{"id":686,"date":"2026-09-03T14:06:11","date_gmt":"2026-09-03T21:06:11","guid":{"rendered":"https:\/\/www.ultalabtests.com\/blog\/?p=686"},"modified":"2026-09-03T14:20:02","modified_gmt":"2026-09-03T21:20:02","slug":"how-to-increase-white-blood-cells","status":"publish","type":"post","link":"https:\/\/www.ultalabtests.com\/blog\/blood-disorders\/how-to-increase-white-blood-cells\/","title":{"rendered":"High and Low White Blood Cell Counts: WBC Differential, ANC, Causes, and Follow-Up"},"content":{"rendered":"\n<figure class=\"wp-block-image size-large\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/white-blood-cell-count-high-low-hero.webp?resize=1024%2C576&#038;quality=100&#038;ssl=1\" alt=\"Patient and clinician reviewing a laboratory report with white blood cells illustrated in the foreground\" class=\"wp-image-4210\" srcset=\"https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/white-blood-cell-count-high-low-hero.webp?resize=1024%2C576&amp;quality=100&amp;ssl=1 1024w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/white-blood-cell-count-high-low-hero.webp?resize=300%2C169&amp;quality=100&amp;ssl=1 300w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/white-blood-cell-count-high-low-hero.webp?resize=768%2C432&amp;quality=100&amp;ssl=1 768w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/white-blood-cell-count-high-low-hero.webp?resize=1536%2C864&amp;quality=100&amp;ssl=1 1536w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/white-blood-cell-count-high-low-hero.webp?w=1600&amp;quality=100&amp;ssl=1 1600w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><figcaption class=\"wp-element-caption\">A white blood cell result is interpreted with the differential, ANC, symptoms, history, and prior results\u2014not as an isolated number.<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">A <strong>white blood cell count<\/strong> measures the total number of white blood cells in a blood sample. A high result is called leukocytosis; a low result is called leukopenia. Neither result names a cause by itself. A WBC differential separates the major cell types, and absolute counts\u2014especially the absolute neutrophil count (ANC)\u2014can make the pattern more useful. Follow-up depends on symptoms, medications, recent illness, prior results, the laboratory\u2019s reference interval, and whether red blood cells or platelets are also abnormal. A CBC can support an evaluation, but it cannot identify a particular infection or reliably label an illness as bacterial or viral on its own.<sup><a href=\"#ref-1\" aria-label=\"Reference 1\">1<\/a>,<a href=\"#ref-2\" aria-label=\"Reference 2\">2<\/a><\/sup><\/p>\n\n\n\n<h2 id=\"key-takeaways-heading\" class=\"wp-block-heading\">Key Takeaways<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Interpret the total WBC count together with the differential, absolute subtype counts, symptoms, and prior results.<\/li>\n\n\n\n<li>The ANC is often more relevant to infection risk than the total WBC count when neutrophils are low.<\/li>\n\n\n\n<li>A high WBC count does not automatically mean infection, and a normal count does not rule infection out.<\/li>\n\n\n\n<li>There is no universal food, supplement, or lifestyle method that safely \u201cboosts\u201d WBCs. Management should address the cause.<\/li>\n\n\n\n<li>Fever during chemotherapy is a medical emergency. Contact the cancer care team immediately for a temperature of 100.4\u00b0F (38\u00b0C) or higher.<sup><a href=\"#ref-6\" aria-label=\"Reference 6\">6<\/a><\/sup><\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">On This Page<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"#what-wbc-measures\">What a WBC count measures<\/a><\/li>\n\n\n\n<li><a href=\"#differential-and-anc\">WBC differential, absolute counts, and ANC<\/a><\/li>\n\n\n\n<li><a href=\"#low-wbc-causes\">Common reasons for a low count<\/a><\/li>\n\n\n\n<li><a href=\"#high-wbc-causes\">Common reasons for a high count<\/a><\/li>\n\n\n\n<li><a href=\"#infection-limits\">What a CBC can and cannot say about infection<\/a><\/li>\n\n\n\n<li><a href=\"#follow-up\">A practical follow-up framework<\/a><\/li>\n\n\n\n<li><a href=\"#testing-options\">Testing options<\/a><\/li>\n\n\n\n<li><a href=\"#when-to-seek-care\">When to seek prompt or urgent care<\/a><\/li>\n\n\n\n<li><a href=\"#frequently-asked-questions\">Frequently asked questions<\/a><\/li>\n<\/ul>\n\n\n\n<h2 id=\"related-guides-heading\" class=\"wp-block-heading\">Start With These Related Guides<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.ultalabtests.com\/blog\/blood-disorders\/cbc-anemia-blood-tests\/\">CBC, Anemia, Iron, and Blood Cell Testing<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.ultalabtests.com\/blog\/lab-testing-knowledge-center\/complete-guide-to-lab-tests-and-blood-work\/\">Complete Guide to Lab Tests and Blood Work<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.ultalabtests.com\/blog\/lab-testing-knowledge-center\/how-to-read-lab-results\/\">How to Read and Understand Lab Results<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.ultalabtests.com\/blog\/lab-testing-knowledge-center\/direct-access-lab-testing\/\">Direct Access Lab Testing: What to Know<\/a><\/li>\n<\/ul>\n\n\n\n<h2 id=\"what-wbc-measures\" class=\"wp-block-heading\">What Does a White Blood Cell Count Measure?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">White blood cells, also called leukocytes, are produced mainly in bone marrow and participate in immune defense, inflammation, allergic responses, and tissue repair. A total WBC count reports how many white blood cells are present in a specified volume of blood. It does not show how well each cell functions and does not measure \u201cimmune strength.\u201d<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2025\/01\/How-Red-Blood-Cells-Help-Detect-Infections-and-Immune-Issues-2.jpg?quality=100&#038;ssl=1\" alt=\"Stylized red and white blood cells circulating together in a blood vessel\" style=\"aspect-ratio:16\/9;object-fit:cover\" title=\"Red and White Blood Cells in Circulation\"\/><figcaption class=\"wp-element-caption\">A CBC measures patterns across white blood cells, red blood cells, and platelets. Those patterns can guide follow-up, but they do not identify a specific infection by themselves.<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">A CBC reports the WBC count alongside red blood cell and platelet measurements. A CBC with differential also separates the five major types of white blood cells. Because a change in one subtype can alter the total\u2014and can make another subtype\u2019s percentage look lower or higher\u2014clinicians often look beyond percentages to the <strong>absolute number<\/strong> of each cell type.