All Liver Tests

All Liver Tests brings together the core blood tests that assess liver injurybile-flow (cholestasis), and liver function, while helping uncover common causes such as viral hepatitismetabolic/fatty liver diseasealcohol-related injuryautoimmune conditions, and genetic disorders. Early liver problems are often silent, so a proactive testing plan can identify issues before symptoms start.

Start with a hepatic function panelAST, ALT, alkaline phosphatase, GGT, total/direct bilirubin, albumin, total protein (± A/G ratio)—and add PT/INRplatelets/CBC, and basic metabolic safety labs (sodium, creatinine). Based on your history and results, include hepatitis A/B/C screeningautoimmune markers, and iron/copper/alpha-1 antitrypsin studies. Noninvasive fibrosis scores calculated from routine labs (e.g., FIB-4, APRI) help estimate scarring risk. Labs support screeningdiagnosisstaging, and monitoring, but they do not replace a clinician’s exam, ultrasound/elastography, endoscopy, or urgent care for severe symptoms.

Signs, Symptoms & Related Situations

  • Often silent early: abnormal enzymes on a routine wellness panel

  • Skin/eyes & digestion: jaundice, dark urine, pale stools, itching, low appetite, nausea

  • Abdomen & fluid: bloating or ascites, rapid weight change, leg swelling

  • Bleeding/energy: easy bruising/bleeding, fatigue, weakness

  • Thinking changes: sleep reversal, confusion (possible encephalopathy)

  • Risks & exposures: viral hepatitis risks, alcohol use, metabolic syndrome (central weight, diabetes, high triglycerides), family history of iron/copper/A1AT disorders, long-term or new medications/supplements

  • Seek urgent care now: vomiting blood or black stools, severe abdominal swelling with pain/fever, confusion or extreme sleepiness, chest pain, or trouble breathing

All symptoms and risks should be evaluated by a qualified clinician.

Why These Tests Matter

What testing can do

  • Reveal injury patterns (hepatocellular vs. cholestatic) and assess synthetic function (albumin, PT/INR)

  • Suggest causes using targeted add-ons (hepatitis panels, autoimmune markers, iron/copper/A1AT)

  • Provide risk clues for scarring via platelets and fibrosis scores (FIB-4/APRI; ELF where available)

  • Track trends over time to guide follow-up and imaging

What testing cannot do

  • Confirm cirrhosis or cancer on labs alone—imaging/elastography (and sometimes biopsy) may be needed

  • Replace medication/alcohol review, lifestyle counseling, or a clinician’s examination

  • Provide treatment or dosing advice—use results to plan with your clinician

What These Tests Measure (at a glance)

  • AST & ALT: enzymes of liver-cell injury; ALT is more liver-specific. (AST can rise with muscle injury/exercise.)

  • Alkaline Phosphatase (ALP) & GGT: cholestasis markers; GGT helps confirm that elevated ALP is liver-related (vs. bone).

  • Bilirubin (total/direct): high levels cause jaundicedirect (conjugated) bilirubin rises with cholestasis/obstruction.

  • Albumin & Total Protein (± A/G ratio): reflect protein-making (synthetic) function and nutrition/inflammation context.

  • PT/INR: clotting proteins made by the liver; prolonged INR indicates reduced synthesis.

  • Platelets & CBC: low platelets may track with portal hypertension; CBC adds anemia/infection context.

  • Safety labs (BMP): sodium and creatinine/eGFR support risk assessment and MELD-type scoring.

  • Hepatitis testing: HBsAg, anti-HBs, total anti-HBcHCV Ab with reflex RNAHAV IgM/totalHDV/HEV in select settings.

  • Autoimmune markers: ANA, ASMA, AMAIgG/IgM—support autoimmune hepatitis or primary biliary cholangitis patterns.

  • Iron & genetics: Ferritin, iron/TIBC, transferrin saturation (hemochromatosis risk); HFE testing as directed.

  • Wilson/A1AT: Ceruloplasmin (± copper studies) for Wilson disease; alpha-1 antitrypsin level/phenotype for A1AT deficiency.

