Ulta Lab Tests

Celiac & Gluten Response Panel — Comprehensive

The Celiac & Gluten Response Panel — Comprehensive provides an in-depth evaluation of gluten-related immune response, intestinal inflammation, and nutrient status. By measuring celiac-specific antibodies, total IgA, stool calprotectin, CRP, CBC, iron stores, vitamin D, B12, folate, and zinc, this panel offers a comprehensive view of how gluten exposure may affect immune activity, gut health, and nutritional balance.

Serum, Stool/Feces, Blood, Plasma-Unspecified Vial Pour
Phlebotomist

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Also known as: C-Reactive Protein, CReactive Protein CRP, CRP

C-REACTIVE PROTEIN

C-reactive protein is produced by the liver. The level of CRP rises when there is inflammation throughout the body.

Also known as: Calprotectin Stool

Calprotectin, Stool

Also known as: CBC, CBC includes Differential and Platelets, CBC/PLT w/DIFF, Complete Blood Count (includes Differential and Platelets)

NOTE: Ulta Lab Tests provides CBC test results from Quest Diagnostics as they are reported. Often, different biomarker results are made available at different time intervals. When reporting the results, Ulta Lab Tests denotes those biomarkers not yet reported as 'pending' for every biomarker the test might report. Only biomarkers Quest Diagnostics observes are incorporated and represented in the final CBC test results provided by Ulta Lab Tests.

Absolute Band Neutrophils (Only Reported If Detected)

Immature forms of neutrophils are called neutrophilic band cells. Neutrophils are a type of white blood cell that is responsible for much of the body's protection against infection. Neutrophils are produced in the bone marrow and released into the bloodstream to travel to wherever they are needed. Large numbers of immature forms of neutrophils, called neutrophilic band cells, are produced by the bone marrow when the demand is high.

Absolute Basophils

Basophils normally constitute 1% or less of the total white blood cell count but may increase or decrease in certain diseases and are thought to be involved in allergic reactions.

Absolute Blasts (Only Reported If Detected)

Blasts are immature forms of white blood cells.

Absolute Eosinophils

Eosinophils (eos) respond to infections caused by parasites and play a role in allergic reactions (hypersensitivities)

Absolute Lymphocytes

Lymphocytes are white blood cells that exist in both the blood and the lymphatic system. They are divided into three types. The B lymphocytes (B cells) are antibody-producing cells that are essential for acquired, antigen-specific immune responses. The second type are T lymphocytes (T cells) some T cells help the body distinguish between "self" and "non-self" antigens while others initiate and control the extent of an immune response, boosting it as needed and then slowing it as the condition resolves. Other types of T cells directly attack and neutralize virus-infected or cancerous cells. The third type are natural killer cells (NK cells) that directly attack and kill abnormal cells such as cancer cells or those infected with a virus.

Absolute Metamyelocytes (Only Reported If Detected)

Metamyelocytes are immature forms of white blood cells.

Absolute Monocytes

Monocytes (mono), similar to neutrophils, move to an area of infection and engulf and destroy bacteria. They are associated more often with chronic rather than acute infections. They are also involved in tissue repair and other functions involving the immune system.

Absolute Myelocytes (Only Reported If Detected)

Myelocytes are immature forms of white blood cells.

Absolute Neutrophils

Neutrophils (neu) normally make up the largest number of circulating WBCs. They move into an area of damaged or infected tissue, where they engulf and destroy bacteria or sometimes fungi. Young neutrophils, recently released into circulation, are called bands.

Absolute Nucleated Rbc (Only Reported If Detected)

Nucleated Red Blood Cells (nRBC) ) the presence of NRBCs in the adult blood is usually associated with malignant neoplasms, bone marrow diseases, and other serious disorders.

Absolute Promyelocytes (Only Reported If Detected)

Promyelocytes are immature forms of white blood cells.

