Cardio IQ® Diabetes and ASCVD Risk Panel with Scores

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.






Chol/HDLC Ratio

Cholesterol, Total

Cholesterol is a waxy, fat-like substance that occurs naturally in all parts of the body. Your body needs some cholesterol to work properly. But if you have too much in your blood, it can combine with other substances in the blood and stick to the walls of your arteries. This is called plaque. Plaque can narrow your arteries or even block them. High levels of cholesterol in the blood can increase your risk of heart disease. Your cholesterol levels tend to rise as you get older. There are usually no signs or symptoms that you have high blood cholesterol, but it can be detected with a blood test. You are likely to have high cholesterol if members of your family have it, if you are overweight or if you eat a lot of fatty foods. You can lower your cholesterol by exercising more and eating more fruits and vegetables. You also may need to take medicine to lower your cholesterol.





A blood glucose test measures the amount of a sugar called glucose in a sample of your blood. Glucose is a major source of energy for most cells of the body, including those in the brain. The hormones insulin and glucagon help control blood glucose levels.

HDL Cholesterol

Height Feet

Hemoglobin A1c

The A1c test evaluates the average amount of glucose in the blood over the last 2 to 3 months. It does this by measuring the concentration of glycated (also often called glycosylated) hemoglobin A1c. Hemoglobin is an oxygen-transporting protein found inside red blood cells (RBCs). There are several types of normal hemoglobin, but the predominant form – about 95-98% – is hemoglobin A. As glucose circulates in the blood, some of it spontaneously binds to hemoglobin A. The hemoglobin molecules with attached glucose are called glycated hemoglobin. The higher the concentration of glucose in the blood, the more glycated hemoglobin is formed. Once the glucose binds to the hemoglobin, it remains there for the life of the red blood cell – normally about 120 days. The predominant form of glycated hemoglobin is referred to as HbA1c or A1c. A1c is produced on a daily basis and slowly cleared from the blood as older RBCs die and younger RBCs (with non-glycated hemoglobin) take their place. This test is used to monitor treatment in someone who has been diagnosed with diabetes. It helps to evaluate how well their glucose levels have been controlled by treatment over time. This test may be used to screen for and diagnose diabetes or risk of developing diabetes. In 2010, clinical practice guidelines from the American Diabetes Association (ADA) stated that A1c may be added to fasting plasma glucose (FPG) and oral glucose tolerance test (OGTT) as an option for diabetes screening and diagnosis. For monitoring purposes, an A1c of less than 7% indicates good glucose control and a lower risk of diabetic complications for the majority of diabetics. However, in 2012, the ADA and the European Association for the Study of Diabetes (EASD) issued a position statement recommending that the management of glucose control in type 2 diabetes be more "patient-centered." Data from recent studies have shown that low blood sugar (hypoglycemia) can cause complications and that people with risk of severe hypoglycemia, underlying health conditions, complications, and a limited life expectancy do not necessarily benefit from having a stringent goal of less than 7% for their A1c. The statement recommends that people work closely with their doctor to select a goal that reflects each person's individual health status and that balances risks and benefits.



Non HDL Cholesterol





Triglycerides are a form of fat and a major source of energy for the body. This test measures the amount of triglycerides in the blood. Most triglycerides are found in fat (adipose) tissue, but some triglycerides circulate in the blood to provide fuel for muscles to work. After a person eats, an increased level of triglycerides is found in the blood as the body converts the energy not needed right away into fat. Triglycerides move via the blood from the gut to adipose tissue for storage. In between meals, triglycerides are released from fat tissue to be used as an energy source for the body. Most triglycerides are carried in the blood by lipoproteins called very low density lipoproteins (VLDL). High levels of triglycerides in the blood are associated with an increased risk of developing cardiovascular disease (CVD), although the reason for this is not well understood. Certain factors can contribute to high triglyceride levels and to risk of CVD, including lack of exercise, being overweight, smoking cigarettes, consuming excess alcohol, and medical conditions such as diabetes and kidney disease.


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The Cardio IQ® Diabetes and ASCVD Risk Panel with Scores test contains 1 test with 21 biomarkers.

