The Plasma Renin Activity, LC/MS/MS test contains 1 test with 1 biomarker.
Renin plays a central role in maintaining blood pressure by enzymatically converting angiotensinogen to angiotensin I, which is then cleaved by angiotensin converting enzyme to form angiotensin II. Angiotensin II increases blood pressure directly through vasoconstriction and indirectly by stimulating secretion of aldosterone, a hormone that promotes sodium retention and potassium loss. Renin secretion is inhibited by high blood pressure and stimulated by factors that lower blood pressure, such as upright posture and sodium deprivation. A variety of drug classes also physiologically affect plasma renin activity (PRA) levels (Table). PRA is typically used in conjunction with the measurement of aldosterone, sodium, and potassium levels in plasma and/or urine.