Band Neutrophils (Only Reported If Detected)

Immature forms of neutrophils are called neutrophilic band cells. Neutrophils are a type of white blood cell that is responsible for much of the body's protection against infection. Neutrophils are produced in the bone marrow and released into the bloodstream to travel to wherever they are needed. Large numbers of immature forms of neutrophils, called neutrophilic band cells, are produced by the bone marrow when the demand is high.

Basophils

Basophils normally constitute 1% or less of the total white blood cell count but may increase or decrease in certain diseases and are thought to be involved in allergic reactions.

Blasts (Only Reported If Detected)

Blasts are immature forms of white blood cells.

Eosinophils

Eosinophils are specialized white blood cells produced in the bone marrow and released into the bloodstream, where they normally make up only 0–6 % of circulating leukocytes. Their cytoplasm is packed with reddish‑orange granules that contain potent enzymes (e.g., major basic protein, eosinophil cationic protein) and inflammatory mediators. When the immune system detects large, multicellular invaders—such as helminth (worm) parasites—eosinophils migrate out of the blood and surround the pathogen, releasing these granule contents to damage the parasite’s outer surface and aid its destruction. Beyond parasite defense, eosinophils act as key orchestras of the allergic response. They accumulate in tissues exposed to allergens (airways in asthma, skin in eczema, GI tract in eosinophilic esophagitis) and secrete cytokines and lipid mediators that amplify inflammation, recruit additional immune cells, and contribute to symptoms like swelling, mucus production, and itching. Because of this pro‑inflammatory role, persistently elevated eosinophil counts—termed eosinophilia—can signal allergic disorders, drug hypersensitivity, or certain autoimmune and malignant conditions. Conversely, counts drop toward zero after glucocorticoid therapy or in acute stress states, reflecting the cells’ sensitivity to hormonal and immune regulation.

Hematocrit

Hematocrit is a blood test that measures the percentage of the volume of whole blood that is made up of red blood cells. This measurement depends on the number of red blood cells and the size of red blood cells.

Hemoglobin

Serum hemoglobin is a blood test that measures the level of free hemoglobin in the liquid part of the blood (the serum). Free hemoglobin is the hemoglobin outside of the red blood cells. Most of the hemoglobin is found inside the red blood cells, not in the serum.

Lymphocytes

Lymphocytes are white blood cells that exist in both the blood and the lymphatic system. They are divided into three types. The B lymphocytes (B cells) are antibody-producing cells that are essential for acquired, antigen-specific immune responses. The second type are T lymphocytes (T cells) some T cells help the body distinguish between "self" and "non-self" antigens while others initiate and control the extent of an immune response, boosting it as needed and then slowing it as the condition resolves. Other types of T cells directly attack and neutralize virus-infected or cancerous cells. The third type are natural killer cells (NK cells) that directly attack and kill abnormal cells such as cancer cells or those infected with a virus.

MCH

Mean corpuscular hemoglobin (MCH) is a calculation of the average amount of oxygen-carrying hemoglobin inside a red blood cell.

MCHC

Mean corpuscular hemoglobin concentration (MCHC) is a calculation of the average percentage of hemoglobin inside a red cell.

MCV

Mean corpuscular volume (MCV) is a measurement of the average size of RBCs.

Metamyelocytes (Only Reported If Detected)

Metamyelocytes are immature forms of white blood cells.

Monocytes

Monocytes (mono), similar to neutrophils, move to an area of infection and engulf and destroy bacteria. They are associated more often with chronic rather than acute infections. They are also involved in tissue repair and other functions involving the immune system.

MPV

Mean Platelet Volume (MPV) - When it indicates average size of platelets are small; older platelets are generally smaller than younger ones and a low MPV may mean that a condition is affecting the production of platelets by the bone marrow. When it indicates a high number of larger, younger platelets in the blood; this may be due to the bone marrow producing and releasing platelets rapidly into circulation.

Myelocytes (Only Reported If Detected)

Myelocytes are immature forms of white blood cells.

Neutrophils

Neutrophils are a type of white blood cell that is responsible for much of the body's protection against infection. Neutrophils are produced in the bone marrow and released into the bloodstream to travel to wherever they are needed.

