Autoimmune Disorder Diagnostic Panel

Blood
Blood Draw, Phlebotomist

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Also known as: ANA, ANA Screen IFA with Reflex to Titer and Pattern IFA, ANA with Reflux

ANA Screen, IFA

The antinuclear antibody (ANA) test is ordered to help screen for autoimmune disorders and is most often used as one of the tests to diagnose systemic lupus erythematosus (SLE).

Also known as: C-Reactive Protein, CReactive Protein CRP, CRP

C-REACTIVE PROTEIN

C-reactive protein is produced by the liver. The level of CRP rises when there is inflammation throughout the body.

Complement Component C3c

Complement Component C4c

Also known as: ACPA, Anti-CCP, Anti-citrulline Antibody, Anti-cyclic Citrullinated Peptide, Anti-Cyclic Citrullinated Peptide (CCP) Antibody IgG, CCP, CCP Antibody, Citrullinated Peptide (CCP) IgG, Cyclic Citrullinated Peptide Antibody, Cyclic Citrullinated Peptide CCP Antibody IgG

Cyclic Citrullinated

Also known as: (dsDNA), Anti-DNA, DNA ds Antibody, Double-Stranded DNA Antibody, dsDNA, Native DNA

Dna (Ds) Antibody

Also known as: RF

Rheumatoid Factor

Rheumatoid factor (RF) is a blood test that measures the amount of the RF antibody in the blood. An abnormal result means the test is positive, which means higher levels of rheumatoid factor have been detected in your blood. Most patients with rheumatoid arthritis or Sjogren syndrome have positive RF tests. The higher the level, the more likely one of these conditions is present. Not everyone with higher levels of rheumatoid factor has rheumatoid arthritis or Sjogren syndrome.

Also known as: ESR, SED RATE, Sed Rate by Modified Westergren ESR

Sed Rate By Modified

Erythrocyte sedimentation rate (ESR) is an indirect measure of the degree of inflammation present in the body. It actually measures the rate of fall (sedimentation) of erythrocytes (red blood cells) in a sample of blood.
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The Autoimmune Disorder Diagnostic Panel panel contains 8 tests with 8 biomarkers .

Autoimmune Disorder Diagnostic Panel

Comprehensive screening & monitoring for systemic and organ-specific autoimmune disease

Why this panel matters

Autoimmune disorders often start with vague symptoms—fatigue, joint pain, rashes, or unexplained fevers. Left unchecked, the immune system can damage joints, nerves, kidneys, skin, and blood vessels. This panel bundles eight cornerstone biomarkers so your healthcare provider can detect disease early, confirm a diagnosis, track flare-ups, and fine-tune treatment—all from a single blood draw.


What’s included & how each test helps

Test What it Measures Key Autoimmune Conditions Affected
ANA Screen, IFA with Reflex to Titer & Pattern Autoantibodies targeting cell nuclei; reflex testing identifies the strength (titer) and pattern First-line screen for systemic lupus erythematosus (SLE)Sjögren’s syndromesclerodermamixed connective-tissue disease (MCTD)polymyositis/dermatomyositis
C-Reactive Protein (CRP) Acute-phase protein that rises with systemic inflammation Gauges disease activity in rheumatoid arthritis (RA)vasculitidespsoriatic arthritisinflammatory bowel disease (IBD); useful for monitoring flare severity and treatment response
Complement Component C3c & C4c Core proteins of the complement cascade; low values signal ongoing immune-complex consumption Activity marker for SLE (especially lupus nephritis)cryoglobulinemiaimmune-complex vasculitishereditary angioedema
Cyclic Citrullinated Peptide (CCP) Antibody (IgG) Autoantibodies against citrullinated proteins Highly specific for RA—helps differentiate RA from other arthritides, predicts erosive disease, and guides early aggressive therapy
DNA (ds) Antibody Autoantibodies to double-stranded DNA Gold-standard marker for SLE; titers correlate with renal involvement and overall disease activity
Rheumatoid Factor (RF) Autoantibodies (usually IgM) against the Fc portion of IgG Classic diagnostic test for RA; also seen in Sjögren’sMCTDcryoglobulinemia; elevated levels often parallel joint destruction
Sed Rate by Modified Westergren (ESR) Speed at which red cells settle; rises with chronic inflammation Broad indicator for RApolymyalgia rheumaticagiant-cell arteritissystemic vasculitisIBD

 


Who should consider this panel?

  • Persistent joint pain, swelling, or morning stiffness

  • Recurrent fevers, rashes, photosensitivity, or mouth ulcers

  • Unexplained fatigue, muscle weakness, or neuropathy

  • Positive family history of autoimmune disease

  • Need to track known autoimmune conditions or medication response


How the results guide care

  • Early detection: High-specificity markers (dsDNA, CCP) confirm diagnoses sooner, enabling prompt therapy.

  • Activity monitoring: Trends in CRP, ESR, dsDNA, and complement pinpoint flares vs. remission.

  • Therapy optimization: Falling titers or normalized complement levels signal effective treatment; rising levels prompt medication adjustment.


Fast, convenient testing

  • Sample: 1 standard blood draw (≈15 minutes)

  • Turnaround: Most results in 24–48 hours

  • Actionable report: Plain-language explanations plus physician-ready detail

Take charge of your health: order the Autoimmune Disorder Diagnostic Panel today and give your care team the data they need to protect your joints, organs, and quality of life.

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