Ulta Lab Tests

Frozen Shoulder Lab Plus Panel

Blood
Blood Draw, Phlebotomist

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Also known as: Chem 12, Chemistry Panel, Chemistry Screen, CMP, Complete Metabolic Panel, Comprehensive Metabolic Panel CMP, SMA 12, SMA 20

Albumin

Albumin is a protein made by the liver. A serum albumin test measures the amount of this protein in the clear liquid portion of the blood.

Albumin/Globulin Ratio

The ratio of albumin to globulin (A/G ratio) is calculated from measured albumin and calculated globulin (total protein - albumin). Normally, there is a little more albumin than globulins, giving a normal A/G ratio of slightly over 1. Because disease states affect the relative amounts of albumin and globulin, the A/G ratio may provide a clue as to the cause of the change in protein levels. A low A/G ratio may reflect overproduction of globulins, such as seen in multiple myeloma or autoimmune diseases, or underproduction of albumin, such as may occur with cirrhosis, or selective loss of albumin from the circulation, as may occur with kidney disease (nephrotic syndrome). A high A/G ratio suggests underproduction of immunoglobulins as may be seen in some genetic deficiencies and in some leukemias. More specific tests, such as liver enzyme tests and serum protein electrophoresis, must be performed to make an accurate diagnosis. With a low total protein that is due to plasma expansion (dilution of the blood), the A/G ratio will typically be normal because both albumin and globulin will be diluted to the same extent.

Alkaline Phosphatase

Alkaline phosphatase (ALP) is a protein found in all body tissues. Tissues with higher amounts of ALP include the liver, bile ducts, and bone.

Alt

Alanine transaminase (ALT) is an enzyme found in the highest amounts in the liver. Injury to the liver results in release of the substance into the blood.

AST

AST (aspartate aminotransferase) is an enzyme found in high amounts in liver, heart, and muscle cells. It is also found in lesser amounts in other tissues.

Bilirubin, Total

Bilirubin is a yellowish pigment found in bile, a fluid made by the liver. A small amount of older red blood cells are replaced by new blood cells every day. Bilirubin is left after these older blood cells are removed. The liver helps break down bilirubin so that it can be removed from the body in the stool.

Bun/Creatinine Ratio

A ratio between a person’s BUN and blood creatinine to help determine what is causing these concentrations to be higher than normal. The ratio of BUN to creatinine is usually between 10:1 and 20:1. An increased ratio may be due to a condition that causes a decrease in the flow of blood to the kidneys, such as congestive heart failure or dehydration. It may also be seen with increased protein, from gastrointestinal bleeding, or increased protein in the diet. The ratio may be decreased with liver disease (due to decrease in the formation of urea) and malnutrition.

Calcium

You have more calcium in your body than any other mineral. Calcium has many important jobs. The body stores more than 99 percent of its calcium in the bones and teeth to help make and keep them strong. The rest is throughout the body in blood, muscle and the fluid between cells. Your body needs calcium to help muscles and blood vessels contract and expand, to secrete hormones and enzymes and to send messages through the nervous system.

Carbon Dioxide

CO2 is carbon dioxide. Measures the amount of carbon dioxide in the liquid part of your blood, called the serum. In the body, most of the CO2 is in the form of a substance called bicarbonate (HCO3-). Therefore, the CO2 blood test is really a measure of your blood bicarbonate level.

Chloride

Chloride is a type of electrolyte. It works with other electrolytes such as potassium, sodium, and carbon dioxide (CO2). These substances help keep the proper balance of body fluids and maintain the body's acid-base balance. This is a measure of the amount of chloride in the fluid portion (serum) of the blood.

Creatinine

The creatinine blood test measures the level of creatinine in the blood. This test is done to see how well your kidneys work.

Egfr African American

Glomerular filtration rate (GFR) is a test used to check how well the kidneys are working. Specifically, it estimates how much blood passes through the glomeruli each minute. Glomeruli are the tiny filters in the kidneys that filter waste from the blood.

Egfr Non-Afr. American

Glomerular filtration rate (GFR) is a test used to check how well the kidneys are working. Specifically, it estimates how much blood passes through the glomeruli each minute. Glomeruli are the tiny filters in the kidneys that filter waste from the blood.

GFR-AFRICAN AMERICAN

GFR-NON AFRICAN AMERICAN

Globulin

Globulins is the collective term for most blood proteins other than albumin. Identifying the types of globulins can help diagnose certain disorders. Globulins are roughly divided into three groups: alpha, beta, and gamma globulins. Gamma globulines include various types of antibodies such as immunoglobulins (Ig) M, G, and A.

