Liver Health

Liver Health Tests help you understand how well your liver is working and whether there is irritation, blockage of bile flow, or reduced protein-making capacity. Because early liver problems are often silent, proactive testing can find issues before symptoms start—especially if you have metabolic risk (central weight, high triglycerides, diabetes), alcohol exposure, hepatitis risks, or take medicines that affect the liver.

A smart first step is a hepatic function panel (AST, ALT, alkaline phosphatase, GGT, total/direct bilirubin, albumin, total protein ± A/G ratio). Add PT/INR ... See more

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The Albumin Test measures albumin, the main protein made by the liver that maintains fluid balance and transports hormones, vitamins, and medications. Low albumin may indicate liver disease, kidney problems, malnutrition, or chronic inflammation, while high levels may reflect dehydration. Doctors order this test to evaluate swelling, fatigue, or abnormal labs. Results provide key insight into nutritional status, liver and kidney function, and overall metabolic health.

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Also Known As: ALB Test

The ALP Test measures alkaline phosphatase enzyme levels in blood to evaluate liver, bone, and bile duct health. High ALP may indicate liver disease, bile duct obstruction, bone disorders, or certain cancers, while low levels may suggest malnutrition or deficiency. Doctors order this test to investigate symptoms like fatigue, abdominal pain, or bone pain and often pair it with other liver function tests. Results provide key insight into metabolic and organ health.

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Also Known As: Alkaline Phosphatase Test, Alk Phos Test, Alkp Test

The Alpha-1-Antitrypsin Quantitative Test measures levels of alpha-1-antitrypsin (AAT), a protein that protects the lungs and liver from damage. Low levels may indicate alpha-1-antitrypsin deficiency, a genetic disorder linked to emphysema, COPD, and liver disease. Doctors use this test to investigate unexplained lung or liver problems, confirm hereditary AAT deficiency, and guide treatment or monitoring strategies for long-term health management.

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Also Known As: Alpha-1 Antitrypsin Test, A1AT Test, AAT Test, Alpha-1 Antitrypsin Serum Test

The Alpha-Fetoprotein (AFP) and AFP-L3 Test measures total AFP and the AFP-L3 fraction, which is more specific for liver cancer risk. Elevated AFP may indicate liver disease, germ cell tumors, or hepatitis, while AFP-L3 is strongly associated with hepatocellular carcinoma (HCC). Doctors order this test to assess liver function, screen high-risk patients, and monitor cancer treatment. Results provide critical insight into liver health and cancer detection.

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Also Known As: AFP Test, Total AFP Test, Alpha-Fetoprotein Tumor Markers, Alpha-Fetoprotein Test

The ALT Test measures alanine aminotransferase, an enzyme mainly found in the liver. Elevated ALT may indicate liver damage from hepatitis, fatty liver disease, cirrhosis, alcohol use, or medication effects. Doctors order this test to evaluate symptoms such as fatigue, abdominal pain, or jaundice and often pair it with AST for accurate liver assessment. Results provide essential insight into liver health, enzyme activity, and overall metabolic function.

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Also Known As: Alanine Aminotransferase Test, GPT Test, SGPT Test, Serum Glutamic Pyruvic Transaminase Test

The Ammonia Plasma Test measures ammonia levels in blood to evaluate liver function and metabolic health. Elevated ammonia may result from liver disease, cirrhosis, Reye’s syndrome, or urea cycle disorders, causing confusion or altered mental status. Doctors order this test for patients with unexplained behavioral changes, lethargy, or suspected hepatic encephalopathy. Results provide key insight into liver function, metabolic disorders, and treatment monitoring.

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Also Known As: NH3 Test, NH3 Plasma Test, Ammonia Blood Test

The Amylase Test measures amylase enzyme levels in blood to evaluate pancreatic and digestive health. Elevated amylase may indicate pancreatitis, gallbladder disease, intestinal blockage, or salivary gland disorders, while low levels may suggest chronic pancreatitis or liver damage. Doctors order this test to investigate abdominal pain, nausea, or fever. Results provide vital insight into pancreatic function, digestive disorders, and overall metabolic health.