  • Fibrosis indicators: FIB-4, APRI from routine labs; ELF where available.

  • HCC marker (context): AFP may support surveillance with ultrasound.

Quick Build Guide

Clinical goal Start with Add if needed
Wellness baseline / risk check Hepatic function panel (AST/ALT, ALP/GGT, bilirubin, albumin/TP) PT/INR • Platelets/CBC
Abnormal enzymes on wellness panel Liver panel • PT/INR • Platelets/CBC • BMP (Na, creatinine) HBV/HCV panels • Ferritin/Iron/TIBC • A1c/Lipids
Metabolic/fatty liver risk AST/ALT • GGT • Platelets • Albumin • A1c • Lipids Calculate FIB-4/APRI; rule out HBV/HCV
Cholestatic pattern (ALP/GGT high) Liver panel • Direct bilirubin • GGT AMA • IgM (PBC context); clinician-directed imaging
Viral hepatitis screen HBV triple panel • HCV Ab with reflex RNA Hepatic panel for injury context
Autoimmune pattern suspected Liver panel • Immunoglobulins ANA • ASMA • AMA; consider IgGsubclassing
Iron overload/elevated ferritin Ferritin • Iron/TIBC • Transferrin saturation HFE genotype per clinician
Unclear cause Liver panel • PT/INR • CBC Ceruloplasmin • Alpha-1 Antitrypsin • HBV/HCV
Monitoring known cirrhosis Bilirubin • INR • Creatinine • Sodium • Albumin • Platelets AFP per surveillance; track MELD-type labs

How the Testing Process Works

  1. Pick your starting set: most users begin with a hepatic function panelPT/INRCBC/platelets, and BMP.

  2. Provide a blood sample: no routine fasting (fast only if lipids are included). List all medications and supplements.

  3. Layer cause-finding tests: add hepatitis panelsautoimmune markers, and iron/copper/A1AT studies based on patterns and history.

  4. Get results securely: most values post within a few days.

  5. Plan next steps: your clinician may recommend ultrasound/FibroScan, MRI, or endoscopy; set a monitoring schedule to trend results.

Interpreting Results (General Guidance)

  • AST/ALT predominant elevation: hepatocellular injury (e.g., viral hepatitis, metabolic/fatty liver, alcohol, medication).

  • ALP ± GGT predominant elevation: cholestasis or bile-duct disease.

  • Rising bilirubin, high INR, low albumin: reduced synthetic function—requires closer follow-up.

  • Low platelets: may signal portal hypertension; correlate with imaging and exam.

  • High ferritin + high transferrin saturation: consider iron overload; discuss HFE testing.

  • High FIB-4/APRI: suggests advanced fibrosis; confirm with elastography.
    Always interpret patterns and trends with a qualified healthcare professional.

Choosing Panels vs. Individual Tests

  • Core liver set (most adults): AST • ALT • ALP • GGT • Total/Direct Bilirubin • Albumin • Total Protein (± A/G)

  • Function/severity add-ons: PT/INR • Platelets/CBC • Sodium • Creatinine

  • Cause-finding add-ons: HBV/HCV panels • ANA/ASMA/AMA • Ferritin/Iron/TIBC • Ceruloplasmin • Alpha-1 Antitrypsin • A1c/Lipids

  • Fibrosis assessment: calculate FIB-4/APRI (± ELF where available); imaging/elastography remains key

  • Monitoring: repeat the same markers on the same method to compare trends reliably.

FAQs

Do I need to fast for liver tests?
No. Fast only if your order includes lipids.

Can medicines or supplements affect results?
Yes. Many drugs and some supplements alter enzymes. List everything you take on the order.

Are normal liver tests a clean bill of health?
Not always. Compensated disease can test near normal; risk-based screening still matters.

What is the difference between LFTs and “liver function”?
“LFTs” include injury markers (AST/ALT, ALP/GGT) and function markers (albumin, PT/INR)—both are important.

