ADAMTS13 Activity with Reflex to Inhibitor

The ADAMTS13 Activity with Reflex to Inhibitor test contains 1 test with 1 biomarker.

ADAMTS-13 is a zinc metalloprotease that cleaves ultra large vWF multimers. Studies have shown that low levels of ADAMTS-13 activity are associated with thrombotic thrombocytopenic purpura (TTP), a life-threatening hematological condition characterized by a low platelet count, microvascular thrombi, red cell fragmentation, and renal complications. Congenital TTP is a rare inherited disease caused by mutations within the ADAMTS-13 gene, which result in the production of non-functional protein. The acquired form of TTP is an autoimmune-like disorder caused by the development of autoantibodies to ADAMTS-13 that inhibits enzyme activity.  

Additional test processing fees will be charged if initial results dictate Reflex (further) testing.

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The following is a list of what is included in the item above. Click the test(s) below to view what biomarkers are measured along with an explanation of what the biomarker is measuring.

Also known as: von Willebrand Factor Protease Activity (ADAMTS-13, VWF Cleaving Protease (vWF-CP), VWF Cleaving Protease (vWF-CP)(ADAMTS-13), vWF Protease Activity (ADAMTS-13)

Adamts13 Activity

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