Neuropathy

Neuropathy refers to damage or dysfunction of the peripheral nerves that carry signals for sensation, movement, and autonomic functions. Symptoms often begin gradually with numbness, tingling, burning pain, or weakness—frequently in the feet and hands. Because many conditions can cause or worsen neuropathy (diabetes, thyroid disease, vitamin deficiencies, autoimmune disorders, toxins, infections, and medications), targeted blood tests are a practical first step.

A proactive lab approach starts with general health and metabolic screens (CBC, CMP, A1c/glucose, TSH) and vitamin B12 with methylmalonic acid (MMA), ... See more

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The Thyroid Peroxidase and Thyroglobulin Antibodies Test measures TPO and TgAb antibodies that target thyroid enzymes and proteins essential for hormone production. High levels are linked to autoimmune thyroid disorders such as Hashimoto’s thyroiditis and Graves’ disease. Doctors order this test to evaluate fatigue, weight changes, neck swelling, or irregular heartbeat and to confirm thyroid autoimmunity. It provides vital insight into thyroid function and endocrine health.

Also Known As: Thyroid Antibodies Test, TPO and TgAb Test

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The Thyroid Stimulating Hormone (TSH) Test measures TSH levels in blood to assess thyroid function and diagnose hypothyroidism or hyperthyroidism. It evaluates how the thyroid controls metabolism, energy, weight, and heart rate. Doctors use the TSH test to investigate symptoms such as fatigue, hair loss, or mood changes. Frequently included in routine health exams, it is also key for monitoring thyroid disease treatment and overall endocrine balance.

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Also Known As: Thyroid Stimulating Hormone Test, Thyrotropin Test

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The Thyroid Stimulating Immunoglobulin (TSI) Test detects antibodies that stimulate the thyroid gland, often causing hyperthyroidism and Graves’ disease. High TSI levels may lead to symptoms such as weight loss, rapid heartbeat, or eye problems. Doctors order this test to confirm Graves’ disease, monitor treatment, or assess relapse risk. Results provide essential insight into autoimmune thyroid disorders and guide personalized management strategies.

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Also Known As: Thyroid Stimulating Immunoglobulin Test

The Varicella Titer Test is a blood test that measures antibodies to the varicella-zoster virus (VZV), which causes chickenpox and shingles. A positive result indicates past infection, while a negative suggests no exposure. This test is not considered reliable for confirming immunity from vaccination. Doctors use it to evaluate history of natural infection, meet school or work requirements, and provide documentation of varicella exposure status.

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Also Known As: Varicella Zoster Virus IgG Antibody Test, Chicken Pox Titer Test, Shingles Titer Test

The Vitamin B1 Blood Test measures thiamine levels to assess nutritional status and detect deficiency. Vitamin B1 is essential for energy metabolism, nerve function, and muscle health. Low levels may cause weakness, fatigue, irritability, or serious conditions such as beriberi or Wernicke-Korsakoff syndrome. Doctors order this test for patients with poor diet, alcoholism, or unexplained neurological symptoms. Results provide key insight into vitamin balance and metabolic health.

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Also Known As: Thiamine Blood Test

The Vitamin B1 Blood Micronutrient Test measures thiamine levels in the blood to assess nutritional status and detect deficiencies. Thiamine is essential for energy production, nerve function, and carbohydrate metabolism. This test helps identify malnutrition, absorption disorders, or risk from poor diet or alcohol use, supporting diagnosis and management of overall health.

Patient must be 18 years of age or older.
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Also Known As: Thiamine Blood Test

The Vitamin B1 Plasma/Serum Test measures thiamine levels in blood to evaluate nutritional status and detect deficiencies. Thiamine is essential for energy metabolism, nerve function, and muscle health. Low levels may result from poor diet, alcoholism, malabsorption, or chronic illness and can lead to conditions like beriberi or Wernicke-Korsakoff syndrome. Doctors use this test to confirm deficiency and monitor supplementation or therapy effectiveness.

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Also Known As: Thiamine Serum/Plasma Test

The Vitamin B12 Micronutrient Test measures blood levels of vitamin B12, essential for red blood cell production, nerve health, and DNA synthesis. Deficiency can cause anemia, fatigue, neurological issues, and cognitive changes. This test helps identify dietary deficiencies, absorption problems, or related health conditions, supporting diagnosis and ongoing management of overall wellness.