When should I add hepatitis or autoimmune testing?
When enzymes are persistently abnormal or risk/history suggests infection or autoimmune disease.

What is FIB-4?
noninvasive fibrosis score using age, AST, ALT, and platelets; high values suggest more scarring and prompt elastography.

How often should I recheck labs?
It depends on results and risk. Many people recheck every 3–12 months—follow your clinician’s plan.

Related Categories & Key Tests

  • Liver & Gallbladder Tests Hub

  • Hepatic Function Tests • Hepatitis Screening Tests • Hepatitis Tests • Cirrhosis Tests • Fatty Liver (Metabolic) • Autoimmune Liver Disease

  • Key Tests: AST • ALT • Alkaline Phosphatase • GGT • Total/Direct Bilirubin • Albumin • Total Protein • A/G Ratio • PT/INR • Platelets/CBC • Sodium • Creatinine/eGFR • HBsAg • Anti-HBs • Anti-HBc • HCV Ab ± RNA • ANA • ASMA • AMA • Ferritin • Iron/TIBC • Transferrin Saturation • Ceruloplasmin • Alpha-1 Antitrypsin Level/Phenotype • A1c • Lipid Panel • FIB-4/APRI (calculated) • ELF (where available) • AFP

References

  • American Association for the Study of Liver Diseases (AASLD) — Guidance on evaluation of abnormal liver chemistries and chronic liver diseases.
  • AASLD — Guidance on MASLD/NAFLD, autoimmune liver disease, and cholestatic disease.
  • European Association for the Study of the Liver (EASL) — Clinical practice guidelines on liver disease assessment and fibrosis.
  • World Health Organization — Hepatitis B and C testing guidelines.
  • U.S. Preventive Services Task Force — Screening for Hepatitis B and C.
  • Clinical reviews on noninvasive fibrosis scores (FIB-4, APRI, ELF) and laboratory monitoring in liver disease.

Available Tests & Panels

Your All Liver Tests menu is pre-populated in the Ulta Lab Tests system. Use filters to build the right package—hepatic function panelPT/INRCBC/plateletsBMP, plus hepatitis panelsautoimmune markersiron/copper/A1ATstudies, and fibrosis scoring support. Review results with your clinician to set imaging, follow-up timing, and an ongoing monitoring plan.

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The Herpes Virus 6 IgG IgM Antibodies Test detects immune response to HHV-6, a virus linked to roseola and other illnesses. IgM antibodies suggest recent or acute infection, while IgG indicates past exposure or reactivation. This test supports evaluation of fever, rash, or neurologic symptoms and may help identify complications in immunocompromised patients, providing valuable insight into HHV-6 infection status and immune activity.

Blood
Blood Draw

The HLA DRB1 DQB1 Low Resolution Test determines genetic variations within the HLA class II region, specifically DRB1 and DQB1 alleles. These markers play an important role in immune system regulation and are associated with autoimmune conditions such as type 1 diabetes, celiac disease, and rheumatoid arthritis. This test provides insight into genetic predisposition, transplant matching, and immune-related disease risk.

Blood
Blood Draw
Also Known As: HLA Class II DNA Typing Test, HLA DR DQ Test

The HLA-B27 Antigen Test detects the presence of the HLA-B27 protein on white blood cells, which is linked to autoimmune conditions. A positive result may indicate higher risk for ankylosing spondylitis, reactive arthritis, or other spondyloarthropathies. Doctors order this test to investigate chronic back pain, joint inflammation, or autoimmune family history. Results provide critical insight into genetic predisposition, immune system activity, and inflammatory disease risk.

Blood
Blood Draw

Most Popular

The Immunoglobulin A (IgA) Test measures IgA antibody levels in blood to evaluate immune system health and mucosal defense in the respiratory and digestive tracts. Low IgA may indicate immune deficiency, celiac disease, or recurrent infections, while high levels may suggest autoimmune disorders, liver disease, or chronic inflammation. Doctors use this test to assess unexplained illness or immune imbalance. Results provide key insight into antibody function and overall immunity.