Brief Description: The Cardio IQ® Diabetes and ASCVD Risk Panel with Scores is a comprehensive diagnostic tool designed to simultaneously evaluate a patient's risk for diabetes and atherosclerotic cardiovascular disease (ASCVD). It combines markers associated with both conditions to provide an encompassing view of a patient's metabolic and cardiovascular health, further aiding in the identification of risks.

Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: If a cholesterol measurement is to be performed along with Triglycerides, but not part of a lipid panel, then the patient should be fasting 9-12 hours prior to collection. If the cholesterol is ordered as part of a lipid panel, then a fasting sample is not required.
The assay manufacturer Beckman Coulter advises: "N-Acetyl Cysteine (NAC), when administered in therapeutic concentrations (for the treatment of acetaminophen overdose), has been. . . determined to interfere with assays for. . . cholesterol, uric acid" where "NAC interference may lead to falsely low results." According to Beckman Coulter, the NAC interference should be insignificant by 12 hours after completion of the initial loading dose of an IV infusion treatment regimen consisting of an initial loading dose of 150 mg/kg administered over 1 hour, a second dose of 50 mg/kg administered over 4 hrs and a third dose of 100 mg/kg administered over 16 hrs.

This is a Cardio IQ™ test and will likely need an additional 5-7 days for processing.

IMPORTANT: For risk calculations to be performed, the following patient-specific information must be provided and recorded at the time of specimen collection:
  • Age: Years 
  • Gender: M (for male) or F (for female) 
  • Height Feet: Feet 
  • Height Inches: Inches 
  • Weight: lbs 
  • Race-African American: Y (for yes) or N (for no) 
  • Systolic Blood Pressure: mmHg
  • Diastolic Blood Pressure: mmHg
  • Treatment for High B.P.: Y (for yes) or N (for no) 
  • Diabetes Status: Y (for yes) or N (for no)
  • Parental History of Diab: Y (for yes) or N (for no) 
  • Smoking Status: Y (for Yes) or N (for no)

When and Why a Cardio IQ® Diabetes and ASCVD Risk Panel with Scores Test May Be Ordered

This test is particularly pertinent in several scenarios:

  • High-risk Groups: For individuals with known risk factors such as obesity, hypertension, family history of heart disease or diabetes, or other underlying health conditions.

  • Symptom Presentation: In patients showing symptoms of diabetes or cardiovascular issues, such as fatigue, frequent urination, chest pain, or shortness of breath.

  • Regular Health Screenings: Especially recommended for adults over a certain age or those with specific risk factors.

What the Cardio IQ® Diabetes and ASCVD Risk Panel with Scores Test Checks For

This panel is multifaceted and typically looks at:

  • Blood Sugar Markers: Such as fasting glucose and Hemoglobin A1c, indicating the body's ability to regulate sugar levels over short and long periods.

  • Cholesterol Levels: Including LDL, HDL, and triglycerides, which are directly linked to cardiovascular health.

  • Other Cardiovascular Markers: Like apolipoproteins, which can give a more detailed view of ASCVD risk.

The "scores" component quantifies the results into a risk percentage or numerical value, providing both the patient and healthcare provider with a digestible understanding of the individual's relative risk.

Other Lab Tests Ordered Alongside Cardio IQ® Diabetes and ASCVD Risk Panel with Scores Test

  • Blood Pressure Measurements: Given its direct correlation with cardiovascular health.

  • Kidney Function Tests: Such as serum creatinine or urine albumin, as both diabetes and cardiovascular disease can affect kidney health.

  • C-Reactive Protein Test: To measure inflammation, which can be a marker for cardiovascular disease risk.

Conditions or Diseases that Require a Cardio IQ® Diabetes and ASCVD Risk Panel with Scores Test

  • Diabetes and Prediabetes: Identifying early signs or risk of developing the condition.

  • Atherosclerotic Cardiovascular Disease (ASCVD): Which includes conditions such as coronary artery disease, peripheral arterial disease, and stroke.

  • Metabolic Syndrome: A combination of conditions like hypertension, high blood sugar, and abnormal cholesterol or triglyceride levels, increasing the risk of chronic diseases.