Glucose

A blood glucose test measures the amount of a sugar called glucose in a sample of your blood. Glucose is a major source of energy for most cells of the body, including those in the brain. The hormones insulin and glucagon help control blood glucose levels.

Potassium

Potassium is a mineral that the body needs to work normally. It helps nerves and muscles communicate. It also helps move nutrients into cells and waste products out of cells. A diet rich in potassium helps to offset some of sodium's harmful effects on blood pressure.

Protein, Total

The total protein is the total amount of two classes of proteins, albumin and globulin that are found in the fluid portion of your blood. Proteins are important parts of all cells and tissues. Your albumin helps prevent fluid from leaking out of blood vessels and your globulins are an important part of your immune system.

Sodium

Sodium is a substance that the body needs to work properly it is vital to normal body processes, including nerve and muscle function

Urea Nitrogen (Bun)

BUN stands for blood urea nitrogen. Urea nitrogen is what forms when protein breaks down. BUN measures the amount of urea nitrogen in the blood.

Also known as: Cortisol AM

Cortisol, A.M.

A cortisol level is a blood test that measures the amount of cortisol, a steroid hormone produced by the adrenal gland. The test is done to check for increased or decreased cortisol production. Cortisol is a steroid hormone released from the adrenal gland in response to ACTH, a hormone from the pituitary gland in the brain. Cortisol affects many different body systems. It plays a role in: bone, circulatory system, immune system. metabolism of fats, carbohydrates, and protein. ervous system and stress responses.

Also known as: ACPA, Anti-CCP, Anti-citrulline Antibody, Anti-cyclic Citrullinated Peptide, Anti-Cyclic Citrullinated Peptide (CCP) Antibody IgG, CCP, CCP Antibody, Citrullinated Peptide (CCP) IgG, Cyclic Citrullinated Peptide Antibody, Cyclic Citrullinated Peptide CCP Antibody IgG

Cyclic Citrullinated

Also known as: Dehydroepiandrosterone Sulfate, DHEA SO4, DHEA Sulfate Immunoassay, DHEAS, Transdehydroandrosterone

DHEA SULFATE

DHEA-sulfate test measures the amount of DHEA-sulfate in the blood. DHEA-sulfate is a weak male hormone (androgen) produced by the adrenal gland in both men and women.

Estradiol

Estradiol (estradiol-17 beta, E2) is part of an estrogen that is a group of steroids that regulate the menstrual cycle and function as the main female sex hormones. Estrogens are responsible for the development of female sex organs and secondary sex characteristics and are tied to the menstrual cycle and pregnancy. They are considered the main sex hormones in women and are present in small quantities in men. Estradiol (E2) is the predominant form of estrogen and is produced primarily in the ovaries with additional amounts produced by the adrenal glands in women and in the testes and adrenal glands in men. Estradiol levels are used in evaluating ovarian function. Estradiol levels are increased in cases of early (precocious) puberty in girls and gynecomastia in men. Its main use has been in the differential diagnosis of amenorrhea – for example, to determine whether the cause is menopause, pregnancy, or a medical problem. In assisted reproductive technology (ART), serial measurements are used to monitor follicle development in the ovary in the days prior to in vitro fertilization. Estradiol is also sometimes used to monitor menopausal hormone replacement therapy.

Also known as: Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH), Follicle Stimulating Hormone and Luteinizing Hormone

Fsh

Lh

Glucose

A blood glucose test measures the amount of a sugar called glucose in a sample of your blood. Glucose is a major source of energy for most cells of the body, including those in the brain. The hormones insulin and glucagon help control blood glucose levels.

Also known as: A1c, Glycated Hemoglobin, Glycohemoglobin, Glycosylated Hemoglobin, HA1c, HbA1c, Hemoglobin A1c, Hemoglobin A1c HgbA1C, Hgb A1c