Blood
Blood Draw
Also Known As: Immunoglobulin A Test, Immunoglobulin A Antibody Test, IgA Antibody Test

The Iron Total and Total Iron Binding Capacity (TIBC) Test measures iron levels in blood along with the blood’s ability to transport iron. It helps diagnose iron deficiency anemia, iron overload (hemochromatosis), and monitor nutritional or chronic health conditions. Low iron or high TIBC may indicate anemia, while high iron or low TIBC can suggest overload. Doctors use this test to evaluate fatigue, weakness, or other symptoms linked to iron and metabolic health.

Blood
Blood Draw
Also Known As: Serum Iron Test, Total Iron Binding Capacity Test, TIBC Test, UIBC Test

The Iron Micronutrient Test measures blood iron levels to evaluate nutritional status and detect deficiencies or excess. Iron is essential for hemoglobin production, oxygen transport, energy metabolism, and immune function. This test helps identify anemia, iron overload, absorption issues, or dietary imbalances, supporting diagnosis and management of overall health and vital body functions.

Patient must be 18 years of age or older.
Blood
Blood Draw
Also Known As: Serum Iron Test, Serum Fe Test

Most Popular

The Iron Total Test measures iron levels in blood to evaluate nutritional status, red blood cell production, and overall metabolic health. Abnormal levels may indicate iron deficiency anemia, chronic blood loss, or poor absorption, while high levels may suggest hemochromatosis, liver disease, or iron overload. Doctors use this test to investigate fatigue, weakness, or pallor and to monitor treatment. Results provide key insight into anemia and iron balance.

Blood
Blood Draw
Also Known As: Serum Iron Test, Serum Fe Test

The Mineral Micronutrients Test Panel measures minerals: Calcium, Chromium, Copper, Iron, Magnesium RBC, Manganese, Molybdenum, Selenium, and Zinc to assess nutritional balance and overall health. These minerals are essential for bone strength, metabolism, energy production, antioxidant defense, and immune function. The panel helps detect deficiencies, excesses, or absorption issues, guiding health management.

Patient must be 18 years of age or older.

Blood, Urine
Blood Draw, Urine Collection

The Lactate Dehydrogenase (LDH) Test measures LDH enzyme levels in blood to assess tissue damage and overall health. Elevated LDH may indicate conditions such as liver disease, heart attack, anemia, infections, or certain cancers, while low levels are uncommon. Doctors use this test to help diagnose disease, monitor treatment effectiveness, and track cell damage. It provides valuable insight into metabolic activity and organ function.

Blood
Blood Draw
Also Known As: LD Test, LDH Test, Lactic Acid Dehydrogenase Test

The Lactate Dehydrogenase (LDH) Isoenzyme Panel measures total LDH and separates it into isoenzymes (LDH-1 to LDH-5) to identify tissue damage. LDH-1 is linked to heart, LDH-2 to blood, LDH-3 to lungs, LDH-4 to kidneys, and LDH-5 to liver and muscle. Elevated levels may indicate heart attack, liver disease, anemia, or cancer. Doctors order this test to pinpoint tissue injury, monitor disease progression, and guide treatment strategies.


Blood
Blood Draw

Blood
Blood Draw

The Lactoferrin Qualitative Stool Test measures lactoferrin in stool to assess intestinal inflammation. Positive results may signal inflammatory bowel disease, including Crohn’s disease or ulcerative colitis, while negative results often suggest non-inflammatory conditions. This test supports evaluation of gastrointestinal health, immune activity, and disorders affecting digestive function.

Stool
Stool Collection

The Lipid Panel with Ratios Test measures seven key markers: total cholesterol, HDL, LDL, non-HDL cholesterol, triglycerides, Chol/HDL ratio, and LDL/HDL ratio. This advanced panel evaluates cardiovascular risk by assessing cholesterol balance and fat metabolism. Doctors use it to detect high cholesterol, atherosclerosis risk, and heart disease, and to monitor treatment. Often part of routine exams, it provides insight into long-term heart and metabolic health.

