All Stress and Fatigue Tests

All Stress and Fatigue Tests brings together the labs most often used to investigate low energy, burnout, and stress-related symptoms. Because tiredness is multifactorial, we pair HPA-axis checks (cortisol patterns, DHEA-S) with common “look-alikes,” including thyroid imbalanceanemia/iron or B12 deficiencyblood sugar issuesinflammationelectrolyte or liver/kidney problems, and selected hormone markers.

A proactive plan often starts with 8–9 a.m. serum cortisol (± ACTH) ... See more

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The CoQ10 Micronutrient Test measures blood levels of coenzyme Q10, a vital antioxidant involved in energy production within cells. CoQ10 supports heart health, muscle function, and protection against oxidative stress. This test helps detect deficiencies due to aging, poor diet, or certain medications, guiding supplementation and management of cardiovascular, metabolic, and overall health.

Patient must be 18 years of age or older.
Serum
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The Coenzyme Q10 (CoQ10) Test measures blood levels of CoQ10, a nutrient essential for energy production and antioxidant protection. Low levels may be linked to mitochondrial disorders, heart disease, or statin medication use. Doctors order this test for patients with fatigue, muscle weakness, or cardiovascular issues. Results help evaluate nutritional status, guide supplementation, and monitor treatment for metabolic and heart health conditions.

Serum
Phlebotomist
Also Known As: Coenzyme Q10 Test

The Complete Blood Count with Differential and Platelets Test is a comprehensive blood test that checks red blood cells, white blood cells, hemoglobin, hematocrit, and platelets. The differential analyzes types of white blood cells to detect infections, anemia, clotting abnormalities, immune conditions, and certain cancers. This essential test is often ordered for routine health exams, diagnosis, and monitoring treatment progress.

Blood
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Also Known As: CBC Test, CBC with Differential and Platelets Test, CBC w/Diff and Platelets Test, Full Blood Count Test, Complete Blood Count Test

The Comprehensive Metabolic Panel (CMP) Test measures 21 markers to assess metabolic health, liver and kidney function, and electrolyte balance. It includes glucose, calcium, sodium, potassium, chloride, CO2, albumin, globulin, A/G ratio, total protein, bilirubin, ALP, AST, ALT, BUN, creatinine, BUN/creatinine ratio, and eGFR. The CMP helps detect diabetes, liver or kidney disease, and supports routine screening and chronic condition monitoring.

Serum
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Also Known As: CMP Test, Chemistry Panel Test, Chem Test, Chem 21 Test, Chem 14 Test 

The Cortisol Saliva 4 Samples Test measures cortisol levels at four points during the day to assess adrenal gland function and circadian rhythm. Abnormal patterns may indicate adrenal insufficiency, Addison’s disease, Cushing’s syndrome, or chronic stress. Because saliva reflects active hormone levels, this noninvasive test is ideal for evaluating diurnal cortisol changes, supporting diagnosis, and guiding treatment for endocrine and stress-related disorders.

Also Known As: Cortisol Total Test, Cortisol Saliva Test, Cortisol 4 Specimen Test, 4 Specimen Cortisol Test, Cortisol Free Test, Cortisol Kit Test


The Cortisol Test with 2 specimens measures adrenal gland function by evaluating cortisol levels at two collection times. Tracking changes in this stress hormone helps assess adrenal performance, circadian rhythm, and the body’s stress response, while offering insight into conditions such as adrenal insufficiency, Cushing’s syndrome, Addison’s disease, and overall endocrine balance.

Serum
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Also Known As: 2 Specimen Cortisol Blood Test

The Cortisol Test with 3 specimens measures adrenal gland function by evaluating cortisol levels at three collection times. Monitoring this stress hormone helps assess circadian rhythm, adrenal performance, and daily hormone balance, while providing insight into adrenal insufficiency, Addison’s disease, Cushing’s syndrome, and overall endocrine and metabolic health.

Serum
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Also Known As: 3 Specimen Cortisol Blood Test

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The Cortisol AM Test measures morning cortisol levels in blood to evaluate adrenal gland function and stress response. Cortisol peaks in the morning, making this test critical for detecting adrenal insufficiency (Addison’s disease), Cushing’s syndrome, or other hormone imbalances. Doctors also use it to investigate fatigue, weight changes, or high blood pressure. This test provides important insight into endocrine health, metabolism, and long-term stress regulation.