Usage of Results from Cardio IQ® Diabetes and ASCVD Risk Panel with Scores Test by Health Care Providers

These results are instrumental for healthcare providers to:

  • Risk Classification: Properly classify and educate patients on their risks, allowing for early interventions.

  • Formulate Treatment Plans: Interventions may range from lifestyle modifications and dietary changes to prescription medications.

  • Monitor Intervention Efficacy: Repeated tests can help evaluate if interventions or treatments are effectively reducing risk.

In essence, the Cardio IQ® Diabetes and ASCVD Risk Panel with Scores test is a critical tool that offers a two-pronged approach, targeting both diabetes and cardiovascular disease risks. This holistic view is essential for proactive healthcare, emphasizing prevention and early detection.

Most Common Questions About the Cardio IQ® Diabetes and ASCVD Risk Panel with Scores test:

Purpose and Clinical Indications for the Cardio IQ® Diabetes and ASCVD Risk Panel with Scores Test

What is the primary purpose of the Cardio IQ® Diabetes and ASCVD Risk Panel with Scores test?

The Cardio IQ® Diabetes and ASCVD Risk Panel with Scores test is primarily designed to assess an individual's risk for developing diabetes and atherosclerotic cardiovascular disease (ASCVD). It evaluates several biomarkers that are indicators of metabolic health and cardiovascular risk, thus providing a comprehensive outlook on an individual's health status.

Why might a healthcare provider recommend the Cardio IQ® Diabetes and ASCVD Risk Panel with Scores test?

Healthcare providers might recommend the Cardio IQ® Diabetes and ASCVD Risk Panel with Scores test for patients with a family history of diabetes or cardiovascular diseases, those presenting with risk factors for metabolic syndrome, or those who have lifestyle factors that might increase their risk for either condition. It offers a proactive approach to early detection, potentially allowing for timely interventions.

Interpretation of Results

How do clinicians interpret the results of the Cardio IQ® Diabetes and ASCVD Risk Panel with Scores test?

The results of the Cardio IQ® Diabetes and ASCVD Risk Panel with Scores test provide scores that represent the relative risk of developing diabetes and ASCVD. Scores are categorized, often from low to high risk. The presence and levels of specific biomarkers also give insight into metabolic and cardiovascular health. Based on these scores and biomarker levels, clinicians can determine the need for preventive measures or further diagnostic tests.

Implications and Medical Management

If a patient receives a high risk score on the Cardio IQ® Diabetes and ASCVD Risk Panel with Scores test, what might be the subsequent medical recommendations?

A high-risk score suggests an elevated risk of developing diabetes or ASCVD. Medical recommendations might include lifestyle changes like adopting a heart-healthy diet, increasing physical activity, weight management, and potentially medications to address high blood pressure, cholesterol, or glucose levels. Regular follow-up and monitoring would also be essential.

Is the Cardio IQ® Diabetes and ASCVD Risk Panel with Scores test used as a sole diagnostic tool for diabetes and ASCVD?

No, the Cardio IQ® Diabetes and ASCVD Risk Panel with Scores test is a risk assessment tool and doesn't directly diagnose diabetes or ASCVD. A definitive diagnosis would require further clinical evaluations and other specific diagnostic tests.

Test Specifics

What sets the Cardio IQ® Diabetes and ASCVD Risk Panel with Scores test apart from other risk assessment tests?

The Cardio IQ® Diabetes and ASCVD Risk Panel with Scores test is unique in its comprehensive approach. Instead of focusing on a single marker or risk factor, it evaluates multiple biomarkers related to both diabetes and ASCVD. This holistic evaluation provides a broader understanding of an individual's health and risk factors.

Are there conditions or factors that might influence the results of the Cardio IQ® Diabetes and ASCVD Risk Panel with Scores test?

Indeed, certain conditions like polycystic ovary syndrome (PCOS), thyroid disorders, or having metabolic syndrome can influence the results. Lifestyle factors, such as diet, physical activity, and recent illnesses, as well as certain medications, might also affect the biomarkers evaluated by the test. It's crucial for individuals to provide a comprehensive medical history for accurate result interpretation.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

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