Data from recent studies have shown that low blood sugar (hypoglycemia) can cause complications and that people with risk of severe hypoglycemia, underlying health conditions, complications, and a limited life expectancy do not necessarily benefit from having a stringent goal of less than 7% for their A1c. The statement recommends that people work closely with their doctor to select a goal that reflects each person's individual health status and that balances risks and benefits.

Also known as: Cardio IQ hs-CRP , hsCRP Cardio IQ

Hs Crp

A high-sensitivity CRP (hs-CRP) test may be used by itself, in combination with other cardiac risk markers, or in combination with a lipoprotein-associated phospholipase A2 (Lp-PLA2) test that evaluates vascular inflammation. The hs-CRP test accurately detects low concentrations of C-reactive protein to help predict a healthy person's risk of cardiovascular disease (CVD). High-sensitivity CRP is promoted by some as a test for determining a person's risk level for CVD, heart attacks, and strokes. The current thinking is that hs-CRP can play a role in the evaluation process before a person develops one of these health problems.

Also known as: Insulin (fasting)

Insulin

Insulin is a hormone that is produced and stored in the beta cells of the pancreas. It is vital for the transportation and storage of glucose at the cellular level, helps regulate blood glucose levels, and has a role in lipid metabolism. When blood glucose levels rise after a meal, insulin is released to allow glucose to move into tissue cells, especially muscle and adipose (fat) cells, where is it is used for energy production. Insulin then prompts the liver to either store the remaining excess blood glucose as glycogen for short-term energy storage and/or to use it to produce fatty acids. The fatty acids are eventually used by adipose tissue to synthesize triglycerides to form the basis of a longer term, more concentrated form of energy storage. Without insulin, glucose cannot reach most of the body's cells. Without glucose, the cells starve and blood glucose levels rise to unhealthy levels. This can cause disturbances in normal metabolic processes that result in various disorders, including kidney disease, cardiovascular disease, and vision and neurological problems. Thus, diabetes, a disorder associated with decreased insulin effects, is eventually a life-threatening condition.

Interleukin 1 Beta

Also known as: CYTOKINE, IL-6 HS, Interleukin6 Highly Sensitive ELISA

Interleukin 6, Highly

Interleukin-6 (IL-6), Serum - To evaluate the level of IL-6 in serum samples.

Also known as: Cardio IQ Lipid Panel, Cholesterol and Lipids, Lipid Panel Cardio IQ, Lipids

Chol/HDLC Ratio

Cholesterol, Total

Cholesterol is a waxy, fat-like substance that occurs naturally in all parts of the body. Your body needs some cholesterol to work properly. But if you have too much in your blood, it can combine with other substances in the blood and stick to the walls of your arteries. This is called plaque. Plaque can narrow your arteries or even block them. High levels of cholesterol in the blood can increase your risk of heart disease. Your cholesterol levels tend to rise as you get older. There are usually no signs or symptoms that you have high blood cholesterol, but it can be detected with a blood test. You are likely to have high cholesterol if members of your family have it, if you are overweight or if you eat a lot of fatty foods. You can lower your cholesterol by exercising more and eating more fruits and vegetables. You also may need to take medicine to lower your cholesterol.

HDL Cholesterol

LDL-Cholesterol

Non HDL Cholesterol

Triglycerides

Triglycerides are a form of fat and a major source of energy for the body. This test measures the amount of triglycerides in the blood. Most triglycerides are found in fat (adipose) tissue, but some triglycerides circulate in the blood to provide fuel for muscles to work. After a person eats, an increased level of triglycerides is found in the blood as the body converts the energy not needed right away into fat. Triglycerides move via the blood from the gut to adipose tissue for storage. In between meals, triglycerides are released from fat tissue to be used as an energy source for the body. Most triglycerides are carried in the blood by lipoproteins called very low density lipoproteins (VLDL). High levels of triglycerides in the blood are associated with an increased risk of developing cardiovascular disease (CVD), although the reason for this is not well understood. Certain factors can contribute to high triglyceride levels and to risk of CVD, including lack of exercise, being overweight, smoking cigarettes, consuming excess alcohol, and medical conditions such as diabetes and kidney disease.

Also known as: Cardio IQ Lipoprotein (a), Lipoprotein a Cardio IQ

Lipoprotein (A)

Lipoprotein-a, or Lp(a) are molecules made of proteins and fat. They carry cholesterol and similar substances through the blood. A high level of Lp(a) is considered a risk factor for heart disease. High levels of lipoproteins can increase the risk of heart disease. The test is done to check your risk of atherosclerosis, stroke, and heart attack.

