Depression

Depression is a clinical condition, but many medical issues can mimic or worsen depressive symptoms—including thyroid disease, anemia, vitamin and iron deficiencies, diabetes, hormone changes, infections, and some medicines or substances. Blood testing does not diagnose depression itself; instead, it helps find reversible contributors, establish baselines before or during treatment, and monitor overall health.

A proactive plan usually starts with CBC/CMPthyroid (TSH ± Free T4)vitamin B12 with methylmalonic acid (MMA)vitamin ... See more

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The Magnesium RBC Test measures magnesium inside red blood cells, providing a more accurate assessment of magnesium status than serum tests. Magnesium is vital for energy production, muscle and nerve function, heart rhythm, and bone health. Low levels may cause fatigue, cramps, arrhythmias, or weakness, while high levels may signal kidney issues. Doctors order this test to detect deficiency, monitor therapy, and evaluate overall metabolic and nutritional health.

Other
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Also Known As: Magnesium Red Bood Cell Test, Mg Test, Mag Test

The Methylenetetrahydrofolate Reductase (MTHFR) DNA Mutation Analysis detects genetic variants in the MTHFR gene that affect folate metabolism and homocysteine regulation. Mutations may increase risk for blood clots, cardiovascular disease, pregnancy complications, or certain neurological conditions. Doctors use this test to evaluate unexplained blood clotting, high homocysteine levels, or family history of related disorders.

Blood
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Also Known As: MTHFR Factor Test, MTHFR Mutation Test, MTHFR Gene Mutation Test, Methylenetetrahydrofolate Reductase Gene Test, MTHFR Disease Test

The Methylmalonic Acid (MMA) Blood Test measures MMA levels in the bloodstream to help detect vitamin B12 deficiency, often before anemia or neurological symptoms appear. Elevated results may indicate poor B12 absorption, pernicious anemia, or metabolic disorders. Doctors order this test when patients present with fatigue, neuropathy, or unexplained anemia. Results provide early insight into nutritional status, metabolic health, and treatment needs.

Serum
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Also Known As: MMA Test

The Methylmalonic Acid Urine Test measures MMA levels to help detect vitamin B12 deficiency and assess metabolic health. Elevated MMA indicates impaired B12-dependent enzyme function, which may lead to anemia or nervous system damage. Doctors order this test to investigate unexplained fatigue, weakness, or neurological symptoms. It is often used with serum B12 testing for early, accurate detection and monitoring of deficiency.

Random
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Also Known As: MMA Urine Test

The QuestAssureD™ Vitamin D 25-Hydroxy Total Test for Infants measures total vitamin D levels to evaluate bone health, calcium balance, and overall growth. Adequate vitamin D is essential for skeletal development, immune function, and preventing rickets. Physicians use this test to identify deficiency, monitor supplementation, and ensure infants receive the nutrients needed for proper development and long-term health.

Serum
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The RPR (Monitor) with Reflex to Titer Test screens for syphilis by detecting antibodies to Treponema pallidum. If positive, a reflex titer determines antibody concentration to assess disease activity and treatment response. Doctors order this test to diagnose syphilis, monitor therapy, or check reinfection. Results provide essential information for managing active infection, confirming treatment success, and guiding follow-up care.

Also Known As: Syphilis RPR Test, Rapid Plasma Reagin Test

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The T3 Reverse (rT3) Test measures reverse triiodothyronine, an inactive thyroid hormone, to assess thyroid and metabolic function. High rT3 may occur in hypothyroidism, chronic illness, stress, or during certain treatments, while low levels may reflect hormone imbalance. Doctors use this test along with TSH, Free T4, and Free T3 to evaluate fatigue, weight changes, or slow metabolism. The rT3 Test provides insight into thyroid regulation, energy balance, and endocrine health.

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Also Known As: Reverse T3 Test, RT3 Test, T3R Test

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The T3 Total Test measures total triiodothyronine (T3), a combination of both bound and unbound (free) T3, to assess thyroid function. Abnormal levels may indicate hyperthyroidism, hypothyroidism, goiter, or pituitary disorders. Doctors use this test to evaluate symptoms like fatigue, weight changes, anxiety, or irregular heartbeat and to monitor thyroid treatment. The T3 Total Test provides essential insight into metabolism, energy regulation, and overall endocrine health.

