Ugt1a1 Gene Polymorphism (Ta Repeat)

The Ugt1a1 Gene Polymorphism (Ta Repeat) test contains 1 test with 1 biomarker.

Uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) is primarily responsible for the glucuronidation and detoxification of SN-38, the active metabolite of irinotecan (Camptosar), used in the treatment of colorectal cancer. The TA-7 variant referred to as UGT1A1*28, is associated with reduced SN-38 glucuronidation and increased toxicity. Individuals homozygous for the UGT1A1*28 (TA-7) allele have Gilbert syndrome which is a mild form of hyperbilirubinemia.

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Also known as: Ugt1a1 Gene Polymorphism Ta Repeat

Ugt1a1 Ta Repeat