Nucleated Rbc (Only Reported If Detected)

Nucleated Red Blood Cells (nRBC) ) the presence of NRBCs in the adult blood is usually associated with malignant neoplasms, bone marrow diseases, and other serious disorders.

Platelet Count

A platelet count is a test to measure how many platelets you have in your blood. Platelets help the blood clot. They are smaller than red or white blood cells.

Promyelocytes (Only Reported If Detected)

Promyelocytes are immature forms of white blood cells.

RDW

Red cell distribution width (RDW), which may be included in a CBC, is a calculation of the variation in the size of RBCs.

Reactive Lymphocytes (Only Reported If Detected)

Lymphocytes are white blood cells that exist in both the blood and the lymphatic system. They are divided into three types. The B lymphocytes (B cells) are antibody-producing cells that are essential for acquired, antigen-specific immune responses. The second type are T lymphocytes (T cells) some T cells help the body distinguish between "self" and "non-self" antigens while others initiate and control the extent of an immune response, boosting it as needed and then slowing it as the condition resolves. Other types of T cells directly attack and neutralize virus-infected or cancerous cells. The third type are natural killer cells (NK cells) that directly attack and kill abnormal cells such as cancer cells or those infected with a virus.

Red Blood Cell Count

An RBC count is a blood test that tells how many red blood cells (RBCs) you have. RBCs contain hemoglobin, which carries oxygen. How much oxygen your body tissues get depends on how many RBCs you have and how well they work.

White Blood Cell Count

A WBC count is a test to measure the number of white blood cells (WBCs) in the blood. WBCs help fight infections. They are also called leukocytes. There are five major types of white blood cells: basophils, eosinophils, lymphocytes (T cells and B cells), monocytes and neutrophils

Ferritin

Ferritin is a protein found inside cells that stores iron so your body can use it later. A ferritin test indirectly measures the amount of iron in your blood. The amount of ferritin in your blood (serum ferritin level) is directly related to the amount of iron stored in your body.

Also known as: Gliadin Deamidated Peptide Antibody IgA

Gliadin (Deamidated)

Also known as: Anti-Gliadin Antibody (IgG), Celiac Disease, Gliadin Deamidated Peptide Antibody IgG, Gluten IgG (Gliadin)

Gliadin (Deamidated)

Immunoglobulin A

Vitamin D, 25-Oh, D2

Vitamin D2 ((ergocalciferol,) is found in fortified foods and in most vitamin preparations and supplements. Vitamin D comes from two sources: endogenous, which is produced in the skin on exposure to sunlight, and exogenous, which is ingested in foods and supplements. The D2 form is found in fortified foods and in most vitamin preparations and supplements. Vitamin D2 is effective when it is converted by the liver and the kidney into the active form, 1,25-dihydroxyvitamin D.

Vitamin D, 25-Oh, D3

Vitamin D3 (cholecalcifero) which comes from animals. Vitamin D comes from two sources: endogenous, which is produced in the skin on exposure to sunlight, and exogenous, which is ingested in foods and supplements. Vitamin D3 is the form produced in the body and is also used in some supplements. Vitamin D3 are is converted by the liver and the kidney into the active form, 1,25-dihydroxyvitamin D.

Vitamin D, 25-Oh, Total

Vitamin D comes from two sources: endogenous, which is produced in the skin on exposure to sunlight, and exogenous, which is ingested in foods and supplements. The chemical structures of the types of vitamin D are slightly different, and they are named vitamin D2 (ergocalciferol, which comes from plants) and vitamin D3 (cholecalciferol, which comes from animals). The D2 form is found in fortified foods and in most vitamin preparations and supplements. Vitamin D3 is the form produced in the body and is also used in some supplements. Vitamin D2 and D3 are equally effective when they are converted by the liver and the kidney into the active form, 1,25-dihydroxyvitamin D.