Also Known As: Lipid Profile Test, Cholesterol Panel Test, Lipid Blood Test

The Lipid Panel Test with Reflex to Direct LDL measures total cholesterol, HDL, LDL, triglycerides, and cholesterol ratios to assess heart and vascular health. If triglycerides are very high, it automatically reflexes to direct LDL measurement for greater accuracy. Doctors use this test to evaluate cardiovascular risk, guide cholesterol management, and monitor therapy. Results provide key insight into lipid balance, heart disease prevention, and metabolic health.

Also Known As: Lipid Profile with Reflex Test, Lipids with Reflex Test, Cholesterol Profile with Reflex Test

The Liver and Kidney Function Panel measures blood sugar, electrolytes, proteins, and markers of liver and kidney health. It helps detect disease, monitor conditions, and guide treatment decisions.

Blood
Blood Draw

Blood
Blood Draw

Most Popular

The Magnesium Serum Test measures magnesium levels in blood to evaluate electrolyte balance, nerve and muscle function, and overall metabolic health. Abnormal levels may indicate kidney disease, malnutrition, gastrointestinal disorders, or uncontrolled diabetes. Low magnesium can cause weakness, cramps, or irregular heartbeat, while high levels may signal kidney dysfunction. Doctors use this test to diagnose deficiencies, monitor therapy, or assess chronic health conditions.

Blood
Blood Draw
Also Known As: Mg Test, Mag Test

The Metabolic Syndrome & Glucose Control Panel evaluates key biomarkers—fasting glucose, insulin, lipids, and related metrics—to assess insulin resistance, glucose dysregulation, and cardiometabolic risk. This integrated panel helps clinicians identify metabolic syndrome early, monitor glycemic control, and guide interventions to reduce progression to type 2 diabetes and cardiovascular disease.


The Mitochondria M2 IgG Antibody Test measures antibodies linked to autoimmune liver disease, particularly primary biliary cholangitis. These antibodies target mitochondrial enzymes in liver cells, helping to identify immune-related causes of chronic liver dysfunction. Providers use this test when investigating persistent fatigue, elevated liver enzymes, or suspected autoimmune involvement in bile duct damage.

Blood
Blood Draw

The Mitochondrial Antibody with Reflex to Titer Test detects antimitochondrial antibodies (AMAs), most commonly linked to primary biliary cholangitis (PBC), an autoimmune liver disease. If antibodies are present, reflex titers measure their level for greater diagnostic detail. Doctors use this test to investigate unexplained liver abnormalities, chronic fatigue, or jaundice, helping confirm autoimmune liver disease and guide long-term management.

Blood
Blood Draw

The Obstetric Panel is a prenatal blood test panel that screens for conditions affecting pregnancy and maternal health. It typically includes a Complete Blood Count, blood typing with Rh factor, antibody screen, and infectious disease testing such as hepatitis B, syphilis, rubella, and HIV. Doctors use this panel in early pregnancy to evaluate overall health, identify risks, and ensure safe monitoring for both mother and baby.


The Comprehensive Organic Acids Quantitative Urine Test analyzes a broad spectrum of metabolites—organic acids—in urine to assess metabolic pathway function. By quantifying markers of detoxification, mitochondrial energy, and microbial metabolism, this test can help detect inborn errors, mitochondrial dysfunction, or dysbiosis.

Urine
Urine Collection
Also Known As: Organic Acids, Comprehensive, Quantitative, Urine Test

The Parietal Cell Antibody Test detects autoantibodies against stomach parietal cells, which produce intrinsic factor and stomach acid. Their presence is strongly associated with pernicious anemia, vitamin B12 deficiency, and autoimmune gastritis. Doctors use this blood test to help diagnose the cause of anemia, investigate digestive issues, and evaluate patients with suspected autoimmune disorders affecting stomach function and nutrient absorption.

Blood
Blood Draw
Also Known As: Gastric Parietal Cell Antibody Test, Anti-Parietal Cell Antibody Test, Anti-GPA Test, AGPA Test, APCA Test

Nearly 4.5 million Americans — almost 1 in every 50 — live with liver disease. Are you one of them? If you're not sure, it might be time to order a liver function test.

