The Immunoglobulin A (IgA) test contains 1 test with 1 biomarker.
Immunoglobulin A (IgA)
Test Highlight
Clinical Use
Diagnose IgA deficiencies
Determine etiology of recurrent infections
Diagnose infection
Diagnose inflammation
Diagnose IgA monoclonal gammopathy
Clinical Background
IgA is the first line of defense for the majority of infections at mucosal surfaces and consists of 2 subclasses. IgA1 is the dominant subclass, accounting for 80% to 90% of total serum IgA and greater than half of the IgA in secretions such as milk, saliva, and tears. IgA2, on the other hand, is more concentrated in secretions than in blood. IgA2 is more resistant to proteolytic cleavage and may be more functionally active than IgA1.
IgA deficiency is the most prevalent isotype deficiency, occurring in 1/400 to 1/700 individuals. Many patients with IgA deficiency are asymptomatic, while others may develop allergic disease, repeated sinopulmonary or gastroenterologic infections, and/or autoimmune disease. Individuals with complete absence of IgA (<5 mg/dL) may develop autoantibodies to IgA after blood or intravenous immunoglobulin infusions and may experience anaphylaxis on repeat exposure.
Elevated serum IgA levels are associated with infection, inflammation, or IgA monoclonal gammopathy.
The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.
Immunoglobulin A #539
1 Biomarkers - Specimen Type: Serum - Process Time*: Average 2 to 3 days | Up to 7 days
Biomarkers 1
Immunoglobulin A
*Process times are an estimate and are not guaranteed. The lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.