Also known as: Celiac Disease, Dermatitis Herpetiformis, Tissue Antibody IgA, Tissue Transglutaminase tTG Antibody IgA, Transglutaminase, tTG Antibody, tTG IgA

Tissue Transglutaminase

Also known as: Tissue Antibody IgG, Tissue Transglutaminase tTG Antibody IgG, Transglutaminase, tTG IgG

Tissue Transglutaminase

Also known as: Cobalamin, Folic Acid, Vitamin B 12, Vitamin B 12 and Folic Acid, Vitamin B12 Cobalamin and Folate Panel Serum, Vitamin B12/Folic Acid

Folate, Serum

Folate is part of the B complex of vitamins and is measures the levels of folate in the liquid portion of the blood, the serum or plasma, to detect deficiencies. Folate is necessary for normal RBC formation, tissue and cellular repair, and DNA synthesis.. A deficiency inr folate can lead to macrocytic anemia. Megaloblastic anemia, a type of macrocytic anemia, is characterized by the production of fewer but larger RBCs called macrocytes, in addition to some cellular changes in the bone marrow.

Vitamin B12

Vitamin B12 is part of the B complex of vitamins and measurea the levels of vitamin B12 in the liquid portion of the blood, the serum or plasma, to detect deficiencies. Cobalamine, or vitamin B12, is found in animal products such as red meat, fish, poultry, milk, yogurt, and eggs and is not produced in the human body. In recent years, fortified cereals, breads, and other grain products have also become important dietary sources of B12. Vitamin B12 is necessary for normal RBC formation, tissue and cellular repair, and DNA synthesis. B12 is important for nerve health. A deficiency in B12 can lead to macrocytic anemia. Megaloblastic anemia, a type of macrocytic anemia, is characterized by the production of fewer but larger RBCs called macrocytes, in addition to some cellular changes in the bone marrow. B12 deficiency can lead to varying degrees of neuropathy, nerve damage that can cause tingling and numbness in the affected person's hands and feet.

Also known as: ZN, Plasma

Zinc

*Important Information on Lab Test Processing Times: Ulta Lab Tests is committed to informing you about the processing times for your lab tests processed through a national lab. Please note that the estimated processing time for each test, indicated in business days, is based on data from the past 30 days across the 13 laboratories for each test. These estimates are intended to serve as a guide and are not guarantees. Factors such as laboratory workload, weather conditions, holidays, and the need for additional testing or maintenance can influence actual processing times. We aim to offer estimates to help you plan accordingly. Please understand that these times may vary, and processing times are not guaranteed. Thank you for choosing Ulta Lab Tests for your laboratory needs.

The Celiac & Gluten Response Panel — Comprehensive panel contains 12 tests with 47 biomarkers .

Brief Description

The Celiac & Gluten Response Panel — Comprehensive is an in-depth laboratory assessment designed to evaluate immune responses to gluten alongside markers of intestinal inflammation, nutrient absorption, and systemic health. This panel goes beyond basic celiac screening by integrating antibody testing, inflammatory markers, stool-based intestinal assessment, and key nutritional indicators that are commonly affected when gluten-related immune activity or intestinal dysfunction is present.

Celiac disease and other gluten-related immune responses can influence the gastrointestinal tract, immune system, and nutritional status. In some individuals, immune activation against gluten proteins may lead to intestinal inflammation, impaired nutrient absorption, and secondary deficiencies. This panel is structured to capture those interconnected processes by assessing celiac-specific antibodies, total IgA status, inflammatory markers, and micronutrients involved in red blood cell production, bone health, and immune function.

By combining blood-based and stool-based testing, the Celiac & Gluten Response Panel — Comprehensive offers a broader picture of how the body is responding to gluten exposure and whether inflammation or malabsorption may be present. It is commonly used in diagnostic evaluation, baseline assessment prior to dietary changes, and ongoing monitoring in individuals with known or suspected gluten-related conditions.

This panel supports a structured, evidence-based approach to understanding gluten response by emphasizing context, pattern recognition, and comprehensive evaluation rather than reliance on a single marker.

