Vasculitis

Vasculitis is inflammation of blood vessels that can reduce blood flow and damage organs. It ranges from large-artery disorders (e.g., giant cell arteritis) to small-vessel diseases (e.g., ANCA-associated vasculitis). Because symptoms can be vague—fatigue, fevers, weight loss—or organ-specific (skin, kidneys, lungs, nerves), labs play a key role in raising or lowering suspicion, identifying triggers, and monitoring safety once a diagnosis is made.

A proactive approach pairs inflammation markers (ESR/CRP) and organ-function tests (kidney, liver, urinalysis) with disease-specific ... See more

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The Complete Blood Count with Differential and Platelets Test is a comprehensive blood test that checks red blood cells, white blood cells, hemoglobin, hematocrit, and platelets. The differential analyzes types of white blood cells to detect infections, anemia, clotting abnormalities, immune conditions, and certain cancers. This essential test is often ordered for routine health exams, diagnosis, and monitoring treatment progress.

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Also Known As: CBC Test, CBC with Differential and Platelets Test, CBC w/Diff and Platelets Test, Full Blood Count Test, Complete Blood Count Test

The C-Reactive Protein (CRP) Test measures CRP levels in blood to detect inflammation in the body. Elevated CRP may indicate infections, autoimmune disorders, or chronic diseases such as arthritis, cardiovascular disease, or inflammatory bowel disease. Doctors use this test to assess acute illness, monitor treatment response, and evaluate risk for heart disease. The CRP test provides key insight into inflammation, immune health, and overall wellness.

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Also Known As: CRP Test, Inflammation Test

The Comprehensive Metabolic Panel (CMP) Test measures 21 markers to assess metabolic health, liver and kidney function, and electrolyte balance. It includes glucose, calcium, sodium, potassium, chloride, CO2, albumin, globulin, A/G ratio, total protein, bilirubin, ALP, AST, ALT, BUN, creatinine, BUN/creatinine ratio, and eGFR. The CMP helps detect diabetes, liver or kidney disease, and supports routine screening and chronic condition monitoring.

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Also Known As: CMP Test, Chemistry Panel Test, Chem Test, Chem 21 Test, Chem 14 Test 

The Creatinine Test measures creatinine levels in blood to evaluate kidney function and filtration efficiency. Elevated levels may indicate kidney disease, dehydration, or muscle disorders, while low levels may reflect reduced muscle mass. Doctors use this test to monitor chronic kidney disease (CKD), assess treatment response, and detect early signs of renal impairment. It provides key insight into kidney health, metabolic balance, and overall renal function.

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Also Known As: Blood Creatinine Test, Serum Creatinine Test

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The Sed Rate Test, also called the ESR Test, measures how quickly red blood cells settle in a sample of blood. A faster rate may signal inflammation caused by infections, autoimmune diseases, arthritis, or other chronic conditions. Doctors use this test to investigate unexplained fever, joint pain, or muscle aches, and to monitor inflammatory disorders such as lupus or rheumatoid arthritis. The Sed Rate Test provides important insight into overall inflammatory activity.

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Also Known As: Erythrocyte Sedimentation Rate Test, ESR Test, Sedimentation Rate Test, Westergren Sedimentation Rate Test

The Hepatic Function Panel Test measures liver enzymes, proteins, and bilirubin to assess liver health and function. It includes ALT, AST, ALP, albumin, total protein, and bilirubin levels. Abnormal results may indicate hepatitis, cirrhosis, fatty liver, or bile duct problems. Doctors use this test to investigate jaundice, nausea, abdominal pain, or fatigue and to monitor liver disease, alcohol use, or medication side effects affecting liver function.

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Also Known As: Liver Function Panel Test, LFT

The Liver Function Panel, also known as a Hepatic Function Panel, measures proteins, enzymes, and bilirubin to assess liver health and function. It helps detect liver disease, monitor liver conditions, and evaluate the effects of medications or other factors on liver performance.