Also known as: Ion Mobility, Cardio IQ Lipoprotein Fractionation, Ion Mobility , HDL Subfractions, IDL Subfractions, LDL Subfractions, Lipoprotein Fraction, Lipoprotein Fractionation, Lipoprotein Fractionation Ion Mobility Cardio IQ, Quest Diagnostics has replaced the VAP® Cholesterol Test with Lipoprotein Fractionation, Ion Mobility, Cardio IQ™ test

HDL Large

LDL Medium

LDL Particle Number

LDL Pattern

LDL Peak Size

LDL Small

Also known as: ESR, SED RATE, Sed Rate by Modified Westergren ESR

Sed Rate By Modified

Erythrocyte sedimentation rate (ESR) is an indirect measure of the degree of inflammation present in the body. It actually measures the rate of fall (sedimentation) of erythrocytes (red blood cells) in a sample of blood.

Also known as: Tnf Alpha Highly Sensitive

Tnf Alpha, Highly

*Important Information on Lab Test Processing Times: Ulta Lab Tests is committed to informing you about the processing times for your lab tests processed through a national lab. Please note that the estimated processing time for each test, indicated in business days, is based on data from the past 30 days across the 13 laboratories for each test. These estimates are intended to serve as a guide and are not guarantees. Factors such as laboratory workload, weather conditions, holidays, and the need for additional testing or maintenance can influence actual processing times. We aim to offer estimates to help you plan accordingly. Please understand that these times may vary, and processing times are not guaranteed. Thank you for choosing Ulta Lab Tests for your laboratory needs.

The Inflammation, NF-KB Regulation & Healthy Aging Panel panel contains 19 tests with 49 biomarkers .

Overview

Healthy aging begins at the cellular level.
When inflammation, oxidative stress, and metabolic imbalance go unchecked, they trigger NF-κB, the master regulator of inflammation and one of the most important signaling pathways in the human body. Chronic NF-κB activation leads to fatigue, hormonal decline, insulin resistance, tissue breakdown, and accelerated aging.

The Inflammation, NF-κB Regulation & Healthy Aging Panel from Ulta Lab Tests provides the most complete picture of how your cells are functioning, repairing, and defending themselves.

By combining six powerful diagnostic modules—spanning inflammation, immune regulation, oxidative stress, cardiometabolic health, insulin sensitivity, and cellular aging—this all-in-one panel measures the biological processes that determine how fast or how well you age.

Why This Panel Matters

While most tests look for disease after it develops, this panel reveals the early biochemical shifts that lead to disease and accelerated aging years before symptoms arise.

It empowers you and your healthcare provider to:

  • Detect and modulate chronic inflammation and NF-κB activation
  • Identify oxidative stress and antioxidant depletion
  • Evaluate metabolic and cardiometabolic risk
  • Track hormonal balance and cellular repair capacity
  • Personalize diet, exercise, and lifestyle programs for healthy longevity

Panel Composition: Six Foundational Pillars of Healthy Aging

This master panel includes the essential biomarkers from six interrelated domains, each representing a core pathway of inflammation and repair.

1. Cellular Inflammation & NF-κB Control Panel

Category: Inflammation & NF-κB Activation
Key Tests:

Test

Quest Code

Clinical Significance

C-Reactive Protein (CRP), High Sensitivity (hs-CRP)

4420, 91737

Detects low-grade systemic inflammation and early vascular risk.

Erythrocyte Sedimentation Rate (ESR)

809

Reflects chronic immune activity and inflammation duration.

Ferritin

457

Doubles as an iron storage and inflammation marker; rises with oxidative stress.

Fibrinogen Activity

461

Indicates clotting potential and systemic inflammatory load.

Homocysteine

91733

Elevations signal endothelial inflammation and NF-κB activation.

Purpose: Measures the body’s core inflammatory tone and NF-κB pathway activity—the root signal for aging and disease.

2. Immune Balance & Cytokine Activity Panel

Category: Cytokine & Immune Regulation
Key Tests:

Test

Quest Code

Clinical Significance

Interleukin-6 (IL-6)

34473

Cytokine controlled by NF-κB; drives inflammation and metabolic dysfunction.

Tumor Necrosis Factor-α (TNF-α)

34485

“Master cytokine” promoting tissue injury, insulin resistance, and chronic pain.

Interleukin-1β (IL-1β)

1757

Early inflammation trigger linked to autoimmune and degenerative conditions.

