C-Peptide Stimulation by Glucagon

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The C-Peptide Stimulation by Glucagon test contains 1 test.

C-Peptide Stimulation by Glucagon Test: Clinical Significance

The C-Peptide Stimulation by Glucagon test plays a pivotal role in the assessment of pancreatic beta cell function and reserve. This test is particularly valuable for patients suspected of or being managed for Type I diabetes mellitus, where monitoring the progression of beta cell function is critical. In Type I diabetes, the autoimmune destruction of beta cells leads to a progressive decline in their ability to produce insulin, necessitating the need for precise evaluation methods such as this test.


  • Baseline, 5 minutes, 10 minutes, 15 minutes
Patient Preparation

Overnight fasting is required

Clinical Utility:

  • Diagnosis and Monitoring: It aids in diagnosing Type I diabetes by evaluating the residual beta cell function. This is essential for determining the extent of beta cell destruction and can influence the management plan for the patient.
  • Differentiating Diabetes Types: It helps differentiate between Type I and Type II diabetes. Patients with Type II diabetes typically have normal or increased levels of C-Peptide due to insulin resistance, whereas those with Type I diabetes show reduced C-Peptide levels over time due to beta cell destruction.
  • Evaluating Beta Cell Reserve: The test is crucial for assessing the pancreatic beta cell reserve, providing insight into the remaining functional capacity of the pancreas to produce insulin.

Reference Range(s):

  • Baseline: The reference range for baseline C-Peptide levels is 0.80-3.10 ng/mL. This initial measurement provides a snapshot of the resting state of beta cell activity.
  • 5 minutes: Information not available. The response at this time point may vary and is not standardized for clinical reporting.
  • 10 minutes: Information not available. Similar to the 5-minute interval, the C-Peptide response at this time frame is not established for routine clinical interpretation.
  • 15 minutes: The response to glucagon stimulation at 15 minutes should be interpreted based on the laboratory report. This time point is critical for evaluating the dynamic response of the beta cells to stimulation, offering insights into their functional reserve.
Result Code Result Name LOINC Code Component Name
85997203  BASELINE  13037-7  C peptide^post CFst 
85997204  5 MINUTES  13861-0  C peptide^5M post 1 mg glucagon IV 
85997205  10 MINUTES  13859-4  C peptide^10M post 1 mg glucagon IV 
85997206  15 MINUTES  13860-2  C peptide^15M post 1 mg glucagon IV



  • Increased Levels: May indicate insulin resistance, Type II diabetes, or conditions associated with increased beta cell activity.
  • Decreased Levels: Suggestive of reduced beta cell function, commonly seen in Type I diabetes or advanced stages of Type II diabetes where beta cell exhaustion occurs.

The test's outcome must be interpreted within the context of the patient's clinical presentation, history, and other diagnostic findings. The dynamic response of C-Peptide to glucagon stimulation provides a more nuanced understanding of pancreatic function than baseline measurements alone.

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