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Also Known As: Amy Test

The AST Test measures aspartate aminotransferase, an enzyme found in the liver, heart, muscles, and other tissues. Elevated AST may indicate liver disease, heart attack, muscle injury, or other organ damage. Doctors order this test to evaluate symptoms such as fatigue, weakness, or jaundice and often pair it with ALT for accurate liver assessment. Results provide key insight into liver function, muscle health, and overall metabolic balance.

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Also Known As: Aspartate Aminotransferase Test, Serum Glutamic-Oxaloacetic Transaminase Test, SGOT Test

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The Fractionated Bilirubin Test separates total bilirubin into direct and indirect forms to assess liver and blood health. Elevated direct bilirubin may point to hepatitis, cirrhosis, or bile duct obstruction, while elevated indirect levels can signal hemolytic anemia or inherited disorders. Doctors order this test for jaundice, anemia, or suspected liver conditions. Results help guide diagnosis, treatment, and monitoring of liver and blood disorders.

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Also Known As: Fractionated Bilirubin Test

The Bilirubin Total Test measures the overall level of bilirubin in blood to assess liver function, red blood cell breakdown, and bile duct health. Elevated bilirubin may cause jaundice and indicate hepatitis, cirrhosis, gallstones, or hemolytic anemia. Doctors order this test for patients with yellowing skin, fatigue, or abnormal liver results. Results provide essential insight into liver disease, blood disorders, and bile flow problems, guiding diagnosis and treatment.

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Also Known As: Total Bilirubin Test

The BUN Creatinine Ratio Test compares blood urea nitrogen (BUN) to creatinine levels to assess kidney function and hydration status. A high ratio may indicate dehydration, gastrointestinal bleeding, or high protein intake, while a low ratio can suggest liver disease or malnutrition. Doctors order this test with kidney panels to evaluate fatigue, swelling, or abnormal lab results. Results help diagnose renal issues and guide treatment planning.

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Also Known As: Blood Urea Nitrogen to Creatinine Ratio

The C-Reactive Protein (CRP) Test measures CRP levels in blood to detect inflammation in the body. Elevated CRP may indicate infections, autoimmune disorders, or chronic diseases such as arthritis, cardiovascular disease, or inflammatory bowel disease. Doctors use this test to assess acute illness, monitor treatment response, and evaluate risk for heart disease. The CRP test provides key insight into inflammation, immune health, and overall wellness.

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Also Known As: CRP Test, Inflammation Test

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The CA 19-9 Test measures levels of carbohydrate antigen 19-9 in blood, a tumor marker often elevated in pancreatic cancer and sometimes in bile duct, colorectal, or liver cancers. While not used alone for diagnosis, it helps monitor treatment, track disease progression, and detect recurrence. Elevated CA 19-9 may also occur in noncancerous conditions. Doctors use this test to support cancer management and guide therapy decisions.

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Also Known As: CA 19-9 Tumor Marker, Cancer Antigen 19-9 Test

The Cardio IQ™ Fibrinogen Antigen Test evaluates fibrinogen concentration, a key protein that influences clotting and cardiovascular disease risk. It provides insight into vascular inflammation, atherosclerosis, and thrombotic events. This test helps identify factors that contribute to stroke, coronary artery disease, and systemic vascular complications, offering valuable information for assessing overall cardiovascular health.

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Also Known As: Fibrinogen Antigen Nephelometry Test

The Cardio IQ™ Triglycerides Test measures triglyceride levels in the blood, an important marker of lipid metabolism and cardiovascular health. Elevated triglycerides are linked to increased risk of heart disease, pancreatitis, and metabolic syndrome. Physicians use this test to assess risk factors, monitor therapy response, and guide lifestyle or treatment decisions, often as part of a broader lipid or heart health evaluation.

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The Cardio IQ Vitamin D test, also known as a 25-hydroxy vitamin D test, measures the levels of total vitamin D in the blood, including both vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). It provides information about an individual's overall vitamin D status.