Purpose: Reveals the intensity of immune signaling and cytokine imbalance fueling inflammation and aging.

3. Cardiometabolic Inflammation & Vascular Health Panel

Category: Cardiometabolic & Endothelial Function
Key Tests:

Test

Quest Code

Clinical Significance

Cardio IQ® Advanced Lipid + Inflammation Panel

91716 and 91604

Assesses LDL particle size, ApoB, Lp(a), hs-CRP, and fibrinogen to evaluate vascular inflammation and lipid oxidation.

Lipoprotein(a) [Lp(a)]

91729

Genetic lipid factor that elevates inflammatory and clotting risk.

Apolipoprotein B (ApoB)

91726

Measures atherogenic particle number—more predictive than LDL-C for heart risk.

Purpose: Connects inflammation and oxidative stress to cardiovascular and endothelial aging, offering precision lipid insights.

4. Metabolic Resilience & Insulin Sensitivity Panel

Category: Metabolic Health & Insulin Resistance
Key Tests:

Test

Quest Code

Clinical Significance

Hemoglobin A1c

461

Tracks 3-month average glucose; higher levels promote glycation and inflammation.

Insulin, Fasting

561

Early indicator of insulin resistance and metabolic stress.

Comprehensive Metabolic Panel (CMP-14)

10231

Assesses liver, kidney, and electrolyte status; identifies metabolic inflammation or fatty-liver changes.

Purpose: Detects insulin resistance and metabolic inflammation—the hidden drivers of “inflammaging” and fatigue.

5. Cellular Aging & Regeneration Panel

Category: Biological Aging & Repair Potential
Key Tests:

Test

Quest Code

Clinical Significance

Telomere Length (TOOLBOX GENOMICS )

94963

Measures biological age and cumulative cellular wear; shorter telomeres indicate accelerated aging.

DHEA-Sulfate (DHEA-S)

402

Anti-inflammatory adrenal hormone that declines with age; supports immune and tissue repair.

Cortisol, AM & PM

4212 and 4213

Evaluates diurnal stress rhythm; chronic elevations shorten telomeres and activate NF-κB.

Purpose: Determines your true biological age and regenerative capacity by linking stress, hormones, and DNA integrity.

Clinical Applications & Benefits

  • Root-Cause Detection: Identify where chronic inflammation begins—immune imbalance, oxidative stress, metabolism, or hormonal dysregulation.
  • Longevity Optimization: Quantify biological aging and track improvements over time.
  • Personalized Prevention: Design evidence-based plans targeting the exact pathways driving your inflammation or fatigue.
  • Comprehensive Baseline: Establish a 360° snapshot of your cardiovascular, metabolic, and cellular health.
  • Therapeutic Monitoring: Evaluate the impact of dietary, supplement, or hormone-balance interventions on inflammation and repair markers.

Who Should Consider This Panel

  • Individuals pursuing longevity, anti-aging, or regenerative programs
  • Those with chronic inflammation, fatigue, or autoimmune tendencies
  • Patients with heart, metabolic, or cognitive risk factors
  • Anyone experiencing stress, poor recovery, or premature aging signs
  • Functional medicine and integrative health patients seeking comprehensive insight

Sample Requirements & Preparation

  • Specimen: Blood draw (plus urine for 8-OHdG) at a Quest Diagnostics location
  • Fasting: 8–12 hours recommended
  • Timing: AM/PM cortisol samples collected per schedule
  • Turnaround Time: 5–10 business days

Symptoms or Concerns This Panel Addresses

  • Fatigue and low energy
  • Brain fog or memory decline
  • Unexplained weight gain or metabolic slowdown
  • Hormonal imbalance or adrenal stress
  • Joint pain, stiffness, or chronic inflammation
  • Premature aging signs (skin, recovery, cognition)
  • Sleep disruption, anxiety, or burnout

Excellent — here’s a full, professional Results Interpretation Guide for the
?? Inflammation, NF-κB Regulation & Healthy Aging Panel — designed as the master interpretive framework for all six underlying panels.

This guide organizes each biomarker domain into what it measures, how to interpret your results, why it matters, and how to improve your score.
It’s written in the same authoritative but patient-friendly style as your other Ulta Lab Tests guides, suitable for both digital display and printable PDF use.

Results Interpretation Guide

Inflammation, NF-κB Regulation & Healthy Aging Panel

(Cellular | Metabolic | Oxidative | Cardiometabolic | Longevity)

Understanding Your Results

This master panel integrates six biological pathways that define how well your body repairs and renews itself.
Chronic activation of NF-κB, the body’s master inflammatory switch, drives oxidative stress, metabolic dysfunction, and cellular aging.

