UGT1A1 Genotyping

The UGT1A1 Genotyping test contains 1 test with 1 biomarker.

Uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) is primarily responsible for the glucuronidation and detoxification of SN-38, the active metabolite of irinotecan (Camptosar), used in the treatment of colorectal cancer. The TA-7 variant referred to as UGT1A1*28, is associated with reduced SN-38 glucuronidation and increased toxicity. Individuals homozygous for the UGT1A1*28 (TA-7) allele have Gilbert syndrome which is a mild form of hyperbilirubinemia.

The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Result

*Process times are an estimate and are not guaranteed. The lab may need additional time due to weather, holidays, confirmation/repeat testing, or equipment maintenance.