Celiac Disease Comprehensive Panel with Gliadin Antibodies(Age 5 and Under)

The Celiac Disease Comprehensive Panel with Gliadin Antibodies(Age 5 and Under) test contains 1 test with 5 biomarkers.

Clinical Significance

Celiac Disease Comprehensive Panel with Gliadin Antibodies(Age 5 and Under) - This panel is used to assist in the diagnosis of celiac disease (CD) in children ≤5 years old.

Background: CD is caused by an immune response to gluten in genetically sensitive individuals. Diagnosis begins with serologic testing and is confirmed by biopsy. This panel tests all specimens for tissue transglutaminase (tTG) IgA and gliadin (deamidated) IgA and IgG. Although tTG IgA is generally preferred as a single serological test for CD, it may have reduced sensitivity in young children; including DGP IgA and IgG alongside tTG IgA may increase sensitivity for CD. Specimens positive for tTG IgA are tested for endomysial antibody (IgA), which may increase specificity for CD. This panel also evaluates all specimens for total IgA. A total IgA level below the reference range is suggestive of IgA deficiency and reflexes to tTG IgG, which is generally less sensitive than tTG IgA for CD but is useful in the context of IgA deficiency.

Includes

Tissue Transglutaminase (tTG) Antibody (IgA)

Gliadin (Deamidated) Antibody (IgG, IgA)

IgA (Immunoglobulin A)

 

If Tissue Transglutaminase (tTG) Antibody (IgA) is Detected (≥15.0 U/mL), then Endomysial Antibody (IgA) Screen with Reflex to Titer will be performed at an additional charge (CPT code(s):86231).

If Endomysial Antibody (IgA) Screen is Positive, then Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86231).

If Immunoglobulin A is flagged as low based on age appropriate reference range, or if no age is provided and Immunoglobulin A result is <31 mg/dL, then Tissue Transglutaminase (tTG) Antibody (IgG) will be performed at an additional charge (CPT code(s): 86364).

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Gliadin (Deamidated)

Gliadin (Deamidated)

Immunoglobulin A

INTERPRETATION

Tissue Transglutaminase

*Process times are an estimate and are not guaranteed. The lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

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