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Also Known As: Hepatic Function Panel Test, HFP Test

The Urinalysis Complete Test evaluates urine for physical, chemical, and microscopic properties to assess kidney health, urinary tract infections, diabetes, and metabolic disorders. It measures appearance, concentration, pH, protein, glucose, ketones, blood, bilirubin, nitrites, leukocyte esterase, and microscopic cells or crystals. Doctors use this test in routine exams, to diagnose urinary symptoms, and to monitor chronic kidney or metabolic disease.

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Urine Collection
Also Known As: Urine Analysis Test, UA Test, Complete Urinalysis Test

The Complement Component C3c and C4c Test measures levels of two key proteins in the complement system, which supports immune defense and inflammation control. Abnormal results may indicate autoimmune disease, lupus, rheumatoid arthritis, or certain infections. Doctors use this test to investigate unexplained inflammation, monitor disease activity, and guide treatment decisions in patients with suspected immune or inflammatory disorders.

Also Known As: C3 and C4 Test, Complement C3 and C4 Test, Complement Test

The Complement Component C3c Test measures levels of C3c, a protein involved in the immune complement system. Abnormal results may indicate autoimmune disorders, recurrent infections, or kidney disease linked to immune activity. Doctors use this blood test to evaluate complement activation, diagnose immune-related conditions, and monitor disease progression or treatment effectiveness in patients with suspected lupus, glomerulonephritis, or other immune disorders.

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Also Known As: C3 Test, Complement C3 Test, Complement Test

The Complement Component C4c Test measures blood levels of C4c, a protein in the complement system that supports immune defense and inflammation control. Abnormal levels may indicate autoimmune disorders such as lupus, rheumatoid arthritis, or immune complex disease, as well as certain kidney conditions. Doctors use this test to evaluate complement activation, confirm diagnosis, and monitor treatment response in patients with suspected immune-related diseases.

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Also Known As: C4 Test, Complement C4 Test, Complement Test

The Complement Total CH50 Test measures overall activity of the complement system, a key part of the immune response that helps fight infections and regulate inflammation. Abnormal results may indicate autoimmune diseases such as lupus, complement deficiencies, or immune complex disorders. Doctors use this blood test to evaluate immune function, investigate recurrent infections, and monitor treatment in patients with suspected immune or autoimmune conditions.

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Also Known As: Total Complement Test, Total Complement Activity Test

The ANCA Vasculitides Test measures antibodies that target neutrophils, helping identify autoimmune vasculitis. It aids in diagnosing conditions including granulomatosis with polyangiitis and microscopic polyangiitis. This test provides insight into systemic inflammation, kidney disease, and respiratory involvement, supporting evaluation of autoimmune disorders linked to vascular and organ damage.

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The ANA IFA Panel Comprehensive screens for autoimmune disorders by detecting antinuclear antibodies and specific markers including dsDNA, Sm, Sm/RNP, Scl-70, and Sjögren’s SS-A/SS-B. Doctors order this panel for patients with joint pain, rash, fatigue, or suspected lupus, scleroderma, or Sjögren’s syndrome. Results provide critical insight into autoimmune activity, helping confirm diagnosis, monitor disease progression, and guide treatment decisions.

Also Known As: Comprehensive ANA Panel

The ANA Screen IFA with Reflex to Titer and Pattern Test detects antinuclear antibodies in blood to evaluate autoimmune activity. If positive, further testing identifies antibody concentration (titer) and fluorescence pattern, helping diagnose conditions like lupus, rheumatoid arthritis, or Sjögren’s syndrome. Doctors order this test to investigate symptoms such as joint pain, fatigue, rash, or swelling and to guide treatment for autoimmune and connective tissue disorders.

Also Known As: ANA Test, Antinuclear Antibody Screen Test

The ANCA Screen with MPO and PR3 with Reflex to ANCA Titer detects antineutrophil cytoplasmic antibodies linked to autoimmune vasculitis. By targeting myeloperoxidase (MPO) and proteinase 3 (PR3), this test helps evaluate conditions such as granulomatosis with polyangiitis or microscopic polyangiitis. It supports diagnosis, disease activity monitoring, and assessment of autoimmune inflammation.