<sup><a href=\"#ref-1\" aria-label=\"Reference 1\">1<\/a>,<a href=\"#ref-2\" aria-label=\"Reference 2\">2<\/a><\/sup><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th scope=\"col\">Result<\/th><th scope=\"col\">What it reports<\/th><th scope=\"col\">How to use it<\/th><th scope=\"col\">Important limitation<\/th><\/tr><\/thead><tbody><tr><th scope=\"row\">Total WBC count<\/th><td>All white blood cells combined<\/td><td>Shows whether the total is within, above, or below that laboratory\u2019s reference interval<\/td><td>Does not show which subtype changed or why<\/td><\/tr><tr><th scope=\"row\">Differential percentage<\/th><td>The proportion of each major WBC type<\/td><td>Shows the distribution of cell types<\/td><td>A percentage can shift because another cell type changed<\/td><\/tr><tr><th scope=\"row\">Absolute subtype count<\/th><td>The measured or calculated number of a specific WBC type<\/td><td>Clarifies whether that cell type is truly high or low<\/td><td>Still requires clinical context and the report\u2019s interval<\/td><\/tr><tr><th scope=\"row\">ANC<\/th><td>The absolute number of circulating neutrophils<\/td><td>Helps assess neutropenia and infection risk in context<\/td><td>One value cannot establish the cause or predict every infection<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/wbc-count-differential-anc-comparison.webp?quality=100&#038;ssl=1\" alt=\"Comparison of total WBC count, differential percentage, absolute subtype count, and absolute neutrophil count\" title=\"WBC Count, Differential, Absolute Count, and ANC\"\/><figcaption class=\"wp-element-caption\">These four related results answer different questions. Reading them together gives more useful context than relying on the total WBC count or a percentage alone.<\/figcaption><\/figure>\n\n\n\n<h2 id=\"differential-and-anc\" class=\"wp-block-heading\">WBC Differential, Absolute Counts, and ANC<\/h2>\n\n\n\n<figure class=\"wp-block-image size-large\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/wbc-differential-cell-types-square.webp?resize=1024%2C1024&#038;quality=100&#038;ssl=1\" alt=\"Five visually distinct white blood cell types among red blood cells in a bloodstream\" class=\"wp-image-4209\" srcset=\"https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/wbc-differential-cell-types-square.webp?resize=1024%2C1024&amp;quality=100&amp;ssl=1 1024w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/wbc-differential-cell-types-square.webp?resize=300%2C300&amp;quality=100&amp;ssl=1 300w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/wbc-differential-cell-types-square.webp?resize=150%2C150&amp;quality=100&amp;ssl=1 150w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/wbc-differential-cell-types-square.webp?resize=768%2C768&amp;quality=100&amp;ssl=1 768w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/wbc-differential-cell-types-square.webp?resize=600%2C600&amp;quality=100&amp;ssl=1 600w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/wbc-differential-cell-types-square.webp?w=1200&amp;quality=100&amp;ssl=1 1200w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><figcaption class=\"wp-element-caption\">The WBC differential separates the five major white blood cell types so each subtype can be interpreted with its absolute count and clinical context.<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">The differential reports neutrophils, lymphocytes, monocytes, eosinophils, and basophils. Laboratories may report percentages, absolute counts, or both. The ANC is usually reported directly or derived from the total WBC count and neutrophil components. Use the value and units printed on your report; do not compare a result with a range from a different laboratory or with a value reported in different units.A white blood cell count shows a pattern. The differential and absolute neutrophil count add context, while symptoms, history, trends, and other tests help determine what the pattern means<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">The Five Major White Blood Cell Types<\/h3>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th scope=\"col\">Cell type<\/th><th scope=\"col\">General role<\/th><th scope=\"col\">Patterns that may prompt follow-up<\/th><\/tr><\/thead><tbody><tr><th scope=\"row\">Neutrophils<\/th><td>Rapid response to infection, inflammation, and tissue injury<\/td><td>High or low absolute neutrophil counts; immature forms; change from baseline<\/td><\/tr><tr><th scope=\"row\">Lymphocytes<\/th><td>Adaptive immune responses and immune memory<\/td><td>Persistent high or low absolute lymphocyte counts; atypical cells; symptoms<\/td><\/tr><tr><th scope=\"row\">Monocytes<\/th><td>Removal of microbes and damaged cells; regulation of inflammation<\/td><td>Persistent change, especially with other abnormal counts or symptoms<\/td><\/tr><tr><th scope=\"row\">Eosinophils<\/th><td>Participation in allergic disease and responses to some parasites<\/td><td>Degree and persistence of elevation, travel or exposure history, medicines, and symptoms<\/td><\/tr><tr><th scope=\"row\">Basophils<\/th><td>Release of inflammatory mediators in allergic and immune responses<\/td><td>A persistent absolute increase, particularly when other blood-cell results are abnormal<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"768\" src=\"https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/white-blood-cell-types-and-roles.webp?resize=1024%2C768&#038;quality=100&#038;ssl=1\" alt=\"Five white blood cell types with general roles for neutrophils, lymphocytes, monocytes, eosinophils, and basophils\" class=\"wp-image-4207\" srcset=\"https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/white-blood-cell-types-and-roles.webp?resize=1024%2C768&amp;quality=100&amp;ssl=1 1024w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/white-blood-cell-types-and-roles.webp?resize=300%2C225&amp;quality=100&amp;ssl=1 300w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/white-blood-cell-types-and-roles.webp?resize=768%2C576&amp;quality=100&amp;ssl=1 768w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/white-blood-cell-types-and-roles.webp?resize=1536%2C1152&amp;quality=100&amp;ssl=1 1536w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/white-blood-cell-types-and-roles.webp?w=1600&amp;quality=100&amp;ssl=1 1600w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><figcaption class=\"wp-element-caption\">Each white blood cell type has overlapping immune and inflammatory roles. Absolute counts and the total WBC pattern help put a differential percentage in context.