Hemoglobin A1c

The A1c test evaluates the average amount of glucose in the blood over the last 2 to 3 months. It does this by measuring the concentration of glycated (also often called glycosylated) hemoglobin A1c. Hemoglobin is an oxygen-transporting protein found inside red blood cells (RBCs). There are several types of normal hemoglobin, but the predominant form – about 95-98% – is hemoglobin A. As glucose circulates in the blood, some of it spontaneously binds to hemoglobin A. The hemoglobin molecules with attached glucose are called glycated hemoglobin. The higher the concentration of glucose in the blood, the more glycated hemoglobin is formed. Once the glucose binds to the hemoglobin, it remains there for the life of the red blood cell – normally about 120 days. The predominant form of glycated hemoglobin is referred to as HbA1c or A1c. A1c is produced on a daily basis and slowly cleared from the blood as older RBCs die and younger RBCs (with non-glycated hemoglobin) take their place. This test is used to monitor treatment in someone who has been diagnosed with diabetes. It helps to evaluate how well their glucose levels have been controlled by treatment over time. This test may be used to screen for and diagnose diabetes or risk of developing diabetes. In 2010, clinical practice guidelines from the American Diabetes Association (ADA) stated that A1c may be added to fasting plasma glucose (FPG) and oral glucose tolerance test (OGTT) as an option for diabetes screening and diagnosis. For monitoring purposes, an A1c of less than 7% indicates good glucose control and a lower risk of diabetic complications for the majority of diabetics. However, in 2012, the ADA and the European Association for the Study of Diabetes (EASD) issued a position statement recommending that the management of glucose control in type 2 diabetes be more "patient-centered." Data from recent studies have shown that low blood sugar (hypoglycemia) can cause complications and that people with risk of severe hypoglycemia, underlying health conditions, complications, and a limited life expectancy do not necessarily benefit from having a stringent goal of less than 7% for their A1c. The statement recommends that people work closely with their doctor to select a goal that reflects each person's individual health status and that balances risks and benefits.

Also known as: C-Reactive Protein, Cardio CRP, Cardio hs-CRP, CRP, High Sensitivity CRP, High-sensitivity C-reactive Protein, High-sensitivity CRP, Highly Sensitive CRP, hsCRP, Ultra-sensitive CRP

Hs Crp

A high-sensitivity CRP (hs-CRP) test may be used by itself, in combination with other cardiac risk markers, or in combination with a lipoprotein-associated phospholipase A2 (Lp-PLA2) test that evaluates vascular inflammation. The hs-CRP test accurately detects low concentrations of C-reactive protein to help predict a healthy person's risk of cardiovascular disease (CVD). High-sensitivity CRP is promoted by some as a test for determining a person's risk level for CVD, heart attacks, and strokes. The current thinking is that hs-CRP can play a role in the evaluation process before a person develops one of these health problems.

Also known as: Progesterone Immunoassay

Progesterone

Serum progesterone is a test to measure the amount of progesterone in the blood. Progesterone is a hormone produced mainly in the ovaries. In women, progesterone plays a vital role in pregnancy. After an egg is released by the ovaries (ovulation), progesterone helps make the uterus ready for implantation of a fertilized egg. It prepares the womb (uterus) for pregnancy and the breasts for milk production. Men produce some amount of progesterone, but it probably has no normal function except to help produce other steroid hormones.

Also known as: RF

Rheumatoid Factor

Rheumatoid factor (RF) is a blood test that measures the amount of the RF antibody in the blood. An abnormal result means the test is positive, which means higher levels of rheumatoid factor have been detected in your blood. Most patients with rheumatoid arthritis or Sjogren syndrome have positive RF tests. The higher the level, the more likely one of these conditions is present. Not everyone with higher levels of rheumatoid factor has rheumatoid arthritis or Sjogren syndrome.

Also known as: Free T3, FT3, T3 Free

T3, Free

This test measures the amount of triiodothyronine, or T3, in the blood.

Also known as: Free T4, FT4, T4 Free

T4, Free

The free T4 test is not affected by protein levels. Since free T4 is the active form of thyroxine, the free T4 test is may be a more accurate reflection of thyroid hormone function.

Also known as: Thyroid Stimulating Hormone Test, Thyrotropin Test

TSH

A TSH test is a lab test that measures the amount of thyroid stimulating hormone (TSH) in your blood. TSH is produced by the pituitary gland. It tells the thyroid gland to make and release thyroid hormones into the blood.

Also known as: ,25-Hydroxyvitamin D2, 25-Hydroxycholecalciferol (25OHD3), 25-OH-D2,D3 Vitamin, D2 Vitamin,25-Hydroxyvitamin D3,25-OH-D3, QuestAssureD 25Hydroxyvitamin D D2 D3 LCMSMS, Vitamin D, Vitamin D, 25-Hydroxy, Vitamin D2, 25-hydroxy,25-Hydroxyergocalciferol (25OHD2),Vitamin D3, 25-hydroxy

Vitamin D, 25-Oh, Total

Vitamin D comes from two sources: endogenous, which is produced in the skin on exposure to sunlight, and exogenous, which is ingested in foods and supplements. The chemical structures of the types of vitamin D are slightly different, and they are named vitamin D2 (ergocalciferol, which comes from plants) and vitamin D3 (cholecalciferol, which comes from animals). The D2 form is found in fortified foods and in most vitamin preparations and supplements. Vitamin D3 is the form produced in the body and is also used in some supplements. Vitamin D2 and D3 are equally effective when they are converted by the liver and the kidney into the active form, 1,25-dihydroxyvitamin D.
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The Frozen Shoulder Lab Plus Panel panel contains 15 tests with 36 biomarkers .