The ANCA Screen with Reflex to ANCA Titer detects antineutrophil cytoplasmic antibodies, often linked to autoimmune vasculitis such as granulomatosis with polyangiitis and microscopic polyangiitis. If the screen is positive, a titer is performed to measure antibody levels for greater diagnostic accuracy. Doctors use this test to evaluate unexplained inflammation, kidney or lung issues, and guide treatment decisions in autoimmune and systemic vasculitis care.

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Also Known As: ANCA Test, cANCA Test, pANCA Test, Serine Protease 3 Test, Acticytoplasmic Test, 3-ANCA test, PR3-ANCA Test, MPO-ANCA test

The ADMA and SDMA Test measures asymmetric and symmetric dimethylarginine, biomarkers of nitric oxide metabolism and endothelial function. Elevated levels are linked to cardiovascular disease, kidney dysfunction, and metabolic disorders. Doctors order this test to assess vascular health, kidney function, or cardiovascular risk. Results provide critical insight into endothelial damage, early detection of disease, and guidance for preventive or therapeutic strategies.

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Also Known As: ADMA/SDMA Test

The Angiotensin Converting Enzyme (ACE) Test measures ACE levels in the blood to help diagnose and monitor sarcoidosis, a condition marked by granulomas in the lungs, lymph nodes, or other organs. Elevated ACE may also be seen in other granulomatous diseases. Doctors use this test to support diagnosis, track disease activity, and evaluate response to therapy, especially when paired with imaging or additional lab studies.

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Also Known As: ACE Test, SACE Test, Serum Angiotensin Converting Enzyme Test

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The Beta-2-Glycoprotein I IgG IgA IgM Antibodies Test detects autoantibodies linked to antiphospholipid syndrome (APS), a disorder that increases risk of abnormal blood clotting. Measuring all three antibody classes provides a thorough evaluation of immune activity. Elevated results may be associated with recurrent miscarriages, venous or arterial thrombosis, and autoimmune conditions, supporting diagnosis and monitoring of clotting-related disorders.


The Beta-2-Glycoprotein I IgA Antibody Test detects IgA antibodies targeting beta-2 glycoprotein I, helping identify autoimmune conditions and clotting disorders. Positive results may indicate antiphospholipid syndrome, thrombotic risk, or pregnancy complications. This test provides insight into immune activity, vascular health, and systemic conditions linked to abnormal coagulation and inflammation.

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The Beta-2-Glycoprotein I IgG Antibody Test detects IgG antibodies targeting beta-2 glycoprotein I, helping assess autoimmune disorders and clotting risk. Positive results may indicate antiphospholipid syndrome, pregnancy complications, or thrombotic conditions. This test provides insight into vascular health, immune response, and systemic disorders related to antibody activity and coagulation balance.

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The Beta-2-Glycoprotein I IgM Antibody Test detects IgM antibodies targeting beta-2 glycoprotein I to help assess autoimmune activity and clotting disorders. Positive findings may suggest antiphospholipid syndrome, thrombotic risk, or recurrent miscarriage. This test provides insight into vascular health, immune regulation, and systemic disorders tied to antibody activity and coagulation balance.

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The Cardio IQ™ Myeloperoxidase Test measures levels of myeloperoxidase (MPO), an enzyme released by white blood cells linked to vascular inflammation and plaque instability. Elevated MPO is associated with increased risk of coronary artery disease, heart attack, or atherosclerosis. Physicians use this test to evaluate cardiovascular risk, monitor arterial health, and guide prevention strategies for long-term heart health management.

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Also Known As: Cardio IQ™ MPO Test

Vasculitis is a term that is used to describe a group of conditions characterized by inflamed blood vessels. If there is not a clear, obvious cause for the condition, then it is typically referred to as primary vasculitis. When there is a cause, it is called secondary vasculitis. There are a lot of things that can cause secondary vasculitis, such as allergic reactions to medication, infection with hepatitis C, auto-immune diseases such as rheumatoid arthritis, and even complications related to lymphoma or leukemia. 

Vasculitis can affect veins, arteries, and capillaries, resulting in narrowed vessels that limit the circulation of blood and can cause tissue or organ damage. A weakened vessel can lead to an aneurysm, which may, in turn, cause life-threatening internal bleeding. 

There are a lot of different kinds of vasculitis, and they are classified based on the size and type of the blood vessel affected. Understanding the different ... See more