<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">These associations are not one-to-one rules. For example, neutrophils may rise with infection, inflammation, corticosteroid exposure, tissue injury, or physiologic stress. A lymphocyte pattern cannot prove that an illness is viral. The differential narrows questions; it does not provide a stand-alone diagnosis.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Why the ANC Deserves Separate Attention<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Neutropenia means the ANC is below the applicable reference or clinical threshold. The practical significance depends on how low it is, how long it has been low, the person\u2019s baseline, symptoms, medical conditions, medicines, and current treatment. A falling ANC during chemotherapy is a different situation from a stable, mildly lower baseline in a person who feels well. International guidance therefore emphasizes history, repeat measurements when appropriate, medication review, other blood-cell lines, and targeted evaluation\u2014not an isolated number alone.<sup><a href=\"#ref-4\" aria-label=\"Reference 4\">4<\/a><\/sup><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Duffy-Null Associated Neutrophil Count (DANC)<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Some people with the Duffy-null phenotype have a lower baseline ANC without increased infection risk. The American Society of Hematology calls this Duffy-null associated neutrophil count, or DANC. Duffy status is a biological trait; race and ethnicity are not reliable substitutes. A clinician may consider this context when an otherwise well person has a stable lower ANC, but DANC should not be assumed solely from appearance, race, or ancestry\u2014and it should not be used to dismiss new symptoms or a changing blood count.<sup><a href=\"#ref-5\" aria-label=\"Reference 5\">5<\/a><\/sup><\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/duffy-null-associated-neutrophil-count.webp?resize=1024%2C576&#038;quality=100&#038;ssl=1\" alt=\"DANC infographic explaining a stable lower baseline ANC and the need for biological and clinical context\" class=\"wp-image-4205\" srcset=\"https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/duffy-null-associated-neutrophil-count.webp?resize=1024%2C576&amp;quality=100&amp;ssl=1 1024w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/duffy-null-associated-neutrophil-count.webp?resize=300%2C169&amp;quality=100&amp;ssl=1 300w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/duffy-null-associated-neutrophil-count.webp?resize=768%2C432&amp;quality=100&amp;ssl=1 768w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/duffy-null-associated-neutrophil-count.webp?resize=1536%2C864&amp;quality=100&amp;ssl=1 1536w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/duffy-null-associated-neutrophil-count.webp?w=1600&amp;quality=100&amp;ssl=1 1600w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><figcaption class=\"wp-element-caption\">DANC can be associated with a lower baseline ANC without increased infection risk. It should be assessed biologically and clinically\u2014not assumed from race, ethnicity, or appearance<\/figcaption><\/figure>\n\n\n\n<h2 id=\"low-wbc-causes\" class=\"wp-block-heading\">What Can Cause a Low White Blood Cell Count?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">A low total WBC count can result from fewer cells being produced, faster destruction or use of cells, redistribution between blood and tissues, or a lower healthy baseline. The differential helps show whether the decrease is mainly in neutrophils, lymphocytes, or another subtype.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Common Cause Categories<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Medicines and treatment:<\/strong> chemotherapy is a well-known cause, but other prescription medicines can also lower certain WBC types. Never stop a medicine based on a lab result without instructions from the prescriber.<\/li>\n\n\n\n<li><strong>Recent or ongoing infection:<\/strong> some infections can temporarily lower counts. The organism cannot be identified from the WBC pattern alone.<\/li>\n\n\n\n<li><strong>Autoimmune or inflammatory conditions:<\/strong> these can affect production, survival, or distribution of white blood cells.<\/li>\n\n\n\n<li><strong>Bone marrow or blood disorders:<\/strong> concern rises when the change is persistent, substantial, accompanied by abnormal or immature cells, or paired with low red blood cells or platelets.<\/li>\n\n\n\n<li><strong>Selected nutritional deficiencies:<\/strong> vitamin B12, folate, and copper deficiency can contribute to abnormal blood-cell production in the right setting. Nutritional testing should be driven by history and the broader CBC pattern rather than ordered as a universal WBC panel. Copper deficiency, although uncommon, is a recognized cause of leukopenia and neutropenia.<sup><a href=\"#ref-4\" aria-label=\"Reference 4\">4<\/a>,<a href=\"#ref-7\" aria-label=\"Reference 7\">7<\/a><\/sup><\/li>\n\n\n\n<li><strong>Inherited or constitutional patterns:<\/strong> these include DANC and other chronic neutropenia syndromes. Baseline history and longitudinal results matter.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">One low result may be transient or may reflect normal biological and laboratory variation. A repeat test can sometimes confirm whether the change persists, but timing should match the clinical situation. A person with fever, significant symptoms, active chemotherapy, or a critical laboratory alert should not wait for a routine repeat test.<\/p>\n\n\n\n<h2 id=\"high-wbc-causes\" class=\"wp-block-heading\">What Can Cause a High White Blood Cell Count?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">A high total WBC count can occur when the body releases or produces more white cells. The most useful next question is often: <em>which cell type is high, and what else is happening?<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Infection or inflammation:<\/strong> common possibilities, but not the only ones.<\/li>\n\n\n\n<li><strong>Medicines:<\/strong> corticosteroids and some other medicines can change WBC patterns.<\/li>\n\n\n\n<li><strong>Physiologic stress or tissue injury:<\/strong> surgery, trauma, burns, and other acute stressors can raise the count.<\/li>\n\n\n\n<li><strong>Smoking, pregnancy, and recent intense activity:<\/strong> these can influence results and should be included in the interpretation.