Epidermal Antibodies with Reflex to Titer

The Epidermal Antibodies with Reflex to Titer test contains 1 test with 4 biomarkers.

IMPORTANT - THIS IS A REFLEX TEST - ADDITIONAL CHARGES WILL BE APPLIED IF QUEST IS TO RUN THE REFLEX TESTS AS DEFINED BELOW

Epidermal Antibodies with Reflex to Titer Includes

Intercellular and Basement Antibody Screens with Reflex to Titers

  1. If Intercellular Substance Antibody Screen is positive, then Intercellular Substance Antibody Titer will be performed at an additional charge (CPT code(s): 86256).
  2. If Basement Membrane Zone Antibody Screen is positive, then Basement Membrane Zone Titer will be performed at an additional charge (CPT code(s): 86256).

Clinical Significance

The detection of anti-skin antibodies aids in the diagnosis of chronic vesicular-bullous diseases including pemphigus, pemphigoid, cicatricial pemphigoid, and epidermolysis bullosa acquisita (EBA).
Epithelial intercellular antibodies are diagnostic for pemphigus and occur in over 90% of sera from all active forms. Antibodies to basement membrane antigens of stratified squamous epithelium occur in about 70% of active bullous pemphigoid, 50% of vesicular pemphigoid and EBA and 10% of cicatricial pemphigoid patients.

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Basement Membrane Zone

Basement Membrane Zone

Intercellular Substance

Intercellular Substance

*Process times are an estimate and are not guaranteed. The lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

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