Hypersensitivity Pneumonitis Evaluation

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The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.


Aspergillus Fumigatus





S. Rectivirgula

Saccharomonospora Viridis

T. Candidus

T. Sacchari

T. Vulgaris


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The Hypersensitivity Pneumonitis Evaluation test contains 1 test with 12 biomarkers.

Brief Description: Hypersensitivity pneumonitis (HP), also known as extrinsic allergic alveolitis, is an inflammation of the alveoli (tiny air sacs) within the lung, caused by hypersensitivity to inhaled organic dusts. The Hypersensitivity Pneumonitis Evaluation test is a panel of tests that assist in the diagnosis of this condition by identifying specific antibodies in the blood that correlate with exposure to common causative agents of HP.

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: No preparation required

When and Why a Hypersensitivity Pneumonitis Evaluation Test May Be Ordered

A Hypersensitivity Pneumonitis Evaluation test may be ordered when:

  1. Symptoms Suggest HP: A patient presents with symptoms like cough, dyspnea (difficulty in breathing), and fever following exposure to potential allergens.
  2. Clinical Suspicion: When a patient has symptoms that resemble other pulmonary diseases but has a known exposure history to organic dusts.
  3. Monitoring Response to Treatment: In cases already diagnosed with HP to see the effectiveness of the treatment.

What a Hypersensitivity Pneumonitis Evaluation Test Checks For

The test looks for antibodies in the blood that correlate with exposure to specific agents known to cause HP. Examples of such agents include, but are not limited to, bird proteins (from feathers or droppings), molds, and certain chemicals. A positive result indicates exposure to a specific agent, but it doesn't necessarily confirm the disease, as not everyone exposed will develop HP.

Other Lab Tests Ordered Alongside a Hypersensitivity Pneumonitis Evaluation Test

Alongside the HP Evaluation test, a doctor may order:

  1. Pulmonary Function Tests: To assess lung function and determine the extent of lung damage.
  2. Chest X-rays or CT Scans: To visualize the lungs and check for inflammation or other abnormalities.
  3. Bronchoalveolar Lavage: A procedure where a bronchoscope is used to wash out a section of the lung and the fluid is then examined.
  4. Lung Biopsy: In certain cases, to obtain a definitive diagnosis.

Conditions or Diseases Requiring a Hypersensitivity Pneumonitis Evaluation Test

The primary condition related to this test is Hypersensitivity Pneumonitis itself. However, HP can be further classified based on its cause, for instance:

  1. Bird Fancier's Lung: Caused by exposure to proteins from bird feathers or droppings.
  2. Farmer's Lung: Due to exposure to moldy hay or straw.
  3. Humidifier or Air-conditioner Lung: Resulting from exposure to molds from heating or cooling systems.
  4. Chemical Worker’s Lung: From specific chemicals in a working environment.

How Health Care Providers Use the Results of a Hypersensitivity Pneumonitis Evaluation Test

Healthcare providers interpret the results in conjunction with clinical findings and other diagnostic tests:

  1. Diagnosis: A positive result can help establish the diagnosis of HP, especially if there's a known exposure to a specific allergen.
  2. Identification of Causative Agent: By identifying the specific antibodies, the causative agent of HP can often be pinpointed, which is crucial for treatment as the primary intervention is avoiding further exposure.
  3. Guide Treatment: Knowing the specific cause can help in tailoring the treatment, which might include steroids to reduce inflammation.
  4. Monitor Disease Progression: The test might be repeated to see the effectiveness of interventions.

However, it's important to note that while a positive test indicates exposure, it does not confirm the disease. Further diagnostic procedures and clinical correlation are essential.

Most Common Questions About the Hypersensitivity Pneumonitis Evaluation test:

Purpose and Clinical Indications

Why is the Hypersensitivity Pneumonitis Evaluation test ordered?

The Hypersensitivity Pneumonitis Evaluation test is ordered primarily to diagnose or rule out hypersensitivity pneumonitis (HP). HP is an inflammatory lung disease caused by the inhalation of various antigens, which can come from molds, birds, and certain chemicals. This test can help identify the specific antigens responsible for a patient's symptoms, thus guiding appropriate management.

What conditions or disorders can be diagnosed with the Hypersensitivity Pneumonitis Evaluation test?

The main condition diagnosed using the Hypersensitivity Pneumonitis Evaluation test is hypersensitivity pneumonitis. By identifying the specific antigens causing the immune reaction, healthcare professionals can determine the source of exposure and advise patients on how to avoid it. The identification can also help differentiate HP from other conditions with similar clinical presentations, such as asthma or chronic obstructive pulmonary disease (COPD).

Interpretation of Results

How are the results of the Hypersensitivity Pneumonitis Evaluation test interpreted?

The results of the Hypersensitivity Pneumonitis Evaluation test typically include the identification of specific antibodies to various antigens. Elevated levels of these antibodies indicate exposure to and sensitization against the related antigens. The interpretation is combined with the patient's clinical symptoms, exposure history, and other diagnostic tests like imaging studies to confirm a diagnosis of hypersensitivity pneumonitis.

What do negative results in the Hypersensitivity Pneumonitis Evaluation test suggest?

Negative results in the Hypersensitivity Pneumonitis Evaluation test suggest that there is no detectable level of antibodies to the tested antigens in the patient's blood. This can either mean that the patient has not been exposed to those specific antigens or that their immune system hasn't produced a significant amount of antibodies against them. It's important to consider other potential causes for the patient's symptoms when faced with negative test results.

Clinical Implications

How does the Hypersensitivity Pneumonitis Evaluation test aid in clinical management?

The Hypersensitivity Pneumonitis Evaluation test plays a crucial role in clinical management by identifying the antigens causing the disease. Once identified, patients can be advised on how to avoid these antigens, which is the primary step in managing hypersensitivity pneumonitis. Moreover, knowing the specific antigen can help healthcare providers decide on other treatments like corticosteroids or immunosuppressants, particularly in chronic or severe cases.

How does the Hypersensitivity Pneumonitis Evaluation test differentiate HP from other lung diseases?

While the clinical presentation of hypersensitivity pneumonitis can overlap with other lung conditions, the Hypersensitivity Pneumonitis Evaluation test focuses on the detection of antibodies against specific antigens known to cause HP. Identifying these antibodies can point directly to HP as the cause of symptoms, whereas other lung diseases wouldn't typically show these specific antibodies. The test results, combined with a detailed clinical history and imaging studies, help differentiate HP from conditions like asthma, COPD, or interstitial lung diseases.

Relationships with Medications and Treatments

How can certain treatments impact the results of the Hypersensitivity Pneumonitis Evaluation test?

Certain treatments, especially immunosuppressive medications, can influence the immune system's response and potentially affect the production of antibodies. This means that patients on these treatments might have reduced antibody levels even if exposed to antigens. It's essential for healthcare providers to consider ongoing treatments and their potential effects on the immune system when interpreting the results of the Hypersensitivity Pneumonitis Evaluation test.

What are the potential treatments or interventions for patients diagnosed with HP through the Hypersensitivity Pneumonitis Evaluation test?

The primary treatment for hypersensitivity pneumonitis diagnosed through the Hypersensitivity Pneumonitis Evaluation test is the avoidance of the identified antigen. This often involves environmental changes, like removing mold from homes or using protective measures in occupational settings. In cases where the disease is chronic or severe, medications like corticosteroids or other immunosuppressants may be prescribed to reduce inflammation and symptoms. Regular follow-up and monitoring are essential to ensure disease management and to prevent potential complications.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

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