<\/li>\n\n\n\n<li><strong>Allergic or parasitic conditions:<\/strong> these are among the contexts considered when eosinophils are elevated, but the differential cannot identify the trigger by itself.<\/li>\n\n\n\n<li><strong>Bone marrow or blood disorders:<\/strong> persistent or marked abnormalities, immature cells, or changes in red blood cells and platelets may require clinician or hematology evaluation.<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-large\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"768\" src=\"https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/high-low-white-blood-cell-count-causes.webp?resize=1024%2C768&#038;quality=100&#038;ssl=1\" alt=\"Side-by-side categories of common contexts associated with low and high white blood cell counts\" class=\"wp-image-4206\" srcset=\"https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/high-low-white-blood-cell-count-causes.webp?resize=1024%2C768&amp;quality=100&amp;ssl=1 1024w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/high-low-white-blood-cell-count-causes.webp?resize=300%2C225&amp;quality=100&amp;ssl=1 300w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/high-low-white-blood-cell-count-causes.webp?resize=768%2C576&amp;quality=100&amp;ssl=1 768w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/high-low-white-blood-cell-count-causes.webp?resize=1536%2C1152&amp;quality=100&amp;ssl=1 1536w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/high-low-white-blood-cell-count-causes.webp?w=1600&amp;quality=100&amp;ssl=1 1600w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><figcaption class=\"wp-element-caption\">High and low WBC counts each have several possible explanations. The subtype, other CBC findings, symptoms, medicines, and trend help narrow the question.<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">High does not automatically mean dangerous, and low does not automatically mean harmless. Magnitude, persistence, symptoms, subtype, and the rest of the CBC determine the urgency of follow-up.<sup><a href=\"#ref-3\" aria-label=\"Reference 3\">3<\/a><\/sup><\/p>\n\n\n\n<h2 id=\"infection-limits\" class=\"wp-block-heading\">Can a CBC Detect an Infection?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>A CBC can show a blood-cell pattern that is compatible with infection, but it cannot confirm that an infection is present, identify a pathogen, locate the infection, or reliably distinguish a bacterial illness from a viral one by itself.<\/strong> Some people with infection have a normal total WBC count. Some people without infection have a high or low count because of medicine, inflammation, treatment, pregnancy, smoking, physiologic stress, or a blood disorder.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table>\n      <caption>What CBC and WBC results can and cannot do<\/caption>\n      <thead>\n        <tr>\n          <th scope=\"col\">They can help<\/th>\n          <th scope=\"col\">They cannot do alone<\/th>\n        <\/tr>\n      <\/thead>\n      <tbody>\n        <tr>\n          <td>Show whether the total count and cell subtypes are above or below the reporting laboratory\u2019s interval<\/td>\n          <td>Name the bacterium, virus, fungus, or parasite causing an illness<\/td>\n        <\/tr>\n        <tr>\n          <td>Reveal whether red blood cells or platelets are also abnormal<\/td>\n          <td>Determine where an infection is located<\/td>\n        <\/tr>\n        <tr>\n          <td>Provide a baseline and show trends during illness or treatment<\/td>\n          <td>Prove that an illness is bacterial or viral<\/td>\n        <\/tr>\n        <tr>\n          <td>Help a clinician decide whether more targeted evaluation is appropriate<\/td>\n          <td>Replace symptoms, examination, cultures, molecular tests, imaging, or clinical judgment<\/td>\n        <\/tr>\n      <\/tbody>\n    <\/table><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/cbc-infection-testing-limits.webp?resize=1024%2C576&#038;quality=100&#038;ssl=1\" alt=\"Two-column comparison of what a CBC can support and what it cannot determine about infection by itself\" class=\"wp-image-4204\" srcset=\"https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/cbc-infection-testing-limits.webp?resize=1024%2C576&amp;quality=100&amp;ssl=1 1024w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/cbc-infection-testing-limits.webp?resize=300%2C169&amp;quality=100&amp;ssl=1 300w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/cbc-infection-testing-limits.webp?resize=768%2C432&amp;quality=100&amp;ssl=1 768w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/cbc-infection-testing-limits.webp?resize=1536%2C864&amp;quality=100&amp;ssl=1 1536w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/cbc-infection-testing-limits.webp?w=1600&amp;quality=100&amp;ssl=1 1600w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><figcaption class=\"wp-element-caption\">A CBC can reveal blood-cell patterns and trends, but it cannot identify a pathogen, locate an infection, or prove that an illness is bacterial or viral by itself.<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">For a broader explanation of choosing tests based on the suspected organism and body site, see <a href=\"https:\/\/www.ultalabtests.com\/blog\/infectious-disease\/iinfectious-disease-testing\/\">Infectious Disease Testing<\/a>.<\/p>\n\n\n\n<h2 id=\"follow-up\" class=\"wp-block-heading\">How to Follow Up a High or Low WBC Result<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The sequence below is educational and does not replace individualized care. The safest next step depends on symptoms and clinical context.<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong>Check urgency first.<\/strong> Look for a critical-value notice, active chemotherapy, fever, chills, shortness of breath, confusion, severe weakness, rapidly worsening illness, or other concerning symptoms. Follow the laboratory\u2019s and clinician\u2019s instructions immediately.<\/li>\n\n\n\n<li><strong>Identify what is actually abnormal.<\/strong> Is the total WBC high or low? Which absolute subtype count changed? What is the ANC? Are hemoglobin, red-cell indices, or platelets also abnormal?<\/li>\n\n\n\n<li><strong>Use the correct reference interval and units.<\/strong> Read the interval printed on the same report. Intervals vary with method, laboratory, age, pregnancy, and other factors.<\/li>\n\n\n\n<li><strong>Compare with prior results.<\/strong> A new shift, a progressive trend, and a stable personal baseline are different patterns.<\/li>\n\n\n\n<li><strong>Review context.