Patient must be 18 years of age or older.
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Also Known As: B12 Test, Cobalamin Test

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The Vitamin B12 Test measures cobalamin levels in blood to evaluate nutritional health, red blood cell production, and nervous system function. Low B12 can cause anemia, fatigue, weakness, memory problems, and nerve damage, while high levels may indicate liver or kidney disease. Doctors use this test to detect B12 deficiency, monitor treatment, and assess malabsorption conditions like pernicious anemia, Crohn’s disease, or celiac disease.

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Also Known As: B12 Test, Cobalamin Test

The Vitamin B12 and Folate Panel Test measures blood levels of vitamin B12 and folate to evaluate nutritional status, red blood cell production, and nervous system health. Deficiencies may cause anemia, fatigue, weakness, neuropathy, or cognitive decline, while elevated levels can indicate liver or kidney disease. Doctors use this panel to diagnose deficiency, monitor therapy, and assess absorption disorders such as pernicious anemia, Crohn’s disease, or celiac disease.

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Also Known As: Cobalamin and Folic Acid Test, Vitamin B12 and Vitamin B9 Test

The Vitamin B3 Micronutrient Test measures niacin levels in the blood to assess nutritional status and detect deficiencies or excess. Niacin is essential for energy production, nervous system function, and healthy skin and digestion. This test helps identify malnutrition, absorption problems, or toxicity from supplements, supporting diagnosis and monitoring of overall health and metabolic balance.

Patient must be 18 years of age or older.
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Also Known As: Nicotinic Acid Test

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The Vitamin B3 Test measures niacin levels in the blood to evaluate nutritional status and detect deficiencies. Niacin is essential for energy metabolism, DNA repair, and nervous system function. Low levels may lead to pellagra, with symptoms such as diarrhea, dermatitis, dementia, and fatigue. Doctors use this test to assess dietary intake, investigate unexplained symptoms, and monitor patients on supplementation or therapy for metabolic health.

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Also Known As: Nicotinic Acid Test, Niacin Test

The Vitamin B6 Micronutrient Test measures pyridoxine levels in the blood to assess nutritional status and detect deficiencies or excess. Vitamin B6 is essential for protein metabolism, neurotransmitter production, hemoglobin synthesis, and immune function. This test helps identify dietary insufficiency, absorption issues, or toxicity, supporting diagnosis and management of overall health and metabolic balance.

Patient must be 18 years of age or older.
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Also Known As: Pyridoxal Phosphate Test

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The Vitamin B6 Test measures pyridoxal phosphate levels in blood to evaluate vitamin B6 status. Deficiency may cause anemia, confusion, irritability, depression, or weakened immunity, while high levels from supplementation may lead to nerve damage. Doctors use this test to investigate neurological symptoms, nutritional health, or metabolic disorders. Results provide essential insight into vitamin balance, nerve health, red blood cell production, and overall wellness.

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Also Known As:  Pyridoxal Phosphate Test

The Vitamin E Micronutrient Test measures blood levels of vitamin E to assess antioxidant status and detect deficiencies or excess. Vitamin E protects cells from oxidative damage, supports immune function, and promotes cardiovascular and neurological health. This test helps identify poor dietary intake, absorption issues, or toxicity from supplements, aiding in diagnosis and management of overall wellness.

Patient must be 18 years of age or older.
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Also Known As: Tocopherol Test

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The Vitamin E Test measures blood levels of vitamin E, a fat-soluble antioxidant essential for protecting cells, supporting immunity, and maintaining nerve and muscle health. Low levels may result from poor diet, malabsorption, or liver disease, leading to weakness or vision problems. High levels can occur with excessive supplementation. Doctors order this test to assess nutritional status, monitor chronic illness, or guide therapy for deficiency or toxicity.

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Also Known As: Tocopherol Test

More than 20 million people in the United States struggle with neuropathy. These individuals experience pain and weakness that come from a defect in the nervous system.

Unfortunately, there's no cure for neuropathy. However, some available treatments work better for patients who identify their condition early on.

Neuropathy lab tests are the best way to determine whether or not you have neuropathy or are currently developing it.

Keep reading to learn more about neuropathy and the neuropathy tests you need for a diagnosis.

What Is Neuropathy?

Neuropathy is a condition of the nervous system that's associated with nerve damage. The condition can stand alone or develop as a result of another condition.

A couple of the common conditions that may cause neuropathy are diabetes and Guillain-Barre syndrome. Some patients may even develop neuropathy as a side effect of treatments like chemotherapy.

Neuropathy is also called peripheral ... See more