When and Why Someone Would Order This Panel

Evaluating Suspected Gluten-Related Immune Response

This panel is often ordered when individuals or healthcare providers are evaluating symptoms or laboratory trends that raise concern for celiac disease or other gluten-related immune responses. Measuring both tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP) antibodies—across IgA and IgG classes—provides broader immune coverage, particularly in individuals with variable antibody expression.

Assessing Intestinal Inflammation

Intestinal inflammation may occur in association with gluten-related disorders and other gastrointestinal conditions. Stool calprotectin is included to help assess inflammatory activity within the gastrointestinal tract, offering insight beyond blood-based markers alone.

Identifying Nutrient Absorption Patterns

Conditions affecting the small intestine can impair absorption of key nutrients. This panel includes ferritin, vitamin B12, folate, zinc, and vitamin D to help identify nutritional patterns commonly associated with malabsorption or chronic intestinal inflammation.

Considering IgA Deficiency

Total immunoglobulin A (IgA) measurement is an important component of celiac evaluation. In individuals with IgA deficiency, IgA-based antibody tests may appear falsely negative. Including both IgA and IgG-based antibody tests helps support accurate interpretation.

Baseline Testing and Monitoring

This panel may be used before initiating a gluten-free diet, as antibody levels typically decline with gluten avoidance. It is also useful for longitudinal monitoring in individuals with established diagnoses, helping track immune response, inflammation, and nutritional status over time.

What Does the Panel Measure

Celiac- and Gluten-Specific Antibodies

The panel measures tissue transglutaminase (tTG) IgA and IgG antibodies and deamidated gliadin peptide (DGP) IgA and IgG antibodies, which are central to evaluating immune responses associated with celiac disease and gluten exposure. Total IgA is included to assess for IgA deficiency, which can influence test interpretation.

Inflammatory Markers

C-reactive protein (CRP) reflects systemic inflammation, while stool calprotectin is a marker of intestinal inflammation, helping distinguish localized gastrointestinal inflammatory activity from systemic processes.

Hematologic Assessment

A complete blood count (CBC) with differential and platelets evaluates red blood cells, white blood cells, and platelets. This can provide insight into anemia patterns, immune cell distribution, and overall hematologic status.

Nutrient and Micronutrient Status

Ferritin reflects iron stores and may be affected by malabsorption or inflammation. Vitamin B12, serum folate, zinc, and QuestAssureD® Vitamin D 25-Hydroxy Total with D2 and D3 assess nutrients commonly impacted by intestinal disorders and gluten-related conditions.

How Patients and Healthcare Providers Use the Results

Supporting Diagnostic Evaluation

Healthcare providers may use this panel to support evaluation of celiac disease by integrating antibody patterns, IgA status, and inflammatory markers. Results are interpreted in conjunction with clinical history and, when appropriate, additional diagnostic procedures.

Identifying Nutritional and Inflammatory Patterns

The inclusion of nutrient markers and inflammatory tests helps identify patterns consistent with malabsorption, chronic inflammation, or nutrient depletion that may accompany gluten-related disorders.

Monitoring Disease Activity and Dietary Response

For individuals with established diagnoses, repeat testing can help monitor antibody trends, inflammation, and nutrient status over time, particularly in the context of dietary changes such as gluten elimination.

Differentiating Potential Causes of Symptoms

By evaluating both systemic and intestinal inflammation alongside immune response and nutritional markers, this panel helps provide context when differentiating between gluten-related conditions and other gastrointestinal or inflammatory processes.

The Celiac & Gluten Response Panel — Comprehensive offers a thorough and structured evaluation of immune response to gluten, intestinal inflammation, and associated nutritional patterns. By integrating antibody testing, inflammatory markers, stool analysis, and key micronutrients, this panel reflects the complex and interconnected nature of gluten-related disorders.

Its strength lies in providing context—helping patients and healthcare providers understand how immune activity, intestinal health, and nutrient status interact. Whether used for diagnostic assessment, baseline evaluation, or long-term monitoring, this panel delivers reliable laboratory insight that supports informed interpretation and individualized care without assumptions or transactional framing.

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