Ulta Lab Tests

Ugt1a1 Gene Polymorphism (Ta Repeat) Test

The UGT1A1 Gene Polymorphism (TA Repeat) Test detects variations in the promoter region of the UGT1A1 gene that affect bilirubin metabolism and drug clearance. This genetic test helps identify Gilbert syndrome and assess risk for adverse drug reactions, particularly with irinotecan and other UGT1A1-metabolized medications, guiding safe and personalized treatment strategies.

Blood
Blood Draw
There are no preparation instructions.

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Also known as: Ugt1a1 Gene Polymorphism Ta Repeat

Ugt1a1 Ta Repeat

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The Ugt1a1 Gene Polymorphism (Ta Repeat) Test test contains 1 test with 1 biomarker .

Uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) is primarily responsible for the glucuronidation and detoxification of SN-38, the active metabolite of irinotecan (Camptosar), used in the treatment of colorectal cancer. The TA-7 variant referred to as UGT1A1*28, is associated with reduced SN-38 glucuronidation and increased toxicity. Individuals homozygous for the UGT1A1*28 (TA-7) allele have Gilbert syndrome which is a mild form of hyperbilirubinemia.

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