A hepatic function panel tests how well your liver is working. Taking the initiative to check your liver function before noticing a problem could help you avoid serious health issues. 

Keep reading to learn what a hepatic function panel is, how it can help you catch health issues early, and how you can order it yourself online. 

What is a Decline in Hepatic Function?

Your liver is your body's hard-working multitasker. It performs many crucial functions, including:

  • Monitoring and regulating chemicals in your blood
  • Cleaning toxins from your blood
  • Performing functions with your immune system
  • Storing energy in the form of glycogen
  • Helping break down fatty food
  • Breaking down old red blood cells

Your liver is important to almost every function in your body. When your liver works poorly, your whole body can be affected. In medicine, this is known as a decline in hepatic function. 

Declining hepatic function can lead to serious health complications. That's why it's important to check your liver health as soon as you suspect that there may be a problem. 

Risk Factors for a Decline in Hepatic Function

You should watch for signs of liver problems if you have any risk factors for liver damage, including:

  • Traveling without being vaccinated against Hepatitis
  • Drinking more than the recommended maximum amount of alcohol per day
  • Being in contact with needles that aren't clean
  • Taking more than the recommended amount of medication that can harm your liver

While none of these risk factors guarantee that you will have a decline in hepatic function, they make it more likely that you will have liver problems.

Causes of a Decline in Hepatic Function

A decline in hepatic function is usually caused by liver damage or disease, such as:

  • A virus that damages the liver (such as Hepatitis A, B, and C)
  • Naturally occurring toxins
  • Excessive drug use (both street drugs and prescribed drugs)
  • Alcohol-related liver damage (alcoholic cirrhosis)
  • Liver cancer

A chronic disease like alcoholism can damage your liver slowly over a long period of time. Other diseases, such as viruses, can damage your liver quickly and leave you with lasting liver problems.

Signs and Symptoms of a Decline in Hepatic Function

If your liver is damaged, you'll need to get help immediately. Symptoms of low hepatic function include:

  • Jaundice (yellow color of your skin and eyes)
  • Light-colored stool and dark-colored urine
  • Nausea, vomiting, and diarrhea
  • Pain in your lower abdomen
  • Fatigue

If you see any of these symptoms of liver failure develop, you could be at risk for serious illness from liver damage and should have your liver function assessed right away.  

How is Decline in Hepatic Function Diagnosed?

A lab can analyze your hepatic function using blood tests. When you order your liver test online, you'll go to a patient service center to get a blood draw. They will take a sample of blood on which to perform tests.

Lab Tests to Screen, Diagnose, and Monitor Decline in Hepatic Function

Because your liver performs so many functions, a hepatic function panel includes a wide range of tests. These blood tests check how well your liver is doing its various tasks.

There are so many possible liver function tests that they are usually bundled together into a liver function panel. The most common tests included in a liver function panel are:

  • Aspartate transaminase (AST)
  • Alanine transaminase (ALT)
  • Bilirubin
  • Albumin and total protein
  • Blood creatinine 
  • Ammonia

Once you've been diagnosed with a decline in hepatic function, you can continue to order liver function panels to monitor your liver's status. 

You can also get lab tests to diagnose the cause of your liver problems, including:

These tests can help you narrow down the source of damage to your liver.

Frequently Asked Questions About Decline in Hepatic Function

Fortunately, testing hepatic function involves straightforward tests. However, you may still have questions. 

Are There Any Risks Involved in a Hepatic Function Panel?

When you get your hepatic function tested, the only risks involved are the normal side effects of getting a blood test. You may see some bleeding and bruising around the blood test site. To minimize bruising, put a bandage over the site and hold it on with firm pressure for several minutes after the blood test. 

Should I Fast Before My Hepatic Function Tests?

It depends on which tests you order. Some tests do not require you to fast before you have your blood drawn, but others do. Make sure to ask your doctor or online medical professional about the specific tests that you have ordered.