Overview of the Frozen Shoulder Lab Plus Panel

The Frozen Shoulder Lab Plus Panel is an advanced diagnostic tool designed to uncover the underlying causes of adhesive capsulitis, commonly known as frozen shoulder. While frozen shoulder manifests as pain, stiffness, and restricted mobility in the shoulder joint, its origins often extend beyond the musculoskeletal system. Research shows that endocrine imbalances, metabolic dysfunction, chronic inflammation, and autoimmune conditions can significantly increase the risk and severity of this condition.

This expanded panel goes beyond the standard Frozen Shoulder Lab Panel by including additional tests such as the Comprehensive Metabolic Panel (CMP), Cortisol AM, DHEA Sulfate, and Progesterone, offering a more detailed view of hormonal health, adrenal function, and systemic metabolic status. By identifying root causes such as uncontrolled diabetes, hormonal dysregulation, thyroid disorders, autoimmune activity, and nutrient deficiencies, the Frozen Shoulder Lab Plus Panel empowers healthcare professionals to create personalized treatment strategies for improved outcomes.

When and Why the Frozen Shoulder Lab Plus Panel May Be Ordered

Healthcare providers may recommend the Frozen Shoulder Lab Plus Panel for patients experiencing persistent shoulder stiffness, severe pain, and reduced range of motion that does not resolve with standard interventions such as physical therapy or corticosteroid injections. This panel is particularly beneficial for individuals who have:

  • A history of diabetes or insulin resistance

  • Signs of thyroid dysfunction or other hormonal imbalances

  • Menopausal symptoms or suspected estrogen, progesterone, or adrenal hormone issues

  • Clinical suspicion of autoimmune disease (e.g., rheumatoid arthritis)

  • Symptoms of systemic inflammation or metabolic syndrome

  • Recurrent or bilateral frozen shoulder

The expanded panel offers a more comprehensive evaluation than the standard panel by assessing adrenal health through cortisol and DHEA sulfate testing, and by evaluating progesterone levels, which are particularly relevant in women during perimenopause and menopause. These additional markers help identify stress-related hormonal imbalances and their contribution to inflammatory and musculoskeletal disorders.

What the Frozen Shoulder Lab Plus Panel Checks For

The Frozen Shoulder Lab Plus Panel evaluates markers across multiple systems, including metabolic health, autoimmune activity, inflammation, thyroid function, adrenal function, and sex hormone balance. Below is an in-depth explanation of each test and its relevance to frozen shoulder:

Comprehensive Metabolic Panel (CMP)

The CMP assesses kidney and liver function, electrolyte balance, and protein status, all of which provide insight into overall metabolic health. Abnormalities in these areas can influence tissue healing and systemic inflammation, potentially worsening frozen shoulder symptoms. Proper hydration, electrolyte stability, and organ function are essential for musculoskeletal recovery and reducing chronic pain.

Cortisol AM

Cortisol is the body’s primary stress hormone, influencing metabolism, immune response, and inflammation. Elevated or suppressed cortisol levels can disrupt healing, increase pain sensitivity, and contribute to inflammatory processes in connective tissues. Cortisol imbalance may also signal adrenal dysfunction or chronic stress, both of which can exacerbate adhesive capsulitis.

Cyclic Citrullinated Peptide (CCP) Antibody (IgG)

CCP antibodies are highly specific markers for rheumatoid arthritis (RA), an autoimmune condition that causes systemic joint inflammation. While RA is not the most common cause of frozen shoulder, autoimmune activity can complicate recovery and prolong symptoms. A positive CCP result indicates the need for rheumatology evaluation.

DHEA Sulfate

DHEA is an adrenal hormone that serves as a precursor to estrogen and testosterone. Low DHEA levels may indicate adrenal insufficiency or hormonal imbalance, both of which can affect tissue repair and increase inflammatory responses. Adequate adrenal function is critical for stress adaptation and musculoskeletal health.