Serum
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Also Known As: Morning Cortisol Test

The Cortisol Free 24-Hour Urine with Creatinine Test measures cortisol excreted in urine over 24 hours, with creatinine used to validate collection. Elevated cortisol may indicate Cushing’s syndrome, while low levels can suggest Addison’s disease or adrenal insufficiency. Doctors order this test for patients with obesity, fatigue, high blood pressure, or abnormal hormone symptoms. Results provide critical insight into adrenal gland function and hormone regulation.

Urine
Phlebotomist
Also Known As: Unbound Urine Cortisol Test

The Cortisol PM Test measures afternoon cortisol levels to evaluate adrenal and pituitary function. Cortisol normally drops later in the day, so abnormal results may indicate Cushing’s syndrome, adrenal insufficiency (Addison’s disease), or hormone imbalance. Doctors order this test to investigate fatigue, obesity, high blood pressure, or irregular sleep patterns and to monitor adrenal disorders. It provides key insight into stress response and endocrine health.

Serum
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Also Known As: Afternoon Cortisol Test

The Cortisol Total Test measures cortisol levels in blood to assess adrenal gland and pituitary function. Cortisol regulates stress response, metabolism, and immune health. Abnormal results may indicate Cushing’s syndrome, Addison’s disease, or other hormone disorders. Doctors order this test to evaluate symptoms like fatigue, weight changes, weakness, or high blood pressure and to monitor treatment. It provides essential insight into hormone balance and endocrine health.

Serum
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Also Known As: Cortisol Blood Test

The Creatine Kinase (CK) Total Test measures CK enzyme levels in blood to detect muscle injury, inflammation, or stress. Elevated CK may indicate muscle disorders, heart attack, strenuous exercise, or conditions such as rhabdomyolysis, while low levels are less common. Doctors use this test to evaluate unexplained muscle pain, weakness, or chest pain and to monitor recovery. It provides insight into muscle, cardiac, and overall metabolic health.

Serum
Phlebotomist
Also Known As: CK Total Test, Creatine Phosphokinase, CPK Test

The Deoxycorticosterone Test evaluates adrenal gland function by measuring this mineralocorticoid precursor that influences salt retention and blood pressure. Abnormal levels may reflect congenital adrenal hyperplasia, adrenal tumors, or enzyme deficiencies impacting hormone synthesis. Results help providers investigate hypertension, electrolyte imbalance, and suspected adrenal endocrine disorders.

Serum
Phlebotomist

The Dexamethasone Suppression Test measures how cortisol levels respond after dexamethasone administration, assessing feedback within the hypothalamic-pituitary-adrenal (HPA) axis. Lack of suppression may indicate Cushing’s syndrome, pituitary adenoma, or adrenal disease. This test supports evaluation of metabolic disturbances such as obesity, hypertension, or glucose intolerance, offering valuable insight into endocrine balance and adrenal-pituitary function.

Serum
Phlebotomist

The DHEA Unconjugated Test measures levels of dehydroepiandrosterone, an adrenal hormone that serves as a precursor to testosterone and estrogen. Abnormal levels may indicate adrenal tumors, congenital adrenal hyperplasia, or hormone imbalance. Doctors order this test to evaluate infertility, irregular cycles, excess hair growth, or early puberty. Results provide insight into adrenal gland function, reproductive health, and endocrine disorders.

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Also Known As: Dehydroepiandrosterone Test

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The DHEA Sulfate (DHEA-S) Test measures levels of DHEA-S, a hormone made by the adrenal glands, to evaluate adrenal function and hormone balance. It helps detect adrenal tumors, hyperplasia, or insufficiency and assess abnormal hair growth, infertility, or early/late puberty. Doctors also use it to investigate irregular menstrual cycles, monitor androgen disorders, and evaluate symptoms of hormone imbalance affecting reproductive and metabolic health.

Serum
Phlebotomist
Also Known As: DHEA Sulfate Test, Dehydroepiandrosterone Sulfate Test

The Erythropoietin (EPO) Test measures levels of erythropoietin, a hormone made by the kidneys that stimulates red blood cell production. Abnormal levels may indicate anemia, chronic kidney disease, or bone marrow disorders. Elevated EPO can also occur with low oxygen levels or tumors. Doctors order this test for patients with unexplained fatigue, shortness of breath, or abnormal blood counts. Results help guide diagnosis, treatment, and monitoring of anemia-related conditions.