Also Known As: Total T3 Test, Total Triiodothyronine Test, T3 Test, Bound and Unbound T3

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The T3 Free Test measures free triiodothyronine (T3), the active thyroid hormone not bound to proteins, to assess thyroid function. It helps diagnose hyperthyroidism, hypothyroidism, goiter, and pituitary disorders. Doctors order this test to evaluate symptoms like fatigue, weight changes, anxiety, or irregular heartbeat and to monitor thyroid replacement or antithyroid therapy. The Free T3 Test provides key insight into metabolism, energy regulation, and overall endocrine health.

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Also Known As: Free T3 Test, Free Triiodothyronine Test, FT3 Test, T3F Test, Unbound T3 Test

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The T4 Total Test measures total thyroxine (T4) in blood, a combination of both bound and unbound (free) T4, to assess thyroid function. Abnormal levels may indicate hypothyroidism, hyperthyroidism, goiter, or pituitary disorders. Doctors use this test to evaluate symptoms like fatigue, weight changes, hair loss, or irregular heart rate and to monitor thyroid replacement or antithyroid therapy. The T4 Total Test provides key insight into metabolic, hormonal, and endocrine health.

Also Known As: Total T4 Test, Total Thyroxine Test, T4 Test, Bound and Unbound T4 Test

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The T4 Free Test measures the level of free thyroxine (T4) in blood, the active thyroid hormone not bound to proteins. It helps diagnose thyroid disorders such as hypothyroidism, hyperthyroidism, and goiter, as well as pituitary conditions affecting hormone regulation. Doctors use this test to evaluate symptoms like fatigue, weight changes, hair loss, or irregular heartbeat and to monitor thyroid replacement or antithyroid therapy, providing insight into metabolic and endocrine health.

Serum
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Also Known As: Free T4 Test, Free Thyroxine Test, FT4 Test, T4F Test, Unbound T4 Test

The Testosterone Free and Total Test measures total testosterone and free, bioavailable testosterone in blood for both men and women. It helps diagnose hormone imbalance, infertility, low libido, erectile dysfunction in men, irregular periods, or PCOS in women. Doctors also order it to assess fatigue, mood changes, or muscle weakness and to monitor hormone therapy. This test provides key insight into reproductive, endocrine, and overall metabolic health.

Serum
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Also Known As: Bound and Unbound Testosterone, Uncapped Testosterone Test

The Testosterone Free, Bioavailable, and Total Test measures total testosterone, free testosterone, and bioavailable testosterone, along with sex hormone binding globulin (SHBG) and albumin. This test provides a complete evaluation of hormone balance in men and women. Doctors use it to assess infertility, erectile dysfunction, low libido, PCOS, fatigue, or muscle loss and to monitor hormone therapy. Results offer key insight into reproductive, endocrine, and metabolic health.

Serum
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Also Known As: Bound Unbound and Bioavailable Testosterone with SHBG Test, Uncapped Testosterone

The Testosterone Free and Total and Sex Hormone Binding Globulin (SHBG) Test measures total testosterone, free testosterone, and SHBG to assess hormone balance in men and women. It helps diagnose infertility, erectile dysfunction, low libido, irregular periods, PCOS, and abnormal puberty. Doctors also use it to evaluate fatigue, muscle weakness, or mood changes and to monitor hormone therapy. This test provides a comprehensive view of reproductive, endocrine, and metabolic health.

Also Known As: Bound and Unbound Testosterone with SHBG Test, Uncapped Testosterone Test

The Testosterone Total Test measures total testosterone levels in blood to evaluate reproductive, sexual, and endocrine health. In men, it helps diagnose hypogonadism, infertility, erectile dysfunction, or low libido. In women, abnormal levels may indicate PCOS or hormonal imbalance. Doctors use this test to investigate fatigue, muscle weakness, or mood changes and to monitor testosterone therapy. It provides key insight into hormone balance and metabolic health.

