Antidepressants Panel 1, Serum/Plasma

The Antidepressants Panel 1, Serum/Plasma test contains 1 test with 19 biomarkers.

Brief Description: The Antidepressants Panel 1 test is a laboratory assay designed to detect and measure the concentration of specific antidepressant medications in a patient's serum or plasma. This helps in assessing medication adherence, verifying therapeutic levels, or detecting potential drug interactions.

Collection Method: Blood Draw

Specimen Type: Serum or Plasma

Test Preparation: No preparation required

When and Why the Antidepressants Panel 1 May Be Ordered

Healthcare providers may order this test in various circumstances, such as:

  1. Monitoring Treatment Adherence: To confirm whether patients are taking their medications as prescribed.
  2. Therapeutic Drug Monitoring: To ensure that the drug concentrations remain within the therapeutic range, optimizing treatment efficacy while minimizing potential side effects.
  3. Detecting Drug Interactions: If a patient is on multiple medications, there's a risk of drug-drug interactions, which can alter the concentration of the drugs in the bloodstream.
  4. Suspected Overdose: If there's a suspicion that a patient has taken an overdose of their medication, the test can be used to confirm and quantify the levels.

What the Antidepressants Panel 1 Checks For

This test measures the concentration of specific antidepressants in the serum or plasma. The exact list of drugs includes:

  • Amitriptyline
  • Nortriptyline
  • Desipramine
  • Doxepin
  • Nordoxepin
  • Imipramine
  • Maprotiline
  • Protriptyline
  • clomiPRAMINE
  • Norclomipramine
  • Trimipramine
  • Nortrimipramine
  • FLUoxetine
  • Norfluoxetine
  • traZODone
  • Amoxapine
  • Mirtazapine

Other Lab Tests Ordered Alongside the Antidepressants Panel 1

Alongside this test, a healthcare provider may order:

  • Complete Blood Count (CBC): To monitor overall health and detect disorders like anemia or infection.
  • Liver Function Tests: Many drugs, including some antidepressants, are metabolized in the liver. Monitoring liver health can be crucial for patients on long-term medications.
  • Kidney Function Tests: To evaluate the kidneys' ability to filter waste products, which is essential as many drugs are excreted through the kidneys.
  • Electrolyte Panel: In cases of suspected overdose, imbalances in electrolytes like sodium and potassium can be life-threatening.

Conditions or Diseases Requiring the Antidepressants Panel 1

The primary condition leading to the order of this test is:

  • Depression: Patients who are being treated for depression with antidepressant medications may need periodic monitoring to ensure therapeutic drug levels.

Usage of Results by Health Care Providers

Healthcare providers use the results of the Antidepressants Panel 1 to:

  • Adjust Medication Dosages: Based on the detected drug concentrations, a doctor might increase or decrease the dose of an antidepressant to ensure it remains within the therapeutic range.
  • Assess Adherence: If drug levels are lower than expected, it might indicate that the patient isn't taking the medication as prescribed.
  • Detect Potential Overdose: Extremely high levels of a drug can be indicative of an overdose, requiring urgent medical intervention.
  • Inform about Drug Interactions: If the patient is on multiple medications, and one drug's level is unusually high or low, it might be due to interactions with another drug.

In conclusion, the Antidepressants Panel 1 is an essential tool for healthcare providers in managing patients on antidepressant medications. Monitoring drug levels aids in optimizing treatment efficacy, ensuring patient safety, and achieving optimal therapeutic outcomes.


We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Also known as: MAG, Myelin Associated Glycoprotein MAGSGPG Antibody IgM


Screen for the presence of AMITRIPTYLINE


Screen for the presence of AMOXAPINE


Screen for the presence of CLOMIPRAMINE


Screen for the presence of DESIPRAMINE


Screen for the presence of DESMETHYLCLOMIPRAMINE


Screen for the presence of DESMETHYLDOXEPIN


Screen for the presence of DESMETHYLTRIMIPRAMINE


Screen for the presence of DOXEPIN


Screen for the presence of FLUOXETINE


Screen for the presence of IMIPRAMINE


Screen for the presence of MAPROTILINE


Screen for the presence of MIRTAZAPINE


Screen for the presence of NORFLUOXETINE


Screen for the presence of NORTRIPTYLINE


Screen for the presence of PROTRIPTYLINE


Screen for the presence of TRANYLCYPROMINE


Screen for the presence of TRAZODONE


Screen for the presence of TRIMIPRAMINE


Screen for the presence of VENLAFAXINE
*Process times are an estimate and are not guaranteed. The lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.

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