Herpes Simplex Virus 2 (IgG), HerpeSelect® with Reflex to HSV-2 Inhibition

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The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Also known as: Herpes Simplex Virus 2 IgG HerpeSelect with Reflex to HSV2 Inhibition

Hsv 2 IgG Type Specific

Herpes simplex virus testing is performed to identify an acute herpes infection or to detect herpes antibodies, an indication of a previous exposure to herpes. One of the most common viral infections, herpes simplex virus (HSV) exists as two main types, HSV-1 and HSV-2. Both types are contagious and periodically cause small fever blisters (vesicles) that break to form open lesions. HSV-1 primarily causes blisters or "cold sores" around the oral cavity and mouth, while HSV-2 usually causes lesions around the genital area; however, either one can affect the oral or genital area.
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The Herpes Simplex Virus 2 (IgG), HerpeSelect® with Reflex to HSV-2 Inhibition test contains 1 test with 1 biomarker.

Herpes Simplex Virus 2 (IgG), with Reflex to HSV-2 Inhibition Test Description

Herpes Simplex Virus Type 2 (HSV-2) is primarily associated with genital infections, which can range from mild discomfort to severe clinical conditions affecting neonates and adults. Accurate diagnosis of HSV-2 is crucial for effective management and treatment. The Herpes Simplex Virus 2 (IgG), with Reflex to HSV-2 Inhibition test, offers a robust tool for diagnosing and monitoring this virus. This test is specifically designed to distinguish between HSV-1 and HSV-2 infections, utilizing advanced immunoassay techniques.

Test Components and Their Functions:

  • Herpes Simplex Virus 2 (IgG): This initial test measures the IgG antibodies specific to HSV-2, indicating past or present infection.

    • Detection: Positive IgG antibodies suggest exposure to HSV-2.
    • Diagnosis: Differentiates between HSV-1 and HSV-2 infections when symptoms are present.
    • Monitoring: Tracks the presence of antibodies over time to monitor past infections or verify the success of treatments.

  • HSV-2 Inhibition Study: This reflex test is conducted if the HSV-2 IgG test result is greater than 1.09. It helps confirm whether the positive result is true by measuring the ability of specific antibodies to block antigen-antibody reactions.

    • Detection: Confirms the specificity of antibodies to HSV-2.
    • Diagnosis: Helps distinguish false positives from true infection, crucial for accurate clinical decisions.
    • Monitoring: Provides detailed insights into the immune response, particularly in managing known HSV-2 carriers.

Methodology:

  • The tests utilize an Immunoassay (IA) methodology, employing recombinant type-specific antigens to accurately identify HSV-1 and HSV-2.

What are the advantages of the HSV –two IgG INHIBITION assay over the western block assay? The HSV-2 IgG Western blot test has long been seen as the best test for spotting HSV-2 IgG reactivity. But studies, like one by Ashley-Morrow and others, have shown that this test isn't as quick at detecting new HSV-2 infections as the HerpeSelect HSV-2 IgG test. The HerpeSelect test can find antibodies about 21 days after symptoms start, while the Western blot test takes about 68 days. This means there's a period of about 47 days where the Western blot might not show a positive result even if someone has HSV-2. The HSV-2 IgG inhibition assay is different. During this 47-day window, if there's more than 60% inhibition, it means the test result is positive for HSV-2. This test is not only faster at finding new infections, but it also has a quicker turnaround time than the Western blot test.

Sample Ulta Lab Tests View of Herpes 2 Antibody Test Results
Herpes Simplex Virus 2 with Reflex to Inhibition Test Example Ulta Lab Tests Results

 

Sample Quest Result Report View of Herpes 2 Antibody Test Results
Herpes Simplex Virus 2 with Reflex to Inhibition Test Example Quest Diagnostics Results

 

Sample Results of Herpes 2 Antibody Test reflexing into Herpes 2 IgG Inhibition Test.
Herpes 2 Inhibition Test Example Quest Diagnostics Results

Reference Ranges and Interpretations:

  • Negative: <0.90 – No significant levels of HSV-2 IgG detected.
  • Equivocal: 0.90-1.09 – Uncertain presence of HSV-2 IgG; retesting recommended in 4-6 weeks if recent infection is suspected.
  • Positive: >1.09 – Significant levels of HSV-2 IgG detected; reflex inhibition study will follow if necessary.

Symptoms of HSV-2 to Recognize:

  • Genital Lesions: Blisters or sores around the genital area, often painful.
  • Pain During Urination: Especially when urine contacts the sores.
  • Itching or Irritation: Around the infected area.
  • Flu-like Symptoms: Including fever and swollen lymph nodes during the initial outbreak.

Benefits of Using Ulta Lab Tests:

  • Convenience: Easy access to testing without the need for a doctor’s visit.
  • Speed: Quick turnaround times for test results.
  • Confidentiality: Secure and private handling of all medical data.
  • Affordability: Competitive pricing with a 20% discount on tests making it cost-effective.
  • Accuracy: High precision and reliability in results, aiding in correct treatment decisions.

Utilizing the Herpes Simplex Virus 2 (IgG), with Reflex to HSV-2 Inhibition test through Ulta Lab Tests allows for precise and early diagnosis, which is essential for managing and potentially mitigating the impact of HSV-2. With the added advantage of a 20% discount, individuals are empowered to take proactive steps in understanding and managing their health efficiently and affordably. Take control of your health by choosing Ulta Lab Tests for reliable, quick, and confidential testing solutions.

If Herpes Simplex Virus 2 (IgG) result is greater than 1.09, then HSV-2 Inhibition Study will be performed at an additional charge.

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