Serum
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Also Known As: Total Testostone LCMS Test, Uncapped Testosterone Test

 The TH-1 Thyroid Health panel is a basic yet essential set of tests focused on evaluating the primary aspects of thyroid function. This panel includes assessments for Free T4 and Thyroid Stimulating Hormone (TSH), providing a foundational understanding of thyroid health and activity.
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 The TH-2 Thyroid Health panel is a comprehensive set of tests designed to evaluate thyroid function more extensively than basic screenings. It includes assessments of both bound and unbound thyroid hormones, providing a detailed picture of thyroid activity and metabolism.
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 The TH-3 Thyroid Health panel is a comprehensive set of tests designed to provide an in-depth evaluation of thyroid function and autoimmunity. This panel assesses the levels of thyroid hormones, including the active and inactive forms, and checks for antibodies that indicate an autoimmune thyroid disorder.
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 The TH-4 Thyroid Health panel represents the most comprehensive evaluation in the series, designed to assess thyroid function extensively, including thyroid hormone levels, autoimmunity, and specific markers indicative of autoimmune thyroid diseases. This panel is particularly valuable for diagnosing complex thyroid conditions and monitoring autoimmune thyroid disorders.
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The Thyroid Peroxidase and Thyroglobulin Antibodies Test measures TPO and TgAb antibodies that target thyroid enzymes and proteins essential for hormone production. High levels are linked to autoimmune thyroid disorders such as Hashimoto’s thyroiditis and Graves’ disease. Doctors order this test to evaluate fatigue, weight changes, neck swelling, or irregular heartbeat and to confirm thyroid autoimmunity. It provides vital insight into thyroid function and endocrine health.

Also Known As: Thyroid Antibodies Test, TPO and TgAb Test

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The Thyroid Stimulating Hormone (TSH) Test measures TSH levels in blood to assess thyroid function and diagnose hypothyroidism or hyperthyroidism. It evaluates how the thyroid controls metabolism, energy, weight, and heart rate. Doctors use the TSH test to investigate symptoms such as fatigue, hair loss, or mood changes. Frequently included in routine health exams, it is also key for monitoring thyroid disease treatment and overall endocrine balance.

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Also Known As: Thyroid Stimulating Hormone Test, Thyrotropin Test

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The Thyroid Stimulating Immunoglobulin (TSI) Test detects antibodies that stimulate the thyroid gland, often causing hyperthyroidism and Graves’ disease. High TSI levels may lead to symptoms such as weight loss, rapid heartbeat, or eye problems. Doctors order this test to confirm Graves’ disease, monitor treatment, or assess relapse risk. Results provide essential insight into autoimmune thyroid disorders and guide personalized management strategies.

Serum
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Also Known As: Thyroid Stimulating Immunoglobulin Test

The Vitamin B12 Micronutrient Test measures blood levels of vitamin B12, essential for red blood cell production, nerve health, and DNA synthesis. Deficiency can cause anemia, fatigue, neurological issues, and cognitive changes. This test helps identify dietary deficiencies, absorption problems, or related health conditions, supporting diagnosis and ongoing management of overall wellness.

Patient must be 18 years of age or older.
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Also Known As: B12 Test, Cobalamin Test

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The Vitamin B12 Test measures cobalamin levels in blood to evaluate nutritional health, red blood cell production, and nervous system function. Low B12 can cause anemia, fatigue, weakness, memory problems, and nerve damage, while high levels may indicate liver or kidney disease. Doctors use this test to detect B12 deficiency, monitor treatment, and assess malabsorption conditions like pernicious anemia, Crohn’s disease, or celiac disease.

Serum
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Also Known As: B12 Test, Cobalamin Test

Depression afflicts 264 million people across the world.

Amid a pandemic and other traumatic events, mental health is now more important than ever.

You may have down moments, but what if you're not sure if you actually have depression? Or maybe you are certain you are suffering from depression, but don't know why.

Depression can be caused by external factors, but it can also stem from other health issues. Depression blood tests may help you narrow down the cause so you can start working on a solution.

Here is what you need to know about depression and how lab tests for depression can help.

What Is Depression?

At its most simple description, depression causes feelings of sadness. It also causes you to lose interest in people or activities that you previously cared about. Depression is common, but that doesn't take away from the severity of this affliction.

Depression can interfere with personal relationships, work, ... See more