<\/strong> Note recent illness, new symptoms, prescriptions, over-the-counter medicines, supplements, chemotherapy or radiation, pregnancy, smoking, recent surgery or injury, and intense activity near the blood draw.<\/li>\n\n\n\n<li><strong>Confirm persistence when appropriate.<\/strong> A clinician may recommend a repeat CBC with differential after a transient trigger has passed or sooner if the pattern warrants it.<\/li>\n\n\n\n<li><strong>Choose targeted follow-up.<\/strong> Depending on the pattern, evaluation may include selected nutrient tests, infection testing chosen for symptoms and exposure, review of blood-cell appearance, or specialist testing. Broad immune, autoimmune, or inflammation panels are not a universal next step for every abnormal WBC count.<\/li>\n\n\n\n<li><strong>Escalate persistent or complex findings.<\/strong> Abnormal or immature cells, multiple affected cell lines, persistent changes, or unexplained symptoms may require evaluation by a clinician or hematology specialist.<\/li>\n<\/ol>\n\n\n\n<figure class=\"wp-block-image size-full\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/wbc-result-follow-up-pathway.webp?quality=100&#038;ssl=1\" alt=\"Eight-step pathway for following up a high or low WBC result, beginning with urgency and ending with complex findings\" title=\"High or Low WBC Result Follow-Up Pathway\"\/><figcaption class=\"wp-element-caption\">Start with urgency, identify the exact abnormality, compare the correct interval and prior results, then choose targeted follow-up based on the full context.<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"768\" src=\"https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/wbc-result-follow-up-pathway.webp?resize=1024%2C768&#038;quality=100&#038;ssl=1\" alt=\"Eight-step pathway for following up a high or low WBC result, beginning with urgency and ending with complex findings\" class=\"wp-image-4203\" srcset=\"https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/wbc-result-follow-up-pathway.webp?resize=1024%2C768&amp;quality=100&amp;ssl=1 1024w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/wbc-result-follow-up-pathway.webp?resize=300%2C225&amp;quality=100&amp;ssl=1 300w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/wbc-result-follow-up-pathway.webp?resize=768%2C576&amp;quality=100&amp;ssl=1 768w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/wbc-result-follow-up-pathway.webp?resize=1536%2C1152&amp;quality=100&amp;ssl=1 1536w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/wbc-result-follow-up-pathway.webp?w=1600&amp;quality=100&amp;ssl=1 1600w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><figcaption class=\"wp-element-caption\">Start with urgency, identify the exact abnormality, compare the correct interval and prior results, then choose targeted follow-up based on the full context.<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">For help reading flags, units, reference intervals, and trends, use the <a href=\"https:\/\/www.ultalabtests.com\/blog\/lab-testing-knowledge-center\/how-to-read-lab-results\/\">How to Read and Understand Lab Results<\/a> guide.<\/p>\n\n\n\n<h2 id=\"testing-options\" class=\"wp-block-heading\">Which Blood Test Matches the Question?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Choose the narrowest test that answers the question, while recognizing when the broader CBC context matters. The linked Ulta Lab Tests pages below were verified during this update. Review each current product page for specimen and preparation instructions before ordering.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table>\n      <caption>WBC and targeted follow-up testing options<\/caption>\n      <thead>\n        <tr>\n          <th scope=\"col\">Test<\/th>\n          <th scope=\"col\">What it measures<\/th>\n          <th scope=\"col\">When it may fit<\/th>\n          <th scope=\"col\">What it cannot determine alone<\/th>\n        <\/tr>\n      <\/thead>\n      <tbody>\n        <tr>\n          <th scope=\"row\"><a href=\"https:\/\/www.ultalabtests.com\/test\/white-blood-cell-count-wbc\">White Blood Cell Count (Total)<\/a><\/th>\n          <td>Total WBC count<\/td>\n          <td>A focused total-count check when other CBC components are not needed<\/td>\n          <td>Which WBC subtype changed or why<\/td>\n        <\/tr>\n        <tr>\n          <th scope=\"row\"><a href=\"https:\/\/www.ultalabtests.com\/test\/white-blood-cell-count-test-with-differential\">White Blood Cell Count with Differential<\/a><\/th>\n          <td>Total WBC count plus the major WBC types<\/td>\n          <td>Clarifying whether a total-count change is driven by neutrophils, lymphocytes, monocytes, eosinophils, or basophils<\/td>\n          <td>A specific infection, immune disorder, or blood disorder<\/td>\n        <\/tr>\n        <tr>\n          <th scope=\"row\"><a href=\"https:\/\/www.ultalabtests.com\/test\/complete-blood-count-with-differential-and-platelets-cbc-test\/\">Complete Blood Count with Differential and Platelets<\/a><\/th>\n          <td>WBCs and differential, red blood cells and indices, hemoglobin, hematocrit, and platelets<\/td>\n          <td>A broader blood-cell baseline or follow-up when more than the total WBC count matters<\/td>\n          <td>The cause of an abnormal result<\/td>\n        <\/tr>\n        <tr>\n          <th scope=\"row\"><a href=\"https:\/\/www.ultalabtests.com\/test\/vitamin-b12-test\">Vitamin B12 Test<\/a><\/th>\n          <td>Blood vitamin B12 concentration<\/td>\n          <td>Targeted evaluation when history, diet, absorption risk, symptoms, or CBC pattern raises concern for deficiency<\/td>\n          <td>Whether B12 explains an isolated WBC result without the rest of the clinical picture<\/td>\n        <\/tr>\n        <tr>\n          <th scope=\"row\"><a href=\"https:\/\/www.ultalabtests.com\/test\/folate-serum-test\">Folate Serum Test<\/a><\/th>\n          <td>Serum folate concentration<\/td>\n          <td>Targeted evaluation of suspected folate deficiency<\/td>\n          <td>The cause of leukopenia by itself<\/td>\n        <\/tr>\n        <tr>\n          <th scope=\"row\"><a href=\"https:\/\/www.ultalabtests.com\/test\/copper-test\">Copper Test<\/a><\/th>\n          <td>Blood copper concentration<\/td>\n          <td>Selected cases with compatible history or blood-cell and neurologic findings, including malabsorption or excess zinc exposure<\/td>\n          <td>Whether a supplement is appropriate or safe<\/td>\n        <\/tr>\n      <\/tbody>\n    <\/table><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"768\" src=\"https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/white-blood-cell-test-selection.webp?resize=1024%2C768&#038;quality=100&#038;ssl=1\" alt=\"Comparison