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Also Known As: Ergocalciferol Test, Vitamin D2 Test, Cholecalciferol Test, Vitamin D3 Test, Calcidiol Test, 25-hydroxyvitamin D Test, Calcifidiol Test, 25-hydroxy-vitamin D Test

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The CEA Test measures carcinoembryonic antigen levels in blood, a protein that may be elevated in certain cancers, especially colorectal, pancreatic, lung, breast, or ovarian cancer. It is not used alone for diagnosis but helps monitor cancer treatment, detect recurrence, and track disease progression. Elevated CEA can also occur in noncancerous conditions. Doctors use this test to support therapy decisions and provide insight into cancer management.

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Also Known As: Carcinoembryonic Antigen Test

The Ceruloplasmin Test measures levels of ceruloplasmin, a copper-carrying protein made in the liver, to evaluate copper metabolism and related disorders. Low levels may indicate Wilson’s disease, Menkes disease, or severe liver disease, while high levels may suggest inflammation or pregnancy. Doctors order this test for patients with liver problems, neurological symptoms, or abnormal copper levels. Results help diagnose metabolic disorders and guide treatment.

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Also Known As: Copper Oxide Test, Wilson’s Disease Test

The Complement Total CH50 Test measures overall activity of the complement system, a key part of the immune response that helps fight infections and regulate inflammation. Abnormal results may indicate autoimmune diseases such as lupus, complement deficiencies, or immune complex disorders. Doctors use this blood test to evaluate immune function, investigate recurrent infections, and monitor treatment in patients with suspected immune or autoimmune conditions.

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Also Known As: Total Complement Test, Total Complement Activity Test

The Complete Blood Count with Differential and Platelets Test is a comprehensive blood test that checks red blood cells, white blood cells, hemoglobin, hematocrit, and platelets. The differential analyzes types of white blood cells to detect infections, anemia, clotting abnormalities, immune conditions, and certain cancers. This essential test is often ordered for routine health exams, diagnosis, and monitoring treatment progress.

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Also Known As: CBC Test, CBC with Differential and Platelets Test, CBC w/Diff and Platelets Test, Full Blood Count Test, Complete Blood Count Test

The Comprehensive Metabolic Panel (CMP) Test measures 21 markers to assess metabolic health, liver and kidney function, and electrolyte balance. It includes glucose, calcium, sodium, potassium, chloride, CO2, albumin, globulin, A/G ratio, total protein, bilirubin, ALP, AST, ALT, BUN, creatinine, BUN/creatinine ratio, and eGFR. The CMP helps detect diabetes, liver or kidney disease, and supports routine screening and chronic condition monitoring.

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Also Known As: CMP Test, Chemistry Panel Test, Chem Test, Chem 21 Test, Chem 14 Test 

The DCP Test detects des-gamma-carboxy prothrombin, an abnormal form of prothrombin linked to hepatocellular carcinoma and other liver disorders. Elevated levels may reflect tumor activity, chronic liver disease, or cirrhosis. This test provides valuable information for assessing liver function, monitoring cancer progression, and evaluating systemic health in patients with hepatic disease.

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Also Known As: Des-Gamma-Carboxy-Prothrombin Test

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The Ferritin Test measures ferritin, a protein that stores iron in the body, to evaluate iron levels and detect deficiency or overload. It helps diagnose anemia, iron deficiency, hemochromatosis, and chronic disease-related inflammation. Doctors often order the ferritin test to investigate fatigue, weakness, or unexplained symptoms. It is also used to monitor iron supplementation, treatment effectiveness, and overall iron metabolism health.

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Also Known As: Iron Storage Test

The liver is one of the most important organs in the human body. It serves many important roles, from aiding the digestion of food and liquids to filtering harmful toxins from the blood. It also creates important proteins and plays a part in hundreds of functions throughout the body.

With all of this being the case, it's important the liver remains healthy. It's also important to find out as soon as possible when it isn't working as it should. This can be done through a hepatic function panel and other lab tests relating to liver health.

There are several different things that can cause issues with the liver. This article will take a look at possible signs and symptoms of liver damage, who's at risk, and what you can do to assess liver damage.

What Is Liver Health Decline?

Liver health decline refers to a negative change in the liver's ability to function correctly. There can be many reasons a person's liver can become damaged or go into ... See more