Your results reveal how these systems interact — from inflammation and metabolism to hormone balance and telomere repair — to shape your biological age and long-term health trajectory.

Section 1 · Inflammation & NF-κB Activation

(CRP, ESR, Ferritin, Fibrinogen, Homocysteine)

Marker

Optimal Range

Meaning

If Elevated

hs-CRP

< 1.0 mg/L

Detects low-grade inflammation and vascular injury.

Indicates chronic NF-κB activity, infection, or metabolic stress.

ESR

< 15 mm/hr (men) < 20 mm/hr (women)

Reflects long-term inflammatory trends.

Suggests ongoing immune activation.

Ferritin

30–150 ng/mL (women) 50–300 ng/mL (men)

Iron storage and acute-phase reactant.

High = oxidative stress or liver inflammation.

Fibrinogen

200–300 mg/dL

Inflammation and blood viscosity marker.

Elevated = increased clot risk and vascular inflammation.

Homocysteine

< 8 µmol/L

Measures methylation and endothelial integrity.

Elevated = poor B-vitamin status, oxidative stress.

Improvement Strategy:

  • Eat anti-inflammatory foods (fish, leafy greens, turmeric).
  • Supplement with omega-3s, curcumin, folate, B12, and magnesium.
  • Manage stress, improve sleep, and exercise regularly.

Section 2 · Cytokine & Immune Regulation

(IL-6, TNF-α, IL-1β)

Marker

Optimal Range

Meaning

If Elevated

Interleukin-6 (IL-6)

< 1.5 pg/mL

Pro-inflammatory cytokine linked to aging (“inflammaging”).

Chronic immune activation, metabolic syndrome, or obesity.

Tumor Necrosis Factor-α (TNF-α)

< 2.8 pg/mL

“Master” cytokine that amplifies NF-κB.

Tissue injury, autoimmune or insulin resistance.

Interleukin-1β (IL-1β)

< 1.0 pg/mL

Early inflammation initiator.

Active inflammation or infection.

Improvement Strategy:

  • Emphasize gut and immune health (fiber, probiotics, polyphenols).
  • Reduce processed food and sugar.
  • Incorporate regular exercise and stress-reduction techniques.

Section 3 · Cardiometabolic & Endothelial Function

(ApoB, Lp(a), LDL Particle Size, hs-CRP, Fibrinogen)

Marker

Optimal Range

Meaning

If Elevated

ApoB

< 80 mg/dL

True count of atherogenic particles.

Hidden cholesterol risk despite normal LDL-C.

Lp(a)

< 14 mg/dL

Genetic clotting & inflammation risk.

Lifetime atherogenic predisposition; control inflammation.

LDL Particle Size

Pattern A (large buoyant)

Lipid quality & oxidation risk.

Pattern B = small, dense, easily oxidized LDL.

Improvement Strategy:

  • Mediterranean diet rich in omega-3s and fiber.
  • Regular exercise, stress control.
  • Discuss statins or PCSK9 inhibitors for high ApoB/Lp(a).

Section 4 · Metabolic Resilience & Insulin Sensitivity

(A1c, Fasting Insulin, CMP-14)

Marker

Optimal Range

Meaning

If Elevated

Hemoglobin A1c

4.8–5.2 %

3-month glucose average.

> 5.6 % = prediabetes; accelerates aging.

Fasting Insulin

2–8 µIU/mL

Early marker of insulin sensitivity.

> 10 µIU/mL = insulin resistance, metabolic inflammation.

Liver Enzymes (ALT/AST)

ALT < 30 U/L AST < 35 U/L

Detects fatty-liver stress.

Elevated = metabolic overload or toxicity.

Improvement Strategy:

  • Reduce refined carbs and sugary drinks.
  • Intermittent fasting or time-restricted eating.
  • Increase muscle mass and daily activity.
  • Optimize sleep and stress balance.

Section 5 · Biological Aging & Repair Potential

(Telomere Length, DHEA-S, Cortisol AM/PM)

Marker

Optimal Range

Meaning

If Out of Range

Telomere Length

Equal to or “younger” than chronological age

DNA protection & biological age.

Short = accelerated aging, oxidative damage.

DHEA-S

Age-specific upper half of range

Adrenal resilience & anti-inflammatory repair hormone.

Low = stress exhaustion, poor regeneration.