Serum
Phlebotomist
Also Known As: Erythropoietin Test

The Estrogen Total Test measures all forms of estrogen in blood, including estradiol, estrone, and estriol, to assess reproductive and hormonal health. Abnormal levels may indicate menstrual irregularities, menopause status, infertility, or hormone-related disorders. Doctors order this test to evaluate fertility, monitor hormone therapy, and investigate symptoms such as hot flashes, irregular cycles, or abnormal bleeding. It provides key insight into endocrine and reproductive function.

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Also Known As: Total Estrogen Test, Estrogen Serum Test

The F2-Isoprostane/Creatinine Ratio Test evaluates urinary F2-isoprostanes adjusted for creatinine to assess oxidative stress and lipid peroxidation. Abnormal findings may reflect risk for cardiovascular disease, diabetes, or neurological disorders. This test provides insight into systemic oxidative damage, metabolic balance, and health conditions influenced by free radical activity.

Random
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The Ferritin Test measures ferritin, a protein that stores iron in the body, to evaluate iron levels and detect deficiency or overload. It helps diagnose anemia, iron deficiency, hemochromatosis, and chronic disease-related inflammation. Doctors often order the ferritin test to investigate fatigue, weakness, or unexplained symptoms. It is also used to monitor iron supplementation, treatment effectiveness, and overall iron metabolism health.

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Also Known As: Iron Storage Test

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The Glucose Test measures blood sugar levels to evaluate energy metabolism and screen for diabetes or prediabetes. Abnormal glucose may indicate hyperglycemia, hypoglycemia, or metabolic disorders. Doctors use this test during routine exams, to investigate symptoms like fatigue, excessive thirst, or frequent urination, and to monitor treatment for diabetes. It provides essential insight into how the body regulates blood sugar and overall metabolic health.

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Also Known As: Fasting Glucose Test, Fasting Blood Sugar Test

The Hemoglobin A1c (HbA1c) Test measures average blood glucose over 2–3 months by detecting sugar attached to hemoglobin in red blood cells. It is used to diagnose diabetes, identify prediabetes, and monitor long-term blood sugar control. Doctors rely on the HbA1c test to evaluate treatment effectiveness, guide adjustments, and assess risk for complications, making it essential for diabetes care and metabolic health screening.

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Also Known As: A1c Test, HbA1c Test, Glycated Hemoglobin Test

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The IGF-1 Test measures insulin-like growth factor 1, a hormone regulated by growth hormone (GH), to assess growth and endocrine function. Abnormal levels may indicate growth disorders, acromegaly, gigantism, or GH deficiency. Doctors order this test to evaluate delayed growth, short stature, excessive growth, or pituitary disease and to monitor GH therapy. Results provide valuable insight into hormone balance, metabolism, and overall endocrine health.

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Also Known As: Insulin-like Growth Factor 1 Test, Somatomedin-C Test, IGF-I Test

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The Insulin Test measures insulin levels in blood to assess how the body regulates glucose and metabolism. It helps diagnose insulin resistance, hypoglycemia, type 2 diabetes, and metabolic syndrome. Doctors also use it to evaluate pancreatic function and monitor treatment effectiveness. Frequently ordered with glucose testing, the insulin test provides critical insight into endocrine health, blood sugar control, and risk for diabetes-related complications.

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Also Known As: Fasting Insulin Blood Test

A shocking statistic you may not know is that 55 percent of Americans experience stress during the day. That’s about one in two people! 

It’s a statistic that should get one concerned, considering what stress can do to our bodies. 

If you feel overwhelmed by stress in your day-to-day life, you should consider a stress lab test. A lab test can check various biomarkers that can help establish whether or not your well-being is taking a hit from your level of stress. 

Let’s start by learning more about stress.

What is Stress? 

Stress is the body’s reaction upon being put under pressure by internal or external stimuli. Whenever your body responds to stressful stimuli, you may have a physical, emotional, or mental response. 

It is normal for every person to deal with stress at a point in their life. ... See more