of total WBC count, WBC differential, CBC with differential and platelets, and targeted nutrient tests\" class=\"wp-image-4202\" srcset=\"https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/white-blood-cell-test-selection.webp?resize=1024%2C768&amp;quality=100&amp;ssl=1 1024w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/white-blood-cell-test-selection.webp?resize=300%2C225&amp;quality=100&amp;ssl=1 300w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/white-blood-cell-test-selection.webp?resize=768%2C576&amp;quality=100&amp;ssl=1 768w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/white-blood-cell-test-selection.webp?resize=1536%2C1152&amp;quality=100&amp;ssl=1 1536w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/white-blood-cell-test-selection.webp?w=1600&amp;quality=100&amp;ssl=1 1600w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><figcaption class=\"wp-element-caption\">Match the test to the question. A total WBC count is narrow, a CBC with differential provides broader blood-cell context, and nutrient tests are targeted\u2014not universal WBC panels.<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">A total WBC count is narrower than a differential. A CBC with differential is broader because it also shows red-cell and platelet patterns. That broader view can be important when more than one blood-cell line is affected. If the concern is a specific infection, select testing based on symptoms, timing, body site, and exposure\u2014not from the WBC pattern alone.<\/p>\n\n\n\n<h2 id=\"can-you-increase-wbc\" class=\"wp-block-heading\">Can You Increase White Blood Cells?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">There is no universal, evidence-based way to increase a WBC count with a particular food, supplement, exercise plan, sleep schedule, or stress-reduction technique. Those measures may support general health, but they should not be presented as treatments for leukopenia or neutropenia.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img data-recalc-dims=\"1\" decoding=\"async\" src=\"https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2023\/11\/How-to-Increase-White-Blood-Cells.jpg?quality=100&#038;ssl=1\" alt=\"Person seated at home beside stylized blood cells, representing general wellness while a low white blood cell count is evaluated\" style=\"aspect-ratio:4\/3;object-fit:cover\" title=\"General Wellness and Cause-Directed WBC Follow-Up\"\/><figcaption class=\"wp-element-caption\">Healthy routines can support general well-being, but no food, supplement, or lifestyle method reliably raises white blood cells for everyone. Follow-up should address the cause of the abnormal result.<\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">The right response is cause-directed. That may mean monitoring a transient change, treating an identified condition, correcting a confirmed deficiency, or having a prescriber reassess a medicine. In selected medical settings, clinicians may use prescription treatment to stimulate neutrophil production. That decision depends on the cause, expected benefit, and risks; it is not a self-treatment strategy.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Do not start high-dose vitamin or mineral supplements simply to change a WBC result. Too much of a nutrient can be harmful, and supplementation can obscure the underlying question. Copper is a good example: deficiency can affect blood counts, but excess copper can be toxic, and high zinc intake can contribute to copper deficiency. Test and treat in context.<sup><a href=\"#ref-7\" aria-label=\"Reference 7\">7<\/a><\/sup><\/p>\n\n\n\n<h2 id=\"preparation-and-trends\" class=\"wp-block-heading\">Preparation, Repeat Testing, and Trends<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Follow the exact test-page instructions.<\/strong> A CBC or differential usually does not require special preparation, but another test collected at the same time may. Some nutrient-test instructions may differ.<\/li>\n\n\n\n<li><strong>Do not stop medicines or supplements on your own.<\/strong> Ask the prescriber or testing service if a product could affect the result or preparation.<\/li>\n\n\n\n<li><strong>Record relevant context.<\/strong> Recent illness, intense activity, smoking, pregnancy, surgery, injury, treatment, and medicine changes can help explain a shift.<\/li>\n\n\n\n<li><strong>Compare like with like.<\/strong> Use the same units and, when practical, the same laboratory method when evaluating trends.<\/li>\n\n\n\n<li><strong>Look at the whole CBC.<\/strong> WBC findings may mean something different when hemoglobin or platelets are also abnormal.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Direct-access testing can provide useful data, but it does not replace urgent care or medical evaluation. Learn more in <a href=\"https:\/\/www.ultalabtests.com\/blog\/lab-testing-knowledge-center\/direct-access-lab-testing\/\">Direct Access Lab Testing: What to Know<\/a>.<\/p>\n\n\n\n<h2 id=\"when-to-seek-care\" class=\"wp-block-heading\">When to Seek Prompt or Urgent Care<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Do not use an online article or a repeat lab order to delay care when symptoms are concerning.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>During chemotherapy:<\/strong> a temperature of 100.4\u00b0F (38\u00b0C) or higher is a medical emergency. Contact the cancer care team immediately, even if the WBC result is not yet available.<sup><a href=\"#ref-6\" aria-label=\"Reference 6\">6<\/a><\/sup><\/li>\n\n\n\n<li><strong>With known or suspected neutropenia:<\/strong> fever, chills, a new cough, shortness of breath, painful urination, mouth sores, confusion, rapidly worsening symptoms, or redness and swelling can require prompt assessment.<\/li>\n\n\n\n<li><strong>With any result:<\/strong> follow a laboratory critical-value notification or clinician instruction immediately.<\/li>\n\n\n\n<li><strong>Emergency symptoms:<\/strong> call emergency services for severe breathing difficulty, chest pain, fainting, new confusion, blue or gray lips, or signs of severe illness.<\/li>\n\n\n\n<li><strong>Prompt clinical follow-up:<\/strong> arrange review for persistent abnormalities, unexplained fever, recurrent infections, unintentional weight loss, drenching night sweats, unusual bruising or bleeding, swollen lymph nodes, abnormal or immature cells, or changes across several blood-cell lines.<\/li>\n<\/ul>\n\n\n\n<figure class=\"wp-block-image size-large\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/low-wbc-urgent-care-signs.webp?resize=1024%2C576&#038;quality=100&#038;ssl=1\" alt=\"Urgent-care signs for chemotherapy with fever, neutropenia with illness, critical lab notices, and emergency symptoms\" class=\"wp-image-4201\" srcset=\"https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/low-wbc-urgent-care-signs.webp?resize=1024%2C576&amp;quality=100&amp;ssl=1 1024w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/low-wbc-urgent-care-signs.webp?resize=300%2C169&amp;quality=100&amp;ssl=1 300w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/low-wbc-urgent-care-signs.webp?resize=768%2C432&amp;quality=100&amp;ssl=1 768w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/low-wbc-urgent-care-signs.webp?resize=1536%2C864&amp;quality=100&amp;ssl=1 1536w, https:\/\/i0.wp.com\/www.ultalabtests.com\/blog\/wp-content\/uploads\/2026\/09\/low-wbc-urgent-care-signs.webp?w=1600&amp;quality=100&amp;ssl=1 1600w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><figcaption class=\"wp-element-caption\">Symptoms and treatment context can be more urgent than the number itself. Fever during chemotherapy, a critical-value notice, or severe symptoms should never wait for routine retesting.<\/figcaption><\/figure>\n\n\n\n<h2 id=\"questions-for-clinician\" class=\"wp-block-heading\">Questions to Ask About Your Result<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Is the total WBC count abnormal, or is one absolute subtype count driving the flag?<\/li>\n\n\n\n<li>What is my ANC, and how does it affect the urgency of follow-up in my situation?<\/li>\n\n\n\n<li>Are red blood cells, hemoglobin, or platelets also abnormal?<\/li>\n\n\n\n<li>How does this compare with my prior results and usual baseline?<\/li>\n\n\n\n<li>Could a recent illness, medicine, treatment, pregnancy, smoking, injury, or intense activity explain the change?<\/li>\n\n\n\n<li>Should the test be repeated, and if so, when?<\/li>\n\n\n\n<li>Do my history and CBC pattern support targeted nutrient or infection testing?<\/li>\n\n\n\n<li>Which symptoms or temperature should prompt an immediate call or emergency care?<\/li>\n<\/ul>\n\n\n\n<h2 id=\"frequently-asked-questions\" class=\"wp-block-heading\">Frequently Asked Questions<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Does a high white blood cell count always mean infection?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">No. Infection is one possible cause, but inflammation, corticosteroids and other medicines, smoking, pregnancy, tissue injury, physiologic stress, and some blood or bone marrow disorders can also raise the count. The differential, absolute counts, symptoms, and trend help determine what to investigate.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Does a normal WBC count rule out infection?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">No. A person can have an infection with a WBC count inside the reporting laboratory\u2019s reference interval. Diagnosis may depend on symptoms, examination, exposure, the body site involved, and targeted testing. A normal CBC should not override concerning symptoms.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Can a CBC tell whether an infection is bacterial or viral?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Not reliably. Certain differential patterns may be more common in some illnesses, but there is substantial overlap. A CBC cannot identify a pathogen. Clinicians choose cultures, molecular tests, antigen tests, or other evaluations based on the clinical question.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What is the difference between WBC count and ANC?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The WBC count includes all white blood cell types. The ANC focuses on neutrophils. When neutrophils are low, the ANC is often more useful than the total count for assessing infection risk, but it still needs context such as symptoms, treatment, duration, and baseline.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Is a low WBC count always dangerous?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">No. Some results are temporary, mild, or normal for the individual. Risk depends on which cell type is low, how low and persistent it is, symptoms, medicines, medical conditions, and whether other blood cells are affected. Fever or illness with neutropenia deserves prompt attention.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What foods or supplements increase white blood cells?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">No single food or supplement is proven to safely raise WBCs across all causes. If testing confirms a deficiency that affects blood-cell production, targeted treatment may be appropriate under clinical guidance. Taking high doses without evidence of deficiency can cause harm and may delay the correct evaluation.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Can stress, exercise, smoking, or medicine change a WBC count?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Yes. Physiologic stress, recent intense activity, smoking, corticosteroids, chemotherapy, and other medicines can affect the total count or differential. Report these factors when interpreting an unexpected result. Never stop a prescribed medicine without speaking with the prescriber.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Should an abnormal WBC count be repeated?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Sometimes. Repeating the test can show whether a result was transient or persistent, but the appropriate timing depends on the value, symptoms, recent illness, treatment, and other CBC findings. Critical values, chemotherapy fever, or significant symptoms need immediate guidance rather than routine retesting.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">What is Duffy-null associated neutrophil count?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">DANC is a lower baseline ANC associated with the Duffy-null phenotype and is not linked to increased infection risk. It should be considered using biological and clinical context, not assumed from race or ethnicity. A new change or symptoms still require appropriate evaluation.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">When is a low WBC result an emergency?<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The result alone does not define every emergency. Fever during chemotherapy is an emergency at 100.4\u00b0F (38\u00b0C) or higher. Fever or rapidly worsening infection symptoms with known or suspected neutropenia, a critical-value alert, severe breathing difficulty, chest pain, fainting, or confusion requires immediate guidance or emergency care.