Cortisol AM/PM

High AM / Low PM

Stress rhythm and recovery cycle.

Flat = adrenal fatigue; High PM = sleep & repair disruption.

Improvement Strategy:

  • Manage stress through meditation and consistent sleep.
  • Maintain moderate exercise; avoid overtraining.
  • Nutrient support: vitamin C, magnesium, adaptogens.
  • Support DHEA levels via lifestyle or supplementation if medically advised.

Interpreting Combined Patterns

Pattern

Interpretation

Next Steps

High Inflammation + High Cytokines

Active NF-κB signaling driving systemic aging.

Focus on anti-inflammatory diet, antioxidants, and stress reduction.

High Oxidative Stress + High ApoB/Lp(a)

Oxidized lipids and endothelial injury.

Combine antioxidant therapy with lipid management.

High Insulin + High Cortisol

Metabolic stress and HPA overdrive.

Balance meals, manage stress, and prioritize recovery.

Short Telomeres + Low DHEA-S

Accelerated biological aging and poor repair.

Address hormonal and antioxidant support, reduce stress load.

Optimal Markers Across Systems

Balanced inflammation, strong resilience, healthy biological age.

Maintain habits; re-test annually to monitor progress.

Global Longevity Score 

Domain

Weight

Optimal Trend

Inflammation & NF-κB

20 %

Low-normal CRP/ESR/Fibrinogen

Cytokine Activity

10 %

IL-6 < 1.5 pg/mL TNF-α < 2.8 pg/mL

Oxidative Stress

15 %

High GSH:GSSG + Normal 8-OHdG

Cardiometabolic

20 %

ApoB < 80 mg/dL Pattern A LDL

Metabolic

20 %

A1c < 5.2 Insulin < 8 µIU/mL

Biological Aging

15 %

Age-appropriate telomeres DHEA-S high-normal Balanced cortisol

Longevity Optimization Goal:
Maintain > 80 % of markers in the optimal range to slow biological aging and extend healthspan.

Re-Testing Recommendations

Purpose

Interval

Baseline longevity assessment

Once annually

Active lifestyle or therapeutic change

Every 3–6 months

Tracking inflammation reversal or stress recovery

8–12 weeks

When to Consult a Provider

  • Persistently elevated hs-CRP (> 3 mg/L) or IL-6 (> 2 pg/mL)
  • Shortened telomeres relative to age
  • Fasting insulin > 10 µIU/mL or A1c > 5.7 %
  • High ApoB/Lp(a) with cardiovascular family history
  • Flattened cortisol curve with fatigue or insomnia

Action Framework

Focus Area

Top Interventions

Nutrition

Anti-inflammatory Mediterranean diet; limit refined carbs; add antioxidants.

Exercise

Mix of resistance, aerobic, and mobility training.

Stress & Sleep

Consistent circadian rhythm, meditation, deep breathing, adequate rest.

Targeted Supplementation

Omega-3s, CoQ10, NAC, vitamin D, B-complex, adaptogens (under provider supervision).

Environmental Detox

Minimize plastics, heavy metals, and chemical exposure.

Key Takeaway

Inflammation, oxidative stress, and metabolic imbalance are measurable and modifiable.
By optimizing these biomarkers, you can slow cellular aging, improve energy and cognition, and extend both lifespan and healthspan.

Measure → Understand → Rebalance → Renew
Your data-driven path to vitality and longevity.

Frequently Asked Questions

Q1: What makes this panel unique?
It’s the only integrated test bundle measuring inflammation (NF-κB), immune signaling, oxidative stress, metabolism, cardiovascular inflammation, and biological aging—all in one assessment.

Q2: Can lifestyle changes improve these results?
Absolutely. Nutrition, exercise, stress management, and antioxidant support can reduce inflammation, improve insulin sensitivity, lengthen telomeres, and balance cortisol.

Q3: How often should I repeat testing?
Re-test every 6–12 months to monitor progress or adjust interventions. More frequent testing (every 3–6 months) is ideal for active longevity programs.

Q4: Can these results predict lifespan?
No test predicts exact lifespan, but telomere length, oxidative stress, and inflammation levels strongly correlate with biological aging rate and healthspan.

Complementary Tests & Panels

  • Micronutrient Testing – assess nutrient deficiencies influencing inflammation and repair.
  • Genetic Polymorphism Panels (MTHFR, APOE) – identify genetic risk for oxidative and cardiovascular stress.
  • Sex Hormone & Thyroid Panels – evaluate endocrine impact on metabolism and inflammation.

Customer Reviews