Keep in mind that you may want to order other tests in addition to your hepatic function panel, like a comprehensive metabolic panel, and have them all done at once. If you are ordering other tests, you may need to fast for those ones, even if you don't have to fast for your hepatic function tests.

To fast, avoid eating for 12 hours before the test. Avoid drinking anything other than water. 

Do I Have To Wait For a Doctor to Order Hepatic Function Tests For Me?

When you order your lab test online, you don't have to wait for a doctor's referral. This saves you time and money.

Catch Liver Disease Early With a Hepatic Function Panel

Your liver is one of the most essential organs in your body. If your liver is damaged, you should know about it right away. 

Ulta Lab Tests lets you order lab tests with no need for a physician referral, so you can be proactive about your health. You'll get your confidential results in as little as 24 to 48 hours.

Take control of your liver health today with a hepatic function panel test from Ulta Lab Tests.

Jaundice, also called icterus, is a condition where the skin, the whites of the eyes, and even body fluids turn significantly yellow following an increase in the levels of bilirubin in the blood. Bilirubin is a yellowish substance that forms from the normal breakdown of red blood cells (or RBCs). Red blood cells normally live for about 120 days before being broken down by the body, a process that results in the formation of bilirubin. Bilirubin is then transported to the liver where it is metabolized and excreted in bile. Bile is a yellow-green-to-brown fluid that is released into the duodenum to help in the digestion of lipids and the elimination of waste substances like bilirubin and excess cholesterol. Changes to the normal metabolism process or overproduction of bilirubin may lead to jaundice. 

Jaundice is not an illness, per se. Rather, it is a medical condition that may indicate an underlying liver, pancreas, or gallbladder problem. Jaundice can be caused by several factors, including infections, cancer, use of certain drugs, gallstones, blood disorders, inherited conditions, congenital disabilities, among other medical conditions.

Generally, the causes of jaundice may be categorized into these three groups: 

  • Conditions that arise from the inability of the liver to metabolize and eliminate bilirubin 
  • Conditions that cause shortened life for red blood cells, which in turn leads to increased levels of bilirubin 
  • Conditions that inhibit the elimination of bilirubin from the body 

Common Causes of Jaundice 

Acute hepatitis: inflammation of the liver due to various reasons, including hepatitis A, B, C, D, and E, alcohol abuse, viral infections, toxins, and some medicines such as acetaminophen. 

Blockage of the bile duct, which may be caused by: 

  • Damage and Scarring 
  • Biliary atresia, a congenital condition linked to the abnormal development of the bile duct, which results in the backup and pooling of bile and an increase in the level of bilirubin in the blood. 
  • Gallstones 
  • Pancreatic cancer may sometimes lead to the blockage of the bile duct. 

Conditions that result in a significant increase in the rate of red blood cell destruction cause an increase in bilirubin production. Such conditions include hemolytic anemia, due to an abnormal variant of hemoglobin, autoimmune disorders, malaria, or hemolytic disease of the newborn (or HDN). 

Gilbert syndrome: an inherited condition that is associated with reduced bilirubin metabolism due to decreased enzyme activity. Individuals with Gilbert syndrome may have passing jaundice during times of sickness or stress and times of increased levels of unconjugated bilirubin. 

Cirrhosis: jaundice can occur in the late stages of cirrhosis. 

Laboratory Tests 

Some of the tests used to assess liver function and detect liver damage include: 

Liver panel, which often comprises: 

ALT (or Alanine aminotransferase) 

AST (or Aspartate aminotransferase) 

ALP (or Alkaline phosphatase) 

Bilirubin, Total (conjugated and unconjugated), Direct (conjugated) and Indirect (unconjugated) 

GGT (or Gamma-glutamyl transferase) 

Albumin 

Prothrombin time (or PT): the liver produces essential proteins for blood clotting/coagulation. The PT measures the clotting function, which may indicate liver damage if abnormal. 

Urine bilirubin, which often falls under a urinalysis 

Some tests are important for the detection of infections that affect the liver, including: 

Tests that come in handy in detecting reduced red blood cell survival include: