Bullous Pemphigoid BP230 IgG

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Bullous Pemphigoid Bp230

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The Bullous Pemphigoid BP230 IgG test contains 1 test with 1 biomarker.

Clinical Significance

Bullous pemphigoid (BP) is a chronic blistering disorder found mainly in the elderly but occasionally encountered in children. It is characterized by frequent recurring tense blisters and erythema. IgG anti-basement membrane zone (BMZ) antibodies are found in the serum of patients, and immunofluorescence demonstrates linear staining with IgG or C3 at the BMZ of the lesion. Target antigens of the autoantibodies in BP patient serum are BP180 and BP230, also called BPAG1 and BPAG2. Anti-BP230 is highly specific to BP and considered to be a useful serologic marker of the the disease. The BP230 ELISA kit has recombinant protein of both N-terminus and C-terminus of BP230 as solid phase and measures anti-BP230 autoantibodies in patient serum specifically.

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