<\/p>\n\n\n\n<h2 id=\"main-takeaways\" class=\"wp-block-heading\">Main Takeaways<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">A white blood cell count is most useful as part of a pattern. Start with the total count, then review the differential, absolute subtype counts, ANC, other CBC components, symptoms, medicines, and trend. Do not use the result to self-diagnose a specific infection or to choose supplements. Use targeted testing and clinical follow-up when the pattern calls for it, and treat chemotherapy fever or serious symptoms as urgent.<\/p>\n\n\n\n<h2 id=\"related-health-areas\" class=\"wp-block-heading\">Related Health Areas<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.ultalabtests.com\/blog\/blood-disorders\/cbc-anemia-blood-tests\/\">CBC, Anemia, Iron, and Blood Cell Testing<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.ultalabtests.com\/blog\/infectious-disease\/iinfectious-disease-testing\/\">Infectious Disease Testing<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.ultalabtests.com\/blog\/inflammation\/inflammation-autoimmune-blood-tests\/\">Inflammation and Autoimmune Blood Tests<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.ultalabtests.com\/blog\/nutrition\/vitamin-nutrient-deficiency-tests\/\">Vitamin and Nutrient Deficiency Testing<\/a><\/li>\n<\/ul>\n\n\n\n<h2 id=\"references\" class=\"wp-block-heading\">References<\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li id=\"ref-1\"><a href=\"https:\/\/medlineplus.gov\/lab-tests\/complete-blood-count-cbc\/\" target=\"_blank\" rel=\"noopener noreferrer\">MedlinePlus. Complete Blood Count (CBC)<\/a>. U.S. National Library of Medicine. Reviewed October 15, 2024. Accessed September 2, 2026.<\/li>\n\n\n\n<li id=\"ref-2\"><a href=\"https:\/\/medlineplus.gov\/lab-tests\/blood-differential\/\" target=\"_blank\" rel=\"noopener noreferrer\">MedlinePlus. Blood Differential<\/a>. U.S. National Library of Medicine. Reviewed October 9, 2024. Accessed September 2, 2026.<\/li>\n\n\n\n<li id=\"ref-3\"><a href=\"https:\/\/medlineplus.gov\/lab-tests\/white-blood-count-wbc\/\" target=\"_blank\" rel=\"noopener noreferrer\">MedlinePlus. White Blood Count (WBC)<\/a>. U.S. National Library of Medicine. Reviewed August 6, 2024. Accessed September 2, 2026.<\/li>\n\n\n\n<li id=\"ref-4\">Fioredda F, et al. <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10065839\/\" target=\"_blank\" rel=\"noopener noreferrer\">The European Guidelines on Diagnosis and Management of Neutropenia in Adults and Children<\/a>. <em>HemaSphere<\/em>. 2023;7:e872. doi:10.1097\/HS9.0000000000000872.<\/li>\n\n\n\n<li id=\"ref-5\"><a href=\"https:\/\/www.hematology.org\/education\/danc\" target=\"_blank\" rel=\"noopener noreferrer\">American Society of Hematology. Duffy-null Associated Neutrophil Count (DANC)<\/a>. Accessed September 2, 2026.<\/li>\n\n\n\n<li id=\"ref-6\"><a href=\"https:\/\/www.cdc.gov\/cancer-preventing-infections\/patients\/fever.html\" target=\"_blank\" rel=\"noopener noreferrer\">Centers for Disease Control and Prevention. Watch Out for Fever<\/a>. November 14, 2024. Accessed September 2, 2026.<\/li>\n\n\n\n<li id=\"ref-7\">Lazarchick J. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22080848\/\" target=\"_blank\" rel=\"noopener noreferrer\">Update on Anemia and Neutropenia in Copper Deficiency<\/a>. <em>Current Opinion in Hematology<\/em>. 2012;19(1):58-60. doi:10.1097\/MOH.0b013e32834da9d2.<\/li>\n<\/ol>\n\n\n\n<h2 class=\"wp-block-heading\">Editorial and Commercial Disclosure<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">This article is for educational purposes and does not diagnose, treat, or replace medical advice. Ulta Lab Tests is a direct-to-consumer laboratory testing service. When you purchase a test through links in this article, Ulta Lab Tests may receive revenue from that purchase. Test availability and requirements can change; review the current product page before ordering. Seek urgent medical care when symptoms or your treatment team\u2019s instructions indicate it.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><small>Update note: This article replaced advice about \u201cincreasing\u201d white blood cells with cause-based interpretation; clarified that CBC patterns do not identify a specific infection; added WBC differential, absolute-count, ANC, and DANC guidance; and consolidated relevant material from the retired article about red and white blood cell counts.<\/small><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Originally published:<\/strong> December 6, 2023 | <strong>Substantively updated:<\/strong> September 3, 2026<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A white blood cell count measures the total number of white blood cells in a blood sample. A high result is called leukocytosis; a low result is called leukopenia. Neither result names a cause by [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":4217,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"om_disable_all_campaigns":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[40,57,47,45,180,433,194,196,216,211,248],"tags":[5993,5990,4510,1337,5992,5986,5985,5991,5987,5989,5988,5491],"class_list":["post-686","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-autoimmune","category-blood-chemistry-disorder","category-blood-count","category-blood-disorders","category-infectious-disease","category-all-infectious-disease","category-inflammation","category-all-inflammation","category-micronutrients-nutrition","category-nutrition","category-all-nutrition","tag-absolute-neutrophil-count","tag-blood-cell-testing","tag-blood-test-results","tag-complete-blood-count","tag-duffy-null-associated-neutrophil-count","tag-high-white-blood-cell-count","tag-leukocytosis","tag-leukopenia","tag-low-white-blood-cell-count","tag-neutropenia","tag-wbc-differential","tag-white-blood-cell-count"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.3 (Yoast SEO v28.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>High and Low White Blood Cell Counts: WBC Differential, ANC, Causes, and Follow-Up | Ulta Lab Tests<\/title>\n<meta name=\"description\" content=\"Review white blood cell count results: low white blood cell count, high white blood cell count, WBC differential, ANC, causes, and follow-up.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ultalabtests.com\/blog\/blood-disorders\/how-to-increase-white-blood-cells\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"High and Low White Blood Cell Counts: WBC Differential, ANC, Causes, and Follow-Up\" \/>\n<meta property=\"og:description\" content=\"Review white blood cell 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