Estradiol

Estradiol, the primary estrogen hormone, supports collagen synthesis, connective tissue elasticity, and bone strength. Declining estrogen levels, especially during menopause, can increase joint stiffness and pain. Monitoring estradiol helps clinicians identify hormonal imbalances that may predispose individuals to frozen shoulder or slow recovery.

FSH and LH

Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) regulate estrogen and testosterone production. Elevated levels of FSH and LH typically indicate menopause or perimenopause, both of which are linked to hormonal changes affecting connective tissue health and inflammation.

Glucose

Glucose testing measures fasting blood sugar levels and screens for diabetes or prediabetes. Poor glucose control leads to glycation of collagen, making connective tissue less flexible and more prone to stiffness. Diabetes is a major risk factor for adhesive capsulitis, making this marker essential for diagnosis and management.

Hemoglobin A1c (HgbA1C)

Hemoglobin A1c provides an average blood sugar reading over the past 2–3 months. Elevated A1c confirms chronic hyperglycemia, which accelerates tissue degeneration and contributes to joint contractures. This test offers a broader view of metabolic control compared to a single fasting glucose measurement.

hs-CRP (High-Sensitivity C-Reactive Protein)

hs-CRP is a sensitive marker for systemic inflammation. Elevated levels indicate chronic low-grade inflammation, which can impair healing and exacerbate musculoskeletal pain. Reducing inflammation is crucial for frozen shoulder recovery, and this marker helps track systemic inflammatory load.

Progesterone

Progesterone plays a vital role in hormonal balance, particularly in women. Low progesterone relative to estrogen can create a state of hormonal imbalance that influences pain perception and inflammatory processes. Measuring progesterone helps clinicians understand the broader hormonal picture, especially during menopause.

Rheumatoid Factor (RF)

Rheumatoid Factor is an antibody linked to autoimmune diseases, especially rheumatoid arthritis. While not as specific as CCP antibodies, elevated RF levels suggest immune dysregulation that may affect joint health and recovery.

T3, Free

Free T3 is the active form of thyroid hormone that regulates metabolism and tissue repair. Low T3 levels can contribute to fatigue, joint stiffness, and slow healing, all of which can worsen frozen shoulder symptoms.

T4, Free

Free T4, the precursor to T3, helps assess thyroid function and detect hypothyroidism or hyperthyroidism. Thyroid imbalances can impair musculoskeletal health and increase the risk of adhesive capsulitis.

TSH

Thyroid-stimulating hormone (TSH) is a key regulator of thyroid hormone production. Elevated TSH typically indicates hypothyroidism, a well-documented risk factor for frozen shoulder. Comprehensive thyroid evaluation ensures targeted treatment of underlying endocrine disorders.

Vitamin D, 25-Hydroxy, Total, Immunoassay

Vitamin D is essential for bone strength, muscle function, and immune health. Deficiency can impair musculoskeletal repair, weaken connective tissues, and increase inflammation. Maintaining adequate vitamin D levels supports recovery and overall joint health.

How Healthcare Professionals Use the Frozen Shoulder Lab Plus Panel Results

The Frozen Shoulder Lab Plus Panel enables healthcare providers to move beyond symptomatic treatment and address the systemic conditions contributing to adhesive capsulitis. For instance, if results reveal uncontrolled diabetes, aggressive glycemic management becomes essential to improve joint mobility and prevent further complications. Abnormal thyroid results may warrant hormone replacement therapy, while positive autoimmune markers could lead to rheumatology referrals and the initiation of disease-modifying therapies.

Hormonal evaluations—including estradiol, progesterone, cortisol, and DHEA—allow clinicians to correct imbalances that can amplify pain and inflammation. Elevated hs-CRP guides anti-inflammatory interventions, while low vitamin D signals the need for supplementation to support bone and joint health. The inclusion of the CMP ensures clinicians can monitor organ function and electrolyte status for safe and effective treatment planning.

By interpreting these results holistically, providers can create integrated care plans that combine physical therapy, medication, lifestyle modifications, and nutritional support for optimal recovery.

Conclusion

The Frozen Shoulder Lab Plus Panel offers a comprehensive approach to diagnosing and managing adhesive capsulitis by evaluating metabolic health, hormone balance, thyroid function, adrenal status, autoimmune activity, and nutritional factors. This expanded panel helps uncover root causes that standard imaging and musculoskeletal exams often miss, enabling clinicians to develop personalized treatment strategies that accelerate recovery, reduce pain, and improve overall quality of life.

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